D:Extrahepatic Cholestasis

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Disease Term
Synonyms BILE DUCT OBSTRUCTION EXTRAHEPATIC, Biliary Stasis Extrahepatic, Extrahepatic Biliary Stasis
Documents 33
Hot Single Events 19
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Extrahepatic Cholestasis. They are ordered first by their relevance to Extrahepatic Cholestasis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73 87.12
2 INT335020 Fgf23 Positive_regulation of Gene_expression of Cyp24a1 1 0.62 0.82 0.18 74.56
3 INT335021 Fgf23 Negative_regulation of Gene_expression of Cyp27b1 1 0.53 1.49 0.21 74.56
4 INT335018 Vdr Positive_regulation of Gene_expression of Fgf23 1 0.44 0.36 0.17 46.88
5 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39 5.00
6 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38 5.00
7 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38 5.00
8 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32 5.00
9 INT335027 Binding of Vdr and Fgf23 1 0.24 0.34 0.29 5.00
10 INT260739 Mapk14 Regulation of Positive_regulation of Sp1 1 0.01 1.06 0.25 5.00
11 INT335028 Fgf15 Positive_regulation of Fgfr4 1 0.40 0.31 0.25 5.00
12 INT260743 Mapk14 Regulation of Gene_expression of Il10 1 0.04 0.99 0.24 5.00
13 INT335015 Fgf15 Negative_regulation of Gene_expression of Cyp7a1 1 0.57 0.2 0.24 5.00
14 INT283520 Binding of DLAT and Pain1 1 0.27 0.65 0.22 5.00
15 INT335025 Gm7647 Positive_regulation of Gene_expression of Fgf21 1 0.01 0.29 0.21 5.00
16 INT335026 Positive_regulation of Fgf23 Positive_regulation of Gene_expression of Cyp24a1 1 0.45 0.2 0.13 5.00
17 INT335024 Positive_regulation of Fgf23 Negative_regulation of Gene_expression of Cyp27b1 1 0.39 0.19 0.13 5.00
18 INT190684 Binding of A2M and IGF1 1 0.16 1.54 0.1 5.00
19 INT283460 Binding of CTLA4 and DLAT 1 0.06 3.14 0.09 5.00
20 INT283521 PREB Regulation of Fam89b 1 0.00 1.08 0.07 5.00
21 INT335023 Fgf21 Positive_regulation of Gene_expression of Igf1 1 0.49 0.65 0.05 5.00
22 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04 5.00
23 INT335017 Fgf23 Positive_regulation of Fgfr1 1 0.23 0.59 0.04 5.00
24 INT199212 Binding of IGFBP1 and INS 1 0.05 1.77 0.04 5.00
25 INT335016 Fgf23 Negative_regulation of Gene_expression of Slc34a3 1 0.03 0.63 0.03 5.00
26 INT283463 Binding of DLAT and GAGE4 1 0.00 1.1 0.03 5.00
27 INT283462 Binding of DLAT and HLA-DRB1 1 0.07 1.06 0.03 5.00
28 INT335013 Fgf21 Positive_regulation of Localization of Ins1 1 0.06 0.58 0 5.00
29 INT335012 Fgf21 Positive_regulation of Gene_expression of Ins1 1 0.06 0.57 0 5.00
30 INT335022 Fgf15 Regulation of Pbx1 1 0.15 0.17 0 5.00
31 INT335019 Fgf23 Positive_regulation of Phosphorylation of Mapk1 1 0.08 0.45 0 5.00
32 INT283461 Binding of IL2 and SLC4A2 1 0.01 0.98 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Extrahepatic Cholestasis. They are ordered first by their pain relevance and then by number of times they were reported in Extrahepatic Cholestasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT2723 Gene_expression of Salpa1 16 0.64 11.78 3.5 99.92
2 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57 99.84
3 INT334987 Positive_regulation of Fgf15 1 0.66 2.32 0.31 99.28
4 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 98.80
5 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 98.44
6 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 98.24
7 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 98.24
8 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 98.08
9 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 97.96
10 INT334975 Gene_expression of Fgf15 1 0.74 7.12 2.02 97.00
11 INT34848 Positive_regulation of B3gat1 11 0.70 2 1.68 96.44
12 INT108173 Gene_expression of Abcb1b 14 0.75 8.61 4.26 92.44
13 INT108172 Positive_regulation of Gene_expression of Abcb1b 5 0.67 1.64 1.76 92.44
14 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 90.20
