D:Experimental Diabetes Mellitus

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Disease Term
Synonyms Alloxan Diabetes, Diabete Streptozocin, DIABETES ALLOXAN, Diabetes Streptozocin, Diabetes Streptozotocin, Streptozocin Diabete, Streptozocin Diabetes, Streptozotocin Diabetes
Documents 21
Hot Single Events 23
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Experimental Diabetes Mellitus. They are ordered first by their relevance to Experimental Diabetes Mellitus and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT34949 Ins1 Positive_regulation of Negative_regulation of B3gat3 1 0.01 0.49 0.17 94.60
2 INT34950 Ins1 Positive_regulation of B3gat3 1 0.01 0.49 0.17 94.60
3 INT184543 Agt Positive_regulation of Ccl2 1 0.16 3.18 0.43 5.00
4 INT184540 Agt Regulation of Gene_expression of Ccl2 1 0.08 1.66 0.18 5.00
5 INT224040 Mtpn Positive_regulation of P2RY1 1 0.00 0.85 0.12 5.00
6 INT224026 P2RY6 Positive_regulation of NRP2 1 0.10 0.98 0.1 5.00
7 INT224021 PIK3CG Negative_regulation of EPHB2 1 0.03 0.5 0.09 5.00
8 INT184537 Ccl2 Positive_regulation of Spp1 1 0.34 1.37 0.09 5.00
9 INT184542 Positive_regulation of Ccl2 Positive_regulation of Gpbar1 1 0.10 1.39 0.09 5.00
10 INT184538 Positive_regulation of Ccl2 Positive_regulation of Spp1 1 0.34 1.38 0.09 5.00
11 INT184541 Ccl2 Positive_regulation of Gpbar1 1 0.10 1.37 0.09 5.00
12 INT224020 MAPK1 Negative_regulation of EPHB2 1 0.08 0.56 0.09 5.00
13 INT184539 Spp1 Positive_regulation of Gpbar1 1 0.03 1.37 0.09 5.00
14 INT319700 Ins1 Negative_regulation of Lipe 1 0.04 1.22 0.03 5.00
15 INT224022 Binding of P2RY6 and WDTC1 1 0.01 0.7 0 5.00
16 INT224024 Binding of P2RX1 and WDTC1 1 0.01 0.71 0 5.00
17 INT224023 Binding of GOPC and P2RY12 1 0.02 0.69 0 5.00
18 INT224027 Binding of P2RX1 and P2RY12 1 0.10 0.71 0 5.00
19 INT224028 Binding of P2RY6 and P2RY12 1 0.10 0.7 0 5.00
20 INT224025 Binding of WDTC1 and GOPC 1 0.00 0.69 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Experimental Diabetes Mellitus. They are ordered first by their pain relevance and then by number of times they were reported in Experimental Diabetes Mellitus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT84170 Positive_regulation of Gene_expression of Ccl2 58 0.69 48.79 32.43 99.98
2 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 99.98
3 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35 99.22
4 INT20165 Regulation of Abo 7 0.47 0.82 1.84 98.54
5 INT34848 Positive_regulation of B3gat1 11 0.70 2 1.68 98.08
6 INT38706 Positive_regulation of Positive_regulation of Alb 4 0.46 3.53 1.11 97.68
7 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 97.34
8 INT210539 Binding of Ide 11 0.29 6.09 0.52 97.04
9 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 96.88
10 INT34947 Negative_regulation of B3gat3 1 0.02 0.49 0.17 93.52
11 INT83290 Regulation of Gene_expression of Ccl2 8 0.59 9.06 5.56 91.84
12 INT88130 Gene_expression of Spp1 13 0.74 12.96 3.07 91.84
13 INT114218 Gene_expression of Wt1 1 0.62 2.43 0.17 86.52
14 INT191746 Gene_expression of Ptpro 1 0.28 0.85 0.04 86.52
15 INT60412 Negative_regulation of Gene_expression of B3gat1 2 0.36 0.32 0.31 86.28
16 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 85.84
17 INT104250 Positive_regulation of Gene_expression of SPP1 17 0.69 13.22 1.44 85.84
18 INT88933 Regulation of Gene_expression of SPP1 7 0.45 6.05 0.59 85.84
