D:Familial Dysautonomia

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Disease Term
Synonyms Dominant Hereditary Sensory Neuropathy Type Iii, Hereditary Sensory Autonomic Neuropathy Type Iii, HEREDITARY SENSORY NEUROPATHY DOMINANT TYPE 3, Hereditary Sensory Neuropathy Dominant Type Iii, Hereditary Sensory Neuropathy Type 3 Dominant, Hsan Hereditary Sensory Autonomic Neuropathy Type Iii, Hsan Type Iii, Neuropathy Hereditary Autonomic Type Iii, Riley Day Syndrome, Syndrome Riley Day, TYPE 3 HEREDITARY SENSORY NEUROPATHY DOMINANT
Documents 66
Hot Single Events 90
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Familial Dysautonomia. They are ordered first by their relevance to Familial Dysautonomia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT352860 Positive_regulation of POLR2B Positive_regulation of Positive_regulation of IKBKAP 1 0.03 0.74 0 99.84
2 INT351466 NMD3 Positive_regulation of Protein_catabolism of UPF1 1 0.00 0.54 0 99.84
3 INT351465 PRSS1 Regulation of Gene_expression of IKBKAP 1 0.00 0.65 0 94.44
4 INT352857 Positive_regulation of TM4SF1 Positive_regulation of IKBKAP 1 0.45 0.27 0 79.52
5 INT352859 IKBKAP Regulation of Regulation of MAPK8 1 0.10 0.28 0 67.84
6 INT234831 Binding of SPTLC1 and Abo 1 0.00 1.61 0.23 63.00
7 INT234795 Negative_regulation of CHM Negative_regulation of RAB27A 1 0.01 0.8 0 43.44
8 INT234801 RAB3GAP1 Regulation of RAB3A 1 0.08 1.64 0.15 37.28
9 INT261690 Binding of GSC and TCF23 1 0.10 0 0.12 5.00
10 INT234802 Binding of AQP2 and AVPR2 2 0.15 0.84 0.07 5.00
11 INT261691 Binding of TFAM and TCF23 1 0.01 0 0.03 5.00
12 INT234800 RAB27A Positive_regulation of INS 1 0.02 1.26 0 5.00
13 INT234790 B4GALNT1 Positive_regulation of AGFG1 1 0.00 0.08 0 5.00
14 INT234793 RAB27A Positive_regulation of Localization of INS 1 0.03 1.26 0 5.00
15 INT234803 AVP Regulation of AQP2 1 0.11 1.3 0 5.00
16 INT234791 Binding of AVP and AVPR2 1 0.14 0.55 0 5.00
17 INT234794 Binding of GDI1 and AGFG1 1 0.01 0 0 5.00
18 INT234796 Binding of AQP2 and AVP 1 0.15 1.1 0 5.00
19 INT234797 AVP Regulation of GOPC 1 0.01 0.65 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Familial Dysautonomia. They are ordered first by their pain relevance and then by number of times they were reported in Familial Dysautonomia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT116763 Gene_expression of IKBKAP 63 0.78 54.53 0.79 100.00
2 INT351509 Positive_regulation of IKBKAP 19 0.70 29.01 0.63 100.00
3 INT351511 Transcription of IKBKAP 30 0.71 15.51 0.18 100.00
4 INT351501 Regulation of IKBKAP 18 0.62 12.5 0 100.00
5 INT116762 Positive_regulation of Gene_expression of IKBKAP 10 0.70 9.79 0.19 100.00
6 INT37351 Negative_regulation of IKBKAP 16 0.58 9.6 0.56 100.00
7 INT351520 Negative_regulation of Gene_expression of IKBKAP 9 0.59 6.4 0.06 100.00
8 INT351491 Regulation of Gene_expression of IKBKAP 5 0.62 5.34 0 100.00
9 INT351522 Localization of IKBKAP 1 0.80 5.05 0.13 100.00
10 INT248374 Binding of IKBKAP 10 0.42 10.45 1.9 100.00
11 INT351500 Regulation of Transcription of IKBKAP 6 0.45 2.72 0 100.00
12 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 100.00
13 INT351524 Protein_catabolism of IKBKAP 1 0.76 0.54 0 100.00
14 INT73594 Positive_regulation of Gene_expression of ISYNA1 61 0.55 31.35 13.45 100.00
15 INT66040 Positive_regulation of Bdnf 114 0.69 67.67 51.81 100.00
16 INT66039 Positive_regulation of Ntrk2 53 0.69 15.87 17.23 100.00
17 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75 100.00
