D:Familial Hypophosphatemia

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Disease Term
Synonyms Diabetes Phosphate, Familial Hypophosphatemias, HYPERPHOSPHATURIA, Hypophosphatemias Familial, PHOSPHATE DIABETES, PHOSPHATURIA
Documents 52
Hot Single Events 18
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Familial Hypophosphatemia. They are ordered first by their relevance to Familial Hypophosphatemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT266838 Fgf23 Regulation of Slc34a1 1 0.13 0.3 0 89.76
2 INT266835 Pth Regulation of Slc34a3 1 0.19 0.07 0 72.64
3 INT266836 Pth Regulation of Slc34a1 1 0.09 0.07 0 72.64
4 INT170832 Cftr Regulation of Scnn1a 2 0.16 1.2 0.67 5.00
5 INT233303 Binding of CD4 and SRY 1 0.07 0.34 0.05 5.00
6 INT289836 BEST1 Positive_regulation of Gene_expression of Car2 1 0.03 0.08 0 5.00
7 INT233304 Binding of SRY and SLC22A8 1 0.34 0.93 0 5.00
8 INT340379 Binding of Rabep1 and Ocrl 1 0.08 0.62 0 5.00
9 INT340380 Binding of Cfl1 and Clcn4-2 1 0.13 0.82 0 5.00
10 INT266837 Dmp1 Negative_regulation of Gene_expression of Fgf23 1 0.48 2.41 0 5.00
11 INT340378 Binding of Cfl1 and Clcn5 1 0.15 0.82 0 5.00
12 INT266839 Fgf23 Negative_regulation of Slc34a1 1 0.21 0.88 0 5.00
13 INT266834 Pth Negative_regulation of Positive_regulation of Grxcr1 1 0.04 0.51 0 5.00
14 INT266833 Phex Regulation of Gene_expression of Fgf23 1 0.23 0.46 0 5.00
15 INT340377 Binding of Clcn4-2 and Clcn5 1 0.35 0.82 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Familial Hypophosphatemia. They are ordered first by their pain relevance and then by number of times they were reported in Familial Hypophosphatemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT130799 Localization of Fgf23 2 0.63 1.94 0.28 99.84
2 INT118371 Positive_regulation of Fgf23 15 0.69 25.34 0.85 99.36
3 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 99.28
4 INT130797 Gene_expression of Fgf23 6 0.66 4.73 0.77 99.16
5 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 98.88
6 INT9500 Negative_regulation of Ceacam1 26 0.58 6.89 3.91 98.68
7 INT117827 Positive_regulation of PHEX 3 0.41 1.59 0.08 97.76
8 INT289834 Positive_regulation of Protein_catabolism of LRP2 1 0.45 0.65 0.03 96.20
9 INT98016 Protein_catabolism of Pth 2 0.18 2.07 0.18 94.52
10 INT289835 Protein_catabolism of LRP2 1 0.96 0.58 0.03 94.20
11 INT56433 Negative_regulation of Cl 3 0.13 1.87 0.35 90.68
12 INT340358 Negative_regulation of Positive_regulation of Cl 1 0.13 0.79 0.04 90.68
13 INT14587 Positive_regulation of Cl 44 0.20 20.37 16.72 89.96
14 INT69543 Positive_regulation of Negative_regulation of PTH 2 0.43 1.8 0.17 87.68
15 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 83.92
16 INT164753 Negative_regulation of Clcn5 2 0.58 5.13 0.2 83.20
17 INT157409 Negative_regulation of Fgf23 3 0.50 3.21 0.27 82.40
18 INT266828 Negative_regulation of Fgf23 3 0.42 5.63 0.04 80.36
19 INT173912 Negative_regulation of LRP2 5 0.57 6.22 0.42 79.72
20 INT340375 Negative_regulation of Cubn 1 0.24 0.77 0.03 79.72
21 INT130801 Localization of SFRP4 4 0.28 2.41 0.49 75.00
22 INT98645 Gene_expression of FGF23 9 0.78 10.07 0.8 75.00
23 INT130802 Localization of FGF23 2 0.17 1.78 0.2 75.00
24 INT130798 Positive_regulation of Gene_expression of Fgf23 2 0.59 1.12 0.2 75.00
25 INT130800 Localization of Mepe 1 0.30 0.46 0 75.00
26 INT289822 Regulation of Gene_expression of Clcn3 1 0.05 0.91 0.04 74.00
