D:Familial Adenomatous Polyposis

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Disease Term
Synonyms Adenomatous Polyposis, ADENOMATOUS POLYPOSIS COLI, Adenomatous Polyposis Coli Familial, ADENOMATOUS POLYPOSIS FAMILIAL, Adenomatous Polyposis Of The Colon, FAMILIAL ADENOMATOUS POLYPOSIS COLI, Familial Adenomatous Polyposis Syndrome, Familial Intestinal Polyposis, FAMILIAL MULTIPLE POLYPOSIS SYNDROME, FAMILIAL POLYPOSIS, Familial Polyposis Coli
Documents 379
Hot Single Events 200
Hot Interactions 34

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Familial Adenomatous Polyposis. They are ordered first by their relevance to Familial Adenomatous Polyposis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT283361 AXIN2 Negative_regulation of GSK 1 0.09 1.67 0 100.00
2 INT283362 AXIN2 Negative_regulation of APC 1 0.10 1.67 0 100.00
3 INT268342 Binding of APC and ANKS1B 1 0.01 0.92 0 100.00
4 INT236724 Binding of AXIN1 and Ctnnd2 1 0.39 1.03 0 100.00
5 INT236721 Binding of Apc and Ctnnd2 1 0.25 1.03 0 100.00
6 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0 100.00
7 INT286110 Binding of Rpe65 and Gopc 1 0.01 1.97 0 100.00
8 INT286113 Binding of Fap and Rpe65 1 0.04 1.97 0 100.00
9 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23 100.00
10 INT268395 Binding of APC and Kras 1 0.04 1.21 0 100.00
11 INT228055 WNT1 Positive_regulation of CTNND2 1 0.54 1.75 0.42 99.88
12 INT337680 Binding of TP53 and Scrib 1 0.03 1.6 0 99.84
13 INT322558 Binding of AKT1 and TNFSF10 1 0.05 1.59 0 97.92
14 INT236720 Binding of Ctnnd2 and Tcf4 3 0.24 2.8 0 94.08
15 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0 92.96
16 INT25400 Binding of Ptger1 and Ptger2 2 0.11 1.02 0.15 92.88
17 INT302170 PTGER2 Positive_regulation of Gene_expression of BCL2 1 0.04 3.76 0.23 88.52
18 INT302147 PTGER2 Positive_regulation of BAK1 1 0.06 2.08 0.06 88.52
19 INT302177 PTGER2 Positive_regulation of BCL2 1 0.04 2.08 0.06 88.52
20 INT302138 PTGER2 Positive_regulation of Gene_expression of BAK1 1 0.06 2.08 0.06 88.52
21 INT109410 RASGRP1 Regulation of Gene_expression of PPARG 1 0.03 0.76 0.13 88.24
22 INT268398 Binding of LRP1 and Wnt2 1 0.01 0.36 0 86.40
23 INT337639 TP53 Regulation of Gene_expression of MIR34A 1 0.08 1.19 0 86.32
24 INT109409 PPARA Positive_regulation of Gene_expression of SAT1 1 0.54 0.75 0.2 85.12
25 INT322596 Myc Negative_regulation of TNFSF10 Positive_regulation of BIRC3 1 0.12 1.38 0 82.80
26 INT322597 Myc Negative_regulation of Gene_expression of CFLAR 1 0.11 1.35 0 82.80
27 INT107392 PTGS2 Positive_regulation of PTGS1 2 0.31 1.01 0.26 82.48
28 INT130918 HMHA1 Positive_regulation of BAX 1 0.04 1.37 0.14 80.80
29 INT130923 HMHA1 Positive_regulation of Protein_catabolism of CASP8 1 0.04 1.37 0.14 80.80
30 INT130922 HMHA1 Positive_regulation of Protein_catabolism of CYCS 1 0.06 1.39 0.14 80.80
31 INT130917 HMHA1 Positive_regulation of CYCS 1 0.06 1.39 0.14 80.80
32 INT130921 HMHA1 Positive_regulation of CASP9 1 0.03 1.37 0.14 80.80
33 INT130920 HMHA1 Positive_regulation of CASP8 1 0.04 1.36 0.14 80.80
34 INT130919 HMHA1 Positive_regulation of Protein_catabolism of CASP9 1 0.03 1.37 0.14 80.80
35 INT86430 IL6 Positive_regulation of Gene_expression of HP 1 0.15 3.61 0.83 78.88
36 INT302152 PTGER2 Positive_regulation of EMR1 1 0.01 2.02 0.07 78.72
37 INT322555 TNFSF10 Positive_regulation of MCL1 1 0.16 1.26 0 77.20
38 INT322557 TNFSF10 Positive_regulation of BIRC3 1 0.12 1.27 0 77.20
39 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0 76.04
