D:Familial Combined Hyperlipidemia

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Disease Term
Synonyms COMBINED HYPERLIPIDEMIA FAMILIAL, COMBINED HYPERLIPIDEMIAS FAMILIAL, Familial Combined Hyperlipidemias, Hyperlipidemia Multiple Lipoprotein Type, Hyperlipidemias Familial Combined, Hyperlipidemias Multiple Lipoprotein Type, LIPOPROTEIN TYPE HYPERLIPIDEMIA MULTIPLE, Lipoprotein Type Hyperlipidemias Multiple, Multiple Lipoprotein Type Hyperlipidemia, MULTIPLE LIPOPROTEIN TYPE HYPERLIPIDEMIAS
Documents 11
Hot Single Events 60
Hot Interactions 16

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Familial Combined Hyperlipidemia. They are ordered first by their relevance to Familial Combined Hyperlipidemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT279909 Binding of FADS3 and TGS1 1 0.12 6 0 100.00
2 INT279901 Binding of FADS3 and USF1 1 0.35 4.71 0 100.00
3 INT279894 Binding of USF1 and TGS1 1 0.11 3.52 0 100.00
4 INT279903 Binding of EMR1 and USF1 1 0.01 2.24 0.04 100.00
5 INT279893 Binding of SNRNP70 and USF1 1 0.04 0.78 0 100.00
6 INT279895 Binding of ABCC6 and USF1 1 0.31 0.8 0.04 100.00
7 INT279899 Binding of HSD11B1 and USF1 1 0.31 0.79 0.04 100.00
8 INT279905 Binding of SNRNP70 and TGS1 1 0.01 1.85 0 99.48
9 INT279910 SNRNP70 Regulation of TGS1 1 0.01 0.76 0 99.36
10 INT279898 SNRNP70 Regulation of EMR1 1 0.00 0.93 0 98.16
11 INT250554 Binding of F5 and SELS 1 0.24 1.07 0 97.44
12 INT279900 Binding of RS1 and TGS1 1 0.00 1.12 0 92.80
13 INT279904 Binding of FADS3 and RS1 1 0.00 1.12 0 92.80
14 INT279907 Binding of GCLM and IRF8 1 0.22 0.82 0.05 89.68
15 INT279902 Binding of GCLM and CARD8 1 0.28 0.82 0.05 89.68
16 INT279896 Binding of GCLM and STX6 1 0.24 0.82 0.05 89.68
17 INT247439 Binding of APOA1 and HSD11B1 3 0.32 5.01 0.03 75.56
18 INT250553 Binding of RS1 and SUGT1 3 0.00 3.36 0.22 6.64
19 INT250550 Binding of F12 and CHDH 1 0.05 2.26 0.17 5.00
20 INT213144 TIMP1 Negative_regulation of THBD 1 0.04 1.16 0.12 5.00
21 INT213147 DAK Negative_regulation of THBD 1 0.00 1.16 0.12 5.00
22 INT213145 DAK Positive_regulation of TIMP1 1 0.02 0.36 0.09 5.00
23 INT247435 Binding of APOB and SNRNP70 1 0.04 2.2 0 5.00
24 INT213149 DAK Regulation of HSD11B1 1 0.00 1.42 0 5.00
25 INT247441 Binding of APOC3 and SNRNP70 1 0.04 0.26 0 5.00
26 INT250555 Binding of APOBEC2 and CHDH 1 0.04 0.57 0 5.00
27 INT213148 TIMP1 Regulation of DAK 1 0.01 0.73 0 5.00
28 INT247444 Binding of APOA1 and APOC3 1 0.28 0.39 0 5.00
29 INT247436 Binding of APOA1 and SACM1L 1 0.27 0.39 0 5.00
30 INT250551 Binding of USF1 and CHDH 1 0.04 0.7 0 5.00
31 INT250557 Binding of PITX2 and CHDH 1 0.00 2.83 0 5.00
32 INT213146 TIMP1 Regulation of HSD11B1 1 0.02 0.7 0 5.00
33 INT213143 DAK Regulation of TIMP1 1 0.01 0.73 0 5.00
34 INT247438 Binding of APOB and SACM1L 1 0.28 2 0 5.00
35 INT250556 Binding of FGA and HSD11B1 1 0.33 0.57 0 5.00
36 INT247437 Binding of HSD11B1 and SACM1L 1 0.01 0.98 0 5.00
37 INT247440 Binding of APOA1 and APOB 1 0.28 1.02 0 5.00
38 INT247442 Binding of HSD11B1 and SNRNP70 2 0.04 1.3 0 5.00
39 INT250552 Binding of FGG and HSD11B1 1 0.25 0.57 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Familial Combined Hyperlipidemia. They are ordered first by their pain relevance and then by number of times they were reported in Familial Combined Hyperlipidemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT250576 Gene_expression of USF1 3 0.77 18.99 0.13 100.00
2 INT145018 Binding of USF1 4 0.42 15.42 0.11 100.00
3 INT279940 Regulation of USF1 1 0.61 5.4 0 100.00
4 INT279937 Localization of USF1 1 0.75 2.19 0 100.00
5 INT212382 Positive_regulation of USF1 2 0.50 3.14 0.27 100.00