19 INT35377 Gene_expression of B3gat1 3 0.65 0.32 0.53 85.84
20 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05 84.96
21 INT68545 Negative_regulation of Sord 1 0.43 1.63 0.18 84.72
22 INT35636 Gene_expression of Sord 6 0.78 2.31 1.35 83.92
23 INT21805 Negative_regulation of Hdlbp 7 0.30 9.66 1.43 80.76
24 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 75.00
25 INT5515 Negative_regulation of Positive_regulation of Pomc 25 0.58 8.73 11.88 75.00
26 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63 75.00
27 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24 75.00
28 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5 75.00
29 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 75.00
30 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 75.00
31 INT13504 Positive_regulation of MUC7 19 0.58 2.07 4.5 75.00
32 INT43085 Negative_regulation of Ide 28 0.39 19.96 3.45 75.00
33 INT184546 Regulation of Localization of Gpbar1 1 0.08 1.62 0.12 71.24
34 INT184554 Localization of Gpbar1 1 0.14 3.15 0.17 70.84
35 INT137976 Positive_regulation of ENTPD1 6 0.59 6.74 1.63 63.52
36 INT68544 Regulation of Negative_regulation of Sord 1 0.33 0.52 0.03 63.44
37 INT17349 Negative_regulation of Akr1b1 41 0.59 27.03 10.65 62.36
38 INT51777 Regulation of Negative_regulation of Akr1b1 4 0.45 2.91 1.48 62.36
39 INT137981 Gene_expression of ENTPD1 10 0.65 6.84 1.1 57.52
40 INT224003 Protein_catabolism of ENTPD1 1 0.33 1.75 0.28 57.52
41 INT217053 Positive_regulation of Gene_expression of ENTPD1 2 0.26 3.46 0.19 57.52
42 INT224006 Positive_regulation of Protein_catabolism of ENTPD1 1 0.17 1.18 0.08 57.52
43 INT56494 Localization of Ide 73 0.68 22.9 11.26 50.00
44 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 50.00
45 INT90277 Negative_regulation of Ppp2ca 15 0.41 4.04 4.02 50.00
46 INT191974 Regulation of Ide 16 0.38 9.54 2.52 50.00
47 INT56497 Negative_regulation of Localization of Ide 12 0.44 5.34 1.42 50.00
48 INT141936 Phosphorylation of Mapt 14 0.80 10.59 0.95 50.00
49 INT90757 Gene_expression of Brp8 4 0.14 1.6 0.75 50.00
50 INT286615 Phosphorylation of Ide 7 0.31 5.22 0.7 50.00
51 INT286614 Phosphorylation of Zfp422 1 0.01 1.51 0.36 50.00
52 INT224963 Gene_expression of Pdia6 6 0.22 4.51 0.28 50.00
53 INT202756 Phosphorylation of Brp8 3 0.02 1.23 0.2 50.00
54 INT286616 Phosphorylation of Phf1 3 0.39 1.08 0.1 50.00
55 INT286610 Phosphorylation of Htr7 1 0.02 0.44 0.07 50.00
56 INT286609 Gene_expression of Phf1 1 0.20 0.44 0.05 50.00
57 INT286611 Phosphorylation of Gm270 1 0.01 0.67 0.04 50.00
58 INT286613 Phosphorylation of Pdia6 1 0.01 0.67 0.04 50.00
59 INT45226 Positive_regulation of Hd 8 0.31 3.78 0.16 45.36
60 INT93647 Regulation of P2RY1 7 0.36 2.13 0.55 40.56
61 INT184549 Positive_regulation of Gpbar1 1 0.13 10.35 0.19 34.40
62 INT3526 Regulation of Rnase1 2 0.54 1.7 0.21 31.12
63 INT97128 Localization of SPP1 32 0.80 21.75 4.02 30.88
64 INT3527 Regulation of RNASE1 3 0.15 1.22 0.33 29.84
65 INT7678 Localization of Alb 142 0.81 80.93 22.49 25.00
66 INT45225 Localization of Hd 2 0.53 2.79 0.09 25.00
67 INT34487 Localization of MMP2 56 0.81 31.41 23.61 23.20
68 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76 17.40
69 INT191121 Regulation of Gene_expression of P2RX7 3 0.36 3.69 0.99 17.40
70 INT72865 Localization of Icam1 12 0.68 8.18 2.24 7.52
71 INT65430 Localization of Vcam1 4 0.75 2.53 0.2 7.20
72 INT89592 Localization of Ccl5 10 0.61 7.65 3.62 6.76