40 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9 75.96
41 INT97472 CPOX Regulation of Gene_expression of MRXS5 1 0.02 0.16 0.21 75.00
42 INT326901 Binding of PLD2 and Pld1 1 0.28 0.46 0 69.52
43 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 0.11 1.88 0.8 69.04
44 INT84040 EGF Positive_regulation of CPOX 2 0.07 1.91 0.8 69.04
45 INT193214 Binding of PTGER2 and PTGER4 2 0.08 2.51 0.18 68.32
46 INT199370 DST Regulation of Gene_expression of Igf2 1 0.02 1.07 0 65.72
47 INT302167 PTGER2 Positive_regulation of EGFR 1 0.10 3.08 0.09 62.60
48 INT302165 PTGER2 Positive_regulation of Localization of EGFR 1 0.06 1.73 0.05 62.60
49 INT242167 Binding of Dkk1 and Kremen2 1 0.01 0.06 0.04 62.36
50 INT268397 Binding of Kras and Regulation of ARAF 1 0.03 1.16 0 61.92
51 INT337679 Binding of MSI1 and Scrib 1 0.00 1.61 0 60.88
52 INT177914 PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.02 1.07 0.14 56.48
53 INT177911 PRKG1 Positive_regulation of MAPK8 1 0.02 1.07 0.14 56.48
54 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14 56.48
55 INT172213 Binding of BAX and BCL2L1 3 0.22 4.02 0.35 53.08
56 INT268345 Binding of TGFB1 and TGFBR2 1 0.27 0.62 0 49.80
57 INT268340 TGFBR2 Positive_regulation of Phosphorylation of TGFB1 1 0.25 0.68 0 49.20
58 INT302166 Positive_regulation of PTGER2 Positive_regulation of EGFR 1 0.07 1.49 0.04 47.60
59 INT297351 EWSR1 Positive_regulation of PPARA 1 0.41 1.81 0.33 46.60
60 INT199371 DST Regulation of Transcription of Igf2 1 0.05 1.47 0 43.88
61 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0 42.12
62 INT199368 DST Positive_regulation of Gene_expression of Igf2 1 0.04 1.51 0 41.72
63 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0 41.72
64 INT258173 Negative_regulation of Cpox Negative_regulation of Gene_expression of Gtf3a 1 0.00 1.44 0.33 40.12
65 INT186098 EGF Positive_regulation of MAP2K5 1 0.01 0.19 0.18 39.60
66 INT199359 Igf2 Regulation of Macf1 1 0.11 3.11 0 37.96
67 INT199361 Regulation of Igf2 Regulation of Macf1 1 0.11 1.59 0 37.96
68 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0 35.36
69 INT286111 Binding of Rpa3 and Mutyh 1 0.30 0 0 35.36
70 INT286115 Binding of APEX1 and Mutyh 1 0.10 0 0 35.36
71 INT286109 Binding of Pcna and Mutyh 1 0.30 0 0 35.36
72 INT199362 Igf2 Positive_regulation of Macf1 1 0.11 1.67 0 34.00
73 INT302131 Negative_regulation of SOD2 Regulation of BAK1 1 0.09 1.22 0.07 28.92
74 INT302289 Negative_regulation of Birc5 Regulation of BAK1 1 0.20 1.22 0.07 28.92
75 INT302290 Birc5 Regulation of BAK1 1 0.21 1.22 0.07 28.72
76 INT302128 SOD2 Regulation of BAK1 1 0.09 1.22 0.07 28.72
77 INT234599 Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44 26.60
78 INT234600 Negative_regulation of Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44 26.60
79 INT188067 Rps6kb1 Regulation of Rps6 1 0.10 0.1 0 26.32
80 INT194595 Binding of TNFSF10 and TNFRSF10B 4 0.15 9.3 0.53 24.00
81 INT194596 Binding of HLA-DRB4 and TNFSF10 3 0.08 6 0.38 23.68
82 INT253328 Binding of IL8 and Scrib 1 0.04 0.79 0.12 22.76
83 INT348362 Binding of C2 and Positive_regulation of Localization of PLA2G4A 1 0.02 0.37 0.03 22.00
84 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0 21.20
85 INT302126 PTGER2 Positive_regulation of SRC 1 0.11 1.08 0.03 17.28
86 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0 14.48
87 INT349914 Binding of Cdh1 and Jup 1 0.11 0.47 0.07 14.32
88 INT349916 Binding of Ctnnd1 and Cdh1 1 0.17 0.47 0.07 14.32
89 INT322560 Binding of TNFSF10 and DICER1 1 0.07 1.76 0.07 14.00
