D:Factor Viii Deficiency

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Disease Term
Synonyms A Hemophilia, Ahg Deficiency, Ahg Deficiency Disease, Antihaemophilic Factor A Deficiency, Antihaemophilic Globulin Deficiency, Antihemophilic Factor A Deficiency, Antihemophilic Globulin Deficiency, AS HEMOPHILIA, CLASSICAL HAEMOPHILIA, CLASSICAL HAEMOPHILIAC, Classical Haemophiliacs
Documents 39
Hot Single Events 15
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Factor Viii Deficiency. They are ordered first by their relevance to Factor Viii Deficiency and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT331881 F2 Positive_regulation of F8 1 0.10 0.53 0.03 7.96
2 INT323352 Binding of F8 and VWF 5 0.08 2.22 0.33 5.00
3 INT331875 Binding of GCG and Mst1r 1 0.08 0 0 5.00
4 INT331866 Binding of Csf2 and Mest 1 0.08 0 0 5.00
5 INT331118 Regulation of Binding of KIF22 and EBNA1BP2 1 0.04 0.16 0 5.00
6 INT331874 Positive_regulation of Binding of GCG and Mst1r 1 0.11 0 0 5.00
7 INT331861 Binding of Csf3 and Mst1r 1 0.08 0 0 5.00
8 INT331864 Binding of Mest and Mst1r 1 0.52 0.28 0 5.00
9 INT331880 Binding of GCG and Mest 1 0.08 0 0 5.00
10 INT331878 Binding of F8 and Mst1r 1 0.33 0.2 0 5.00
11 INT331867 Binding of Csf3 and Mest 1 0.08 0 0 5.00
12 INT331115 Binding of KIF22 and EBNA1BP2 1 0.07 0.49 0 5.00
13 INT331877 Binding of F8 and Mest 1 0.49 0.41 0 5.00
14 INT331865 Positive_regulation of Binding of Csf2 and Mst1r 1 0.11 0 0 5.00
15 INT331873 Regulation of Binding of F8 and Mest 1 0.46 0 0 5.00
16 INT331869 Positive_regulation of Binding of Csf3 and Mst1r 1 0.11 0 0 5.00
17 INT331868 Positive_regulation of Binding of Csf2 and Mest 1 0.11 0 0 5.00
18 INT331862 Positive_regulation of Binding of Csf3 and Mest 1 0.11 0 0 5.00
19 INT331879 Positive_regulation of Binding of GCG and Mest 1 0.11 0 0 5.00
20 INT331116 Binding of BLVRB and EBNA1BP2 1 0.04 0.38 0 5.00
21 INT331876 Binding of PAEP and Mst1r 1 0.05 0.39 0 5.00
22 INT285042 Dbi Regulation of Gene_expression of Rho 1 0.01 0 0 5.00
23 INT285047 WTS Regulation of Gene_expression of Rho 1 0.02 0 0 5.00
24 INT331850 Binding of F8 and PAEP 1 0.04 0 0 5.00
25 INT331117 EPO Positive_regulation of FXN 1 0.29 1.09 0 5.00
26 INT331863 Binding of Csf2 and Mst1r 1 0.10 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Factor Viii Deficiency. They are ordered first by their pain relevance and then by number of times they were reported in Factor Viii Deficiency. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT2919 Negative_regulation of F8 47 0.59 23.48 5.1 99.96
2 INT65498 Positive_regulation of F7 4 0.11 8.51 0.79 99.44
3 INT65496 Positive_regulation of Localization of F7 1 0.08 0.39 0.33 99.44
4 INT65494 Positive_regulation of Positive_regulation of F7 2 0.08 2.66 0.28 99.44
5 INT65495 Regulation of Localization of F7 1 0.07 0.2 0.17 99.44
6 INT65493 Regulation of Positive_regulation of F7 1 0.07 0.2 0.17 99.44
7 INT65497 Localization of F7 1 0.11 0.2 0.17 99.44
8 INT25353 Negative_regulation of F8 22 0.59 18.51 1.4 99.32
9 INT270550 Regulation of Negative_regulation of F8 1 0.42 1.79 0 99.32
10 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56 98.96
11 INT315630 Gene_expression of FXN 8 0.64 20.05 0.05 97.28
12 INT331860 Positive_regulation of Mst1r 1 0.67 1.69 0 90.80
13 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 88.04
