D:Familial Amyloidotic Polyneuropathy

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Af Type Amyloidosis, Amyloid Neuropathies Familial, AMYLOID NEUROPATHY, Amyloid Neuropathy Familial, AMYLOID POLYNEUROPATHIES FAMILIAL, AMYLOID POLYNEUROPATHY BRITISH TYPE, Amyloid Polyneuropathy Familial, Amyloid Polyneuropathy Iowa Type, AMYLOID POLYNEUROPATHY SWISS TYPE, Amyloidoses Portuguese Polyneuritic, Amyloidosis Portuguese Polyneuritic
Documents 76
Hot Single Events 39
Hot Interactions 8

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Familial Amyloidotic Polyneuropathy. They are ordered first by their relevance to Familial Amyloidotic Polyneuropathy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT327366 Binding of Fap and Ttr 1 0.33 2.9 0.28 100.00
2 INT224922 Binding of FAP and TARM1 1 0.06 1.4 0.06 100.00
3 INT130554 Binding of TTR and Fap 1 0.02 0.72 0.07 100.00
4 INT85816 Binding of CEL and TTR 1 0.39 0.77 0.14 100.00
5 INT224921 Binding of TTR and TARM1 1 0.06 1.06 0 96.88
6 INT166214 Binding of CTS and TTR 1 0.13 1.63 0.55 96.40
7 INT256586 Binding of RBP4 and TTR 1 0.07 1.92 0.18 94.44
8 INT256587 Binding of ALB and TTR 1 0.35 0.69 0 90.32
9 INT55809 Binding of Ttr and Fap 1 0.12 2.56 0.19 75.00
10 INT340742 Positive_regulation of CSF2 Regulation of BDNF 1 0.22 1.46 0.14 36.52
11 INT340744 CSF2 Regulation of BDNF 1 0.13 1.45 0.14 36.16
12 INT275670 Binding of HBP1 and DEFB103A 1 0.03 0.23 0.09 5.00
13 INT217402 Binding of Bace1 and PSENEN 1 0.02 0.72 0 5.00
14 INT217399 Binding of Bace1 and Ncstn 1 0.05 0.72 0 5.00
15 INT273136 Binding of CHED1 and VSX1 1 0.15 0.12 0 5.00
16 INT340743 Negative_regulation of CSF2 Positive_regulation of ZNF807 1 0.00 1.77 0 5.00
17 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0 5.00
18 INT340745 CSF2 Positive_regulation of ZNF807 1 0.00 1.76 0 5.00
19 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0 5.00
20 INT275703 Binding of TTR and Ebf1 1 0.37 0.08 0 5.00
21 INT217396 Binding of Abca1 and App 1 0.26 0.83 0 5.00
22 INT275702 Binding of F3 and DEFB103A 1 0.01 0.16 0 5.00
23 INT217397 Binding of Bace1 and Alph1 1 0.02 0.73 0 5.00
24 INT349296 Binding of CSF2 and PARK7 1 0.24 1.24 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Familial Amyloidotic Polyneuropathy. They are ordered first by their pain relevance and then by number of times they were reported in Familial Amyloidotic Polyneuropathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT23660 Negative_regulation of Fap 5 0.35 8.93 0.95 100.00
2 INT18156 Gene_expression of Fap 18 0.73 27.02 1.46 100.00
3 INT326623 Binding of Ttr 2 0.35 4.76 0.46 100.00
4 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 100.00
5 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 100.00
6 INT73627 Binding of Fap 8 0.36 11.14 0.4 100.00
7 INT171716 Regulation of Fap 4 0.27 4.05 0.23 100.00
8 INT265588 Localization of Fap 4 0.47 5.67 0 100.00
9 INT265580 Positive_regulation of Gene_expression of Fap 3 0.28 2.78 0.1 100.00
10 INT39212 Binding of Ttr 14 0.48 9.62 2.31 99.98
11 INT9310 Negative_regulation of Ssr1 20 0.49 6.55 4.73 99.88
12 INT44223 Positive_regulation of TTR 10 0.70 10.98 1.95 99.82
13 INT192423 Positive_regulation of TARM1 5 0.34 10.77 0.51 99.74
14 INT327362 Regulation of Gene_expression of Ttr 1 0.42 0.52 0 99.74
15 INT6891 Binding of TTR 72 0.48 22.81 6.51 99.52
16 INT327363 Negative_regulation of Ttr 8 0.40 8.21 0.82 99.48
17 INT119543 Gene_expression of Ttr 10 0.74 5.14 0.22 99.44
18 INT56342 Gene_expression of TTR 34 0.78 16.5 2.05 99.36
19 INT327364 Negative_regulation of Gene_expression of Ttr 1 0.40 0.94 0 98.92
20 INT87361 Negative_regulation of TTR 25 0.57 5.74 1.51 98.76
21 INT349302 Localization of PARK7 1 0.78 3.09 0 97.68