90 INT302142 PTGER3 Positive_regulation of SRC 1 0.09 1.07 0 13.24
91 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0 13.20
92 INT302174 Positive_regulation of SRC Positive_regulation of Phosphorylation of STAT3 1 0.11 1.01 0 10.12
93 INT268396 Binding of BRAF and Ebp 1 0.01 1.72 0 8.72
94 INT144030 STAT3 Regulation of CCND1 2 0.09 1.05 0 7.72
95 INT302154 STAT3 Regulation of Transcription of CCND1 1 0.04 0.99 0 7.72
96 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73 5.00
97 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 5.00
98 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14 5.00
99 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27 5.00
100 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15 5.00
101 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83 5.00
102 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83 5.00
103 INT184116 Il10 Positive_regulation of Stat3 2 0.18 1.15 0.77 5.00
104 INT184125 Il12a Positive_regulation of Stat4 2 0.11 1.04 0.7 5.00
105 INT171901 Binding of TNF and Il1 2 0.18 1.07 0.7 5.00
106 INT184120 Il4 Positive_regulation of Stat6 3 0.09 2.39 0.67 5.00
107 INT181471 Binding of Il10 and Ptbp1 1 0.05 2.14 0.58 5.00
108 INT184100 Il6 Positive_regulation of Stat1 1 0.16 0.68 0.58 5.00
109 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57 5.00
110 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57 5.00
111 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57 5.00
112 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
113 INT184111 Epo Positive_regulation of Il7 1 0.06 0.26 0.52 5.00
114 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52 5.00
115 INT184088 Epo Positive_regulation of Il2 1 0.07 0.26 0.52 5.00
116 INT184096 Il7 Positive_regulation of Stat5a 1 0.07 0.26 0.51 5.00
117 INT184132 Il2 Positive_regulation of Stat5a 1 0.09 0.26 0.51 5.00
118 INT184099 Il4 Positive_regulation of Stat4 1 0.13 0.28 0.49 5.00
119 INT184105 Il6 Positive_regulation of Socs3 2 0.42 1.34 0.48 5.00
120 INT184094 Gene_expression of Socs3 Negative_regulation of Positive_regulation of Il6 1 0.12 1.49 0.48 5.00
121 INT351771 Il6 Positive_regulation of Localization of Crp 1 0.01 0.94 0.48 5.00
122 INT184117 Il12a Positive_regulation of Stat6 1 0.07 0.28 0.48 5.00
123 INT252634 Binding of TNF and Tnfrsf1a 4 0.02 2.4 0.46 5.00
124 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45 5.00
125 INT290671 Binding of Socs3 and Stat3 2 0.23 1.59 0.45 5.00
126 INT184124 Socs3 Regulation of Il6 1 0.13 1.4 0.43 5.00
127 INT184138 Ik Positive_regulation of Stat3 1 0.01 0.29 0.43 5.00
128 INT316493 Il6 Positive_regulation of Il11ra1 1 0.64 1.69 0.4 5.00
129 INT156438 Cpox Positive_regulation of Nos2 3 0.14 1.24 0.4 5.00
130 INT279414 Binding of CPOX and ACTR1B 1 0.04 1.55 0.4 5.00
131 INT184135 Il11ra1 Positive_regulation of Stat3 1 0.20 0.3 0.4 5.00
132 INT234608 Socs3 Negative_regulation of SOAT1 1 0.01 0.54 0.39 5.00
133 INT184092 Il11ra1 Positive_regulation of Jak1 1 0.17 0.3 0.39 5.00
134 INT234607 Socs3 Negative_regulation of JAK1 1 0.01 0.54 0.39 5.00
135 INT323967 Il6 Positive_regulation of Gene_expression of App 1 0.10 0.86 0.38 5.00
136 INT183645 Ppp1r14b Positive_regulation of Macf1 1 0.00 1.23 0.38 5.00
137 INT183647 Dss1 Positive_regulation of Macf1 1 0.01 1.23 0.38 5.00
138 INT183646 Negative_regulation of Ppp1r14b Positive_regulation of Macf1 1 0.00 1.29 0.38 5.00
139 INT350814 Negative_regulation of TNF Positive_regulation of Gene_expression of Cpox 1 0.06 1.33 0.37 5.00