18 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42 100.00
19 INT351502 Positive_regulation of Transcription of IKBKAP 1 0.50 2.86 0.05 99.92
20 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 99.86
21 INT82808 Positive_regulation of ITGA4 7 0.44 5.19 0.71 99.86
22 INT351494 Positive_regulation of Protein_catabolism of GNAS 1 0.00 0.94 0 99.86
23 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94 99.84
24 INT351503 Positive_regulation of Negative_regulation of IKBKAP 1 0.50 1.49 0.11 99.84
25 INT200979 Regulation of Gene_expression of UPF1 4 0.28 2.19 1.31 99.84
26 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 99.84
27 INT290116 Gene_expression of PMEPA1 2 0.58 1 0.25 99.84
28 INT351513 Positive_regulation of Gene_expression of S100A16 1 0.29 0.65 0 99.84
29 INT351487 Gene_expression of S100A16 1 0.48 0.65 0 99.84
30 INT351497 Regulation of Negative_regulation of IKBKAP 1 0.27 0.57 0 99.84
31 INT142435 Gene_expression of NES 86 0.78 47.53 4.92 99.80
32 INT351508 Localization of HPRT1 1 0.41 0.1 0 99.58
33 INT351504 Negative_regulation of Transcription of IKBKAP 1 0.42 1.12 0 99.52
34 INT120650 Negative_regulation of UPF1 14 0.02 6.86 2.14 99.52
35 INT351518 Protein_catabolism of GNAS 1 0.01 1.29 0 99.48
36 INT293912 Protein_catabolism of UPF1 3 0.02 1.2 0.05 99.36
37 INT352882 Negative_regulation of Regulation of IKBKAP 1 0.43 0.67 0 99.34
38 INT351512 Negative_regulation of NMD3 2 0.02 0.93 0.05 99.20
39 INT128788 Positive_regulation of Transcription of Ikbkap 1 0.40 0.66 0.14 99.18
40 INT128791 Positive_regulation of Gene_expression of Ikbkap 1 0.44 0.66 0.14 99.18
41 INT351507 Localization of RPLP0 1 0.38 0.1 0 99.06
42 INT128789 Transcription of Ikbkap 1 0.46 0.66 0.14 99.00
43 INT128790 Gene_expression of Ikbkap 1 0.58 0.66 0.14 99.00
44 INT148702 Positive_regulation of UPF1 29 0.31 12.9 1.91 99.00
45 INT30887 Negative_regulation of Ngf 56 0.59 32.96 20.86 99.00
46 INT351514 Regulation of PMEPA1 1 0.46 1.18 0 98.84
47 INT345013 Regulation of GSN 4 0.51 3.49 1.11 98.84
48 INT116761 Positive_regulation of Gene_expression of Ikbkap 1 0.38 0.62 0.11 98.12
49 INT351516 Regulation of S100A16 1 0.17 0.64 0 97.96
50 INT82803 Positive_regulation of Gene_expression of ITGA4 4 0.57 1.57 0.81 97.80
51 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 97.80
52 INT66042 Positive_regulation of SPTLC2 2 0.68 0.97 0.66 97.66
53 INT254400 Negative_regulation of GSN 22 0.57 18.15 5.89 97.36
54 INT351488 Regulation of Binding of IKBKAP 1 0.45 1.06 0 97.24
55 INT81955 Positive_regulation of SPTLC1 12 0.70 10.25 3.12 97.16
56 INT116760 Gene_expression of Ikbkap 2 0.75 0.95 0.11 97.14
57 INT351490 Positive_regulation of Binding of IKBKAP 1 0.50 0.55 0 96.88
58 INT88726 Gene_expression of HPRT1 36 0.78 10.12 1.58 96.80
59 INT88721 Positive_regulation of Gene_expression of HPRT1 7 0.49 2.16 0.21 96.80
60 INT67254 Gene_expression of RPLP0 6 0.38 2.7 1.24 96.80
61 INT351495 Positive_regulation of Gene_expression of RPLP0 1 0.25 0.54 0 96.80
62 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 96.80
63 INT234417 Positive_regulation of Gene_expression of ABL1 4 0.37 3.65 0.03 96.80
64 INT351498 Negative_regulation of Binding of IKBKAP 1 0.37 0.51 0 96.60
65 INT351499 Positive_regulation of PMEPA1 1 0.33 0.47 0 95.24
66 INT352872 Positive_regulation of POLR2B 1 0.05 0.72 0 95.08
67 INT351510 Regulation of Regulation of IKBKAP 1 0.27 0.45 0 93.28
