D:Facial Paralysis

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Disease Term
Synonyms CENTRAL FACIAL PARALYSES, CENTRAL FACIAL PARALYSIS, FACIAL PALSIES, FACIAL PALSY, Facial Palsy Lower Motor Neuron, Facial Palsy Upper Motor Neuron, Facial Paralyses Central, Facial Paralyses Peripheral, Facial Paralysis Central, FACIAL PARALYSIS PERIPHERAL, Facial Paresis
Documents 569
Hot Single Events 45
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Facial Paralysis. They are ordered first by their relevance to Facial Paralysis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT189958 Binding of FND and SENP8 1 0.05 1.27 0 90.40
2 INT328667 Binding of CD40LG and CSF2 1 0.16 0.59 0.05 52.72
3 INT328668 Binding of CSF2 and IGHG3 1 0.03 0.59 0.05 52.72
4 INT254433 Binding of Lrp5 and Sost 2 0.39 1.51 0.03 47.64
5 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 5.00
6 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07 5.00
7 INT211115 Positive_regulation of Binding of LTBR and TNF 1 0.01 0.31 0.39 5.00
8 INT172004 IL17A Positive_regulation of Gene_expression of IL6 2 0.14 1.35 0.34 5.00
9 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21 5.00
10 INT347868 Ntf3 Negative_regulation of Negative_regulation of Chat 1 0.03 0.22 0.13 5.00
11 INT335890 Binding of Dkk1 and Lrp4 1 0.37 0.64 0.07 5.00
12 INT335886 Binding of Sost and Lrp4 1 0.28 0.65 0.07 5.00
13 INT264148 Binding of CLCN7 and Ostm1 1 0.17 0.72 0.03 5.00
14 INT192678 PTEN Regulation of Dync1h1 1 0.02 0.5 0.03 5.00
15 INT292882 Binding of S100A12 and TP63 1 0.06 0.51 0 5.00
16 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0 5.00
17 INT264143 TCIRG1 Regulation of BSND 1 0.02 0.74 0 5.00
18 INT264144 CLCN7 Regulation of ADO 1 0.04 0.71 0 5.00
19 INT172011 IgG Regulation of Ighm 1 0.00 0.77 0 5.00
20 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0 5.00
21 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0 5.00
22 INT335891 Binding of Dkk1 and Lrp5 1 0.39 0.57 0 5.00
23 INT242102 Nkx2-1 Regulation of Gene_expression of Ttf1 1 0.00 1.55 0 5.00
24 INT335882 Dkk1 Negative_regulation of Wnt2 1 0.02 0.15 0 5.00
25 INT300631 Binding of TSC1 and TSC2 1 0.15 2.59 0 5.00
26 INT349355 CSF2 Negative_regulation of CSTA 1 0.01 1.43 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Facial Paralysis. They are ordered first by their pain relevance and then by number of times they were reported in Facial Paralysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT109451 Binding of PRF1 2 0.35 2.25 0.27 100.00
2 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 99.96
3 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94 99.84
4 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 99.64
5 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 97.56
6 INT5113 Binding of MROS 4 0.31 2.52 0.17 96.96
7 INT32517 Positive_regulation of LRPAP1 13 0.49 7.4 3.44 96.92
8 INT116001 Binding of FND 3 0.06 3.69 0.1 95.84
9 INT126646 Negative_regulation of Gene_expression of Nr5a2 1 0.20 0.1 0.71 95.12
10 INT91929 Gene_expression of Nr5a2 5 0.31 2.15 3.52 94.64
11 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 94.56
12 INT96720 Positive_regulation of GNA11 2 0.60 0.95 0.41 94.56
13 INT335878 Localization of Sost 3 0.69 1.11 0.22 93.36
14 INT105569 Binding of IGFALS 13 0.25 17.31 1.36 93.04
15 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 91.28
16 INT67248 Gene_expression of TACC2 12 0.50 13.51 3.65 91.28
17 INT256622 Regulation of Positive_regulation of Ldha 1 0.08 0.9 0.06 90.56
18 INT8959 Binding of Gnb5 17 0.40 31.38 5.1 90.08
19 INT26311 Negative_regulation of ACE2 8 0.59 16.35 1.94 90.00
20 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 89.92
21 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 89.84
22 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 89.76
23 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 89.44
24 INT99961 Positive_regulation of SYP 13 0.67 15.13 2.79 89.44
25 INT14515 Positive_regulation of Lrrc23 8 0.28 8.51 0.97 89.44
26 INT126220 Positive_regulation of CENPV 2 0.49 1.52 0.17 89.44
27 INT52749 Gene_expression of alp 24 0.44 12.84 5.97 89.20
28 INT8541 Gene_expression of Csrp1 42 0.76 23.72 6.9 88.68
29 INT27683 Gene_expression of Acpp 4 0.66 4.13 0.41 88.64
30 INT4993 Gene_expression of Lrrc23 13 0.66 11.04 1.99 88.60
31 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 87.60
32 INT189960 Gene_expression of SENP8 9 0.54 17.54 0.64 87.28
33 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 86.44
34 INT104533 Gene_expression of CENPV 3 0.75 2.13 0.41 85.32
35 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 85.04
36 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24 84.32
37 INT142958 Positive_regulation of Protein_catabolism of APP 3 0.55 2.04 0.1 84.24
38 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06 84.24
39 INT24983 Binding of MPO 18 0.42 17.56 3.29 83.84