22 INT74638 Transcription of Ttr 1 0.66 0.64 0.08 96.76
23 INT118559 Positive_regulation of Hspa5 20 0.61 15.66 1.45 93.72
24 INT94122 Negative_regulation of Mmp23 21 0.37 15.81 8.03 92.88
25 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 92.88
26 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1 92.88
27 INT198875 Localization of Mmp23 4 0.07 2.05 0.88 92.88
28 INT218314 Binding of RBP4 9 0.36 6.27 0.33 92.44
29 INT224924 Binding of TARM1 4 0.18 3.42 0.39 91.36
30 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 90.96
31 INT113605 Negative_regulation of Gene_expression of Mmp9 25 0.41 22.92 9.98 89.84
32 INT327365 Negative_regulation of Positive_regulation of Hspa5 1 0.21 0.68 0 89.64
33 INT546 Binding of ALB 311 0.48 85.98 60.14 89.48
34 INT23766 Binding of SERPINA7 3 0.36 1.66 0.2 89.48
35 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 89.48
36 INT9801 Regulation of TTR 3 0.45 1.4 0.48 88.04
37 INT9799 Regulation of Ttr 3 0.37 1.96 0.52 88.04
38 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 84.64
39 INT349304 Positive_regulation of PARK7 1 0.67 9.44 0 83.28
40 INT256600 Gene_expression of SERPINA7 1 0.65 0.66 0 79.32
41 INT87360 Binding of ABCC1 6 0.47 1.71 2.38 79.28
42 INT119541 Positive_regulation of Ttr 5 0.58 6.07 0.6 78.12
43 INT327359 Regulation of Positive_regulation of Ttr 1 0.37 0.93 0.09 78.12
44 INT349300 Gene_expression of PARK7 1 0.75 8.65 0.12 76.16
45 INT327361 Regulation of Ttr 1 0.37 2.33 0.28 76.08
46 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 75.32
47 INT16150 Positive_regulation of NKG7 10 0.69 10.26 1.73 75.00
48 INT103164 Binding of UPF1 4 0.29 4.15 1.22 75.00
49 INT68564 Binding of Fap 6 0.32 6.75 0.65 75.00
50 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07 74.60
51 INT170305 Regulation of Gene_expression of Mmp9 11 0.33 5.7 2.8 74.60
52 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 72.12
53 INT73673 Negative_regulation of Mtap2 9 0.32 8.25 1.4 71.96
54 INT99899 Regulation of Mmp23 3 0.17 2.31 0.69 69.32
55 INT158458 Regulation of Gene_expression of Mmp23 4 0.02 1.73 0.25 69.32
56 INT63822 Gene_expression of Mmp23 23 0.43 14.15 5.96 68.92
57 INT16794 Binding of App 103 0.48 64.87 19.79 67.84
58 INT165342 Gene_expression of TGFBI 13 0.59 5.81 0.39 67.20
59 INT14690 Localization of CSF2 124 0.80 85.17 27.26 61.20
60 INT340751 Binding of DLEU1 1 0.20 12.05 0.49 57.72
61 INT14301 Binding of CSF2 82 0.48 67.95 8.98 57.72
62 INT101450 Positive_regulation of DLEU1 2 0.22 2.65 0.12 52.08
63 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 49.28
64 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 46.60
65 INT68576 Positive_regulation of Positive_regulation of CSF2 8 0.40 8.1 2.83 42.08
66 INT349303 Positive_regulation of Positive_regulation of PARK7 1 0.49 1 0 42.08
67 INT161206 Negative_regulation of Localization of Mmp9 10 0.59 9.68 3.59 41.76
68 INT108931 Negative_regulation of BDNF 38 0.59 19.61 8.84 41.24
69 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 40.16
70 INT212510 Binding of Apcs 26 0.48 15.2 0.72 30.96
71 INT327360 Negative_regulation of Regulation of Mmp9 1 0.30 0.17 0 27.68
72 INT289478 Protein_catabolism of TGFBI 1 0.75 0.52 0 25.52
73 INT256594 Binding of HBP1 3 0.32 0.29 0.25 25.04
74 INT275687 Negative_regulation of Binding of HBP1 1 0.12 0.06 0.16 25.04
75 INT14281 Gene_expression of Hspa5 44 0.63 34.19 3.31 22.48
76 INT289479 Binding of FAS-AS1 1 0.07 0.5 0 19.60
77 INT88640 Localization of TTR 5 0.75 1.71 0.3 18.00
78 INT263030 Binding of DEFB103A 2 0.21 0.51 0.37 16.00
79 INT349299 Binding of PARK7 1 0.41 1.86 0 12.76
80 INT256596 Negative_regulation of Localization of TTR 2 0.36 0.1 0.1 7.60
81 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
82 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