15 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 90.20
16 INT108171 Gene_expression of Abcb4 2 0.61 1.46 1.33 87.88
17 INT33857 Negative_regulation of NTS 6 0.42 4.98 3.07 86.64
18 INT199225 Localization of SAMSN1 1 0.62 6.07 0.57 81.84
19 INT22237 Localization of NTS 14 0.75 5.5 2.77 81.12
20 INT101105 Positive_regulation of FUT1 62 0.30 55.96 9.28 79.16
21 INT93578 Localization of Hgf 6 0.77 2.97 1.03 78.96
22 INT86805 Localization of HGF 49 0.71 28.48 6.35 78.56
23 INT96777 Localization of Pdgfa 12 0.79 5.86 3.52 76.40
24 INT262123 Gene_expression of Cyp24a1 17 0.67 6.67 1.38 73.84
25 INT4437 Positive_regulation of ABCB7 11 0.68 11.26 1.33 73.40
26 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 73.12
27 INT11824 Negative_regulation of GGT1 3 0.57 1.39 0.53 73.12
28 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 72.44
29 INT89592 Localization of Ccl5 10 0.61 7.65 3.62 72.44
30 INT283459 Localization of Nup210 1 0.73 0.73 0.08 71.76
31 INT39908 Gene_expression of Cyp27b1 16 0.69 4.8 2.83 71.12
32 INT27754 Positive_regulation of D19Mit9 7 0.52 6.59 0.74 70.80
33 INT47391 Positive_regulation of Paf 16 0.62 12.31 3.79 68.72
34 INT334998 Positive_regulation of Fgf21 1 0.66 4.8 0.14 68.16
35 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 67.36
36 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55 65.84
37 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 65.52
38 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 65.36
39 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 65.36
40 INT158 Localization of Prl 2431 0.81 378.96 952.2 64.80
41 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 64.32
42 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 62.04
43 INT17808 Regulation of NTS 14 0.44 10.7 4.02 58.48
44 INT314554 Gene_expression of Fgf21 3 0.74 7.97 2.48 58.16
45 INT335006 Negative_regulation of Gene_expression of Fgf21 1 0.41 1.33 0.03 58.16
46 INT334980 Negative_regulation of Fgf21 1 0.41 2.31 0.03 58.16
47 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 57.08
48 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 53.56
49 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 53.56
50 INT162249 Gene_expression of Hist1h2aa 8 0.12 6.46 4.35 52.04
51 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 51.84
52 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 51.48
53 INT227413 Gene_expression of DLAT 12 0.44 13.21 1.36 49.52
54 INT28861 Binding of Gh 61 0.46 25.61 6.38 47.04
55 INT118373 Gene_expression of Fgf23 16 0.77 29.62 1.04 46.88
56 INT335007 Protein_catabolism of Fgf23 1 0.59 1.28 0.03 46.60
57 INT1925 Gene_expression of PLAT 47 0.75 34.76 7.88 46.48
58 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 45.92
59 INT27755 Localization of D19Mit9 1 0.01 1.5 0.1 45.68
60 INT27756 Gene_expression of D19Mit9 8 0.08 6.38 0.57 44.72
61 INT334993 Negative_regulation of Gene_expression of Fgf23 1 0.38 4.1 0 40.68
62 INT75434 Gene_expression of Il13 27 0.52 26.19 15.4 40.32
63 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 39.60
64 INT135880 Positive_regulation of Gene_expression of Fgf23 4 0.46 7.52 0.29 39.28
65 INT260741 Gene_expression of Il9 1 0.24 0.67 0.43 39.12
66 INT118371 Positive_regulation of Fgf23 15 0.69 25.34 0.85 38.88
67 INT63401 Gene_expression of Il5 33 0.72 18.66 8.2 38.72
68 INT233765 Binding of HAP1 1 0.03 4.11 0.42 38.60
69 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 38.32
70 INT262107 Binding of Vdr 9 0.48 6.56 0.71 37.92
71 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 31.20
72 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17 31.20
73 INT12442 Localization of Vegfa 11 0.73 4.85 1.68 31.20
74 INT260740 Negative_regulation of Localization of Vegfa 1 0.10 0.19 0.12 31.20
75 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 23.52
76 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75 17.52