6 INT279929 Positive_regulation of Positive_regulation of TGS1 1 0.10 1.36 0 100.00
7 INT169235 Negative_regulation of USF1 4 0.37 2.69 0.91 100.00
8 INT82495 Binding of ABCC6 2 0.31 1.05 0.25 100.00
9 INT279936 Positive_regulation of Positive_regulation of USF1 1 0.41 0.88 0 100.00
10 INT279941 Negative_regulation of Gene_expression of USF1 1 0.37 0.74 0 100.00
11 INT113960 Positive_regulation of Gene_expression of APOB 8 0.49 5.88 1.39 99.96
12 INT40877 Positive_regulation of APOB 35 0.68 32.47 1.86 99.92
13 INT279931 Positive_regulation of TGS1 2 0.13 3.04 0 99.90
14 INT165623 Gene_expression of TGS1 5 0.22 3.42 0.13 99.90
15 INT279943 Negative_regulation of Regulation of FADS3 1 0.41 0.91 0 99.84
16 INT214503 Gene_expression of FADS3 3 0.75 7.81 0.18 99.80
17 INT279934 Regulation of Gene_expression of FADS3 1 0.60 1.77 0 99.68
18 INT28673 Gene_expression of APOB 51 0.73 34.02 3.95 99.64
19 INT279927 Negative_regulation of Gene_expression of FADS3 1 0.41 1.35 0 99.36
20 INT178841 Localization of SNRNP70 27 0.78 10.35 1.71 99.36
21 INT279926 Localization of FADS3 1 0.73 0.77 0 99.30
22 INT238902 Binding of TGS1 3 0.07 2.86 0.36 99.16
23 INT279925 Positive_regulation of FADS3 1 0.49 1.34 0 99.12
24 INT37799 Gene_expression of Apob 13 0.56 10.59 1.36 99.04
25 INT317658 Positive_regulation of Gene_expression of Apob 1 0.17 1.59 0 99.04
26 INT279942 Gene_expression of FADS1 1 0.69 2.5 0 98.84
27 INT279938 Negative_regulation of Gene_expression of FADS1 1 0.38 1.49 0 98.84
28 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 98.76
29 INT279933 Regulation of FADS3 1 0.60 0.9 0 98.64
30 INT279935 Localization of TGS1 1 0.15 0.8 0 98.10
31 INT239411 Localization of APOB 10 0.76 5.71 0.04 97.60
32 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 97.08
33 INT19967 Gene_expression of C9orf3 18 0.75 26.51 4.6 96.64
34 INT247452 Gene_expression of APOA5 4 0.54 5.71 0.22 96.64
35 INT72676 Gene_expression of APOA1 34 0.75 34.15 1.67 96.64
36 INT113996 Gene_expression of RS1 23 0.72 7.7 3.16 96.60
37 INT11030 Binding of LPA 70 0.48 40.35 4.81 96.20
38 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 95.68
39 INT279944 Positive_regulation of Gene_expression of USF1 1 0.50 3.33 0.08 94.32
40 INT100254 Binding of SELS 6 0.36 4.54 0.4 94.32
41 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 94.28
42 INT156180 Positive_regulation of Gene_expression of SNRNP70 14 0.49 4.54 2.13 93.56
43 INT186261 Gene_expression of ME1 3 0.10 2.87 0 93.28
44 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 92.64
45 INT46430 Binding of ME1 4 0.28 1.22 0.88 92.56
46 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 91.96
47 INT177992 Positive_regulation of SNRNP70 28 0.49 16.14 4.28 91.52
48 INT239247 Positive_regulation of APOA5 7 0.37 3.68 0.51 90.72
49 INT146563 Gene_expression of PROK2 15 0.75 4.12 0.61 90.56
50 INT211806 Gene_expression of PLXNC1 4 0.63 2.95 0.07 89.76
51 INT279932 Gene_expression of PLXDC1 1 0.61 0.61 0.07 89.12
52 INT21712 Positive_regulation of APOA1 32 0.67 21.64 2.64 88.00
53 INT172527 Gene_expression of IGFBP7 6 0.60 4.76 0.36 87.84
54 INT279930 Gene_expression of GALR2 3 0.60 0.6 0.16 87.20
55 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 87.04
56 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 86.64
57 INT279921 Gene_expression of AK5 1 0.59 0.6 0.06 86.16
58 INT37800 Positive_regulation of Apob 7 0.18 11.01 0.48 85.64
59 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 82.48
60 INT138799 Regulation of Gene_expression of Ppara 40 0.60 29.42 6.89 82.08
61 INT100384 Regulation of SNRNP70 24 0.60 11 3.56 79.84
62 INT197681 Binding of CHDH 40 0.48 33.72 2.13 70.88
63 INT91147 Positive_regulation of Positive_regulation of Ppara 30 0.69 19.31 5.56 67.76
64 INT79166 Regulation of TNC 12 0.44 9.42 8.13 67.72
65 INT122041 Binding of Ppara 308 0.48 189.17 51.48 66.32
66 INT274529 Localization of Lpl 2 0.46 2.31 0.32 40.16
67 INT317659 Protein_catabolism of Lpl 1 0.65 0.72 0 38.00
68 INT92619 Binding of LCT 4 0.48 2.32 0.14 21.08
69 INT250571 Binding of APOBEC2 1 0.31 1.21 0 20.76
70 INT317660 Positive_regulation of Localization of Lpl 1 0.40 0.49 0 11.76
71 INT35359 Negative_regulation of LCT 23 0.59 9.13 2.29 8.88
72 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
73 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
74 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
75 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
76 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
77 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
78 INT55671 Gene_expression of Ik 151 0.27 80.1 48.49 5.00
79 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
80 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
81 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 5.00
82 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
83 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
84 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 5.00
85 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
86 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 5.00
87 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
88 INT106745 Localization of CRP 65 0.81 66.44 15.21 5.00
89 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8 5.00
90 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
91 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 5.00
92 INT122037 Regulation of Ppara 93 0.62 56.28 12.89 5.00
93 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55 5.00
94 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 5.00
95 INT194462 Localization of Ppara 94 0.78 68.33 12.09 5.00
96 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 5.00
97 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95 5.00
98 INT80549 Binding of ICAM1 53 0.47 42.76 9.72 5.00
99 INT36678 Binding of TIMP1 33 0.36 14.99 7.87 5.00
100 INT181817 Negative_regulation of Gene_expression of Ppara 58 0.58 43.24 7.67 5.00
101 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 5.00
102 INT32709 Negative_regulation of Hbb 30 0.54 18.27 6.97 5.00
103 INT17086 Binding of HSD11B1 84 0.47 122.28 6.16 5.00
104 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 5.00
105 INT34232 Regulation of TIMP1 37 0.61 18.76 6.05 5.00
106 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 5.00
107 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82 5.00
108 INT23551 Negative_regulation of CNDP2 13 0.38 3.05 5.05 5.00
109 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69 5.00
110 INT197171 Negative_regulation of Binding of Ppara 15 0.43 11.51 4.41 5.00
111 INT57525 Negative_regulation of Ltf 9 0.50 4.2 4.03 5.00
112 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72 5.00
113 INT69593 Negative_regulation of PSMD1 11 0.57 4.06 3.33 5.00
114 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
115 INT250581 Gene_expression of SELS 4 0.78 47.37 3.27 5.00
116 INT19393 Gene_expression of Gfm1 31 0.51 18.9 3.2 5.00
117 INT17562 Negative_regulation of Lipg 32 0.51 16.91 3.17 5.00
118 INT164633 Gene_expression of EGFL7 23 0.53 10.46 3.1 5.00
119 INT24443 Gene_expression of PSMD2 20 0.54 7.29 2.77 5.00
120 INT207165 Gene_expression of DAK 18 0.08 9.41 2.69 5.00
121 INT115250 Positive_regulation of Slc2a4 16 0.67 8.13 2.64 5.00
122 INT73460 Positive_regulation of Gene_expression of Myc 26 0.67 20.44 2.61 5.00
