D:Familial Mediterranean Fever

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Disease Term
Synonyms Fever Familial Mediterranean, Hereditary Periodic Fever Syndromes, MEDITERRANEAN FEVER FAMILIAL, PERIODIC DISEASE, Periodic Disease Wolff S, Periodic Fever Syndromes Hereditary, WOLFF PERIODIC DISEASE, Wolff S Periodic Disease
Documents 93
Hot Single Events 59
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Familial Mediterranean Fever. They are ordered first by their relevance to Familial Mediterranean Fever and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT297347 Binding of MEFV and SAA@ 1 0.03 1.33 0 100.00
2 INT290377 NOD2 Negative_regulation of Positive_regulation of TLR2 1 0.24 0.95 0.23 92.52
3 INT100456 Binding of Gm694 and Ighd 1 0.00 0.78 0.16 88.44
4 INT290378 NOD2 Negative_regulation of TLR2 1 0.27 0.83 0.23 87.56
5 INT282398 Binding of Mefv and Nlrp3 1 0.40 6.8 1.72 75.00
6 INT317832 Binding of Mefv and Il1 1 0.03 3.89 0.7 72.80
7 INT317831 Binding of Mefv and Nlrx1 1 0.00 1.77 0.2 72.80
8 INT317835 Nlrp3 Positive_regulation of Il18 1 0.08 1.49 0.31 69.68
9 INT150393 Binding of CASP1 and MEFV 2 0.16 2.48 0.45 50.20
10 INT282397 Binding of Irgm1 and Atg16l1 1 0.17 1.18 0.39 50.00
11 INT282399 Binding of Mefv and Uncv 1 0.07 1.02 0.26 50.00
12 INT334879 CASP1 Regulation of IL1B 1 0.03 1.63 0.31 49.00
13 INT290376 Binding of CSF1R and MEFV 1 0.29 0.31 0.24 24.08
14 INT317836 Binding of Fibp and Pycard 1 0.00 2.68 0.98 5.00
15 INT317834 Binding of Pstpip1 and Il1 1 0.00 2.03 0.48 5.00
16 INT278379 Binding of Pstpip1 and Mefv 3 0.03 2.02 0.48 5.00
17 INT279265 Binding of MEFV and NLRP3 1 0.07 2.79 0.28 5.00
18 INT279266 CADPS Positive_regulation of Regulation of IL1B 1 0.22 1.43 0.28 5.00
19 INT317833 Nlrp3 Positive_regulation of Localization of Il1 1 0.06 1.38 0.26 5.00
20 INT279267 Binding of RIPK2 and Positive_regulation of Gene_expression of CASP1 1 0.26 1.12 0.14 5.00
21 INT342887 Binding of IFNG and IFNGR1 1 0.02 0.65 0.05 5.00
22 INT342886 Binding of C3 and CD40 1 0.02 0.66 0.05 5.00
23 INT279268 CARD8 Positive_regulation of CASP1 1 0.32 0.3 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Familial Mediterranean Fever. They are ordered first by their pain relevance and then by number of times they were reported in Familial Mediterranean Fever. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT56985 Gene_expression of MEFV 56 0.71 46.71 9.47 100.00
2 INT153297 Regulation of MEFV 6 0.40 11.09 0.71 100.00
3 INT125392 Regulation of Mefv 3 0.45 7.2 1.06 100.00
4 INT174653 Localization of MEFV 15 0.70 12.06 1.93 100.00
5 INT183147 Positive_regulation of Gene_expression of MEFV 6 0.50 4.67 1.73 100.00
6 INT149669 Positive_regulation of MEFV 12 0.46 14.17 2.07 100.00
7 INT67374 Gene_expression of Mefv 15 0.74 49.1 8.07 100.00
8 INT183144 Positive_regulation of Localization of MEFV 2 0.42 2.61 0.51 100.00
9 INT125391 Gene_expression of Rim5 2 0.01 1.94 0.11 100.00
10 INT125390 Positive_regulation of Gene_expression of Rim5 1 0.00 1.15 0.11 100.00
11 INT100455 Binding of Ighd 1 0.37 1.61 0.31 99.96
12 INT110394 Regulation of CSF1R 3 0.38 2.49 1.12 99.80
13 INT17417 Positive_regulation of Ighd 16 0.69 24.29 2.8 99.66
14 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 99.60
15 INT15982 Positive_regulation of NLRP3 25 0.65 23.19 3.57 99.46
16 INT52899 Positive_regulation of TNFRSF1A 16 0.46 19.04 3.34 99.46
17 INT222205 Positive_regulation of PSTPIP1 8 0.69 4.69 0.62 99.46
18 INT28815 Gene_expression of Ighd 18 0.65 11.02 2.48 99.42
19 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 99.42
20 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 99.32
21 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 99.04
22 INT17692 Negative_regulation of C5AR1 5 0.57 2.99 1.04 99.04