77 INT260735 Protein_catabolism of Acin1 1 0.06 0.35 0.03 16.88
78 INT8667 Localization of HSD11B1 22 0.73 22.74 1.25 12.32
79 INT199226 Positive_regulation of SAMSN1 6 0.57 10.2 0.9 9.52
80 INT214132 Regulation of Nucb2 2 0.04 0.33 0.14 8.16
81 INT334991 Positive_regulation of Positive_regulation of Fgf23 1 0.39 1.5 0 8.00
82 INT173974 Positive_regulation of Localization of Il10 25 0.68 16.81 5.87 6.44
83 INT56594 Positive_regulation of Localization of Il4 17 0.48 10.17 4.15 6.44
84 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97 6.44
85 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 6.40
86 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 6.40
87 INT173505 Localization of Hand2 63 0.57 45.32 13.66 6.12
88 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.28
89 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.28
90 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
91 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
92 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
93 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
94 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
95 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
96 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
97 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
98 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
99 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
100 INT46 Localization of Ren 233 0.81 46.15 62.44 5.00
101 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
102 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
103 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
104 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
105 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68 5.00
106 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
107 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
108 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63 5.00
109 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
110 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
111 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
112 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
113 INT134651 Binding of TLR4 89 0.48 66.96 23.19 5.00
114 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
115 INT1721 Negative_regulation of HP 148 0.42 86.82 16.89 5.00
116 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 5.00
117 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
118 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 5.00
119 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
120 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 5.00
121 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 5.00
122 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
123 INT79656 Positive_regulation of NR3C1 14 0.68 6.38 10.83 5.00
124 INT6499 Localization of Ntrk2 44 0.79 11.78 8.75 5.00
125 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 5.00
126 INT132278 Binding of CTLA4 32 0.39 18.69 8.17 5.00
127 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 5.00
128 INT177759 Negative_regulation of IFN1@ 51 0.57 31.81 7.76 5.00
129 INT43721 Gene_expression of Vegfa 49 0.77 36.18 6.63 5.00
130 INT8106 Gene_expression of GGT1 31 0.75 18.65 6.1 5.00
131 INT96778 Positive_regulation of Pdgfa 22 0.46 12.7 5.31 5.00
132 INT31991 Gene_expression of NTS 33 0.75 12.98 4.99 5.00
133 INT18011 Positive_regulation of HP 60 0.50 31.88 4.75 5.00
134 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27 5.00
135 INT41791 Positive_regulation of NTS 12 0.49 5.69 4.15 5.00
136 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 5.00
137 INT9854 Localization of GGT1 11 0.78 6.09 3.57 5.00
138 INT171233 Binding of Ecm1 25 0.07 12.41 3.36 5.00
139 INT41559 Positive_regulation of Sp1 7 0.45 2.65 3.24 5.00
140 INT9110 Binding of PAH 32 0.41 42.1 3.1 5.00
