D:Fabry Disease

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Disease Term
Synonyms A Galactosidase A Deficiency, Alpha Galactosidase A Deficiency, Anderson Disease, ANDERSON FABRY DISEASE, Anderson Syndrome, Angiokeratoma Corporis Diffusum, Angiokeratoma Corporis Diffusum Universale, Chylomicron Retention Disease, Disease Anderson Fabry, Disease Fabry, Disease Fabry S
Documents 203
Hot Single Events 113
Hot Interactions 12

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Fabry Disease. They are ordered first by their relevance to Fabry Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171616 Sh2d1b2 Negative_regulation of Pitm1 1 0.01 0.47 0.08 99.92
2 INT279242 Negative_regulation of Binding of GLA and SH3GL3 1 0.08 1.22 0 99.14
3 INT279240 Binding of GLA and SH3GL3 1 0.07 1.21 0 99.14
4 INT347806 Binding of MOCS1 and SMAP2 1 0.00 0.48 0.12 98.96
5 INT244328 ELF3 Negative_regulation of Positive_regulation of SH3GL3 3 0.20 1.26 0.04 98.40
6 INT352175 USE1 Regulation of NAGA 1 0.01 0.33 0 97.84
7 INT277890 Binding of Ids and Tas2r111-ps2 1 0.08 0.5 0.09 97.76
8 INT277889 Regulation of Binding of Ids and Tas2r111-ps2 1 0.09 0.5 0.09 97.76
9 INT279241 Binding of ELF3 and GLA 1 0.20 0.53 0 96.48
10 INT347807 GLA Positive_regulation of Positive_regulation of A4GALT 1 0.05 1.57 0.13 86.80
11 INT285406 ELF3 Positive_regulation of Binding of ROS1 1 0.08 0.9 0.03 80.24
12 INT285407 ELF3 Regulation of ICAM1 1 0.03 0.91 0.03 80.24
13 INT241793 NBL1 Negative_regulation of B4GALNT1 1 0.00 0.83 0 73.08
14 INT244329 ELF3 Positive_regulation of Gene_expression of SH3GL3 1 0.27 0.66 0 72.80
15 INT346595 Binding of Mapk3 and Sh2d1b2 1 0.19 0.2 0 63.28
16 INT346598 Negative_regulation of Binding of Mapk3 and Sh2d1b2 1 0.22 0.2 0 63.28
17 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
18 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
19 INT277892 IDS Regulation of Ids 1 0.18 0.41 0 5.00
20 INT273136 Binding of CHED1 and VSX1 1 0.15 0.12 0 5.00
21 INT346596 Sh2d1b2 Negative_regulation of Umod 1 0.23 0 0 5.00
22 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 5.00
23 INT277891 Binding of TPBG and M6pr-ps 1 0.02 0.06 0 5.00
24 INT279239 ELF3 Regulation of SH3GL3 1 0.11 0.44 0 5.00
25 INT346597 Binding of Sh3gl3 and Sh2d1b2 1 0.09 0 0 5.00
26 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0 5.00
27 INT346599 Sh2d1b2 Negative_regulation of Sh3gl3 1 0.10 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Fabry Disease. They are ordered first by their pain relevance and then by number of times they were reported in Fabry Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171614 Positive_regulation of Runx2 13 0.63 3.04 0.19 100.00
2 INT188774 Binding of RAPGEF5 12 0.29 13.55 1.04 100.00
3 INT346581 Gene_expression of Sh3gl3 1 0.25 4.08 0.11 100.00
4 INT277778 Regulation of AFD1 1 0.01 0.88 0.13 100.00
5 INT156639 Localization of Hcm 5 0.64 7.65 0.16 100.00
6 INT44873 Negative_regulation of LCAT 16 0.59 6.92 3.13 100.00
7 INT273143 Negative_regulation of Tat 1 0.01 2.3 0 100.00
8 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26 99.96
9 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14 99.96