140 INT350816 TNF Positive_regulation of Gene_expression of Cpox 1 0.05 1.33 0.37 5.00
141 INT184128 Socs3 Negative_regulation of Il6 1 0.12 1.14 0.36 5.00
142 INT184142 Il6 Negative_regulation of Positive_regulation of TNF 1 0.02 0.48 0.35 5.00
143 INT297352 KLF2 Regulation of PPARA 1 0.12 1.31 0.35 5.00
144 INT242162 Binding of Ccnd1 and Wnt2 1 0.10 0.23 0.34 5.00
145 INT184095 Il10 Positive_regulation of Socs3 1 0.21 0.49 0.34 5.00
146 INT184082 Binding of Socs3 and Il6 1 0.11 0.49 0.33 5.00
147 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33 5.00
148 INT184110 Jak1 Positive_regulation of Stat1 1 0.32 0.3 0.33 5.00
149 INT184107 Cish Negative_regulation of Ik 1 0.01 0.1 0.32 5.00
150 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32 5.00
151 INT316488 Il22 Positive_regulation of Il10 1 0.29 0.63 0.32 5.00
152 INT316483 Il22ra1 Positive_regulation of Il10 1 0.27 0.62 0.31 5.00
153 INT316487 Il22 Regulation of Il22ra1 1 0.12 0.61 0.31 5.00
154 INT351770 Binding of Il6 and Ikbkb 1 0.10 1.06 0.29 5.00
155 INT184141 Il6 Positive_regulation of Gene_expression of IFNA1 1 0.01 0.43 0.28 5.00
156 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27 5.00
157 INT237928 BCL2 Positive_regulation of FAS 1 0.02 1.41 0.26 5.00
158 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26 5.00
159 INT237925 BCL2 Positive_regulation of Protein_catabolism of PARP1 1 0.02 1.42 0.26 5.00
160 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26 5.00
161 INT245072 PPARA Regulation of Gene_expression of CXCR4 1 0.07 0.68 0.26 5.00
162 INT302169 PTGER2 Positive_regulation of DYNC1LI1 1 0.02 1.51 0.25 5.00
163 INT297376 Binding of RARS and Rxra 1 0.01 3.27 0.24 5.00
164 INT348364 PROC Negative_regulation of TNF 1 0.01 0.89 0.23 5.00
165 INT173120 Binding of PPARA and NR1H4 8 0.09 2.79 0.23 5.00
166 INT316491 Socs3 Positive_regulation of Il11ra1 1 0.45 0.92 0.22 5.00
167 INT183644 Nos2 Positive_regulation of Gene_expression of Macf1 1 0.05 0.84 0.21 5.00
168 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21 5.00
169 INT348363 PCTP Positive_regulation of PROC 1 0.01 0.41 0.2 5.00
170 INT348372 Binding of PROC and Stard10 1 0.01 0.41 0.2 5.00
171 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2 5.00
172 INT237924 PTPN1 Regulation of Gene_expression of CFLAR 1 0.01 0.7 0.19 5.00
173 INT279965 STAT3 Regulation of Transcription of BCL2L1 1 0.10 2.31 0.19 5.00
174 INT290672 Stat3 Negative_regulation of Il6 1 0.08 0.4 0.18 5.00
175 INT316477 Stat3 Positive_regulation of Il10 1 0.39 0.35 0.18 5.00
176 INT184103 Binding of Socs3 and Il11ra1 1 0.12 0 0.17 5.00
177 INT290670 Binding of Nos2 and Ppara 1 0.17 0.41 0.16 5.00
178 INT316484 Akt1 Positive_regulation of Positive_regulation of Stat3 1 0.01 0.87 0.16 5.00
179 INT184086 Socs5 Negative_regulation of Binding of Jak1 1 0.20 0 0.16 5.00
180 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16 5.00
181 INT350815 Negative_regulation of Binding of TNF and Il1 1 0.05 0.37 0.16 5.00
182 INT184098 Binding of Il4 and Socs5 1 0.09 2.05 0.15 5.00
183 INT316479 Il6 Positive_regulation of Snai1 1 0.24 0.33 0.15 5.00
184 INT316482 Il6 Positive_regulation of Cdh1 1 0.03 0.33 0.15 5.00
185 INT316490 Il6 Positive_regulation of Positive_regulation of Stat3 1 0.50 0.33 0.15 5.00
186 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14 5.00
187 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14 5.00
188 INT287890 THEMIS Regulation of Gene_expression of EPHB2 1 0.00 0.87 0.14 5.00
189 INT184109 Binding of Gopc and Sh2 1 0.03 0 0.14 5.00