73 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
74 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
75 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
76 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
77 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
78 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 5.00
79 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 5.00
80 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 5.00
81 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
82 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
83 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 5.00
84 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 5.00
85 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 5.00
86 INT49105 Gene_expression of Vcam1 157 0.78 157.27 43.01 5.00
87 INT82883 Positive_regulation of Ccl2 105 0.69 84.96 42.27 5.00
88 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
89 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
90 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
91 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
92 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
93 INT82882 Localization of Ccl2 61 0.80 41.96 28 5.00
94 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 5.00
95 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 5.00
96 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62 5.00
97 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
98 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
99 INT24684 Localization of PLAT 30 0.78 26.21 13.56 5.00
100 INT2578 Binding of Ins1 74 0.48 33.57 12.92 5.00
101 INT174844 Binding of Fig4 81 0.41 18.03 12.87 5.00
102 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34 5.00
103 INT73829 Positive_regulation of Gene_expression of VCAM1 41 0.61 35.96 11.92 5.00
104 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83 5.00
105 INT105816 Gene_expression of P2RY2 53 0.78 16.47 9.67 5.00
106 INT62944 Regulation of Icam1 33 0.47 23.52 7.94 5.00
107 INT48404 Regulation of Gene_expression of Icam1 21 0.62 15.1 7.81 5.00
108 INT81399 Regulation of Vcam1 24 0.46 23.53 7.68 5.00
109 INT76253 Positive_regulation of P2RY2 29 0.70 13.99 7.33 5.00
110 INT82881 Regulation of Ccl2 19 0.57 15.29 7.19 5.00
111 INT185691 Positive_regulation of WDTC1 24 0.48 12.57 6.49 5.00
112 INT71758 Gene_expression of P2RX1 40 0.75 9.01 6.14 5.00
113 INT74422 Regulation of Localization of IL8 21 0.62 10.19 5.99 5.00
114 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61 5.00
115 INT92330 Gene_expression of WDTC1 22 0.47 13.12 5.15 5.00
116 INT109848 Gene_expression of P2RY1 26 0.62 6.71 4.98 5.00
117 INT130203 Gene_expression of P2ry4 14 0.50 8.79 4.82 5.00
118 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77 5.00
119 INT24412 Localization of WDTC1 18 0.68 12.45 4.5 5.00
120 INT36855 Gene_expression of P2RY6 19 0.42 6.16 4.45 5.00
121 INT56404 Gene_expression of EDA 16 0.75 7.09 4.24 5.00
122 INT19847 Positive_regulation of Localization of Alb 21 0.70 13.89 4.16 5.00
123 INT215517 Gene_expression of Entpd2 3 0.36 3.91 3.63 5.00
124 INT117518 Transcription of Ccl2 12 0.68 11.12 3.61 5.00
125 INT118270 Regulation of P2RY2 16 0.45 7.02 3.45 5.00
126 INT63506 Localization of F2 21 0.77 7.53 3.41 5.00
127 INT126560 Binding of P2RY2 12 0.44 6.43 3.4 5.00
128 INT82879 Regulation of Ccl5 9 0.30 6.19 3.17 5.00