10 INT172328 Negative_regulation of Phl1 1 0.03 61.51 0.97 99.92
11 INT171610 Negative_regulation of Sh2d1b2 2 0.30 1.25 0.04 99.92
12 INT171611 Negative_regulation of Nudt10 1 0.01 0.54 0.07 99.88
13 INT209387 Negative_regulation of Ugcg 9 0.25 7.61 0.9 99.86
14 INT121513 Positive_regulation of A4GALT 21 0.63 16.06 1.59 99.84
15 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 99.84
16 INT56223 Positive_regulation of MPO 35 0.70 43 8.2 99.84
17 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 99.80
18 INT68829 Binding of ELF3 14 0.47 7.96 2 99.80
19 INT245115 Positive_regulation of Gene_expression of ELF3 8 0.40 2.23 0.06 99.80
20 INT142724 Negative_regulation of A4GALT 11 0.53 8.23 2.61 99.76
21 INT352186 Negative_regulation of Gene_expression of A4GALT 1 0.20 2.56 1.06 99.76
22 INT23638 Negative_regulation of GAL 17 0.42 5.68 5.04 99.66
23 INT117050 Binding of GLA 8 0.47 2.41 0.22 99.48
24 INT100203 Localization of Ggta1 1 0.78 0.57 0.06 99.48
25 INT167153 Gene_expression of A4GALT 10 0.49 10.45 1.71 99.46
26 INT346565 Positive_regulation of Sh3gl3 1 0.26 2.93 0.42 99.44
27 INT210060 Localization of SH3GL3 4 0.59 6.61 1.37 99.40
28 INT210064 Negative_regulation of Localization of SH3GL3 3 0.31 1.44 0.54 99.40
29 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59 99.32
30 INT5219 Negative_regulation of DBP 43 0.57 23.35 4.26 99.28
31 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 99.28
32 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 99.24
33 INT210070 Localization of GLA 1 0.70 1.96 0.24 99.16
34 INT346566 Negative_regulation of Positive_regulation of Sh3gl3 1 0.14 0.69 0 99.16
35 INT57560 Positive_regulation of GLA 14 0.54 5.01 0.83 99.14
36 INT39997 Negative_regulation of Gla 8 0.59 6.38 1.51 99.06
37 INT100202 Negative_regulation of Ggta1 2 0.41 0.9 0.21 99.06
38 INT347808 Binding of SMAP2 1 0.00 0.47 0.12 98.96
39 INT145884 Negative_regulation of SH3GL3 19 0.43 12.67 1.72 98.92
40 INT55784 Negative_regulation of Neu1 4 0.24 1.93 0.33 98.90
41 INT129970 Negative_regulation of Binding of GLA 1 0.41 0.41 0 98.86
42 INT244330 Localization of ELF3 8 0.56 2.71 0.18 98.72
43 INT142723 Negative_regulation of Positive_regulation of A4GALT 4 0.38 1.65 0.34 98.70
44 INT352181 Regulation of NAGA 1 0.11 0.34 0 98.68
45 INT16131 Negative_regulation of GBE1 37 0.30 10.32 8.15 98.66
46 INT150476 Positive_regulation of ELF3 32 0.56 13.61 2.39 98.52
47 INT346567 Negative_regulation of Sh3gl3 1 0.19 2.25 0.03 98.48
48 INT210065 Positive_regulation of SH3GL3 8 0.45 6.45 0.96 98.40
49 INT210063 Negative_regulation of Positive_regulation of SH3GL3 4 0.28 1.84 0.31 98.40
50 INT172322 Negative_regulation of Gene_expression of Nt5e 1 0.41 1.03 0.04 98.36
51 INT19391 Gene_expression of Nt5e 44 0.72 13.99 5.14 98.36
52 INT279249 Regulation of Localization of SCGB1A1 1 0.44 1.07 0 98.32
53 INT279251 Localization of SCGB1A1 1 0.73 1.07 0 98.32
54 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 98.30
55 INT14306 Positive_regulation of Gal 36 0.70 21.66 18.51 98.24
56 INT200462 Binding of IDS 13 0.31 4.95 1 98.24
57 INT277878 Binding of Ids 4 0.34 0.8 0.24 98.24
