D:Eyelid Disease

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Disease Term
Synonyms BLEPHARITIS, Chalazion, CHRONIC GRANULOMATOUS MEIBOMIAN GLAND ENLARGEMENT, DISEASE EYELID, Diseases Eyelid, ECTROPION, Entropion, External Hordeolum Internal Hordeolum, Eyelid Diseases, Hordeolum, Lid Edema
Documents 87
Hot Single Events 25
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Eyelid Disease. They are ordered first by their relevance to Eyelid Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT273774 Binding of GPER and RB1 1 0.01 0.45 0 96.08
2 INT279633 Binding of Ar and Abpe 1 0.01 0.99 0 71.04
3 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88 58.28
4 INT279632 Positive_regulation of Binding of Ar and Nr4a1 1 0.01 0.86 0.03 54.40
5 INT279634 Binding of Ar and Nr4a1 1 0.01 0.85 0.03 54.00
6 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
7 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
8 INT311432 Binding of TSHR and TAOK1 1 0.12 1.05 0.07 5.00
9 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
10 INT354789 Tnc Regulation of HSPG2 1 0.02 1.38 0 5.00
11 INT279635 Ar Regulation of Abpe 1 0.01 1.55 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Eyelid Disease. They are ordered first by their pain relevance and then by number of times they were reported in Eyelid Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT238522 Localization of ATG9A 1 0.54 3.68 0.27 100.00
2 INT238525 Binding of ATG9A 1 0.33 1.51 0.12 100.00
3 INT227699 Gene_expression of ATG9A 3 0.46 1.95 0.25 100.00
4 INT238521 Positive_regulation of Localization of ATG9A 1 0.34 1.91 0.16 100.00
5 INT279628 Negative_regulation of Ar 5 0.04 6.1 0.25 98.28
6 INT194993 Binding of RB1 15 0.37 10.96 0.4 96.08
7 INT238523 Regulation of MGS 1 0.16 0.55 0.08 95.00
8 INT311438 Gene_expression of COL13A1 1 0.24 6.56 0.17 93.68
9 INT311452 Gene_expression of CASQ1 1 0.74 7.58 0.14 93.68
10 INT238524 Localization of MGS 1 0.44 1.59 0.05 92.64
11 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26 91.56
12 INT257732 Regulation of Positive_regulation of RB1 2 0.39 2.35 0.09 91.56
13 INT207289 Gene_expression of G0S2 5 0.59 2 0.07 91.28
14 INT63905 Regulation of RB1 13 0.62 12.67 1.28 90.12
15 INT123520 Gene_expression of Ar 12 0.32 6.98 0.25 90.12
16 INT54897 Negative_regulation of HSPA9 3 0.41 5.08 1.19 89.84
17 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 89.40
18 INT265440 Gene_expression of Abpe 2 0.19 10.64 1.07 89.12
19 INT299153 Negative_regulation of Tnc 2 0.42 8.14 0.98 87.80
20 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31 86.24
21 INT32581 Positive_regulation of C4B 9 0.45 11.17 9.05 85.04
22 INT75382 Negative_regulation of HSPG2 20 0.57 15.18 7.03 83.12
23 INT174195 Negative_regulation of HLA-E 31 0.42 11.98 3.88 83.12
24 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 82.44
25 INT85861 Localization of Abpe 6 0.21 1.33 0.66 82.08
26 INT17312 Binding of HSPG2 30 0.41 33.01 4.88 79.08
27 INT311455 Negative_regulation of Gene_expression of COL13A1 1 0.13 2 0.04 79.04
28 INT311451 Negative_regulation of COL13A1 1 0.13 1.3 0 79.04
29 INT33845 Binding of GPER 20 0.36 5.61 1.81 78.40
30 INT240359 Binding of Tnc 2 0.35 11.67 1.48 78.24
31 INT32579 Binding of C4B 14 0.36 14.99 7.79 75.88
32 INT273783 Regulation of Gene_expression of RB1 1 0.29 0.67 0 68.28
33 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 63.08
34 INT160553 Regulation of C4B 3 0.14 1.54 1.16 59.88
35 INT243082 Binding of Ar 2 0.11 1.81 0.06 56.36
36 INT114279 Positive_regulation of Nr4a1 9 0.59 3.37 1.59 54.40
37 INT99720 Positive_regulation of SAT1 21 0.69 26.55 1.56 48.48
38 INT243079 Regulation of Ar 3 0.08 1.22 0.12 34.08
39 INT33517 Gene_expression of TSHR 20 0.71 14.65 1.45 32.32
40 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 28.00
41 INT279630 Regulation of Abpe 1 0.13 1.07 0.09 20.68
