D:Familial Partial Lipodystrophy

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Disease Term
Synonyms Dunnigan Syndrome, Familial Partial Lipodystrophies, Familial Partial Lipodystrophy Kobberling Type, Familial Partial Lipodystrophy Type 1, FAMILIAL PARTIAL LIPODYSTROPHY TYPE 2, Familial Partial Lipodystrophy Type 3, Koberling Dunnigan Syndrome, Lipodystrophies Familial Partial, Lipodystrophy Familial Partial Dunnigan Type, LIPODYSTROPHY FAMILIAL PARTIAL TYPE 1, LIPODYSTROPHY FAMILIAL PARTIAL TYPE 2
Documents 5
Hot Single Events 2
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Familial Partial Lipodystrophy. They are ordered first by their relevance to Familial Partial Lipodystrophy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT297377 Binding of PPARA and Rxra 1 0.02 0.25 0.03 54.48
2 INT297374 Binding of TXNRD1 and Rxra 1 0.01 0.2 0.03 5.44
3 INT297375 Binding of VDR and Rxra 1 0.02 0.2 0.03 5.12
4 INT297352 KLF2 Regulation of PPARA 1 0.12 1.31 0.35 5.00
5 INT297351 EWSR1 Positive_regulation of PPARA 1 0.41 1.81 0.33 5.00
6 INT297376 Binding of RARS and Rxra 1 0.01 3.27 0.24 5.00
7 INT291714 Binding of RARA and Rxra 3 0.07 0.2 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Familial Partial Lipodystrophy. They are ordered first by their pain relevance and then by number of times they were reported in Familial Partial Lipodystrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 88.44
2 INT122196 Gene_expression of TAL1 5 0.47 2.07 0.63 82.52
3 INT3041 Positive_regulation of MIA3 34 0.56 21.11 6.49 75.68
4 INT105572 Negative_regulation of TAL1 3 0.23 1.05 0.06 75.00
5 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 69.16
6 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 52.52
7 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 50.00
8 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 50.00
9 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 50.00
10 INT103094 Binding of PPARA 308 0.47 177.26 34.75 50.00
11 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 50.00
12 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 50.00
13 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 50.00
14 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 50.00
15 INT100144 Negative_regulation of Positive_regulation of PPARA 17 0.49 12.71 2.68 50.00
16 INT67332 Negative_regulation of ITGA4 8 0.51 7.95 2.14 50.00
17 INT156064 Gene_expression of LMNA 50 0.65 13.38 2.01 50.00
18 INT91550 Gene_expression of PPM1D 7 0.10 0.68 1.81 50.00
19 INT79691 Regulation of Gene_expression of PPARG 10 0.50 10.44 1.62 50.00
20 INT78210 Gene_expression of MCC 7 0.65 1.8 0.98 50.00
21 INT190363 Positive_regulation of Negative_regulation of PPARA 10 0.44 4.8 0.87 50.00
22 INT190361 Protein_catabolism of PPARA 12 0.97 3.01 0.87 50.00
23 INT175483 Positive_regulation of Gene_expression of PPM1D 2 0.06 0 0.66 50.00
24 INT190362 Negative_regulation of Transcription of PPARA 5 0.42 3.19 0.42 50.00
25 INT122194 Negative_regulation of Gene_expression of TAL1 2 0.03 0.75 0.24 50.00
26 INT136488 Regulation of LMNA 13 0.60 3.53 0.2 50.00
27 INT19741 Positive_regulation of PPP1R3A 2 0.40 0.91 0.16 50.00
28 INT62690 Gene_expression of PPOX 7 0.77 3.3 0.13 50.00
29 INT190360 Negative_regulation of Protein_catabolism of PPARA 1 0.11 0.18 0 50.00
30 INT199723 Localization of Rxra 8 0.59 1.31 0.58 40.48
31 INT173159 Localization of PPARA 96 0.74 64.55 10.26 40.16
32 INT297363 Localization of NCOA1 1 0.05 0.06 0 39.20
33 INT172620 Localization of CREBBP 2 0.09 0.06 0 38.40
34 INT181186 Binding of Rxra 78 0.35 14.93 4.87 27.28
35 INT222961 Negative_regulation of Binding of PPARA 22 0.41 10.76 2.72 25.04
36 INT173162 Phosphorylation of PPARA 22 0.80 11.09 1.38 13.80
37 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 13.68
38 INT297359 Phosphorylation of LPL 1 0.19 0.62 0.03 12.80
39 INT297362 Phosphorylation of SLC27A1 1 0.61 0.61 0.03 11.56