83 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
84 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
85 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
86 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
87 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65 5.00
88 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 5.00
89 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
90 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 5.00
91 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
92 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 5.00
93 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 5.00
94 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 5.00
95 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
96 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
97 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
98 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
99 INT15148 Gene_expression of Vip 51 0.77 25.61 18.33 5.00
100 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87 5.00
101 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
102 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83 5.00
103 INT131296 Positive_regulation of Bace1 208 0.70 170.1 15.79 5.00
104 INT11508 Positive_regulation of TGFBI 24 0.70 19.81 15.78 5.00
105 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 5.00
106 INT96775 Gene_expression of Pdgfa 42 0.54 29.78 15.46 5.00
107 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 5.00
108 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
109 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21 5.00
110 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38 5.00
111 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12 5.00
112 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48 5.00
113 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15 5.00
114 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 5.00
115 INT6431 Positive_regulation of Ass1 36 0.24 8.08 10.43 5.00
116 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48 5.00
117 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 5.00
118 INT178198 Gene_expression of C3 62 0.78 39.5 7.69 5.00
119 INT202868 Positive_regulation of Car1 30 0.44 15.48 7.42 5.00
120 INT53189 Gene_expression of VSX1 32 0.69 10.59 7.21 5.00
121 INT197493 Localization of Apoe 61 0.79 27.48 7.06 5.00
122 INT156489 Positive_regulation of Gene_expression of Bace1 67 0.69 41.07 7.02 5.00
123 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94 5.00
124 INT55655 Gene_expression of DCN 17 0.75 7.98 5.98 5.00
125 INT63042 Binding of Apoe 59 0.48 31.23 5.88 5.00
126 INT18677 Gene_expression of F3 50 0.65 30.86 5.86 5.00
127 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 5.00
128 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
129 INT160853 Gene_expression of Syp 87 0.72 20.06 5.31 5.00
130 INT18681 Gene_expression of Thy1 80 0.71 38.8 5.23 5.00
131 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81 5.00
132 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19 5.00
133 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
134 INT159119 Negative_regulation of Car1 17 0.37 6.6 4.01 5.00
135 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71 5.00
136 INT52678 Positive_regulation of VSX1 15 0.42 3.94 3.64 5.00
137 INT2117 Regulation of VSX1 15 0.30 3.38 3.38 5.00
138 INT110245 Gene_expression of SNCA 11 0.77 8.29 3.36 5.00
139 INT134786 Gene_expression of Adam10 17 0.68 7.61 3.29 5.00
140 INT48390 Negative_regulation of Localization of CSF2 10 0.51 7.39 3.28 5.00
141 INT217389 Negative_regulation of Gene_expression of Bace1 43 0.59 18.57 3.27 5.00
142 INT4596 Positive_regulation of SCD 18 0.42 22.59 3.26 5.00