190 INT287883 FOS Regulation of Gene_expression of EPHB2 1 0.01 0.87 0.14 5.00
191 INT234604 Tlr4 Positive_regulation of Ptges 1 0.04 0 0.14 5.00
192 INT184104 Binding of Socs3 and Gopc 1 0.10 0 0.14 5.00
193 INT184122 Binding of Socs1 and Sh2 1 0.14 0 0.14 5.00
194 INT263321 Akt1 Regulation of Bad 1 0.00 0.74 0.13 5.00
195 INT184129 Socs2 Negative_regulation of Stat5a 1 0.22 0.05 0.13 5.00
196 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13 5.00
197 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13 5.00
198 INT184091 Socs2 Negative_regulation of Gh 1 0.11 0.05 0.13 5.00
199 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13 5.00
200 INT302156 AKT1 Positive_regulation of E2F2 1 0.02 0.88 0.13 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Familial Adenomatous Polyposis. They are ordered first by their pain relevance and then by number of times they were reported in Familial Adenomatous Polyposis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 100.00
2 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 100.00
3 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 100.00
4 INT220177 Binding of Apc 21 0.37 15.34 1.37 100.00
5 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69 100.00
6 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14 100.00
7 INT14470 Gene_expression of HCC 83 0.67 110.55 4.61 100.00
8 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 100.00
9 INT57062 Regulation of APC 24 0.58 14.3 0.7 100.00
10 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 100.00
11 INT18156 Gene_expression of Fap 18 0.73 27.02 1.46 100.00
12 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 100.00
13 INT242823 Binding of CTNND2 1 0.36 6 0 100.00
14 INT286102 Positive_regulation of Fap 5 0.30 8.58 0.04 100.00
15 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1 100.00
16 INT234454 Regulation of Gene_expression of HCC 6 0.18 8.3 0.06 100.00
17 INT73627 Binding of Fap 8 0.36 11.14 0.4 100.00
18 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 100.00
19 INT63121 Binding of APC 29 0.41 23.02 3.8 100.00
20 INT242819 Negative_regulation of Gene_expression of Apc 4 0.37 5.6 0.1 100.00
21 INT167101 Positive_regulation of Gene_expression of HCC 4 0.20 7.49 0.07 100.00
22 INT198032 Negative_regulation of Gene_expression of HCC 4 0.21 8.16 0.08 100.00
23 INT268374 Gene_expression of FAP 2 0.37 6.6 0 100.00
24 INT23660 Negative_regulation of Fap 5 0.35 8.93 0.95 100.00
25 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91 100.00
26 INT3818 Regulation of Apc 13 0.39 12.52 1.68 100.00
27 INT286096 Phosphorylation of Fap 1 0.49 4.87 0 100.00
28 INT265588 Localization of Fap 4 0.47 5.67 0 100.00
29 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15 100.00
30 INT68564 Binding of Fap 6 0.32 6.75 0.65 100.00
31 INT286107 Positive_regulation of Phosphorylation of Fap 1 0.30 3.5 0 100.00
32 INT99176 Positive_regulation of Fap 4 0.13 7.5 0.22 100.00
33 INT21487 Negative_regulation of HCC 18 0.49 29.81 1.88 100.00
34 INT286092 Positive_regulation of Afap1 1 0.06 2.48 0 100.00
35 INT208551 Gene_expression of Mutyh 6 0.48 6.28 0.12 100.00
36 INT300618 Negative_regulation of Gene_expression of FAP 1 0.21 2.05 0 100.00
37 INT171716 Regulation of Fap 4 0.27 4.05 0.23 100.00
38 INT116836 Binding of FAP 6 0.37 6.76 1.47 100.00
39 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 100.00
40 INT242821 Negative_regulation of Localization of Fap 1 0.11 1.91 0 100.00
41 INT182664 Positive_regulation of Gene_expression of Fap 1 0.16 4.01 0 100.00
