D:Falciparum Malaria

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Disease Term
Synonyms MALARIA PLASMODIUM FALCIPARUM, Plasmodium Falciparum Malaria
Documents 136
Hot Single Events 23
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Falciparum Malaria. They are ordered first by their relevance to Falciparum Malaria and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT316355 Binding of CR1 and Hmgcr 1 0.01 0.59 0 70.08
2 INT188836 Binding of LHCGR and C4b 1 0.39 0.76 0 68.08
3 INT231771 Binding of HMOX1 and TNF 2 0.14 1.41 0.04 64.80
4 INT321530 Ubp1 Regulation of Abcb1b 1 0.43 0.06 0 38.88
5 INT303759 IGHG3 Regulation of Localization of ROS1 1 0.07 0 0.09 5.00
6 INT226044 Lta Positive_regulation of Ecm1 1 0.02 0.44 0.08 5.00
7 INT226043 Epo Positive_regulation of Ecm1 1 0.04 1.35 0.05 5.00
8 INT335492 CREM Positive_regulation of Transcription of HMOX1 1 0.00 0.9 0.03 5.00
9 INT199041 AGRP Regulation of IGHE 1 0.00 1.39 0.03 5.00
10 INT316354 Binding of CR1 and Gypa 1 0.05 0.43 0 5.00
11 INT283630 Cd36 Regulation of Positive_regulation of Ie 1 0.00 0 0 5.00
12 INT283633 Binding of Vcam1 and Ie 1 0.00 0.17 0 5.00
13 INT226045 Binding of Casp1 and Lta 1 0.04 0.73 0 5.00
14 INT303758 Binding of ADRB1 and IGHG3 1 0.06 0.09 0 5.00
15 INT213947 Binding of CD302 and MIR301A 1 0.00 0.16 0 5.00
16 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 5.00
17 INT226042 Binding of Casp1 and Casp3 1 0.02 0.73 0 5.00
18 INT283632 Binding of Selp and Ie 1 0.00 0.22 0 5.00
19 INT283631 Positive_regulation of Binding of Cd36 and Ie 1 0.00 0 0 5.00
20 INT283629 Binding of Cd36 and Ie 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Falciparum Malaria. They are ordered first by their pain relevance and then by number of times they were reported in Falciparum Malaria. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT251459 Binding of Ie 18 0.20 6.62 0.75 100.00
2 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 96.80
3 INT179450 Positive_regulation of NCF1 5 0.50 1.04 0.17 96.08
4 INT165681 Positive_regulation of Transcription of HMOX1 2 0.69 4.29 0.53 94.76
5 INT165680 Transcription of HMOX1 7 0.71 11.2 1.41 94.28
6 INT38885 Regulation of ICT1 3 0.20 2.02 0.26 93.56
7 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 92.96
8 INT102664 Regulation of DNAJC5 3 0.14 0.94 0.59 92.52
9 INT255408 Protein_catabolism of Pymr 2 0.06 1.71 0 92.20
10 INT71385 Regulation of Hephl1 1 0.03 0.29 0.06 90.40
11 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 89.56
12 INT812 Localization of INS 1026 0.81 515.6 145.31 89.00
13 INT100420 Regulation of HMOX1 10 0.35 6.68 1.48 87.08
14 INT94827 Gene_expression of HBS1L 24 0.67 26.11 1.61 86.92
15 INT60162 Gene_expression of Ie 41 0.58 23.77 1.52 86.52
16 INT242902 Gene_expression of NCF1 12 0.78 9.34 1.36 85.92
17 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92 85.72
18 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 85.72
19 INT206657 Positive_regulation of NAPEPLD 4 0.07 1.05 0.05 83.52
20 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 82.68
21 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 82.68
22 INT303769 Positive_regulation of CKAP5 1 0.08 0.51 0.04 82.32
23 INT116529 Binding of HMOX1 10 0.47 15.38 1.04 81.76
24 INT174656 Binding of NCF1 5 0.37 6.46 1.65 78.72
25 INT69304 Negative_regulation of Il10 47 0.59 36.88 19.79 75.48
26 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 75.00
27 INT138488 Negative_regulation of Il13 3 0.23 1.1 1.29 75.00
28 INT138489 Negative_regulation of Il18 1 0.02 0.48 0.7 75.00
29 INT94127 Positive_regulation of Il18 14 0.69 14 7.47 75.00
30 INT138490 Positive_regulation of Il13 9 0.36 5.42 2.06 75.00
31 INT123704 Binding of SMARCB1 12 0.36 5.49 0.61 75.00
32 INT93240 Gene_expression of Pgpep1 7 0.59 1.69 0.44 73.44
33 INT116527 Positive_regulation of Gene_expression of HMOX1 29 0.70 25.79 4.87 73.28
34 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 72.80
35 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64 72.72
36 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 71.00
37 INT6481 Binding of TNF 624 0.48 510.2 214.82 70.36
38 INT152503 Binding of CR1 3 0.45 8.64 1.03 68.64
39 INT260351 Regulation of Gene_expression of NCF1 1 0.27 0.84 0.04 67.28
40 INT172104 Binding of C4b 4 0.41 3.89 0.13 66.60
41 INT84909 Positive_regulation of SUGT1 22 0.08 22.01 5.43 65.24
42 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 63.28
43 INT7776 Gene_expression of Abcb1b 63 0.75 21.35 14.92 62.56
44 INT117828 Regulation of Gene_expression of Abcb1b 7 0.60 1.8 3.76 62.56
45 INT295162 Transcription of Abcb1b 4 0.59 1.69 0.11 62.56
46 INT321527 Regulation of Transcription of Abcb1b 1 0.51 0.14 0 62.56
47 INT80983 Regulation of Abcb1b 16 0.60 1.95 4.32 60.32
