D:Eye Malformation

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Disease Term
Synonyms ABNORMALITIES EYE, ABNORMALITY EYE, CONGENITAL ABNORMALITIES OF THE EYE, Congenital Abnormality Of The Eye, Congenital Anomalies Of The Eye Orbit, Congenital Anomalies Of The Globe, CONGENITAL ANOMALY OF EYE, Congenital Anomaly Of Eyes, Congenital Anomaly Of The Eye, CONGENITAL ANOMALY OF THE EYE ORBIT, Congenital Anomaly Of The Eyes
Documents 35
Hot Single Events 19
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Eye Malformation. They are ordered first by their relevance to Eye Malformation and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT267117 Lmx1b Regulation of Col7a1 1 0.02 1.29 0 89.16
2 INT267115 Lmx1b Regulation of Gene_expression of Col4a1 1 0.09 1.37 0 86.12
3 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.00
4 INT262939 PAX6 Regulation of CDH4 1 0.02 0.97 0.08 5.00
5 INT262937 PAX6 Regulation of CDH8 1 0.03 0.98 0.08 5.00
6 INT262944 PAX6 Regulation of CDH6 1 0.03 0.97 0.08 5.00
7 INT279889 Il6 Regulation of Socs3 1 0.21 0.17 0.05 5.00
8 INT279885 Ctcf Regulation of H19 1 0.12 0 0 5.00
9 INT262938 Binding of PAX6 and SIX3 1 0.13 0.9 0 5.00
10 INT279891 Shbdp1 Negative_regulation of PCDHB@ 1 0.01 0.09 0 5.00
11 INT279886 Shbdp1 Negative_regulation of Pcdhb1 1 0.10 0.09 0 5.00
12 INT279884 Nipbl Regulation of Transcription of Pcdhb1 1 0.25 0.05 0 5.00
13 INT306339 Binding of CRX and PAX6 1 0.53 0.27 0 5.00
14 INT279892 Shbdp1 Negative_regulation of Gene_expression of PCDHB@ 1 0.01 0.09 0 5.00
15 INT267116 Binding of Lmx1b and Nps 1 0.30 1.95 0 5.00
16 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 5.00
17 INT267119 Lmx1b Regulation of Regulation of Col4a1 1 0.09 0.67 0 5.00
18 INT262940 Regulation of Binding of PAX6 and SIX3 1 0.16 0.91 0 5.00
19 INT267118 Lmx1b Regulation of Regulation of Col7a1 1 0.06 0.47 0 5.00
20 INT262942 Binding of PAX6 and SOX2 1 0.18 0.9 0 5.00
21 INT262943 Regulation of Binding of PAX6 and SOX2 1 0.17 0.91 0 5.00
22 INT279888 Binding of Rec8 and Nipbl 1 0.01 0.81 0 5.00
23 INT279890 Nipbl Regulation of Gene_expression of PCDHB@ 1 0.07 0.1 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Eye Malformation. They are ordered first by their pain relevance and then by number of times they were reported in Eye Malformation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT91436 Localization of MCOLN1 1 0.27 0.36 0.13 99.12
2 INT216380 Gene_expression of PAX6 49 0.78 15.63 1.22 98.52
3 INT143833 Positive_regulation of Foxc1 2 0.42 1.02 0.09 98.44
4 INT143832 Positive_regulation of Barx1 1 0.19 0.86 0.09 98.44
5 INT143834 Positive_regulation of Pitx2 1 0.22 0.86 0.09 98.44
6 INT123422 Gene_expression of Lmx1b 18 0.78 6.93 5.17 96.24
7 INT267113 Regulation of Gene_expression of Lmx1b 2 0.62 1.36 0.44 96.24
8 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 95.44
9 INT262961 Gene_expression of ELP4 1 0.01 0.16 0.05 94.92
10 INT262960 Gene_expression of TBX5 1 0.23 0.09 0.03 89.20