27 INT289814 Negative_regulation of Clcn3 1 0.05 2.54 0.14 73.76
28 INT215807 Gene_expression of Clcn3 5 0.19 3.2 0.48 73.76
29 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 73.60
30 INT218315 Gene_expression of RBP4 25 0.76 18.19 0.85 73.60
31 INT233570 Gene_expression of Rbp4 4 0.66 3.4 0.17 73.60
32 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72 73.32
33 INT477 Localization of Avp 813 0.81 131.58 300.4 72.76
34 INT120540 Negative_regulation of FGF23 1 0.38 2.16 0.11 66.80
35 INT16003 Gene_expression of Phex 3 0.65 4.68 0.77 66.36
36 INT340373 Negative_regulation of Rbp4 1 0.17 1.96 0.16 66.32
37 INT135920 Binding of SRY 9 0.45 3.57 1.45 63.88
38 INT266824 Regulation of Positive_regulation of Fgf23 1 0.27 1.22 0 62.36
39 INT266827 Positive_regulation of Mepe 1 0.67 1.25 0 60.32
40 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 57.36
41 INT266822 Negative_regulation of Grxcr1 10 0.10 8.12 0.17 53.52
42 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 50.16
43 INT9118 Gene_expression of Ceacam1 37 0.75 17.19 6.12 49.76
44 INT340366 Gene_expression of Clcn5 1 0.77 4.8 0 47.68
45 INT266832 Positive_regulation of Grxcr1 9 0.12 7.91 0.19 47.36
46 INT118373 Gene_expression of Fgf23 16 0.77 29.62 1.04 46.88
47 INT135880 Positive_regulation of Gene_expression of Fgf23 4 0.46 7.52 0.29 46.88
48 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 45.20
49 INT107033 Gene_expression of Slc37a4 66 0.62 27.34 12.35 43.68
50 INT167957 Gene_expression of Grxcr1 8 0.10 3.43 0.14 42.72
51 INT14880 Positive_regulation of Car3 14 0.65 9.19 3.73 42.52
52 INT266821 Positive_regulation of Negative_regulation of Grxcr1 1 0.06 1.51 0.06 42.08
53 INT266820 Positive_regulation of Positive_regulation of Grxcr1 1 0.06 1.58 0.06 41.04
54 INT289825 Positive_regulation of Aqp6 2 0.21 0.62 0.07 39.88
55 INT266823 Regulation of Grxcr1 3 0.06 1.4 0.03 31.68
56 INT207727 Positive_regulation of SRY 2 0.56 1.94 0.03 27.92
57 INT266818 Localization of Grxcr1 7 0.12 3.9 0 24.96
58 INT340359 Binding of Clcn5 1 0.48 1.91 0 23.80
59 INT340363 Regulation of Clcn5 1 0.45 0.85 0 23.16
60 INT340371 Regulation of Tal 1 0.10 0.85 0 22.28
61 INT1893 Localization of Gh 1041 0.79 340.23 256.58 17.76
62 INT125804 Localization of Pth 9 0.69 3.93 0.29 16.40
63 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 14.16
64 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
65 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
66 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
67 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
68 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
69 INT91360 Negative_regulation of Slc12a2 16 0.54 10.46 12.89 5.00
70 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 5.00
71 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
72 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97 5.00
73 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
74 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
75 INT130300 Gene_expression of Abcc3 14 0.70 5.34 4.96 5.00
76 INT67182 Gene_expression of Tms 10 0.53 5.14 4.29 5.00
77 INT93110 Regulation of CDCP1 16 0.03 7.98 3.83 5.00
78 INT101068 Negative_regulation of CDCP1 27 0.03 17.67 3.45 5.00
79 INT136964 Gene_expression of Dmp1 10 0.75 3.69 2.83 5.00
80 INT22500 Negative_regulation of Pth 6 0.43 3.41 2.83 5.00
81 INT262474 Gene_expression of Aqp6 26 0.77 2.08 2.49 5.00