58 INT3731 Negative_regulation of Neu1 17 0.39 8.35 5.67 98.20
59 INT160942 Negative_regulation of Negative_regulation of GLA 1 0.41 0.39 0.06 98.12
60 INT172323 Gene_expression of Phl1 1 0.03 14 0.16 98.08
61 INT263255 Negative_regulation of Negative_regulation of AGTR1 2 0.30 2.88 0.25 98.04
62 INT16671 Gene_expression of MBTPS1 7 0.30 4.8 0.52 97.84
63 INT210057 Gene_expression of SH3GL3 24 0.50 8.69 0.94 97.76
64 INT234263 Negative_regulation of ELF3 6 0.39 3.9 0.04 97.68
65 INT142722 Positive_regulation of Positive_regulation of A4GALT 1 0.42 1.49 0.25 97.62
66 INT16723 Regulation of GBE1 16 0.11 4.3 3.7 97.60
67 INT74441 Positive_regulation of Negative_regulation of GLA 1 0.50 1.33 0.25 97.56
68 INT1755 Gene_expression of GBE1 28 0.26 8.32 5.18 97.52
69 INT208522 Gene_expression of SCGB1A1 7 0.65 3.2 0.58 97.24
70 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 97.20
71 INT217723 Regulation of IDS 15 0.25 2.12 0.49 96.84
72 INT245116 Regulation of Gene_expression of ELF3 3 0.41 1.36 0.14 96.24
73 INT155248 Positive_regulation of Negative_regulation of Ggta1 1 0.31 0.52 0.19 95.52
74 INT155249 Positive_regulation of Negative_regulation of Gla 1 0.50 0.52 0.19 95.52
75 INT126675 Negative_regulation of NAT8 2 0.42 1.95 0.33 94.92
76 INT155033 Gene_expression of Phlda2 18 0.30 9.45 0.5 94.68
77 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 94.64
78 INT210059 Negative_regulation of Localization of GLA 1 0.40 0.77 0.12 94.44
79 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 93.12
80 INT36179 Regulation of GLA 11 0.44 6.56 1.12 93.08
81 INT346579 Regulation of Sh2d1b2 1 0.16 0.46 0 92.64
82 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 92.56
83 INT183207 Negative_regulation of USE1 14 0.18 10.97 4 92.00
84 INT127459 Negative_regulation of PAH 18 0.56 15.15 1.05 91.80
85 INT346572 Regulation of Binding of Sh2d1b2 1 0.27 1.14 0.06 91.60
86 INT4866 Positive_regulation of GAL 32 0.67 13.02 16.16 91.60
87 INT171612 Gene_expression of Cebpz 5 0.58 2.61 0.62 91.32
88 INT352176 Localization of Cst3 1 0.78 1.71 0.04 91.20
89 INT171605 Negative_regulation of Runx2 4 0.46 2.14 0.17 90.76
90 INT90938 Gene_expression of Eng 48 0.72 15.76 1.24 90.48
91 INT210072 Negative_regulation of Gene_expression of SH3GL3 13 0.31 2.94 0.47 90.44
92 INT210073 Regulation of Negative_regulation of SH3GL3 2 0.20 1.24 0.35 90.44
93 INT352185 Negative_regulation of PCDH11X 1 0.01 0.83 0 90.24
94 INT4681 Localization of RAPGEF5 12 0.68 8.69 0.93 90.20
95 INT311174 Binding of Sh2d1b2 2 0.26 2.42 0.37 90.04
96 INT210061 Regulation of SH3GL3 6 0.20 1.81 0.5 89.60
97 INT18773 Localization of ALB 117 0.80 69.18 13.8 89.08
98 INT49632 Negative_regulation of NBL1 11 0.57 1.11 5.67 88.40
99 INT210071 Positive_regulation of Transcription of GLA 2 0.54 0.67 0.03 87.64
100 INT210062 Transcription of GLA 2 0.56 0.67 0.03 87.16
101 INT285409 Positive_regulation of Positive_regulation of ELF3 2 0.27 1.21 0 85.52
102 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 85.52
103 INT171609 Positive_regulation of Positive_regulation of Cebpz 1 0.43 2.2 0.34 85.40
104 INT352183 Positive_regulation of Gene_expression of A4GALT 1 0.23 0.84 0 85.20