40 INT1011 Positive_regulation of Ebp 3 0.50 1.59 0.86 82.80
41 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 81.76
42 INT68216 Binding of NF1 40 0.48 51.24 4.59 81.60
43 INT25 Positive_regulation of LAMC2 19 0.67 8.64 7.06 81.48
44 INT25271 Positive_regulation of MTG1 21 0.67 13.59 5.96 81.28
45 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 80.44
46 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 79.52
47 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 79.20
48 INT64700 Binding of Nf1 14 0.45 15.24 2.29 78.64
49 INT14690 Localization of CSF2 124 0.80 85.17 27.26 77.44
50 INT48393 Positive_regulation of Localization of CSF2 14 0.60 8.92 6.1 77.44
51 INT70538 Regulation of Localization of CSF2 4 0.54 3.08 1.9 77.44
52 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 76.88
53 INT16385 Regulation of C3 20 0.41 9.98 1.92 76.28
54 INT23621 Regulation of C4A 10 0.44 5.07 0.84 76.28
55 INT125725 Regulation of C1QC 1 0.06 0.83 0.18 76.28
56 INT46383 Negative_regulation of TRGC1 42 0.55 44.03 6.2 75.88
57 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 75.40
58 INT23620 Negative_regulation of C4A 24 0.57 15.1 2.23 75.40
59 INT125724 Negative_regulation of C1QC 1 0.10 0.82 0.18 75.40
60 INT163613 Transcription of CSF2 16 0.60 12.98 1.62 72.56
61 INT756 Gene_expression of C3 138 0.75 100.6 19.2 72.16
62 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 71.92
63 INT335868 Negative_regulation of Gene_expression of Sost 2 0.58 1.12 0.04 69.88
64 INT335864 Gene_expression of Sost 4 0.77 2.36 0.2 69.16
65 INT2271 Gene_expression of F2 51 0.76 30.21 7.97 68.84
66 INT125796 Regulation of Gene_expression of APP 8 0.59 5.95 1.41 67.36
67 INT41569 Regulation of APP 32 0.62 17.15 9.4 66.64
68 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 65.64
69 INT335876 Negative_regulation of Sost 11 0.51 6.77 0.67 64.28
70 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2 63.28
71 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27 59.92
72 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 58.48
73 INT108519 Binding of Lrp6 8 0.44 1.47 1.19 58.00
74 INT254427 Binding of Lrp5 10 0.48 5.43 0.26 58.00
75 INT305170 Gene_expression of Man2c1 1 0.05 1.89 0 52.00
76 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 51.04
77 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 51.04
78 INT112968 Negative_regulation of Gnb5 5 0.34 7.79 1.81 50.96
79 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 50.00
80 INT52021 Regulation of IGHG3 34 0.39 22.43 3.3 50.00
81 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 49.24
82 INT335980 Regulation of Igfals 1 0.17 2.26 0.12 48.28
83 INT335869 Binding of Sost 6 0.32 1.79 0.18 47.64
84 INT305171 Binding of Man2c1 1 0.03 1.75 0 45.24
85 INT48192 Gene_expression of Setd1a 8 0.42 4.41 1.26 38.32
86 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 36.48
87 INT25402 Binding of Ptcra 10 0.34 3.54 1.85 35.00
88 INT58003 Localization of APP 32 0.80 13.75 4.2 34.56
89 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 29.64
90 INT335861 Localization of Lrp6 1 0.69 0.54 0.17 27.36
91 INT64689 Positive_regulation of Gene_expression of Fgf2 30 0.70 12.05 6.2 25.72
92 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48 25.08
93 INT80237 Regulation of Copg2as2 1 0.00 0.64 0 25.00
94 INT75361 Gene_expression of Cntn1 1 0.45 0.6 0 25.00
95 INT104731 Positive_regulation of NEFL 13 0.67 9.22 1.37 22.64
96 INT3797 Positive_regulation of Gene_expression of Ighm 16 0.47 9.4 2.01 22.44
97 INT89543 Gene_expression of NEFL 18 0.75 10.6 2.67 15.12
98 INT61547 Regulation of Fgf2 21 0.47 7.23 3.24 14.92
99 INT33039 Regulation of Ptcra 3 0.04 1.16 0.37 14.92
100 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 13.36
101 INT139738 Gene_expression of Ptcra 9 0.63 2.75 1.14 10.56
102 INT312270 Positive_regulation of Xcl1 4 0.31 3.32 0.44 10.48
103 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 6.40
104 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
105 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 5.00
106 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
107 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
108 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
109 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
110 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
111 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
112 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
113 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 5.00
114 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
115 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
116 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
117 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
118 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
119 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
120 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