14 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 88.04
15 INT10889 Gene_expression of F8 60 0.78 41.36 5.06 87.28
16 INT103327 Gene_expression of F8 45 0.71 32.5 2.12 78.84
17 INT295593 Gene_expression of Mst1r 2 0.65 1.56 0 78.84
18 INT203617 Localization of F8 9 0.74 4.36 0.1 78.00
19 INT331855 Localization of Mst1r 1 0.68 0.4 0 78.00
20 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 75.00
21 INT213647 Gene_expression of F9 10 0.65 6.48 0 71.48
22 INT103328 Binding of F8 9 0.44 11.89 0.93 69.76
23 INT48009 Gene_expression of Pde6b 38 0.68 15.03 11.41 59.24
24 INT128773 Regulation of Gene_expression of Pde6b 4 0.45 1.41 2.5 59.24
25 INT331135 Binding of KIF22 1 0.07 0.18 0 57.68
26 INT9840 Positive_regulation of F7 17 0.57 17.83 2.08 50.00
27 INT88726 Gene_expression of HPRT1 36 0.78 10.12 1.58 45.84
28 INT88724 Regulation of Gene_expression of HPRT1 2 0.27 1.04 0.09 45.84
29 INT44323 Positive_regulation of F8 32 0.60 24.88 3.89 24.08
30 INT48239 Binding of Gtf3a 52 0.33 23.14 6.45 11.00
31 INT10893 Binding of VWF 27 0.47 25.02 2.82 11.00
32 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
33 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
34 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
35 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
36 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
37 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
38 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
39 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
40 INT939 Gene_expression of PAEP 86 0.77 31.02 8.59 5.00
41 INT60034 Positive_regulation of VWF 40 0.68 30.42 8.15 5.00
42 INT75932 Binding of Csf2 45 0.37 33.2 8.01 5.00
43 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02 5.00
44 INT56160 Binding of Ifx 14 0.36 11.39 5.74 5.00
45 INT32458 Gene_expression of VWF 57 0.78 28.97 5.56 5.00
46 INT22839 Gene_expression of F2 31 0.74 15.53 5.56 5.00
47 INT163913 Gene_expression of Il11ra1 18 0.69 12.62 5.34 5.00
48 INT73117 Positive_regulation of DNMT3B 20 0.47 10.31 5.31 5.00
49 INT201130 Localization of AES 31 0.63 25.45 5.12 5.00
50 INT20650 Positive_regulation of F2 26 0.69 15.49 5.08 5.00
51 INT169756 Binding of CFTR 9 0.35 9.65 4.55 5.00
52 INT151099 Negative_regulation of CFTR 12 0.59 10.28 3.79 5.00
53 INT136106 Gene_expression of DNMT3B 30 0.58 8.43 3.7 5.00
54 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 5.00
55 INT133038 Binding of DNMT3B 26 0.40 5.97 2.83 5.00
56 INT81154 Gene_expression of HCRT 10 0.75 5.32 2.22 5.00
57 INT48007 Regulation of Pde6b 6 0.39 4.4 2.2 5.00
58 INT48141 Binding of Csf3 18 0.39 9.93 1.71 5.00
59 INT253751 Localization of Lif 3 0.73 3.94 1.58 5.00
60 INT109881 Positive_regulation of Gene_expression of F8 11 0.47 12.97 1.54 5.00
61 INT146200 Positive_regulation of Rho 20 0.45 2.1 1.23 5.00
62 INT234473 Gene_expression of HDAC4 8 0.18 6.28 0.99 5.00
63 INT200750 Gene_expression of Rho 19 0.65 6.52 0.69 5.00
64 INT69098 Positive_regulation of Gene_expression of F2 5 0.66 3.79 0.58 5.00
65 INT213651 Binding of HCRT 2 0.36 1.08 0.56 5.00
66 INT3201 Positive_regulation of F9 11 0.49 5.12 0.56 5.00
67 INT63615 Negative_regulation of pn 2 0.04 0 0.43 5.00
68 INT228298 Gene_expression of INVS 10 0.65 6.44 0.43 5.00
69 INT213648 Phosphorylation of S100A6 2 0.30 1.43 0.36 5.00
70 INT114313 Binding of RHO 7 0.36 1.45 0.36 5.00