40 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
41 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
42 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
43 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
44 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
45 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
46 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
47 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
48 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
49 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
50 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 5.00
51 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 5.00
52 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
53 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5 5.00
54 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 5.00
55 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82 5.00
56 INT86025 Positive_regulation of Positive_regulation of PPARA 34 0.52 22.89 5.74 5.00
57 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
58 INT4864 Regulation of BGLAP 22 0.34 10.8 5.07 5.00
59 INT35765 Gene_expression of TXNRD1 47 0.56 9.16 4.43 5.00
60 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28 5.00
61 INT101857 Negative_regulation of BCL2L1 22 0.57 23.56 3.95 5.00
62 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45 5.00
63 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 5.00
64 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 5.00
65 INT102638 Regulation of VDR 21 0.44 9.92 2.54 5.00
66 INT102639 Positive_regulation of VDR 31 0.69 18.05 2.38 5.00
67 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31 5.00
68 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
69 INT230954 Negative_regulation of RUNX2 3 0.39 4.54 1.79 5.00
70 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57 5.00
71 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47 5.00
72 INT63905 Regulation of RB1 13 0.62 12.67 1.28 5.00
73 INT132577 Binding of RXRB 12 0.30 6.58 1.25 5.00
74 INT253957 Gene_expression of THRA 14 0.58 7.07 0.97 5.00
75 INT78877 Gene_expression of EWSR1 10 0.75 11.16 0.97 5.00
76 INT102816 Positive_regulation of TCEAL1 6 0.37 7.08 0.96 5.00
77 INT182968 Positive_regulation of Gene_expression of VDR 22 0.58 15.22 0.89 5.00
78 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 5.00
79 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7 5.00
80 INT113840 Negative_regulation of Gene_expression of JUN 10 0.58 5.23 0.56 5.00
81 INT68302 Gene_expression of JUNB 4 0.75 1.58 0.38 5.00
82 INT201389 Positive_regulation of RARS 3 0.27 2.58 0.38 5.00
83 INT297364 Positive_regulation of KLF2 1 0.18 1.24 0.34 5.00
84 INT297366 Binding of EWSR1 1 0.36 1.8 0.33 5.00
85 INT221419 Regulation of BRCA1 5 0.35 6.18 0.31 5.00
86 INT197599 Transcription of Rb1 4 0.63 0.87 0.3 5.00
87 INT119049 Negative_regulation of TCEAL1 3 0.15 2.29 0.28 5.00
88 INT141791 Regulation of Ucp3 3 0.53 1.27 0.28 5.00
89 INT297365 Negative_regulation of ZNF197 1 0.06 0.73 0.18 5.00
90 INT163262 Transcription of ADIPOQ 5 0.52 2.81 0.14 5.00
91 INT245905 Negative_regulation of Transcription of ADIPOQ 1 0.42 1.26 0.05 5.00
92 INT189954 Negative_regulation of Positive_regulation of TCEAL1 2 0.07 2.03 0.04 5.00
93 INT245901 Positive_regulation of Dlk1 1 0.25 0.48 0.04 5.00
94 INT245910 Regulation of Ucp2 1 0.12 0.93 0.04 5.00
95 INT245906 Regulation of Transcription of Ucp2 1 0.12 0.93 0.04 5.00
96 INT245909 Positive_regulation of Transcription of Rb1 1 0.05 0.49 0.04 5.00
97 INT228578 Transcription of Ucp2 2 0.29 1.19 0.04 5.00
98 INT245908 Regulation of Transcription of Ucp3 1 0.09 0.92 0.04 5.00
99 INT245907 Transcription of Ucp3 2 0.63 0.99 0.04 5.00
100 INT297368 Regulation of Positive_regulation of VDR 1 0.27 1.66 0 5.00
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