68 INT352870 Positive_regulation of Positive_regulation of IKBKAP 1 0.70 1.54 0 92.72
69 INT217067 Regulation of Positive_regulation of MAPK8 7 0.45 3.09 0.43 92.68
70 INT351515 Positive_regulation of Localization of IKBKAP 1 0.43 1.22 0 92.60
71 INT57008 Positive_regulation of HPRT1 11 0.50 2.81 0.74 92.44
72 INT351496 Positive_regulation of RPLP0 1 0.25 0.52 0 92.44
73 INT109594 Positive_regulation of ABL1 10 0.49 7.19 0.05 92.44
74 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 92.24
75 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17 91.92
76 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 91.92
77 INT93109 Phosphorylation of NTRK1 5 0.80 3.22 2.99 91.76
78 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26 91.76
79 INT52344 Localization of NTRK2 2 0.81 0.56 0.3 90.60
80 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 90.00
81 INT200963 Regulation of UPF1 10 0.01 2.18 2.67 88.48
82 INT66043 Regulation of SPTLC2 3 0.44 1.62 1.09 87.36
83 INT352861 Positive_regulation of Transcription of POLR2B 1 0.04 0.73 0 87.04
84 INT298408 Transcription of POLR2B 3 0.12 2.78 0 86.24
85 INT654 Localization of REN 250 0.81 75.12 47.86 83.68
86 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69 83.16
87 INT17109 Regulation of Gene_expression of PSMD1 3 0.44 0.86 0.58 83.16
88 INT59464 Regulation of ISYNA1 21 0.43 12.15 4.63 82.56
89 INT151323 Positive_regulation of MAP2 7 0.50 1.36 1.71 82.32
90 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 82.16
91 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 79.80
92 INT352881 Positive_regulation of Positive_regulation of TM4SF1 1 0.42 0.27 0 79.12
93 INT352880 Positive_regulation of Transcription of TM4SF1 1 0.39 0.27 0 78.32
94 INT180889 Transcription of TM4SF1 2 0.61 1.03 0 78.32
95 INT73854 Transcription of ABL1 4 0.52 2.26 0.34 77.56
96 INT163461 Regulation of ABL1 8 0.32 5.98 0.14 77.56
97 INT351489 Regulation of Transcription of ABL1 1 0.28 0.08 0 77.56
98 INT352871 Positive_regulation of TM4SF1 1 0.58 0.27 0 77.36
99 INT234817 Gene_expression of GDI1 4 0.17 2.99 0.25 75.04
100 INT261705 Binding of TCF23 1 0.15 1.09 0.03 70.56
101 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28 68.24
102 INT164261 Binding of NDRG1 3 0.37 0.87 0.37 65.08
103 INT82798 Regulation of MYC 19 0.60 12.06 2.31 64.00
104 INT352865 Regulation of RCAN2 1 0.22 0.13 0 64.00
105 INT352867 Regulation of CYP7B1 1 0.20 0.13 0 64.00
106 INT352866 Regulation of DCTPP1 1 0.48 0.13 0 64.00
107 INT352869 Regulation of TM4SF1 1 0.52 0.13 0 64.00
108 INT352873 Regulation of YWHAH 1 0.46 0.13 0 64.00
109 INT352878 Regulation of ITGB8 1 0.19 0.13 0 64.00
110 INT352864 Regulation of BRIP1 1 0.51 0.13 0 64.00
111 INT352868 Regulation of ROBO2 1 0.19 0.13 0 64.00
112 INT94146 Regulation of SPTLC1 2 0.51 2.39 0.36 62.76
113 INT352875 Regulation of BLM 1 0.33 0.12 0 62.52
114 INT352879 Gene_expression of LZIC 1 0.37 0.11 0 54.88
115 INT352862 Positive_regulation of Gene_expression of LZIC 1 0.28 0.11 0 54.88
116 INT80338 Gene_expression of SPTLC1 10 0.78 4.06 1.09 51.00
117 INT183814 Transcription of HPRT1 6 0.69 1.04 0.29 50.00
118 INT267892 Gene_expression of Prkag2 3 0.62 3.59 0 48.56
119 INT330511 Gene_expression of Bmpr1a 1 0.54 1.9 0 48.56
120 INT234828 Gene_expression of RAB3A 2 0.30 2.05 0.37 44.40
121 INT52347 Negative_regulation of CHM 17 0.58 13.03 0.59 40.48
122 INT234815 Phosphorylation of RAB27A 1 0.37 0.77 0 36.00
123 INT234816 Phosphorylation of CHM 1 0.04 0.79 0 35.20