23 INT103638 Negative_regulation of MEFV 7 0.39 5.88 0.54 99.02
24 INT24453 Binding of NLRP3 18 0.48 13.7 1.93 98.92
25 INT178002 Positive_regulation of CSF1R 2 0.37 6.52 2.74 98.54
26 INT152254 Gene_expression of CSF1R 16 0.75 12.93 3.81 98.52
27 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 98.52
28 INT108347 Regulation of Adm 5 0.26 2.55 1.04 98.48
29 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 98.08
30 INT3058 Gene_expression of IGKV2-19 3 0.58 4.02 0.81 98.00
31 INT274601 Regulation of PSTPIP1 3 0.45 3.76 0.28 96.88
32 INT8798 Positive_regulation of Csrp1 61 0.69 63.86 14.14 96.00
33 INT1941 Binding of PSTPIP1 36 0.48 5.92 1.16 95.76
34 INT290391 Binding of ASCC1 1 0.01 0.91 0.35 95.76
35 INT151160 Regulation of Mefv 2 0.39 1.36 0.25 94.80
36 INT183240 Negative_regulation of NOD2 6 0.43 1.52 0.33 94.60
37 INT10605 Positive_regulation of Ltc4s 21 0.68 17.22 4.8 93.72
38 INT117219 Positive_regulation of NOD2 9 0.69 4.66 1.31 92.52
39 INT25607 Binding of Il1 82 0.47 64.4 23.9 91.60
40 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 91.36
41 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 91.36
42 INT282384 Negative_regulation of Gene_expression of Pain1 3 0.42 2.7 1.59 91.36
43 INT290394 Negative_regulation of Positive_regulation of TLR2 4 0.34 2.8 0.65 90.76
44 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4 90.40
45 INT91667 Localization of IL12A 39 0.74 25.51 7.36 88.56
46 INT290393 Regulation of Localization of IL12A 1 0.16 1.02 0.48 88.56
47 INT186480 Positive_regulation of Transcription of F8 1 0.06 2.08 0.4 88.48
48 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67 88.44
49 INT60115 Transcription of F8 2 0.08 3.05 0.58 88.08
50 INT76875 Positive_regulation of Adm 12 0.58 3.36 2.72 87.60
51 INT100454 Binding of Gm694 2 0.00 0.82 0.16 87.28
52 INT186482 Regulation of Transcription of ANGPTL5 1 0.03 2.05 0.4 86.76
53 INT186481 Transcription of ANGPTL5 1 0.04 2.04 0.39 86.36
54 INT150395 Binding of MEFV 55 0.44 31.18 3.42 86.12
55 INT151209 Transcription of Adm 1 0.26 0.17 0 83.56
56 INT19775 Localization of Il1 183 0.78 145.5 50.91 83.04
57 INT1901 Binding of Mefv 24 0.48 32.26 4.5 81.84
58 INT290388 Regulation of Gene_expression of CSF1R 1 0.24 0.84 0.25 81.08
59 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 80.04
60 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 78.92
61 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 78.64
62 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 78.44
63 INT146829 Negative_regulation of Mefv 2 0.39 5.73 0.95 77.16
64 INT99020 Gene_expression of Nlrp3 23 0.75 18.86 4.4 75.00
65 INT148576 Gene_expression of rs 26 0.37 8.96 2.17 75.00
66 INT97514 Positive_regulation of Gene_expression of Mefv 2 0.47 10.98 1.97 75.00
67 INT125204 Transcription of Gm694 1 0.00 1.28 0.2 75.00
68 INT120895 Binding of CCL2 22 0.37 15.86 6.55 74.36
69 INT290397 Positive_regulation of Binding of CCL2 1 0.22 0.99 0.46 74.36
70 INT202161 Negative_regulation of CSF1R 3 0.31 3.36 1.22 70.64
71 INT78702 Positive_regulation of CCL11 13 0.68 12.94 2.74 67.44
72 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 67.12
73 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1 67.12
74 INT317821 Regulation of Gene_expression of Casp1 1 0.05 1.74 0.24 67.12
75 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26 66.60
76 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 66.20
77 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 62.80
78 INT54662 Positive_regulation of Positive_regulation of Il1 21 0.43 19.33 7.14 62.48
79 INT132278 Binding of CTLA4 32 0.39 18.69 8.17 60.88
80 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 59.12
81 INT24685 Localization of Serpine1 12 0.59 7.76 1.32 58.48
82 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 50.72