143 INT102255 Regulation of Prnp 35 0.62 18.97 3.25 5.00
144 INT44873 Negative_regulation of LCAT 16 0.59 6.92 3.13 5.00
145 INT156488 Binding of Bace1 46 0.48 15.64 3.04 5.00
146 INT178291 Gene_expression of Hps1 26 0.67 8.2 2.52 5.00
147 INT210527 Positive_regulation of Gene_expression of Tenc1 14 0.38 6.37 2.45 5.00
148 INT111072 Protein_catabolism of Bace1 26 0.98 14.07 2.41 5.00
149 INT57970 Positive_regulation of Rb1 17 0.67 7.03 2.36 5.00
150 INT27590 Negative_regulation of Phex 5 0.36 2.38 2.26 5.00
151 INT142265 Regulation of Apoe 20 0.60 9.52 2.23 5.00
152 INT161382 Localization of KRT20 25 0.61 12.97 2.13 5.00
153 INT124772 Regulation of Binding of App 6 0.45 4.92 2.09 5.00
154 INT51980 Protein_catabolism of Mme 6 0.89 2.49 2.06 5.00
155 INT60723 Localization of Psen2 5 0.68 2.11 2.02 5.00
156 INT193939 Binding of PSEN1 10 0.36 6.16 1.93 5.00
157 INT190883 Gene_expression of Apoc3 16 0.38 14.18 1.93 5.00
158 INT198885 Gene_expression of Lrp1 33 0.57 10.2 1.91 5.00
159 INT2116 Negative_regulation of VSX1 29 0.36 10.67 1.89 5.00
160 INT258135 Gene_expression of CARTPT 3 0.40 5.25 1.88 5.00
161 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 5.00
162 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77 5.00
163 INT217382 Regulation of Gene_expression of Bace1 26 0.61 17 1.76 5.00
164 INT163613 Transcription of CSF2 16 0.60 12.98 1.62 5.00
165 INT203508 Gene_expression of Eno2 12 0.65 4.98 1.55 5.00
166 INT133863 Positive_regulation of Protein_catabolism of App 12 0.59 7.53 1.52 5.00
167 INT121335 Localization of SCD 10 0.68 6.81 1.51 5.00
168 INT256598 Gene_expression of DEFB103A 8 0.65 5.06 1.49 5.00
169 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4 5.00
170 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35 5.00
171 INT45075 Gene_expression of Sugt1 24 0.27 8.5 1.33 5.00
172 INT61999 Gene_expression of MAPT 19 0.75 15.4 1.3 5.00
173 INT126370 Localization of VSX1 6 0.56 1.7 1.28 5.00
174 INT170900 Regulation of Positive_regulation of Gopc 10 0.20 3.44 1.24 5.00
175 INT110244 Positive_regulation of Gene_expression of SNCA 5 0.69 4.66 1.19 5.00
176 INT217390 Negative_regulation of Positive_regulation of Apoe 3 0.37 1.95 1.05 5.00
177 INT179535 Negative_regulation of C1qa 10 0.57 4.7 1.03 5.00
178 INT147113 Binding of LTF 14 0.29 18.24 0.98 5.00
179 INT73450 Gene_expression of Pilra 7 0.05 2.87 0.97 5.00
180 INT70323 Negative_regulation of Gene_expression of CA2 13 0.41 6.55 0.97 5.00
181 INT15310 Gene_expression of DLEU1 8 0.67 20.57 0.96 5.00
182 INT185969 Regulation of Syp 5 0.57 2.58 0.92 5.00
183 INT263027 Positive_regulation of DEFB103A 5 0.45 2.89 0.92 5.00
184 INT198872 Binding of Lrp1 9 0.36 2.73 0.89 5.00
185 INT185973 Negative_regulation of Syp 16 0.54 2.83 0.87 5.00
186 INT167607 Positive_regulation of Binding of App 8 0.50 2.97 0.86 5.00
187 INT24142 Regulation of DLEU1 1 0.21 1.01 0.85 5.00
188 INT197494 Gene_expression of Apoa4 9 0.05 7.33 0.78 5.00
189 INT68297 Binding of MAPT 9 0.47 4.45 0.75 5.00
190 INT59175 Localization of TNMD 4 0.70 4.14 0.71 5.00
191 INT63133 Gene_expression of Pd 13 0.18 5.31 0.61 5.00
192 INT236837 Regulation of Negative_regulation of CSF2 2 0.32 1.83 0.61 5.00
193 INT14318 Negative_regulation of MAPT 3 0.57 2.05 0.59 5.00
194 INT118716 Positive_regulation of MAPT 4 0.49 7.25 0.54 5.00
195 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53 5.00
196 INT334212 Negative_regulation of DLEU1 2 0.28 8.84 0.53 5.00
197 INT148884 Negative_regulation of HCRTR1 7 0.23 7.23 0.53 5.00
198 INT4597 Regulation of SCD 5 0.39 2.25 0.5 5.00
199 INT189634 Regulation of DCN 3 0.25 1.69 0.49 5.00
200 INT84573 Regulation of Mavs 1 0.01 1.37 0.49 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox