D:Facial Pain

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Disease Term
Synonyms Atypical Facial Pain, Craniofacial Pain, FACE PAIN, FACIAL PAIN NEURALGIC, Facial Pain Referred, MYOFACIAL PAIN, Neuralgic Facial Pain, Orofacial Pain, Pain Craniofacial, Pain Face, Pain Facial
Documents 1117
Hot Single Events 72
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Facial Pain. They are ordered first by their relevance to Facial Pain and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT138273 Gtf3a Regulation of Paf 1 0.39 0.26 0.34 97.92
2 INT317184 BMS1 Regulation of Gene_expression of NAV1 1 0.03 1.94 1.62 75.32
3 INT252869 Binding of Trpv1 and Phax 2 0.01 0.18 0.6 50.00
4 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06 5.00
5 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97 5.00
6 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94 5.00
7 INT265651 Binding of ITGAL and MYCN 1 0.00 0.46 0.62 5.00
8 INT265652 Binding of CISH and MYCN 1 0.00 0.28 0.28 5.00
9 INT229601 Binding of DIS3 and RLS 1 0.14 2.19 0.06 5.00
10 INT229602 Binding of ETFA and DIS3 1 0.08 1.12 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Facial Pain. They are ordered first by their pain relevance and then by number of times they were reported in Facial Pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT53460 Gene_expression of tn 13 0.66 7.97 5.2 100.00
2 INT163157 Binding of BMS1 3 0.42 3.6 1.77 100.00
3 INT168681 Gene_expression of BMS1 5 0.37 2.7 1.62 100.00
4 INT5039 Positive_regulation of Gal 67 0.68 27.97 37.36 99.98
5 INT158540 Negative_regulation of HTN1 4 0.34 7.25 1.22 99.84
6 INT13501 Binding of Drd2 65 0.48 23.76 35.6 99.84
7 INT265662 Negative_regulation of Binding of COMT 4 0.37 1.29 2.42 99.80
8 INT118156 Binding of Prkcz 2 0.08 2.68 2.89 99.76
9 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 99.72
10 INT158541 Positive_regulation of Gene_expression of HTN1 3 0.40 5.88 0.97 99.68
11 INT158542 Gene_expression of HTN1 10 0.75 10.69 1.07 99.68
12 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 99.60
13 INT131413 Positive_regulation of Gene_expression of NAV1 35 0.70 17.5 36.83 99.56
14 INT135629 Binding of COMT 33 0.48 16.68 19.37 99.52
15 INT202257 Localization of COMT 7 0.75 2.13 2.65 99.52
16 INT160666 Binding of Prdm6 2 0.31 0.73 0.35 99.42
17 INT2824 Positive_regulation of HTN1 10 0.40 10.41 1.4 99.40
18 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 99.40
19 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 99.32
20 INT81087 Gene_expression of ASIC3 30 0.75 13.62 16.54 99.16
21 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 99.12
22 INT48883 Negative_regulation of GRIN3B 19 0.54 14.53 11.5 99.08
23 INT136339 Gene_expression of Mmp10 3 0.07 1.05 1.75 99.08
24 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 99.04
25 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 99.00
26 INT66394 Regulation of Pdc 6 0.32 1.27 3.99 98.80
27 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05 98.64
28 INT265659 Positive_regulation of Negative_regulation of COMT 1 0.43 0.78 1.57 98.64
29 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 98.20
30 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 97.92
31 INT98927 Localization of Grm1 4 0.71 0.42 1.97 97.80
32 INT121019 Positive_regulation of Remslp1 1 0.10 0.57 0.66 97.76
33 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 97.72
34 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 97.56
35 INT38698 Positive_regulation of COP 9 0.59 2.05 4.48 97.52
36 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 97.00
37 INT167057 Binding of Myo5a 1 0.46 0.37 1.88 96.76
38 INT160021 Negative_regulation of Slc12a4 2 0.06 0.42 0.47 96.68
39 INT76428 Gene_expression of Sstr2 24 0.76 6.09 12.32 96.52
40 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 96.32
41 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 96.32
42 INT5199 Gene_expression of Fosl1 44 0.78 8.66 24.8 95.96
43 INT5201 Negative_regulation of Gene_expression of Fosl1 8 0.54 1.63 5.06 95.96
44 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 95.64
45 INT5587 Regulation of Fos 191 0.62 40.81 99.7 95.64
46 INT18190 Regulation of DRD2 11 0.60 9.01 7.63 95.64
47 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 95.24
48 INT103262 Localization of Nav1 53 0.81 19.23 34.44 95.24
49 INT5040 Regulation of Gal 42 0.60 12.72 21.18 95.16
50 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 94.72
51 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 94.04
52 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 93.52
53 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43 93.12
54 INT136334 Negative_regulation of Mmp10 1 0.04 0.51 1.41 93.04
55 INT136338 Negative_regulation of Regulation of Mmp10 1 0.03 0.51 1.41 93.04
56 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 92.96
57 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 92.72
58 INT317185 Positive_regulation of Positive_regulation of NAV1 1 0.47 1.51 2.08 92.48
59 INT4925 Binding of Tacr1 57 0.48 17.39 38.38 92.44
60 INT89048 Gene_expression of P2RX2 28 0.75 8.75 7.9 92.04
61 INT144736 Negative_regulation of Gene_expression of COMT 13 0.58 6.47 9.28 92.04
62 INT10568 Regulation of H2-Ab1 9 0.20 1.86 6.79 91.68
63 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46 91.60
64 INT103791 Positive_regulation of Positive_regulation of F2rl1 10 0.50 11.24 7.41 91.60
65 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49 91.56
66 INT136335 Regulation of Mmp10 4 0.11 1.53 2.54 90.64
67 INT71916 Gene_expression of TTN 9 0.75 1.69 0.97 89.88
68 INT100569 Positive_regulation of Binding of Tacr1 1 0.50 0.66 1.37 88.68
69 INT77339 Positive_regulation of RRM2 5 0.41 1.36 2.88 88.04
70 INT85766 Gene_expression of Scn11a 19 0.78 6.82 8.24 87.36
71 INT122458 Transcription of Scn11a 1 0.69 0.32 0 87.36
72 INT117205 Transcription of Esr1 23 0.65 9.4 4.14 85.84
73 INT32074 Positive_regulation of TAR 4 0.40 1.44 0.98 79.92
74 INT58477 Gene_expression of Chdh 33 0.74 39.48 19.78 79.40
75 INT22909 Positive_regulation of Chdh 26 0.68 28.69 16.13 78.92
76 INT180035 Positive_regulation of Gene_expression of Chdh 2 0.22 8.21 5.78 78.92
77 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 78.40
78 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67 78.40
79 INT16356 Regulation of NPPA 33 0.62 13.24 9.53 76.92
80 INT317187 Positive_regulation of BMS1 1 0.04 0.98 1.48 76.08
81 INT149518 Regulation of Gene_expression of NAV1 7 0.62 6.73 9.62 75.32
82 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 75.00
83 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 75.00
84 INT57866 Positive_regulation of Gene_expression of Adarb1 2 0.04 0.25 1.44 75.00
85 INT6165 Gene_expression of Adarb1 85 0.58 18.39 51.03 75.00
86 INT84430 Negative_regulation of Smpd1 22 0.59 10.33 3.95 75.00
87 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 75.00
88 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 75.00
89 INT160022 Transcription of Slc12a2 2 0.53 0.75 0.97 75.00
90 INT160020 Transcription of Slc12a5 2 0.53 0.75 0.83 75.00
91 INT160019 Regulation of Transcription of Slc12a2 1 0.26 0.41 0.46 75.00
92 INT160670 Negative_regulation of Pdia3 3 0.42 0.7 0.22 75.00
93 INT127576 Transcription of Gal 6 0.67 4.36 3.04 74.64
94 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 74.64
95 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 74.64
96 INT21795 Transcription of Npy 7 0.57 2.94 2.27 74.64
97 INT113391 Regulation of Positive_regulation of Tacr1 2 0.35 0.5 0.27 73.84
98 INT122459 Positive_regulation of Transcription of Scn11a 1 0.50 0.15 0 73.16
99 INT122460 Positive_regulation of Gene_expression of Scn11a 1 0.47 0.15 0 73.16
100 INT51158 Positive_regulation of Tacr1 33 0.70 15.22 13.91 72.60
101 INT317186 Regulation of BMS1 1 0.04 3.9 3.17 72.32
102 INT27260 Gene_expression of DYNLL1 8 0.75 7.72 2.78 72.20
103 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 71.92
104 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 70.56
105 INT11766 Negative_regulation of H2-Ab1 15 0.43 5.27 12.32 70.16
106 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 69.68
107 INT63169 Positive_regulation of Gene_expression of Selp 35 0.69 21.95 7.16 69.68
108 INT157575 Positive_regulation of Gene_expression of Ccl12 3 0.63 3.05 1.59 69.68
109 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 69.28
110 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 69.28
111 INT117551 Regulation of Gene_expression of Selp 15 0.44 7.32 4.2 69.28
112 INT62545 Regulation of Gene_expression of Icam1 17 0.49 14.26 4.06 69.28
113 INT157572 Gene_expression of Ccl12 10 0.70 10.52 3.09 69.28
114 INT157571 Regulation of Gene_expression of Ccl12 1 0.41 0.58 0.47 69.28
115 INT24525 Regulation of Gal 19 0.60 10.17 9.57 67.36
116 INT2541 Binding of Calca 200 0.48 67.14 134.62 64.68
117 INT12424 Binding of Npy 48 0.48 8.23 24.26 64.68
118 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21 63.80
119 INT5283 Positive_regulation of Npy 191 0.70 66.77 109.2 63.80
120 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16 63.40
121 INT63170 Positive_regulation of Selp 27 0.68 24.1 6.3 63.40
122 INT157576 Positive_regulation of Localization of Selp 2 0.49 1.19 0.59 63.40
123 INT157574 Positive_regulation of Localization of Icam1 1 0.46 0.56 0.51 63.40
124 INT156579 Localization of Selp 14 0.73 6.53 2.69 62.88
125 INT60768 Negative_regulation of Pdc 5 0.48 1.5 2.67 62.48
126 INT144946 Localization of Icam1 21 0.75 21.84 5.33 62.28
127 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25 61.84
128 INT307700 Regulation of HOPX 4 0.53 7.64 3.5 61.68
129 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 61.16
130 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 60.88
131 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 60.04
132 INT105157 Positive_regulation of Phosphorylation of Gfap 8 0.67 6.48 6.38 60.04
133 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46 59.20
134 INT105156 Phosphorylation of Gfap 23 0.79 11.85 13.76 57.44
135 INT157573 Localization of Vwf 9 0.69 2.93 0.97 57.04
136 INT66023 Positive_regulation of Gene_expression of Itgam 25 0.64 12.65 16.56 56.76
137 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26 56.76
138 INT108098 Positive_regulation of Itgam 19 0.70 8.09 8.86 56.76
139 INT10917 Positive_regulation of ITGAM 31 0.67 16.39 6.69 56.28
140 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24 55.56
141 INT324955 Phosphorylation of Itgam 1 0.37 1.96 2.4 55.40
142 INT169375 Phosphorylation of ITGAM 1 0.61 0.16 0 54.92
143 INT136337 Positive_regulation of Mmp10 1 0.12 0.91 1.2 54.08
144 INT60769 Positive_regulation of Pdc 3 0.33 0.2 1.7 54.00
145 INT66025 Gene_expression of Itgam 61 0.78 31.26 26.08 53.28
146 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 52.80
147 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 51.20
148 INT130369 Binding of COP 1 0.30 0.05 0 50.48
149 INT112 Gene_expression of Pdia3 11 0.74 0.18 3.74 50.00
150 INT62850 Negative_regulation of COP 8 0.37 0.18 0.38 50.00
151 INT138438 Gene_expression of Smpd1 7 0.67 2.67 0.21 50.00
152 INT21956 Negative_regulation of Mmp7 12 0.34 7.32 5.34 49.48
153 INT200738 Gene_expression of HIST2H4A 7 0.18 4.65 0.91 45.64
154 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 44.56
155 INT125897 Binding of Mmp9 3 0.36 2.36 1.32 40.72
156 INT97891 Gene_expression of Ghrl 108 0.77 24.85 9.7 40.64
157 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 36.08
158 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 34.56
159 INT3362 Negative_regulation of Emg1 21 0.57 10.03 15.93 33.44
160 INT11303 Gene_expression of Avp 116 0.78 39.23 23.88 33.12
161 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97 29.08
162 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 25.00
163 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58 25.00
164 INT132411 Positive_regulation of Ghrl 25 0.69 12.05 2.59 25.00
165 INT123843 Gene_expression of soc 14 0.58 5.22 1.96 25.00
166 INT101495 Regulation of Positive_regulation of F2rl1 1 0.26 0.88 0.91 25.00
167 INT111416 Positive_regulation of Trpm8 65 0.70 14.62 17.13 22.80
168 INT55168 Binding of NFKB1 55 0.48 22.94 13.15 16.48
169 INT252576 Binding of Emg1 1 0.32 0.77 0.56 7.20
170 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
171 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 5.00
172 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
173 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 5.00
174 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 5.00
175 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
176 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 5.00
177 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
178 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
179 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
180 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
181 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
182 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
183 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9 5.00
184 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
185 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
186 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
187 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
188 INT74826 Gene_expression of Slc1a2 131 0.78 61.83 100.84 5.00
189 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7 5.00
190 INT4830 Binding of Trpv1 158 0.48 45.11 84.2 5.00
191 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 5.00
192 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37 5.00
193 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 5.00
194 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 5.00
195 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
196 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 5.00
197 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 5.00
198 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
199 INT9489 Gene_expression of SFTPA1 112 0.66 55.38 66.45 5.00
200 INT10706 Regulation of Il6 150 0.62 93.23 62.34 5.00
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