105 INT52509 Positive_regulation of Cebpz 9 0.59 2.63 2.42 84.96
106 INT210058 Regulation of ELF3 11 0.29 7.93 2.51 84.60
107 INT117348 Regulation of EGFR 75 0.61 47.73 3.09 84.36
108 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 83.36
109 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 82.92
110 INT16385 Regulation of C3 20 0.41 9.98 1.92 82.48
111 INT279246 Positive_regulation of Gene_expression of SH3GL3 1 0.12 0.59 0 82.28
112 INT121514 Localization of A4GALT 7 0.25 4.77 0.58 82.24
113 INT277884 Binding of Tas2r111-ps2 1 0.09 0.95 0.19 81.64
114 INT352180 Negative_regulation of Gene_expression of GLA 1 0.42 1.06 0.13 79.84
115 INT94784 Binding of ROS1 113 0.40 71.57 10.26 79.52
116 INT172325 Positive_regulation of Gene_expression of Phl1 1 0.02 2.65 0.04 78.72
117 INT137221 Gene_expression of Sh2d1b2 6 0.47 1.99 0.6 78.56
118 INT46640 Negative_regulation of Cebpz 9 0.37 2.67 1.52 78.16
119 INT80549 Binding of ICAM1 53 0.47 42.76 9.72 77.56
120 INT51898 Binding of PECAM1 26 0.36 18.87 4.22 77.56
121 INT171607 Regulation of Cebpz 5 0.23 0.94 0.31 76.88
122 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 75.48
123 INT210069 Regulation of Gene_expression of SH3GL3 1 0.03 0.45 0.04 74.00
124 INT137222 Positive_regulation of Sh2d1b2 5 0.30 1.26 0.6 73.76
125 INT51244 Gene_expression of Umod 7 0.60 2.03 0.95 73.52
126 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14 73.12
127 INT155290 Negative_regulation of Negative_regulation of GBE1 2 0.03 1 0.48 73.00
128 INT75742 Binding of RLS 86 0.42 95.27 19.04 71.68
129 INT164258 Positive_regulation of Gene_expression of GLA 6 0.47 0.55 0.65 70.00
130 INT43141 Negative_regulation of Hrasls 5 0.14 1.26 0.41 66.80
131 INT352187 Phosphorylation of A4GALT 1 0.27 0.13 0 66.64
132 INT346570 Negative_regulation of Rraga 1 0.03 0.13 0.12 65.92
133 INT320171 Positive_regulation of Gene_expression of MOCS1 2 0.01 0.87 0.25 65.36
134 INT51165 Binding of Gal 10 0.48 2.56 8.41 65.12
135 INT134944 Gene_expression of MOCS1 37 0.06 10.76 2.17 64.48
136 INT65545 Localization of EGFR 35 0.79 20.8 1.88 62.24
137 INT26167 Positive_regulation of Hrasls 18 0.23 8.67 4.87 61.68
138 INT172326 Regulation of Hrasls 1 0.02 0.77 0 61.68
139 INT172320 Positive_regulation of Regulation of Hrasls 1 0.03 0.77 0 61.68
140 INT172324 Protein_catabolism of Hrasls 1 0.04 0.77 0 61.68
141 INT285408 Regulation of Gene_expression of A4GALT 1 0.22 0.06 0 61.44
142 INT279250 Regulation of Localization of SH3GL3 1 0.12 0.42 0.07 60.96
143 INT346569 Positive_regulation of Gene_expression of Sh2d1b2 1 0.30 0.46 0.04 60.56
144 INT346575 Regulation of Rraga 1 0.03 0.58 0.13 59.52
145 INT279245 Regulation of Regulation of SH3GL3 1 0.11 0.59 0.11 55.44
146 INT346577 Negative_regulation of Localization of Sh3gl3 1 0.14 0.22 0 53.68
147 INT346578 Localization of Sh3gl3 1 0.25 0.22 0 53.68
148 INT71946 Negative_regulation of Ass1 7 0.41 1.9 2.68 52.00
149 INT55529 Negative_regulation of Gba 13 0.59 7.91 2.1 51.60
150 INT3359 Regulation of YY1 32 0.60 8.19 19.2 50.00
151 INT112459 Localization of Gba 12 0.80 1.45 6.4 50.00
152 INT22335 Regulation of Negative_regulation of ACE 10 0.44 7.01 1.77 50.00