11 INT170307 Regulation of Gene_expression of Col4a1 2 0.16 1.45 0.1 84.68
12 INT92835 Gene_expression of Col4a1 22 0.49 13.5 2.27 84.24
13 INT143835 Gene_expression of Foxc1 2 0.39 1.17 0.09 81.72
14 INT143836 Negative_regulation of Foxc1 1 0.35 0.92 0.09 81.72
15 INT143830 Gene_expression of Barx1 1 0.23 0.91 0.09 81.28
16 INT143831 Negative_regulation of Barx1 1 0.16 0.91 0.09 81.28
17 INT143837 Negative_regulation of Pitx2 1 0.19 0.91 0.09 81.00
18 INT143838 Gene_expression of Pitx2 3 0.53 1.86 0.09 81.00
19 INT45272 Regulation of Nps 15 0.39 8.08 2.69 80.80
20 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26 79.28
21 INT267112 Regulation of Lmx1b 3 0.61 2.21 0.16 77.44
22 INT235783 Positive_regulation of Gene_expression of PAX6 7 0.50 1.59 0.03 76.56
23 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0 75.28
24 INT262963 Negative_regulation of PAX6 4 0.59 4.92 0.04 70.36
25 INT157805 Negative_regulation of Gene_expression of Col7a1 22 0.34 12.85 3.51 68.04
26 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 58.00
27 INT262964 Negative_regulation of Binding of PAX6 1 0.43 0.44 0 57.88
28 INT262953 Binding of PAX6 13 0.48 5.28 0.06 57.48
29 INT159127 Gene_expression of Nps 49 0.75 16.91 12.06 56.88
30 INT279838 Protein_catabolism of Rec8 1 0.02 0.81 0 55.64
31 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 50.08
32 INT99095 Binding of COL4A4 7 0.37 3.51 0.29 37.24
33 INT178513 Binding of COL4A3 3 0.35 0.8 0.04 37.24
34 INT213649 Positive_regulation of AGPS 1 0.08 1.35 0 34.24
35 INT213650 Gene_expression of AGPS 1 0.11 1.35 0 34.24
36 INT262952 Regulation of Binding of PAX6 1 0.27 0.06 0 28.96
37 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 25.32
38 INT279863 Localization of Pds5a 1 0.47 0.93 0 24.92
39 INT279844 Localization of Pds5b 1 0.65 0.94 0 24.92
40 INT279849 Binding of Pds5b 1 0.32 0.93 0 9.72
41 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
42 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
43 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35 5.00
44 INT7035 Regulation of CGA 87 0.45 29.04 28.45 5.00
45 INT19763 Gene_expression of CTs 69 0.78 32.92 18.87 5.00
46 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
47 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
48 INT17451 Positive_regulation of Tst 23 0.67 8.85 9.52 5.00
49 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
50 INT228870 Negative_regulation of Lpar1 17 0.51 20.97 8.77 5.00
51 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
52 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 5.00
53 INT103260 Positive_regulation of Nps 35 0.48 23.8 5.67 5.00
54 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
55 INT31991 Gene_expression of NTS 33 0.75 12.98 4.99 5.00
56 INT78393 Gene_expression of Adm 16 0.78 8.4 4.92 5.00
57 INT111739 Negative_regulation of Npy 15 0.43 4.9 4.65 5.00
58 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 5.00
59 INT94303 Gene_expression of Upf1 44 0.04 11.62 3.87 5.00
60 INT173878 Gene_expression of ACAN 32 0.75 9.35 3.55 5.00