124 INT201261 Regulation of AGFG1 4 0.09 2.72 0.9 19.04
125 INT234826 Positive_regulation of Regulation of AGFG1 1 0.10 0.87 0 19.04
126 INT234822 Positive_regulation of CHML 2 0.06 1.76 0 15.92
127 INT261711 Binding of GSC 1 0.32 0 0.11 8.68
128 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
129 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 5.00
130 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
131 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
132 INT139613 Binding of pr 16 0.47 5.52 8.46 5.00
133 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 5.00
134 INT85923 Positive_regulation of CREM 25 0.67 7.03 6.53 5.00
135 INT234813 Gene_expression of RAB5A 58 0.66 3.67 6.48 5.00
136 INT91100 Binding of SPTLC1 10 0.47 12.85 5.71 5.00
137 INT39000 Regulation of pr 24 0.44 12.51 4.36 5.00
138 INT261712 Regulation of GABRB3 6 0.09 3.03 3.14 5.00
139 INT234825 Positive_regulation of Gene_expression of RAB5A 16 0.59 1.15 2.71 5.00
140 INT2695 Regulation of DBH 5 0.45 1.09 2.48 5.00
141 INT47780 Gene_expression of CREM 17 0.74 5.37 2.13 5.00
142 INT22087 Negative_regulation of DBH 3 0.59 1.45 1.84 5.00
143 INT234827 Positive_regulation of RAB5A 3 0.59 0.54 1.69 5.00
144 INT73432 Gene_expression of Nppa 32 0.59 21.04 1.39 5.00
145 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22 5.00
146 INT183046 Transcription of INS 25 0.70 11.14 1.13 5.00
147 INT59768 Regulation of TFAM 7 0.45 4.64 1.08 5.00
148 INT51704 Phosphorylation of AVP 2 0.79 0.33 0.86 5.00
149 INT234820 Localization of AGFG1 3 0.14 0.86 0.74 5.00
150 INT229789 Regulation of RAB7A 4 0.42 7.09 0.72 5.00
151 INT109081 Localization of Nppa 9 0.59 2.72 0.61 5.00
152 INT183375 Binding of Nppa 14 0.38 8.95 0.51 5.00
153 INT57163 Gene_expression of AGFG1 11 0.75 2.45 0.48 5.00
154 INT64965 Binding of AGFG1 8 0.10 3.53 0.45 5.00
155 INT158764 Binding of SPINK5 7 0.35 8.84 0.37 5.00
156 INT53212 Negative_regulation of RAB27A 4 0.57 2.46 0.26 5.00
157 INT192748 Localization of BCR 4 0.68 2.4 0.18 5.00
158 INT183377 Positive_regulation of Nppa 7 0.38 1.46 0.16 5.00
159 INT234810 Regulation of RAB5A 3 0.38 1.64 0.16 5.00
160 INT119145 Binding of RAC2 2 0.13 0.47 0.14 5.00
161 INT234814 Positive_regulation of AGFG1 6 0.10 2.33 0.07 5.00
162 INT228295 Negative_regulation of Transcription of INS 2 0.43 1.1 0.07 5.00
163 INT261706 Regulation of Binding of GSC 1 0.34 0 0.03 5.00
164 INT261708 Regulation of Binding of TCF23 1 0.14 0 0.03 5.00
165 INT234821 Positive_regulation of Gene_expression of AGFG1 1 0.10 0.07 0 5.00
166 INT193210 Gene_expression of TCF23 2 0.46 0.44 0 5.00
167 INT261713 Regulation of GSC 2 0.34 0.91 0 5.00
168 INT234809 Phosphorylation of MYO5A 1 0.61 0.23 0 5.00
169 INT261709 Protein_catabolism of ADRM1 1 0.13 0.5 0 5.00
170 INT234812 Binding of AVPR2 1 0.17 0.55 0 5.00
171 INT330508 Gene_expression of Ranbp9 1 0.03 0.27 0 5.00
172 INT234829 Phosphorylation of AVPR2 1 0.29 0.24 0 5.00
173 INT261710 Phosphorylation of ADRM1 1 0.08 0.44 0 5.00
174 INT234811 Binding of GDI1 2 0.47 0.13 0 5.00
175 INT234819 Regulation of Binding of AGFG1 1 0.05 0.19 0 5.00
176 INT234824 Negative_regulation of SYTL4 1 0.07 0.95 0 5.00
177 INT234823 Negative_regulation of RAB1A 1 0.13 0.84 0 5.00
178 INT330509 Negative_regulation of Binding of pr 1 0.31 0 0 5.00
179 INT234818 Positive_regulation of Binding of AGFG1 1 0.10 0.08 0 5.00
180 INT330510 Binding of Ranbp9 1 0.02 0.05 0 5.00
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