129 INT38030 Positive_regulation of P2RY1 15 0.67 5.54 3.17 5.00
130 INT10136 Negative_regulation of PLAT 23 0.42 11.18 3.02 5.00
131 INT191120 Regulation of P2RX7 8 0.41 5.29 2.96 5.00
132 INT137978 Localization of P2RX7 6 0.73 5.04 2.84 5.00
133 INT61075 Gene_expression of PMP2 23 0.61 7.42 2.79 5.00
134 INT117519 Positive_regulation of Transcription of Ccl2 5 0.49 6.01 2.54 5.00
135 INT137972 Binding of P2RX7 12 0.36 8.01 2.18 5.00
136 INT113907 Regulation of Localization of CCL2 5 0.62 2.46 2.05 5.00
137 INT216715 Gene_expression of P2RY12 24 0.72 3.42 1.77 5.00
138 INT106984 Regulation of P2RX1 12 0.60 2.05 1.75 5.00
139 INT86250 Regulation of WDTC1 11 0.31 4.2 1.64 5.00
140 INT88136 Positive_regulation of Gene_expression of Spp1 8 0.66 4.5 1.57 5.00
141 INT105815 Positive_regulation of Gene_expression of P2RY2 9 0.50 3.62 1.52 5.00
142 INT21011 Positive_regulation of P2RY6 7 0.37 3.58 1.38 5.00
143 INT88133 Positive_regulation of Spp1 8 0.66 10.07 1.33 5.00
144 INT108241 Negative_regulation of P2ry4 3 0.27 1.78 1.1 5.00
145 INT185687 Protein_catabolism of WDTC1 4 0.46 2.62 1.1 5.00
146 INT196863 Positive_regulation of P2ry4 4 0.27 1.87 1.07 5.00
147 INT30257 Regulation of PMP2 4 0.06 1.04 1.04 5.00
148 INT184547 Localization of Spp1 4 0.58 4.44 1.02 5.00
149 INT107143 Negative_regulation of P2RX1 11 0.56 2.92 1.01 5.00
150 INT217004 Positive_regulation of Gene_expression of P2RY6 3 0.28 2.15 0.95 5.00
151 INT224007 Positive_regulation of PMP2 6 0.40 3.46 0.94 5.00
152 INT224011 Binding of P2RX1 7 0.45 1.12 0.6 5.00
153 INT185693 Positive_regulation of Localization of WDTC1 2 0.48 1.22 0.56 5.00
154 INT185684 Positive_regulation of Positive_regulation of WDTC1 2 0.32 1.32 0.47 5.00
155 INT154302 Gene_expression of Nphs1 4 0.77 7.37 0.41 5.00
156 INT224010 Negative_regulation of ENTPD1 4 0.16 1.27 0.41 5.00
157 INT121141 Transcription of Spp1 6 0.34 5.02 0.38 5.00
158 INT216723 Regulation of P2RY12 5 0.42 1.82 0.33 5.00
159 INT109852 Binding of P2RY1 3 0.35 1.04 0.33 5.00
160 INT172280 Binding of P2RY12 3 0.35 0.77 0.33 5.00
161 INT216482 Regulation of P2RY6 2 0.14 0.68 0.25 5.00
162 INT224009 Negative_regulation of Protein_catabolism of ENTPD1 1 0.16 0.58 0.21 5.00
163 INT65873 Regulation of Gpbar1 2 0.10 1.76 0.19 5.00
164 INT224030 Localization of Cacna1c 1 0.01 2.01 0.18 5.00
165 INT154301 Negative_regulation of Nphs1 2 0.58 2.41 0.18 5.00
166 INT224005 Negative_regulation of Gene_expression of P2RX1 3 0.40 0.48 0.17 5.00
167 INT154297 Negative_regulation of Gene_expression of Nphs1 2 0.58 2.43 0.15 5.00
168 INT184550 Positive_regulation of Regulation of Ccl2 1 0.46 1.11 0.09 5.00
169 INT184553 Positive_regulation of Regulation of Gpbar1 1 0.11 1.11 0.09 5.00
170 INT184552 Regulation of Spp1 1 0.17 1.55 0.08 5.00
171 INT224029 Negative_regulation of Trpc3 2 0.57 0.68 0.05 5.00
172 INT224001 Phosphorylation of ENTPD1 1 0.30 0.69 0.04 5.00
173 INT224008 Regulation of Localization of P2RX7 1 0.22 0.74 0.03 5.00
174 INT191743 Binding of Wt1 1 0.29 0.74 0 5.00
175 INT144750 Gene_expression of Slc2a2 2 0.20 0.86 0 5.00
176 INT184551 Gene_expression of Gpbar1 1 0.14 5.59 0 5.00
177 INT184548 Positive_regulation of Gene_expression of Gpbar1 1 0.09 1.98 0 5.00
178 INT191745 Regulation of Gene_expression of Nphs1 1 0.15 2.96 0 5.00
179 INT191744 Binding of Ptpro 1 0.15 0.79 0 5.00
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