42 INT242820 Localization of Fap 1 0.20 1.9 0 100.00
43 INT225667 Transcription of Apc 3 0.52 3.73 0.32 100.00
44 INT286097 Binding of Afap1 1 0.05 1.72 0 100.00
45 INT283365 Positive_regulation of Binding of APC 1 0.50 1.43 0 100.00
46 INT97473 Positive_regulation of FAP 4 0.34 2.72 0.18 100.00
47 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 100.00
48 INT195679 Positive_regulation of Positive_regulation of APC 6 0.50 4.43 0.05 100.00
49 INT195681 Positive_regulation of Negative_regulation of APC 5 0.47 3.9 0 100.00
50 INT151720 Negative_regulation of Positive_regulation of Apc 3 0.37 2.15 0.46 100.00
51 INT242134 Localization of Apc 8 0.74 4.83 0.88 100.00
52 INT268372 Phosphorylation of APC 3 0.81 3.39 0.09 100.00
53 INT286093 Regulation of Binding of Apc 1 0.39 1.08 0 100.00
54 INT286108 Negative_regulation of Afap1 1 0.08 3.35 0.18 100.00
55 INT286095 Gene_expression of Afap1 1 0.09 2.42 0.03 100.00
56 INT123738 Regulation of Fap 2 0.39 2.59 0.08 100.00
57 INT270992 Positive_regulation of Positive_regulation of HCC 2 0.13 2.22 0.12 100.00
58 INT283364 Positive_regulation of Negative_regulation of HCC 1 0.13 1.78 0.05 100.00
59 INT140494 Negative_regulation of Fap 3 0.37 2.3 0.08 100.00
60 INT268370 Phosphorylation of FAP 1 0.24 1.11 0 100.00
61 INT286106 Positive_regulation of Gene_expression of Mutyh 1 0.36 0.66 0 100.00
62 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 100.00
63 INT88924 Negative_regulation of FAP 2 0.41 1.77 0.2 100.00
64 INT286103 Regulation of Gene_expression of Fap 1 0.16 1.49 0 100.00
65 INT18995 Binding of CEL 23 0.47 14.46 4.5 100.00
66 INT193336 Negative_regulation of Positive_regulation of FAP 1 0.29 1.23 0 100.00
67 INT73628 Regulation of Binding of Fap 1 0.44 1.05 0.23 100.00
68 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54 100.00
69 INT337673 Regulation of Positive_regulation of APC 1 0.38 1.44 0 100.00
70 INT242822 Transcription of Fap 1 0.18 1.2 0 100.00
71 INT69417 Positive_regulation of Positive_regulation of RASGRP1 4 0.29 3.92 0.49 100.00
72 INT109415 Negative_regulation of Positive_regulation of RASGRP1 5 0.34 2.16 0.22 100.00
73 INT195672 Localization of APC 7 0.74 3.76 0.3 100.00
74 INT337667 Regulation of Transcription of APC 1 0.23 1 0 100.00
75 INT118243 Transcription of APC 4 0.45 3.33 0.33 100.00
76 INT337657 Negative_regulation of Negative_regulation of APC 1 0.37 0.99 0 100.00
77 INT173166 Negative_regulation of Binding of APC 3 0.40 3.01 0.19 100.00
78 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 100.00
79 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 99.98
80 INT86813 Gene_expression of Pla2g4a 26 0.75 42.31 10.07 99.96
81 INT215117 Gene_expression of Ctsa 14 0.33 8.66 1.18 99.96
82 INT205888 Positive_regulation of Gene_expression of Pla2g4a 7 0.67 8 0.9 99.96
83 INT240422 Negative_regulation of Binding of Ctsa 1 0.23 0.47 0 99.92
84 INT240424 Binding of Ctsa 4 0.20 3.94 0.16 99.92
85 INT260174 Gene_expression of Rpe65 29 0.78 4.2 0.19 99.90
86 INT286105 Positive_regulation of Mutyh 1 0.36 1.94 0.04 99.90
87 INT130343 Gene_expression of CTNND2 5 0.75 6.98 1.38 99.88
88 INT286099 Negative_regulation of Gene_expression of Ctnnd2 1 0.41 1.06 0 99.84
89 INT145328 Negative_regulation of Scrib 25 0.16 26.79 2.66 99.76
90 INT214067 Regulation of Scrib 11 0.20 12.48 0.45 99.76
91 INT60585 Regulation of TP53 59 0.59 54.55 5.21 99.76
92 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 99.62
93 INT286104 Negative_regulation of Mutyh 1 0.35 2.24 0 99.62