83 INT9899 Gene_expression of Vwf 91 0.74 45.06 9.13 50.72
84 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72 50.72
85 INT15920 Regulation of Serpine1 34 0.42 17.36 4.89 50.72
86 INT11634 Regulation of SERPINE1 24 0.62 20.06 4.26 50.72
87 INT25962 Gene_expression of COX8A 25 0.75 20.04 2.62 50.72
88 INT30545 Regulation of COX8A 8 0.44 7.74 2.42 50.72
89 INT68087 Regulation of Vwf 9 0.39 8.06 2.36 50.72
90 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 50.00
91 INT28891 Localization of Selp 13 0.60 8.23 2.83 50.00
92 INT92260 Binding of Nlrp3 14 0.46 8.94 2.13 50.00
93 INT97513 Localization of Mefv 6 0.71 8.14 1.55 50.00
94 INT39444 Negative_regulation of Positive_regulation of F2 7 0.59 5.82 1.42 50.00
95 INT204766 Gene_expression of Nod2 4 0.75 4.14 1.3 50.00
96 INT278350 Regulation of Nlrp3 3 0.38 2.8 0.95 50.00
97 INT219135 Positive_regulation of Gene_expression of Nlrp3 4 0.49 3.52 0.93 50.00
98 INT67373 Regulation of Gene_expression of Mefv 2 0.39 6.28 0.75 50.00
99 INT282385 Binding of Irgm1 2 0.20 3.18 0.7 50.00
100 INT111205 Positive_regulation of Mefv 3 0.43 4.07 0.66 50.00
101 INT183942 Binding of rs 7 0.02 8.71 0.61 50.00
102 INT282380 Binding of Atg16l1 4 0.38 2.06 0.58 50.00
103 INT168448 Localization of Nlrp3 5 0.73 3.75 0.58 50.00
104 INT217083 Gene_expression of Rrm2 10 0.47 4.16 0.47 50.00
105 INT282383 Negative_regulation of Gene_expression of Mefv 1 0.37 1.55 0.4 50.00
106 INT282381 Transcription of Mefv 1 0.60 0.6 0.08 50.00
107 INT282382 Regulation of Transcription of Mefv 1 0.39 0.6 0.08 50.00
108 INT213886 Binding of IL23R 7 0.46 16.79 6.94 49.76
109 INT22383 Binding of IL2 59 0.48 39.06 8.56 49.48
110 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 46.48
111 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 44.12
112 INT71308 Gene_expression of CCL11 33 0.76 25.66 7.83 44.12
113 INT236278 Negative_regulation of CADPS 4 0.36 2.16 0.22 41.60
114 INT113906 Regulation of Positive_regulation of CCL2 4 0.27 3.2 2.17 40.64
115 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 39.72
116 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 39.72
117 INT92237 Positive_regulation of Gene_expression of CXCL10 43 0.70 43.67 13.65 39.72
118 INT56342 Gene_expression of TTR 34 0.78 16.5 2.05 38.88
119 INT44223 Positive_regulation of TTR 10 0.70 10.98 1.95 38.88
120 INT36221 Positive_regulation of Nlrp3 25 0.68 19.7 4.5 38.64
121 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 38.52
122 INT6484 Binding of IL1B 122 0.47 75.84 35.07 33.04
123 INT6852 Localization of TNF 883 0.81 705.95 270.84 31.28
124 INT221795 Negative_regulation of Localization of TH1L 2 0.31 2.17 1.07 24.16
125 INT58904 Localization of TH1L 40 0.68 27.11 10.52 23.84
126 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 22.16
127 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 20.72
128 INT73503 Positive_regulation of Gene_expression of IL13 16 0.37 14.6 4.23 20.72
129 INT140650 Positive_regulation of Gene_expression of CCL11 10 0.68 5.43 2.08 19.04
130 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 18.28
131 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 15.68
132 INT18844 Binding of IAPP 11 0.36 11.01 1.45 14.96
133 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 13.20
134 INT317823 Positive_regulation of Negative_regulation of Mvk 2 0.30 3.33 0.62 7.44
135 INT284362 Positive_regulation of Mvk 3 0.44 3.32 0.46 7.44
136 INT284359 Negative_regulation of Mvk 4 0.37 6.62 0.99 6.92
137 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
138 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
139 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
140 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
141 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
142 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