48 INT140858 Negative_regulation of SUGT1 9 0.05 8.41 1.4 56.80
49 INT298220 Negative_regulation of Negative_regulation of SUGT1 1 0.01 0.94 0 56.80
50 INT13995 Gene_expression of gr 96 0.74 48.21 26.54 54.56
51 INT93061 Binding of gr 31 0.48 10.93 6.45 54.56
52 INT93062 Negative_regulation of Binding of gr 2 0.43 1.18 0.44 54.56
53 INT170090 Gene_expression of ICT1 6 0.07 3.96 0.37 53.36
54 INT206698 Regulation of HBS1L 4 0.09 3.06 0 53.16
55 INT75923 Positive_regulation of IL6ST 5 0.45 2.49 1.21 50.64
56 INT178029 Gene_expression of Epo 25 0.76 14.98 1.46 50.24
57 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 50.00
58 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 50.00
59 INT12290 Gene_expression of Dhfr 7 0.76 2.04 1.47 50.00
60 INT20604 Gene_expression of FAM176C 2 0.65 2.12 0.72 50.00
61 INT198170 Positive_regulation of SALL1 4 0.49 1.5 0.32 50.00
62 INT241468 Binding of Dhfr 2 0.13 1.41 0.17 50.00
63 INT278585 Binding of Nudc 1 0.12 1.53 0.1 50.00
64 INT195608 Gene_expression of Nudc 3 0.22 3.38 0.09 50.00
65 INT197481 Gene_expression of Etfa 1 0.03 0.38 0.04 50.00
66 INT299472 Positive_regulation of Gene_expression of Dhfr 1 0.20 0 0 50.00
67 INT258619 Transcription of Acta1 1 0.06 0.48 0 50.00
68 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16 49.84
69 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 46.64
70 INT9261 Gene_expression of CR1 15 0.73 15.58 1.85 44.32
71 INT178026 Positive_regulation of Epo 12 0.70 8.14 0.95 43.96
72 INT49846 Localization of HBS1L 4 0.24 1.31 0.86 37.84
73 INT80680 Negative_regulation of Atn1 3 0.42 1.5 0.64 35.12
74 INT206658 Negative_regulation of NAPEPLD 2 0.04 2.18 0.1 25.20
75 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 15.80
76 INT297682 Binding of Atn1 4 0.16 1.58 0.28 10.84
77 INT128793 Gene_expression of HBB 16 0.78 10.69 0.42 8.96
78 INT128794 Negative_regulation of Gene_expression of HBB 1 0.59 5.98 0.06 8.96
79 INT78226 Gene_expression of Mbp 43 0.75 22.14 7.79 7.76
80 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
81 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
82 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
83 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
84 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
85 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
86 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
87 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
88 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
89 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
90 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
91 INT2893 Localization of Oxt 219 0.80 28.96 79.43 5.00
92 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
93 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 5.00
94 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
95 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 5.00
96 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
97 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
98 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
99 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
100 INT49105 Gene_expression of Vcam1 157 0.78 157.27 43.01 5.00
101 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
102 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
103 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
104 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
105 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03 5.00
106 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
107 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
108 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
109 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
110 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
111 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 5.00
112 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32 5.00
113 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
114 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
115 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
116 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84 5.00
117 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 5.00
118 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
119 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
120 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62 5.00
121 INT7994 Gene_expression of Lta 113 0.67 69.81 19.59 5.00
122 INT19509 Localization of Ifng 55 0.78 28.25 18.67 5.00
123 INT24209 Negative_regulation of Ifng 37 0.57 16.52 17.15 5.00
124 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
125 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
126 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