94 INT183629 Gene_expression of Ctnnd2 14 0.75 11.78 0.48 99.60
95 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 99.60
96 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 99.52
97 INT286101 Protein_catabolism of Ctnnd2 1 0.64 1.14 0 99.52
98 INT103094 Binding of PPARA 308 0.47 177.26 34.75 99.48
99 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 99.40
100 INT242139 Protein_catabolism of Apc 1 0.17 0.27 0.03 99.40
101 INT98592 Gene_expression of ILK 6 0.78 5.23 0.53 99.36
102 INT98597 Positive_regulation of Gene_expression of ILK 4 0.70 3.08 0.23 99.36
103 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 99.34
104 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 99.32
105 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 99.32
106 INT114372 Negative_regulation of Tcf4 2 0.25 0.7 0.2 99.32
107 INT265491 Gene_expression of CSPG4 16 0.58 7.27 1.07 99.28
108 INT146546 Gene_expression of MSI1 22 0.48 22.91 1.15 99.24
109 INT337653 Gene_expression of BAAT 1 0.06 1.51 0 99.16
110 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 99.16
111 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 99.08
112 INT114371 Negative_regulation of Tcf7l2 1 0.05 0.7 0.2 99.04
113 INT301995 Regulation of Cdh1 5 0.44 3.8 0.48 98.96
114 INT234858 Binding of Cdh1 11 0.47 4.58 0.22 98.96
115 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 98.94
116 INT107988 Regulation of MRC1 2 0.40 0.56 0 98.90
117 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 98.86
118 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 98.84
119 INT181817 Negative_regulation of Gene_expression of Ppara 58 0.58 43.24 7.67 98.84
120 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 98.76
121 INT236704 Binding of Tcf4 3 0.28 3.3 0.1 98.72
122 INT98594 Positive_regulation of ILK 3 0.70 1.74 0.49 98.68
123 INT98591 Positive_regulation of Regulation of ILK 1 0.47 0.7 0.18 98.68
124 INT118293 Regulation of Phosphorylation of EGFR 2 0.61 1.01 1.1 98.64
125 INT53081 Negative_regulation of Gene_expression of Ptgs2 29 0.59 15.83 10.39 98.64
126 INT82798 Regulation of MYC 19 0.60 12.06 2.31 98.62
127 INT228057 Positive_regulation of WNT1 1 0.49 1.8 0.44 98.56
128 INT16814 Negative_regulation of COX5A 74 0.57 33.72 28.63 98.56
129 INT248755 Binding of SS18L1 1 0.31 5.25 0.35 98.56
130 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21 98.56
131 INT75775 Negative_regulation of Mpg 1 0.12 0.79 0.09 98.56
132 INT190031 Binding of Scrib 19 0.36 21.9 1.01 98.48
133 INT140753 Gene_expression of NTN1 2 0.05 4.67 0.06 98.28
134 INT268376 Positive_regulation of Gene_expression of NTN1 1 0.04 3.16 0 98.28
135 INT100078 Positive_regulation of Positive_regulation of PPARG 11 0.70 3.6 5.86 98.24
136 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 98.24
137 INT98595 Regulation of ILK 6 0.62 3.84 1.16 98.16
138 INT236690 Transcription of Tcf4 2 0.41 0.98 0 98.08
139 INT236696 Positive_regulation of Transcription of Tcf4 1 0.08 0.98 0 98.08
140 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 98.04
141 INT117547 Gene_expression of SND1 2 0.57 1.27 0.71 98.04
142 INT337668 Positive_regulation of Gene_expression of SND1 1 0.51 0.99 0 98.04
143 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95 97.96
144 INT87715 Negative_regulation of Negative_regulation of Ptgs2 1 0.16 0.68 0.17 97.92
145 INT106253 Positive_regulation of HNF4A 14 0.29 3.88 0.34 97.88
146 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 97.76
147 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 97.66