153 INT37485 Regulation of RAPGEF5 10 0.44 6.64 1.51 50.00
154 INT131125 Negative_regulation of Localization of Gba 2 0.08 0.24 1.48 50.00
155 INT47734 Positive_regulation of RAPGEF5 19 0.56 13.16 1.41 50.00
156 INT287436 Positive_regulation of HTs 9 0.60 2.27 1.14 50.00
157 INT11118 Gene_expression of RAPGEF5 13 0.65 9.35 0.43 50.00
158 INT173211 Regulation of MOCS1 4 0.01 1.94 0.22 50.00
159 INT210066 Negative_regulation of Regulation of SH3GL3 1 0.03 0.28 0.14 50.00
160 INT210068 Positive_regulation of Negative_regulation of SH3GL3 1 0.03 0.54 0.12 50.00
161 INT164479 Positive_regulation of Gene_expression of RAPGEF5 2 0.49 1.3 0.08 50.00
162 INT307030 Localization of LAMP1 4 0.42 0.57 0.03 50.00
163 INT347809 Negative_regulation of Binding of A4GALT 1 0.05 0 0 50.00
164 INT347810 Binding of A4GALT 1 0.04 0 0 50.00
165 INT172327 Binding of Phl1 1 0.02 0.29 0 50.00
166 INT172321 Localization of Phl1 1 0.03 1.41 0 50.00
167 INT210067 Protein_catabolism of RAPGEF5 1 0.05 0.24 0 50.00
168 INT191807 Gene_expression of CD24 75 0.78 53.92 3.34 47.88
169 INT8792 Gene_expression of GBA 20 0.78 14.73 1.98 47.88
170 INT346574 Negative_regulation of Gene_expression of Sh2d1b2 1 0.26 0 0 47.20
171 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 46.64
172 INT114519 Gene_expression of Hcm 10 0.57 13.01 0.57 45.76
173 INT346573 Binding of Sh3gl3 1 0.14 0.2 0.08 45.56
174 INT38252 Positive_regulation of Hcm 7 0.40 9.96 0.59 43.52
175 INT171606 Regulation of Localization of Sh2d1b2 2 0.13 0.41 0.42 43.40
176 INT352188 Negative_regulation of Localization of A4GALT 1 0.17 0 0 43.28
177 INT171608 Localization of Sh2d1b2 2 0.21 0.4 0.42 42.52
178 INT27446 Negative_regulation of CTSA 11 0.57 5.58 3.08 41.20
179 INT107294 Positive_regulation of Cdt1 3 0.24 1.52 0.43 39.80
180 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 37.76
181 INT352182 Regulation of A4GALT 1 0.15 0.18 0 37.44
182 INT241800 Negative_regulation of Positive_regulation of GBA 2 0.36 1.05 0.24 36.40
183 INT277886 Localization of Ids 3 0.73 1.09 0.48 36.16
184 INT241803 Positive_regulation of GBA 6 0.70 2.41 0.3 34.56
185 INT331119 Gene_expression of Rraga 3 0.05 0.07 0.07 33.04
186 INT26477 Regulation of ACE 26 0.45 16.31 4.33 30.08
187 INT346571 Negative_regulation of Gene_expression of Sh3gl3 1 0.16 0.96 0.06 23.44
188 INT206440 Binding of MOCS1 13 0.01 3.76 0.35 22.24
189 INT171613 Positive_regulation of Positive_regulation of Runx2 1 0.01 0 0 19.20
190 INT346563 Regulation of Sh3gl3 1 0.15 0 0 18.88
191 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 18.08
192 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 14.04
193 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 11.84
194 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
195 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
196 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
197 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
198 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
199 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
200 INT23564 Negative_regulation of Car2 103 0.50 27.28 21.86 5.00
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