123 INT1928 Negative_regulation of Lpl 18 0.51 11.22 2.49 5.00
124 INT1153 Negative_regulation of FUT3 17 0.38 8.61 2.21 5.00
125 INT197166 Gene_expression of Cyp4a10 27 0.75 15.63 1.81 5.00
126 INT4188 Binding of NF2 7 0.46 3.52 1.79 5.00
127 INT197173 Positive_regulation of Cyp4a10 29 0.62 15.68 1.61 5.00
128 INT9466 Binding of APOB 27 0.41 19.36 1.56 5.00
129 INT178890 Localization of CHDH 12 0.62 15.76 1.49 5.00
130 INT83891 Gene_expression of FUT3 20 0.61 10.49 1.41 5.00
131 INT179693 Positive_regulation of DAK 14 0.04 6.02 1.4 5.00
132 INT197174 Positive_regulation of Gene_expression of Cyp4a10 17 0.67 8.65 1.4 5.00
133 INT108327 Negative_regulation of Gene_expression of Ccnd1 18 0.38 14.36 1.31 5.00
134 INT96141 Gene_expression of ASPSCR1 9 0.68 11.46 1.29 5.00
135 INT197167 Positive_regulation of Localization of Ppara 18 0.67 9.51 1.21 5.00
136 INT23199 Binding of LDLR 22 0.47 17.08 1.16 5.00
137 INT79780 Gene_expression of Cyp4a3 14 0.56 5.19 1.12 5.00
138 INT80047 Regulation of Cyp4a3 5 0.45 2.11 1 5.00
139 INT138980 Binding of PITX2 15 0.47 10.34 0.88 5.00
140 INT24845 Gene_expression of Gnptg 9 0.48 11.42 0.8 5.00
141 INT84979 Regulation of CHDH 22 0.38 22.34 0.78 5.00
142 INT57526 Regulation of Ltf 8 0.45 2.73 0.56 5.00
143 INT203763 Localization of EGFL7 4 0.08 3 0.56 5.00
144 INT213154 Positive_regulation of Binding of TIMP1 2 0.41 1.33 0.55 5.00
145 INT172066 Binding of Mtpn 3 0.02 1.51 0.52 5.00
146 INT221932 Gene_expression of F12 4 0.66 2.61 0.5 5.00
147 INT57462 Gene_expression of Cyp4a 5 0.65 2.4 0.48 5.00
148 INT194467 Binding of Rxrb 3 0.12 1.17 0.43 5.00
149 INT57460 Positive_regulation of Gene_expression of cyp4a 3 0.45 1.05 0.42 5.00
150 INT197168 Regulation of Localization of Ppara 6 0.39 3.7 0.41 5.00
151 INT11689 Binding of PSMD2 16 0.36 2.77 0.34 5.00
152 INT189968 Binding of APOA1 12 0.47 10.1 0.3 5.00
153 INT197016 Positive_regulation of Gene_expression of LDLR 13 0.50 5.82 0.24 5.00
154 INT102071 Negative_regulation of Gene_expression of Myc 8 0.57 3.5 0.22 5.00
155 INT175417 Binding of SACM1L 8 0.29 6.06 0.22 5.00
156 INT171597 Gene_expression of APOC3 9 0.77 3.18 0.2 5.00
157 INT152072 Binding of HDLCQ1 3 0.18 2.18 0.15 5.00
158 INT197170 Positive_regulation of Acox1 2 0.14 1.08 0.12 5.00
159 INT250570 Negative_regulation of Gene_expression of SELS 2 0.43 2.85 0.1 5.00
160 INT188140 Gene_expression of SACM1L 3 0.52 3.2 0.07 5.00
161 INT197169 Binding of Gnptg 1 0.04 0.21 0.05 5.00
162 INT197172 Negative_regulation of Gene_expression of Gfm1 2 0.02 1.68 0.04 5.00
163 INT192519 Positive_regulation of ASPSCR1 2 0.30 2.17 0 5.00
164 INT250575 Positive_regulation of APOBEC2 1 0.43 1.57 0 5.00
165 INT250573 Localization of APOBEC2 1 0.64 0.7 0 5.00
166 INT171594 Binding of APOC3 5 0.37 3.97 0 5.00
167 INT250577 Negative_regulation of Localization of CHDH 1 0.04 0.74 0 5.00
168 INT213155 Positive_regulation of Regulation of HSD11B1 1 0.04 0.41 0 5.00
169 INT250574 Positive_regulation of PITX2 2 0.02 1.79 0 5.00
170 INT247462 Regulation of ASPSCR1 1 0.06 0.53 0 5.00
171 INT250582 Positive_regulation of APOBEC1 1 0.44 0.7 0 5.00
172 INT247458 Binding of APOA5 2 0.38 0.52 0 5.00
173 INT250569 Negative_regulation of OR1E3 1 0.02 0.63 0 5.00
174 INT250578 Gene_expression of APOBEC2 1 0.66 1.45 0 5.00
175 INT250579 Transcription of F12 1 0.62 0.77 0 5.00
176 INT250580 Localization of APOBEC1 1 0.57 0.7 0 5.00
177 INT206466 Regulation of IARS 2 0.17 0.56 0 5.00
178 INT213159 Localization of DAK 1 0.02 0.2 0 5.00
179 INT242043 Positive_regulation of Binding of CHDH 2 0.15 1.17 0 5.00
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