143 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
144 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
145 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
146 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
147 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 5.00
148 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
149 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
150 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 5.00
151 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
152 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
153 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
154 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
155 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34 5.00
156 INT20129 Regulation of Il1 53 0.53 44.14 19.89 5.00
157 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
158 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
159 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 5.00
160 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
161 INT61171 Gene_expression of S100A8 92 0.76 57.74 9.98 5.00
162 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37 5.00
163 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 5.00
164 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
165 INT6891 Binding of TTR 72 0.48 22.81 6.51 5.00
166 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 5.00
167 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36 5.00
168 INT50050 Gene_expression of CSRP1 23 0.76 16.84 5.86 5.00
169 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 5.00
170 INT152433 Binding of CSF1R 6 0.33 10.97 5.54 5.00
171 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44 5.00
172 INT174688 Binding of Tlr2 45 0.42 36.65 5.25 5.00
173 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 5.00
174 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77 5.00
175 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57 5.00
176 INT35609 Negative_regulation of F10 37 0.57 17.15 4.41 5.00
177 INT46121 Negative_regulation of SERPINH1 14 0.38 10.84 4.41 5.00
178 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12 5.00
179 INT16976 Negative_regulation of IL36RN 6 0.49 5.08 3.31 5.00
180 INT177993 Localization of CSF1R 4 0.73 7.49 2.94 5.00
181 INT131929 Positive_regulation of Gene_expression of S100B 25 0.67 12.61 2.83 5.00
182 INT110210 Negative_regulation of CSRP1 12 0.59 8.96 2.81 5.00
183 INT71794 Binding of SERPINC1 17 0.39 10.5 2.64 5.00
184 INT94042 Positive_regulation of Gene_expression of S100A8 15 0.67 13.52 2.44 5.00
185 INT209501 Gene_expression of CADPS 15 0.65 20.7 2.22 5.00
186 INT95592 Positive_regulation of Gene_expression of CASP1 15 0.48 13.06 2.1 5.00
187 INT126759 Negative_regulation of Nlrp3 5 0.41 2.95 1.58 5.00
188 INT53236 Positive_regulation of Binding of Il1 5 0.40 3.84 1.41 5.00
189 INT101653 Negative_regulation of SAA1 7 0.39 7 1.33 5.00
190 INT96073 Localization of Casp1 11 0.78 4.91 1.29 5.00
191 INT209915 Protein_catabolism of Il1 6 0.57 3.97 1.17 5.00
192 INT191527 Positive_regulation of Gene_expression of NLRP3 6 0.50 8.65 1.15 5.00
193 INT209912 Gene_expression of Pycard 17 0.22 12.04 1.04 5.00
194 INT186483 Negative_regulation of MYOM2 3 0.04 2.92 0.79 5.00
195 INT219136 Positive_regulation of Positive_regulation of Nlrp3 3 0.49 2.61 0.58 5.00
196 INT290389 Positive_regulation of Binding of CSF1R 1 0.25 1.14 0.4 5.00
197 INT213887 Gene_expression of MICB 10 0.19 15.33 0.39 5.00
198 INT72455 Transcription of S100A8 3 0.69 1.66 0.36 5.00
199 INT298971 Positive_regulation of Localization of Casp1 2 0.06 0.97 0.28 5.00
200 INT334889 Positive_regulation of Transcription of MRPL14 1 0.07 0.79 0.21 5.00
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