42 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 18.56
43 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74 17.28
44 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65 16.96
45 INT195080 Positive_regulation of Tnc 4 0.45 26.67 2.34 16.96
46 INT173911 Regulation of CD69 3 0.22 2.95 0.25 13.04
47 INT279631 Negative_regulation of Abpe 1 0.12 1.29 0.04 9.80
48 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
49 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
50 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
51 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
52 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
53 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
54 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
55 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
56 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 5.00
57 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
58 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
59 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
60 INT79227 Negative_regulation of Gene_expression of Icam1 45 0.59 41.65 14.97 5.00
61 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
62 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
63 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
64 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 5.00
65 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06 5.00
66 INT25585 Positive_regulation of DNAH8 39 0.70 17.96 7.85 5.00
67 INT32580 Gene_expression of C4B 24 0.75 17.95 7.75 5.00
68 INT144945 Negative_regulation of Icam1 27 0.50 26.23 7.08 5.00
69 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 5.00
70 INT144946 Localization of Icam1 21 0.75 21.84 5.33 5.00
71 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 5.00
72 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64 5.00
73 INT107771 Localization of HSPG2 10 0.78 8.47 4.3 5.00
74 INT24278 Gene_expression of FUT4 33 0.75 26.7 4.29 5.00
75 INT134296 Positive_regulation of Ptges2 20 0.19 14.85 3.8 5.00
76 INT47678 Positive_regulation of Positive_regulation of HSPG2 7 0.49 3.94 3.56 5.00
77 INT1727 Gene_expression of Cndp2 22 0.74 4.28 3.34 5.00
78 INT133768 Regulation of Fasl 10 0.44 10.24 3.32 5.00
79 INT188406 Binding of Fasl 19 0.44 24.67 3.17 5.00
80 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 5.00
81 INT78190 Gene_expression of Tnc 10 0.75 21.23 2.91 5.00
82 INT27652 Gene_expression of TG 36 0.78 22.36 2.74 5.00
83 INT168188 Gene_expression of PLXNA2 13 0.58 9 2.73 5.00
84 INT115300 Negative_regulation of Napa 7 0.23 1 2.68 5.00
85 INT165841 Gene_expression of BPIFA4P 17 0.65 6.48 2.38 5.00
86 INT137960 Positive_regulation of FASLG 8 0.67 6.5 2.34 5.00
87 INT54615 Gene_expression of GPER 25 0.75 8.23 2.27 5.00
88 INT98132 Regulation of FAS 16 0.42 20.57 2.06 5.00
89 INT216065 Localization of C4B 2 0.21 2.86 2.01 5.00
90 INT1650 Regulation of TSHR 3 0.28 0.88 1.99 5.00
91 INT89971 Localization of Sparc 10 0.80 10.25 1.85 5.00
92 INT245259 Localization of Mmp3 6 0.68 4.49 1.58 5.00
93 INT47186 Localization of SCTR 8 0.50 5.07 1.55 5.00
94 INT160264 Localization of Fn1 10 0.40 3.95 1.51 5.00
95 INT33516 Positive_regulation of TSHR 4 0.49 2.5 0.93 5.00
96 INT94563 Gene_expression of H2-Q10 7 0.42 7 0.88 5.00
97 INT159988 Localization of Ctsk 5 0.70 2.9 0.74 5.00
98 INT71188 Binding of Cyp1a2 5 0.44 0.58 0.68 5.00
99 INT242745 Regulation of FANCE 2 0.28 1.98 0.66 5.00
100 INT649 Positive_regulation of Afp 10 0.55 6.5 0.62 5.00
101 INT194794 Binding of TTPA 7 0.08 2.56 0.57 5.00
102 INT354785 Regulation of Binding of Tnc 1 0.06 1.63 0.53 5.00
103 INT354787 Regulation of Binding of HSPG2 1 0.23 1.63 0.53 5.00
104 INT163872 Negative_regulation of TSHR 4 0.42 3.52 0.49 5.00
105 INT82177 Negative_regulation of H2-Q10 5 0.58 5.83 0.45 5.00