61 INT108793 Gene_expression of PITX2 12 0.75 3.91 2.89 5.00
62 INT65258 Regulation of Gene_expression of Col7a1 17 0.55 8.26 2.57 5.00
63 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 5.00
64 INT81154 Gene_expression of HCRT 10 0.75 5.32 2.22 5.00
65 INT144364 Negative_regulation of Lmx1b 5 0.45 3.35 2.12 5.00
66 INT65855 Localization of TP53 18 0.76 17.08 1.89 5.00
67 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
68 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 5.00
69 INT59837 Regulation of Upf1 5 0.03 1.37 1.45 5.00
70 INT103907 Negative_regulation of Upf1 15 0.37 4.3 1.4 5.00
71 INT65261 Regulation of Col7a1 18 0.55 8.7 1.33 5.00
72 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29 5.00
73 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26 5.00
74 INT81311 Gene_expression of FOXC1 9 0.44 3.46 1.18 5.00
75 INT36461 Regulation of Col4a1 10 0.26 5.43 1.17 5.00
76 INT135039 Gene_expression of Cd1 11 0.60 5.66 1.05 5.00
77 INT116797 Gene_expression of Osmr 9 0.73 1.12 1 5.00
78 INT95561 Negative_regulation of Vldlr 9 0.53 2.59 0.84 5.00
79 INT105344 Gene_expression of Cited2 5 0.78 3.65 0.76 5.00
80 INT142416 Binding of Ptch1 6 0.34 4.92 0.74 5.00
81 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67 5.00
82 INT267114 Positive_regulation of Lmx1b 2 0.50 0.96 0.6 5.00
83 INT161322 Localization of PTEN 9 0.73 5.65 0.57 5.00
84 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56 5.00
85 INT213651 Binding of HCRT 2 0.36 1.08 0.56 5.00
86 INT279846 Gene_expression of Nipbl 1 0.68 11.1 0.56 5.00
87 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 5.00
88 INT225355 Gene_expression of Set 15 0.37 2.98 0.47 5.00
89 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 5.00
90 INT279847 Negative_regulation of Cebpb 2 0.28 1.82 0.44 5.00
91 INT256628 Regulation of Nsdhl 2 0.11 4.12 0.43 5.00
92 INT238058 Negative_regulation of Shbdp1 4 0.10 1.36 0.42 5.00
93 INT213648 Phosphorylation of S100A6 2 0.30 1.43 0.36 5.00
94 INT287346 Negative_regulation of CORD1 2 0.24 0.4 0.27 5.00
95 INT181059 Gene_expression of Rnase1 5 0.25 0.98 0.19 5.00
96 INT279853 Negative_regulation of Gene_expression of Nipbl 1 0.51 2.37 0.19 5.00
97 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16 5.00
98 INT262958 Localization of PAX2 2 0.32 0.83 0.15 5.00
99 INT197627 Localization of RB1 3 0.69 4.16 0.13 5.00
100 INT262957 Localization of SIX3 1 0.23 0.67 0.09 5.00
101 INT235781 Positive_regulation of PAX6 2 0.50 0.36 0.08 5.00
102 INT213515 Binding of Shh 8 0.37 1.92 0.08 5.00
103 INT279840 Positive_regulation of Gene_expression of Nipbl 1 0.44 0.22 0.07 5.00
104 INT205973 Binding of SHH 3 0.35 1.03 0.07 5.00
105 INT262951 Transcription of PAX6 6 0.72 3.33 0.06 5.00
106 INT262955 Regulation of PAX6 2 0.27 0.87 0.06 5.00
107 INT262962 Localization of PITX2 1 0.42 0.64 0.06 5.00
108 INT279862 Binding of Nipbl 1 0.36 1.22 0.04 5.00
109 INT279851 Positive_regulation of Nipbl 1 0.44 0.19 0.04 5.00
110 INT262954 Regulation of Transcription of PAX6 1 0.62 2.33 0.03 5.00