82 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 5.00
83 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 5.00
84 INT123078 Negative_regulation of Kcnj1 2 0.10 0.87 1.09 5.00
85 INT294932 Negative_regulation of Gc 6 0.17 3.38 0.71 5.00
86 INT167705 Positive_regulation of Clcn2 3 0.46 1.32 0.63 5.00
87 INT124944 Regulation of KIT 15 0.60 11.84 0.24 5.00
88 INT246624 Binding of Abcc3 2 0.00 0.59 0.15 5.00
89 INT118372 Regulation of Fgf23 4 0.55 3.31 0.15 5.00
90 INT262478 Binding of Clcn3 1 0.06 1.23 0.14 5.00
91 INT289815 Gene_expression of Clcnkb 1 0.10 0.97 0.1 5.00
92 INT289820 Regulation of Gene_expression of Clcnkb 1 0.07 0.97 0.1 5.00
93 INT289823 Positive_regulation of Gene_expression of Clcn3 1 0.06 0.07 0.09 5.00
94 INT22413 Positive_regulation of Cyp39a1 2 0.08 2.49 0.09 5.00
95 INT289826 Binding of Clcn2 1 0.25 0.4 0.08 5.00
96 INT266826 Binding of Fgf23 1 0.32 1.26 0.07 5.00
97 INT289819 Localization of Clcn3 1 0.09 0.25 0.06 5.00
98 INT233311 Positive_regulation of Gene_expression of SRY 1 0.41 0.61 0.06 5.00
99 INT121678 Gene_expression of SRY 15 0.68 5.61 0.06 5.00
100 INT156113 Gene_expression of CLCF1 3 0.65 0.28 0.06 5.00
101 INT262477 Positive_regulation of Clcn3 2 0.08 0.31 0.03 5.00
102 INT156739 Localization of SRY 2 0.75 3.21 0.03 5.00
103 INT289824 Positive_regulation of Transcription of Clcn3 1 0.06 0.16 0.03 5.00
104 INT289829 Transcription of Clcn3 1 0.08 0.16 0.03 5.00
105 INT289812 Gene_expression of Ttyh1 1 0.14 0.26 0.03 5.00
106 INT266831 Positive_regulation of Slc34a3 1 0.47 1.79 0 5.00
107 INT340360 Positive_regulation of Clcn5 1 0.50 1.62 0 5.00
108 INT340365 Protein_catabolism of Clcn5 1 0.99 1.03 0 5.00
109 INT266830 Regulation of Slc34a3 1 0.42 1.85 0 5.00
110 INT233314 Positive_regulation of Binding of SRY 1 0.41 0.28 0 5.00
111 INT266829 Regulation of Cyp39a1 1 0.02 0.44 0 5.00
112 INT340362 Gene_expression of Ocrl 3 0.67 2.27 0 5.00
113 INT289830 Negative_regulation of Clcn2 1 0.39 0.23 0 5.00
114 INT340370 Negative_regulation of Ocrl 1 0.43 2.31 0 5.00
115 INT340367 Regulation of Gene_expression of Ocrl 1 0.45 1.11 0 5.00
116 INT289828 Negative_regulation of Bsnd 1 0.07 0.7 0 5.00
117 INT340368 Binding of Ocrl 1 0.37 2.61 0 5.00
118 INT340374 Binding of Rabep1 1 0.05 0.61 0 5.00
119 INT289831 Binding of Bsnd 1 0.06 0.38 0 5.00
120 INT289821 Regulation of Grv 1 0.00 0 0 5.00
121 INT233309 Regulation of Localization of SRY 1 0.37 0.33 0 5.00
122 INT340372 Negative_regulation of Protein_catabolism of Clcn5 1 0.43 1.07 0 5.00
123 INT266825 Positive_regulation of Regulation of Fgf23 1 0.46 0.25 0 5.00
124 INT289817 Negative_regulation of Clcnkb 1 0.09 0.7 0 5.00
125 INT340361 Binding of Clcn4-2 1 0.30 0.82 0 5.00
126 INT266819 Regulation of Localization of Grxcr1 2 0.06 1.28 0 5.00
127 INT233312 Phosphorylation of SRY 1 0.66 0.73 0 5.00
128 INT235353 Gene_expression of Mid1 4 0.04 0.62 0 5.00
129 INT340369 Negative_regulation of Tal 1 0.09 1.04 0 5.00
130 INT340364 Negative_regulation of Gene_expression of Ocrl 1 0.43 1.16 0 5.00
131 INT289818 Positive_regulation of Cdk7 1 0.04 0.05 0 5.00
132 INT70263 Negative_regulation of Cyp39a1 2 0.05 0.96 0 5.00
133 INT289827 Binding of Clcnkb 1 0.06 0.39 0 5.00
134 INT289816 Positive_regulation of Ttyh1 1 0.11 0.23 0 5.00
135 INT289813 Gene_expression of Bsnd 1 0.07 0.49 0 5.00
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