148 INT268383 Gene_expression of MUTYH 1 0.46 2.56 0 97.66
149 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 97.52
150 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 97.48
151 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 97.48
152 INT114370 Negative_regulation of Positive_regulation of Tcf4 1 0.10 0.63 0.17 97.42
153 INT80809 Gene_expression of STMN1 8 0.28 6.71 0.99 97.40
154 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 97.36
155 INT53082 Positive_regulation of Gene_expression of Ptgs2 47 0.64 25.39 11.39 97.36
156 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 97.28
157 INT114369 Positive_regulation of Tcf4 6 0.40 2.7 0.25 97.28
158 INT144700 Gene_expression of Kras 21 0.41 12.28 0.57 97.20
159 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 97.20
160 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47 97.20
161 INT73335 Gene_expression of ACTB 21 0.58 5.62 1.94 97.18
162 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36 97.16
163 INT16612 Localization of STMN1 2 0.33 0.19 0.33 96.92
164 INT221864 Binding of JUP 2 0.36 1.05 0 96.80
165 INT205083 Positive_regulation of JUP 6 0.49 5.51 0.13 96.80
166 INT309874 Positive_regulation of Binding of JUP 1 0.49 0.32 0 96.80
167 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 96.76
168 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 96.76
169 INT58679 Gene_expression of Odc1 13 0.78 9.55 0.45 96.64
170 INT58681 Positive_regulation of Gene_expression of Odc1 2 0.70 1.13 0.07 96.64
171 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07 96.60
172 INT102719 Negative_regulation of PDPK1 1 0.58 3 0.21 96.48
173 INT91220 Positive_regulation of Binding of Ptgs1 1 0.02 0.76 0.47 96.48
174 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 96.40
175 INT124375 Gene_expression of Wnt2 67 0.56 38.03 4.67 96.36
176 INT131384 Binding of Mutyh 5 0.26 2.41 0.78 96.32
177 INT190017 Localization of Scrib 6 0.10 7 0.38 96.32
178 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31 96.28
179 INT188060 Positive_regulation of Fzd1 1 0.25 0.25 0.12 96.28
180 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4 96.24
181 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 96.16
182 INT100144 Negative_regulation of Positive_regulation of PPARA 17 0.49 12.71 2.68 96.16
183 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4 96.12
184 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 96.08
185 INT109417 Positive_regulation of Transcription of SAT1 1 0.66 0.74 0.22 96.00
186 INT109416 Transcription of SAT1 2 0.68 0.96 0.22 96.00
187 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 95.76
188 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 95.68
189 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 95.68
190 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 95.64
191 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 95.64
192 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 95.60
193 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 95.40
194 INT65855 Localization of TP53 18 0.76 17.08 1.89 95.04
195 INT17118 Gene_expression of Plaur 4 0.65 1.22 1.1 95.04
196 INT188046 Regulation of Gene_expression of Plaur 1 0.11 0.25 0.12 95.04
197 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73 95.02
198 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 94.86
199 INT109975 Positive_regulation of Kras 14 0.45 12.72 1.68 94.76
200 INT189877 Gene_expression of Cdh1 55 0.58 9.36 0.66 94.52
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