127 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
128 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
129 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
130 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 5.00
131 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 5.00
132 INT14997 Positive_regulation of FPR1 21 0.66 9.82 13.2 5.00
133 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22 5.00
134 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
135 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
136 INT53201 Negative_regulation of gr 35 0.50 17.76 10.62 5.00
137 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 5.00
138 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
139 INT94784 Binding of ROS1 113 0.40 71.57 10.26 5.00
140 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
141 INT7995 Positive_regulation of Lta 28 0.66 14.98 9.8 5.00
142 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22 5.00
143 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 5.00
144 INT15991 Gene_expression of FPR1 27 0.59 8.22 9.01 5.00
145 INT89180 Gene_expression of Agrp 54 0.78 14.29 8.84 5.00
146 INT63401 Gene_expression of Il5 33 0.72 18.66 8.2 5.00
147 INT77249 Positive_regulation of Gene_expression of gr 24 0.67 16.09 8.17 5.00
148 INT182750 Gene_expression of Hmgcr 61 0.58 17.23 7.4 5.00
149 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 5.00
150 INT91667 Localization of IL12A 39 0.74 25.51 7.36 5.00
151 INT5326 Regulation of Ifng 12 0.55 4.56 7.19 5.00
152 INT11747 Positive_regulation of IL2RA 22 0.67 16.55 6.95 5.00
153 INT17049 Localization of CD4 57 0.75 35.33 6.89 5.00
154 INT98310 Regulation of gr 21 0.39 15.04 6.68 5.00
155 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
156 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 5.00
157 INT22943 Positive_regulation of Positive_regulation of Gpt 23 0.47 16.09 5.55 5.00
158 INT103518 Negative_regulation of SCN2A 17 0.57 8.4 5.4 5.00
159 INT54617 Positive_regulation of Gene_expression of Abcb1b 22 0.67 9.8 5.34 5.00
160 INT81796 Binding of AGRP 62 0.36 37.19 5.3 5.00
161 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 5.00
162 INT141665 Gene_expression of AGRP 83 0.67 43.43 4.24 5.00
163 INT26239 Positive_regulation of Gene_expression of Lta 12 0.36 8.86 4.22 5.00
164 INT128415 Positive_regulation of Agrp 36 0.64 11.87 3.91 5.00
165 INT5408 Localization of Alb 30 0.73 12.1 3.84 5.00
166 INT80681 Positive_regulation of Atn1 20 0.49 11.85 3.76 5.00
167 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 5.00
168 INT9223 Localization of Ighg1 22 0.78 11.03 3.67 5.00
169 INT35864 Regulation of PRSS1 19 0.61 8.14 3.63 5.00
170 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6 5.00
171 INT23220 Positive_regulation of FOXG1 10 0.43 2.86 3.49 5.00
172 INT69438 Negative_regulation of Positive_regulation of ROS1 20 0.48 10.6 3.33 5.00
173 INT98068 Gene_expression of SCN2A 19 0.75 14.42 3.31 5.00
174 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22 5.00
175 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 5.00
176 INT140555 Positive_regulation of Localization of ROS1 29 0.55 23.82 3.14 5.00
177 INT12638 Positive_regulation of Gnai2 5 0.52 1.16 2.91 5.00
178 INT156522 Gene_expression of NAPEPLD 11 0.75 4.25 2.87 5.00
179 INT97398 Localization of gr 12 0.36 6.88 2.59 5.00
180 INT22916 Negative_regulation of CR1 12 0.57 6.31 2.42 5.00
181 INT25666 Negative_regulation of ADRB1 11 0.44 3.12 2.33 5.00
182 INT31118 Localization of Casp3 17 0.73 11.55 2.3 5.00
183 INT67437 Negative_regulation of Localization of Ifng 7 0.47 2.23 2.28 5.00
184 INT123705 Gene_expression of SMARCB1 40 0.73 19.47 2.2 5.00
185 INT60956 Binding of Abcb1b 8 0.47 2.49 2.09 5.00
186 INT127944 Negative_regulation of Localization of ROS1 8 0.36 3.14 2.02 5.00
187 INT297674 Gene_expression of Atn1 11 0.29 6.69 2 5.00
188 INT12637 Negative_regulation of Gnai2 5 0.33 1.07 1.93 5.00
189 INT20227 Regulation of Lta 11 0.35 6.16 1.91 5.00
190 INT36018 Negative_regulation of Gene_expression of CD8A 12 0.42 6.66 1.85 5.00
191 INT21999 Regulation of Gene_expression of IGHG3 8 0.30 3.26 1.84 5.00
192 INT102843 Negative_regulation of PDC 5 0.57 4.26 1.82 5.00
193 INT32795 Positive_regulation of Hypism 17 0.15 20.16 1.73 5.00
194 INT27762 Positive_regulation of Gene_expression of EPO 18 0.70 17.67 1.45 5.00
195 INT144341 Binding of Qrfpr 4 0.36 0.89 1.4 5.00
196 INT85829 Gene_expression of CA9 14 0.68 12.59 1.4 5.00
197 INT73938 Gene_expression of Cd36 20 0.76 12.27 1.35 5.00
198 INT96073 Localization of Casp1 11 0.78 4.91 1.29 5.00
199 INT144342 Transcription of Qrfpr 4 0.69 0.25 1.27 5.00
200 INT178023 Regulation of Epo 11 0.45 3.87 1.22 5.00
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