71 INT268131 Gene_expression of MARCKS 3 0.27 1.09 0.31 5.00
72 INT99095 Binding of COL4A4 7 0.37 3.51 0.29 5.00
73 INT229218 Negative_regulation of Gene_expression of F8 3 0.38 1.62 0.29 5.00
74 INT249115 Localization of Pde6b 6 0.68 1.09 0.21 5.00
75 INT245360 Positive_regulation of Gene_expression of Rho 5 0.49 0.37 0.14 5.00
76 INT136185 Positive_regulation of Binding of F8 2 0.64 1.4 0.14 5.00
77 INT76295 Gene_expression of KIF22 3 0.10 1.29 0.13 5.00
78 INT186837 Gene_expression of EBNA1BP2 9 0.64 8.66 0.13 5.00
79 INT234460 Negative_regulation of Gene_expression of HDAC4 2 0.04 1.55 0.11 5.00
80 INT285043 Regulation of WTS 1 0.06 0 0.09 5.00
81 INT285046 Localization of WTS 1 0.10 0.06 0.08 5.00
82 INT331119 Gene_expression of Rraga 3 0.05 0.07 0.07 5.00
83 INT285045 Gene_expression of WTS 5 0.10 0.48 0.06 5.00
84 INT268127 Binding of MARCKS 2 0.14 0 0.05 5.00
85 INT302533 Gene_expression of Mest 2 0.65 1.86 0.05 5.00
86 INT273458 Regulation of Rho 3 0.36 0.07 0.04 5.00
87 INT178513 Binding of COL4A3 3 0.35 0.8 0.04 5.00
88 INT300190 Positive_regulation of Gene_expression of F8 2 0.50 0.81 0.03 5.00
89 INT278909 Regulation of Gene_expression of Rho 2 0.27 0 0.03 5.00
90 INT229217 Regulation of Gene_expression of F8 2 0.41 0.72 0.03 5.00
91 INT331138 Localization of KIF22 1 0.11 0.15 0 5.00
92 INT275492 Positive_regulation of Gene_expression of Pde6b 3 0.50 0.12 0 5.00
93 INT331131 Regulation of Gene_expression of FXN 1 0.37 1.49 0 5.00
94 INT331852 Phosphorylation of Mst1r 1 0.79 0 0 5.00
95 INT315563 Positive_regulation of Gene_expression of FXN 4 0.41 5.05 0 5.00
96 INT214055 Gene_expression of NSD1 8 0.67 4.46 0 5.00
97 INT331872 Positive_regulation of Binding of VWF 1 0.12 0 0 5.00
98 INT300189 Negative_regulation of Localization of Lif 1 0.41 0.47 0 5.00
99 INT331857 Phosphorylation of Mest 1 0.79 0 0 5.00
100 INT285039 Positive_regulation of Positive_regulation of Rho 2 0.26 0.06 0 5.00
101 INT331859 Regulation of Binding of Mst1r 1 0.44 0.13 0 5.00
102 INT315635 Positive_regulation of FXN 2 0.41 5.76 0 5.00
103 INT295594 Binding of Mst1r 3 0.47 1.62 0 5.00
104 INT213649 Positive_regulation of AGPS 1 0.08 1.35 0 5.00
105 INT285040 Localization of pn 1 0.06 0 0 5.00
106 INT331856 Regulation of Mst1r 1 0.44 0.53 0 5.00
107 INT331129 Protein_catabolism of KIF22 1 0.10 0 0 5.00
108 INT331858 Binding of Mest 1 0.36 0.95 0 5.00
109 INT331136 Gene_expression of LRP1B 1 0.01 0.15 0 5.00
110 INT331134 Gene_expression of BLVRB 1 0.06 0.16 0 5.00
111 INT331137 Regulation of Gene_expression of KIF22 1 0.07 0.29 0 5.00
112 INT285041 Positive_regulation of Localization of pn 1 0.04 0 0 5.00
113 INT331870 Positive_regulation of Localization of F8 1 0.46 1.24 0 5.00
114 INT285044 Positive_regulation of WTS 1 0.06 0 0 5.00
115 INT315628 Negative_regulation of Gene_expression of FXN 2 0.36 2.37 0 5.00
116 INT213650 Gene_expression of AGPS 1 0.11 1.35 0 5.00
117 INT331854 Positive_regulation of Gene_expression of Mest 1 0.49 0.45 0 5.00
118 INT331853 Positive_regulation of Binding of Mst1r 1 0.49 0.22 0 5.00
119 INT186850 Binding of EBNA1BP2 10 0.39 2.9 0 5.00
120 INT331871 Phosphorylation of F8 1 0.75 0 0 5.00
121 INT141226 Regulation of F8 2 0.45 1.02 0 5.00
122 INT331130 Negative_regulation of FXN 1 0.48 4.93 0 5.00
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