106 INT36386 Positive_regulation of Gene_expression of FUT4 3 0.45 2.32 0.38 5.00
107 INT279626 Regulation of Gene_expression of Abpe 1 0.13 3.24 0.38 5.00
108 INT268558 Regulation of CTGF 5 0.23 4.7 0.37 5.00
109 INT25502 Gene_expression of RERE 6 0.53 1.74 0.32 5.00
110 INT311448 Gene_expression of TAOK1 1 0.21 2.47 0.31 5.00
111 INT204566 Negative_regulation of Localization of Icam1 2 0.19 2.11 0.3 5.00
112 INT354784 Positive_regulation of Positive_regulation of Tnc 1 0.07 1.14 0.3 5.00
113 INT241467 Negative_regulation of Impdh1 1 0.01 1.45 0.27 5.00
114 INT274104 Regulation of PLXNA2 2 0.33 2.66 0.25 5.00
115 INT235418 Gene_expression of cla 5 0.58 3.27 0.24 5.00
116 INT76857 Transcription of HSPG2 6 0.60 5.07 0.23 5.00
117 INT208225 Positive_regulation of Gene_expression of TSHR 2 0.46 2.84 0.22 5.00
118 INT264459 Gene_expression of DR1 9 0.13 0.95 0.21 5.00
119 INT279627 Transcription of Abpe 1 0.20 1.38 0.2 5.00
120 INT311439 Positive_regulation of Gene_expression of TAOK1 1 0.15 1.48 0.18 5.00
121 INT311446 Negative_regulation of Gene_expression of PLXNA2 1 0.12 1.1 0.18 5.00
122 INT241468 Binding of Dhfr 2 0.13 1.41 0.17 5.00
123 INT178199 Localization of Tnc 2 0.78 5.29 0.16 5.00
124 INT199644 Positive_regulation of Gene_expression of H2-Q10 3 0.37 2.6 0.15 5.00
125 INT199642 Positive_regulation of Fxn 3 0.41 3.6 0.14 5.00
126 INT199640 Positive_regulation of Positive_regulation of Fxn 2 0.41 2.97 0.14 5.00
127 INT279629 Positive_regulation of Abpe 1 0.20 2.22 0.12 5.00
128 INT199652 Negative_regulation of Fxn 3 0.54 12.37 0.11 5.00
129 INT330980 Regulation of Negative_regulation of Icam1 1 0.21 0.68 0.09 5.00
130 INT311447 Negative_regulation of Gene_expression of TSHR 1 0.39 2.24 0.08 5.00
131 INT199646 Transcription of Fxn 2 0.67 4.78 0.08 5.00
132 INT199643 Phosphorylation of Fxn 1 0.40 1.04 0.08 5.00
133 INT162428 Localization of Ar 4 0.37 2.4 0.07 5.00
134 INT199656 Binding of Pnkp 1 0.07 1.36 0.07 5.00
135 INT250395 Gene_expression of GNLY 5 0.31 1.96 0.07 5.00
136 INT199655 Negative_regulation of Gene_expression of Fxn 2 0.47 3.34 0.07 5.00
137 INT311450 Regulation of Gene_expression of TSHR 1 0.25 1.16 0.06 5.00
138 INT311444 Binding of TAOK1 1 0.11 0.65 0.05 5.00
139 INT273784 Negative_regulation of Gene_expression of DR1 1 0.07 0.43 0.05 5.00
140 INT199654 Positive_regulation of Gene_expression of Fxn 3 0.64 2.95 0.05 5.00
141 INT264453 Positive_regulation of Gene_expression of DR1 6 0.10 0.43 0.05 5.00
142 INT354783 Positive_regulation of Regulation of Fasl 1 0.20 1.49 0.05 5.00
143 INT199650 Negative_regulation of Phyh 1 0.42 2.2 0.04 5.00
144 INT311441 Binding of COL13A1 1 0.11 1 0.04 5.00
145 INT199641 Regulation of Transcription of Fxn 1 0.29 1.89 0.04 5.00
146 INT199648 Regulation of Fxn 1 0.29 2.14 0.04 5.00
147 INT311456 Positive_regulation of Gene_expression of CASQ1 1 0.66 0.79 0.03 5.00
148 INT199651 Binding of Fxn 3 0.30 1.45 0.03 5.00
149 INT250396 Localization of GNLY 2 0.68 1.91 0.03 5.00
150 INT213363 Regulation of Gene_expression of Ar 2 0.11 1.63 0.03 5.00
151 INT311453 Binding of CASQ1 1 0.31 0.44 0 5.00
152 INT279625 Positive_regulation of Gene_expression of Abpe 1 0.14 0.76 0 5.00
153 INT199661 Negative_regulation of TTPA 2 0.04 1.84 0 5.00
154 INT311449 Positive_regulation of CASQ2 1 0.50 0.06 0 5.00
155 INT311440 Binding of G0S2 1 0.00 0.55 0 5.00
156 INT199653 Positive_regulation of Tfrc 2 0.13 1.57 0 5.00
157 INT311445 Positive_regulation of CASQ1 1 0.39 0.7 0 5.00
158 INT354786 Positive_regulation of Gene_expression of GNLY 1 0.01 1.96 0 5.00
159 INT199647 Regulation of Phyh 1 0.27 2.71 0 5.00
160 INT311454 Regulation of CASQ1 1 0.43 0.07 0 5.00
161 INT250402 Positive_regulation of GNLY 2 0.20 1.95 0 5.00
162 INT279624 Negative_regulation of Gpx3 2 0.18 0.67 0 5.00
163 INT311443 Gene_expression of FOXI1 1 0.03 0.49 0 5.00
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