121 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
122 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 5.00
123 INT19511 Localization of Il6 212 0.81 118.17 67.67 5.00
124 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
125 INT10706 Regulation of Il6 150 0.62 93.23 62.34 5.00
126 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
127 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
128 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
129 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
130 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8 5.00
131 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
132 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
133 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
134 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
135 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96 5.00
136 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 5.00
137 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
138 INT9650 Gene_expression of LPA 141 0.75 104.57 29 5.00
139 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
140 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 5.00
141 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 5.00
142 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
143 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
144 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73 5.00
145 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
146 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 5.00
147 INT6866 Regulation of Gfap 51 0.61 19.6 23.56 5.00
148 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
149 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
150 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
151 INT51474 Binding of Il6 55 0.48 44.99 20.52 5.00
152 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
153 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
154 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 5.00
155 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
156 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98 5.00
157 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
158 INT103469 Positive_regulation of Gene_expression of BDNF 59 0.67 24.39 18.36 5.00
159 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96 5.00
160 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68 5.00
161 INT69203 Positive_regulation of Ntf3 43 0.66 19.16 16.49 5.00
162 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
163 INT6381 Negative_regulation of Chat 51 0.59 19.68 15.86 5.00
164 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51 5.00
165 INT8634 Gene_expression of Nfasc 23 0.68 9.16 14.96 5.00
166 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
167 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49 5.00
168 INT39507 Positive_regulation of TXNRD1 37 0.68 12.47 14.25 5.00
169 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
170 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
171 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 5.00
172 INT9649 Positive_regulation of LPA 105 0.69 74.75 13.89 5.00
173 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 5.00
174 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 5.00
175 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
176 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 5.00
177 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52 5.00
178 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
179 INT182240 Gene_expression of CXCL13 25 0.59 22.77 11.96 5.00
180 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 5.00
181 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 5.00
182 INT20721 Localization of ACOT1 47 0.80 11.37 10.95 5.00
183 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 5.00
184 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28 5.00
185 INT68133 Localization of Fgf2 36 0.81 15.37 9.14 5.00
186 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
187 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
188 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
189 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
190 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37 5.00
191 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
192 INT79166 Regulation of TNC 12 0.44 9.42 8.13 5.00
193 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05 5.00
194 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
195 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
196 INT6055 Transcription of Egr1 47 0.69 3.61 7.68 5.00
197 INT153814 Localization of LPA 19 0.65 18.25 7.68 5.00
198 INT182320 Binding of MTX1 14 0.18 8.5 7.65 5.00
199 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56 5.00
200 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 5.00
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