141 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96 5.00
142 INT16130 Binding of IGF1 67 0.48 27.43 2.95 5.00
143 INT120529 Positive_regulation of ABCC2 7 0.49 2.32 2.94 5.00
144 INT163780 Gene_expression of Nucb2 11 0.77 5.1 2.94 5.00
145 INT104182 Gene_expression of ABCC2 19 0.76 5.92 2.88 5.00
146 INT182667 Binding of DLAT 11 0.31 40.75 2.8 5.00
147 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74 5.00
148 INT21712 Positive_regulation of APOA1 32 0.67 21.64 2.64 5.00
149 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 5.00
150 INT699 Positive_regulation of A2M 16 0.66 10.49 2.5 5.00
151 INT200217 Localization of PAH 10 0.36 15.51 2.46 5.00
152 INT176205 Gene_expression of Cyp7a1 8 0.69 2.5 2.45 5.00
153 INT23352 Negative_regulation of A2M 10 0.33 8.35 2.16 5.00
154 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 5.00
155 INT122195 Regulation of Localization of VEGFA 13 0.57 10.61 1.92 5.00
156 INT22863 Negative_regulation of Apoa1 10 0.57 10.68 1.86 5.00
157 INT199222 Gene_expression of SAMSN1 14 0.57 18.97 1.61 5.00
158 INT26606 Gene_expression of RNASE1 19 0.65 7.18 1.46 5.00
159 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 5.00
160 INT283506 Gene_expression of SLC4A2 7 0.47 4 1.4 5.00
161 INT332832 Positive_regulation of Gene_expression of Fgf21 2 0.66 3.18 1.29 5.00
162 INT170900 Regulation of Positive_regulation of Gopc 10 0.20 3.44 1.24 5.00
163 INT209961 Binding of GAGE4 3 0.03 1.8 1.16 5.00
164 INT182666 Negative_regulation of DLAT 2 0.38 9.01 1.16 5.00
165 INT120421 Gene_expression of Fgf13 6 0.68 0.45 1.12 5.00
166 INT227416 Positive_regulation of DLAT 4 0.45 17.02 1.11 5.00
167 INT155838 Binding of GGT1 7 0.47 13.27 1.11 5.00
168 INT334977 Regulation of Gene_expression of Cyp7a1 2 0.40 0.43 0.94 5.00
169 INT114704 Positive_regulation of Fgf1 13 0.50 8.89 0.89 5.00
170 INT145760 Binding of Tlr2 5 0.46 3.59 0.89 5.00
171 INT283494 Positive_regulation of ABCB11 1 0.13 0.81 0.87 5.00
172 INT283514 Localization of NR1I2 2 0.74 3.15 0.87 5.00
173 INT250645 Gene_expression of Samsn1 6 0.33 9.95 0.86 5.00
174 INT137082 Regulation of ABCC2 2 0.16 1.11 0.85 5.00
175 INT179814 Positive_regulation of Protein_catabolism of Ecm1 5 0.06 3.38 0.85 5.00
176 INT164669 Positive_regulation of Nucb2 3 0.31 1.67 0.84 5.00
177 INT130582 Gene_expression of ABCB4 3 0.67 1.05 0.82 5.00
178 INT145986 Positive_regulation of CTLA4 8 0.56 2.66 0.82 5.00
179 INT117031 Binding of Samsn1 6 0.21 6.82 0.76 5.00
180 INT11657 Gene_expression of ALPI 11 0.71 5.13 0.74 5.00
181 INT283501 Positive_regulation of Gene_expression of SLC4A2 1 0.19 1.66 0.73 5.00
182 INT283516 Localization of SLC4A2 1 0.21 0.8 0.69 5.00
183 INT189322 Binding of A2M 7 0.29 12.1 0.66 5.00
184 INT335005 Regulation of Gene_expression of Fgf15 1 0.58 0.8 0.66 5.00
185 INT184030 Gene_expression of Socs2 8 0.74 3.54 0.63 5.00
186 INT283502 Positive_regulation of Gene_expression of ABCB4 1 0.40 0.76 0.62 5.00
187 INT178752 Binding of IGFBP1 8 0.15 4.58 0.61 5.00
188 INT283515 Regulation of ABCB11 2 0.09 0.9 0.58 5.00
189 INT262093 Positive_regulation of Gene_expression of Cyp7a1 2 0.44 0.81 0.55 5.00
190 INT211608 Negative_regulation of Nucb2 4 0.12 2.8 0.55 5.00
191 INT14292 Localization of Agl 2 0.10 1.31 0.53 5.00
192 INT14294 Localization of RNASE1 2 0.36 1.32 0.53 5.00
193 INT184038 Negative_regulation of Socs2 5 0.31 1.68 0.51 5.00
194 INT20239 Regulation of APOA1 10 0.60 10.98 0.51 5.00
195 INT260738 Gene_expression of Ugt1a2 2 0.02 2.22 0.5 5.00
196 INT283507 Negative_regulation of Gene_expression of DLAT 1 0.28 2.2 0.48 5.00
197 INT283518 Negative_regulation of Gene_expression of SLC4A2 1 0.16 0.87 0.48 5.00
198 INT283500 Positive_regulation of Gene_expression of ABCB11 1 0.08 0.41 0.48 5.00
199 INT283495 Gene_expression of ABCB11 1 0.10 0.41 0.47 5.00
200 INT163361 Negative_regulation of SAMSN1 2 0.42 6.6 0.43 5.00
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