111 INT279869 Negative_regulation of Nipbl 1 0.43 4.3 0.03 5.00
112 INT279854 Gene_expression of Ptx3 1 0.48 0.17 0.03 5.00
113 INT244771 Gene_expression of Satb2 4 0.68 1.27 0.03 5.00
114 INT279866 Regulation of Stag1 1 0.38 0.09 0 5.00
115 INT279868 Positive_regulation of Positive_regulation of Pcdhb1 1 0.47 0.08 0 5.00
116 INT243224 Regulation of Plxna2 2 0.13 1.58 0 5.00
117 INT279831 Positive_regulation of Lias 1 0.01 0.26 0 5.00
118 INT279856 Regulation of Pcdhb1 1 0.42 0.89 0 5.00
119 INT213647 Gene_expression of F9 10 0.65 6.48 0 5.00
120 INT279834 Negative_regulation of Pcdhb7 1 0.30 0.09 0 5.00
121 INT279881 Negative_regulation of Gene_expression of PCDHB@ 1 0.05 0.09 0 5.00
122 INT279845 Regulation of Nipbl 1 0.39 0.28 0 5.00
123 INT279839 Regulation of Transcription of Pcdhb1 1 0.42 0.05 0 5.00
124 INT279841 Transcription of Nipbl 1 0.63 1.21 0 5.00
125 INT279857 Localization of Nipbl 1 0.65 0 0 5.00
126 INT279861 Positive_regulation of Gene_expression of Rnase1 1 0.15 0 0 5.00
127 INT279858 Gene_expression of Tcof1 1 0.40 0.47 0 5.00
128 INT279860 Binding of Pcdhb7 1 0.26 0.09 0 5.00
129 INT346708 Regulation of Positive_regulation of RCN1 1 0.43 0.52 0 5.00
130 INT346707 Negative_regulation of Gene_expression of PAX6 1 0.37 0.5 0 5.00
131 INT346712 Localization of RCN1 1 0.72 2.14 0 5.00
132 INT279832 Gene_expression of Pcdhb1 1 0.72 0.06 0 5.00
133 INT279870 Transcription of Hbb-bh1 1 0.25 0 0 5.00
134 INT279833 Transcription of Pcdhb1 1 0.67 0 0 5.00
135 INT279882 Regulation of PCDHB@ 1 0.06 0.89 0 5.00
136 INT279864 Regulation of Ctcf 1 0.14 0.18 0 5.00
137 INT287345 Positive_regulation of CORD1 1 0.26 0.71 0 5.00
138 INT279867 Binding of Rec8 1 0.01 0.81 0 5.00
139 INT256625 Negative_regulation of Ptch2 1 0.42 1.27 0 5.00
140 INT346710 Positive_regulation of RCN1 1 0.48 0.52 0 5.00
141 INT256627 Regulation of Negative_regulation of Ptch2 1 0.32 1.33 0 5.00
142 INT279883 Gene_expression of PCDHB@ 1 0.10 0.19 0 5.00
143 INT279871 Negative_regulation of Transcription of Nipbl 1 0.43 1.22 0 5.00
144 INT279855 Positive_regulation of Pcdhb1 1 0.47 0.08 0 5.00
145 INT339594 Localization of SOX2 2 0.69 0.7 0 5.00
146 INT279830 Regulation of Transcription of Nipbl 1 0.39 0.62 0 5.00
147 INT256626 Regulation of Ptch2 1 0.28 1.11 0 5.00
148 INT279835 Regulation of Transcription of Hbb-bh1 1 0.16 0 0 5.00
149 INT346711 Regulation of RCN1 1 0.43 0.51 0 5.00
150 INT279850 Gene_expression of Trps1 1 0.38 0.47 0 5.00
151 INT279837 Regulation of Gene_expression of Nipbl 1 0.39 0 0 5.00
152 INT262956 Protein_catabolism of PAX6 1 0.66 0.14 0 5.00
153 INT279843 Negative_regulation of Ebf1 1 0.37 0.6 0 5.00
154 INT287344 Regulation of NDUFB11 1 0.01 0.33 0 5.00
155 INT279865 Transcription of Ctcf 1 0.36 0 0 5.00
156 INT346709 Binding of RCN1 1 0.46 1.05 0 5.00
157 INT262959 Localization of PAX6 2 0.75 1.65 0 5.00
158 INT279859 Regulation of Pcdhb2 1 0.54 0 0 5.00
159 INT279842 Regulation of Rec8 1 0.01 0.6 0 5.00
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