D:Fanconi Anemia

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Disease Term
Synonyms ANEMIA FANCONI, ANEMIA FANCONI S, Anemias Fanconi, Congenital Aplastic Anemia, Congenital Pancytopaenia, Congenital Pancytopenia, Constitutional Aplastic Anaemia, Constitutional Aplastic Anemia, Familial Hypoplastic Anemia, Fanconi Anaemia, Fanconi Anemias
Documents 17
Hot Single Events 9
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Fanconi Anemia. They are ordered first by their relevance to Fanconi Anemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT234180 Binding of BRCA1 and BRIP1 1 0.33 1.37 0 91.32
2 INT234182 Binding of BRCA2 and PALB2 1 0.41 1.43 0 85.48
3 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0 59.16
4 INT260070 Binding of PHF2 and SPTLC1 1 0.17 1.93 0.1 42.84
5 INT260071 Binding of FANCC and XPA 1 0.24 0.76 0 5.00
6 INT260066 Binding of PHF2 and XPA 1 0.20 1.04 0 5.00
7 INT260069 Binding of FANCC and PHF2 1 0.28 0.37 0 5.00
8 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0 5.00
9 INT234179 Binding of DDR1 and ESR1 1 0.05 0.86 0 5.00
10 INT260073 Binding of FANCC and PTCH1 1 0.33 0.49 0 5.00
11 INT260067 Binding of PTCH1 and XPA 1 0.26 1.08 0 5.00
12 INT260072 Binding of BRCA2 and FANCC 1 0.37 0.63 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Fanconi Anemia. They are ordered first by their pain relevance and then by number of times they were reported in Fanconi Anemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT334185 Negative_regulation of Brip1 1 0.20 0.81 0 97.76
2 INT147433 Gene_expression of BRCA2 7 0.62 7.02 0.79 95.76
3 INT234190 Gene_expression of BRIP1 1 0.55 0.6 0 95.44
4 INT234184 Gene_expression of PALB2 2 0.55 1.95 0.07 95.04
5 INT221269 Binding of BRCA1 14 0.40 31.77 2.7 94.08
6 INT334189 Regulation of Binding of BRCA1 1 0.13 0.8 0 94.08
7 INT234185 Binding of PALB2 1 0.29 0.71 0 84.92
8 INT205968 Negative_regulation of PTCH1 2 0.58 2.35 0 80.96
9 INT210488 Phosphorylation of CFH 1 0.04 0.48 0.05 80.20
10 INT334188 Binding of Atm 1 0.10 1.18 0 77.20
11 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 76.60
12 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 76.20
13 INT166956 Positive_regulation of LYRM4 2 0.12 2.18 0.47 75.04
14 INT234191 Positive_regulation of Localization of BRCA2 1 0.46 0.68 0 73.32
15 INT234188 Positive_regulation of Localization of BRCA1 1 0.42 0.68 0 73.32
16 INT221268 Localization of BRCA1 7 0.63 4.83 0.18 72.88
17 INT234186 Localization of BRCA2 2 0.69 1.48 0.07 72.88
18 INT334186 Binding of Brip1 1 0.17 0.85 0 68.72
19 INT260080 Negative_regulation of Gene_expression of PTCH1 1 0.58 2.09 0 68.24
20 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26 67.92
21 INT307492 Regulation of Lpp 1 0.13 0.72 0.08 66.48
22 INT199652 Negative_regulation of Fxn 3 0.54 12.37 0.11 66.12
23 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36 64.00
24 INT19359 Binding of BRCA2 5 0.47 2.63 0.19 59.16
25 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 56.12
26 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 56.12
27 INT189353 Binding of RAD51 11 0.40 0.93 0 50.52
28 INT173223 Negative_regulation of BRCA2 7 0.54 6.79 0.25 48.32
29 INT154651 Negative_regulation of Nfe2l2 19 0.59 10.48 2.01 35.84
30 INT76752 Negative_regulation of TOP2B 8 0.42 6.2 0.14 30.28
31 INT80339 Gene_expression of PHF2 3 0.73 2.3 0.26 19.60
32 INT158754 Gene_expression of XPA 3 0.57 4.24 0.2 19.60
33 INT238184 Gene_expression of FANCC 6 0.60 2.92 0.19 19.60
34 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74 7.84
35 INT199655 Negative_regulation of Gene_expression of Fxn 2 0.47 3.34 0.07 7.84
36 INT199654 Positive_regulation of Gene_expression of Fxn 3 0.64 2.95 0.05 7.84
37 INT234187 Positive_regulation of Gene_expression of NRG1 1 0.02 0.32 0 7.04
38 INT30851 Gene_expression of NRG1 8 0.67 4.64 1.12 6.40
39 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 5.00
40 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
41 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
42 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
43 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
44 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85 5.00
45 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
46 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 5.00
47 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
48 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
49 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 5.00
50 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
51 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
52 INT68913 Gene_expression of Cd14 55 0.76 38.99 15.67 5.00
53 INT92354 Localization of ESR1 77 0.75 33.04 15.51 5.00
54 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
55 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
56 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
57 INT52905 Gene_expression of Cd4 84 0.78 45.68 12.75 5.00
58 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 5.00
59 INT3845 Gene_expression of GSR 79 0.76 44.69 11.19 5.00
60 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 5.00
61 INT139613 Binding of pr 16 0.47 5.52 8.46 5.00
62 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
63 INT14238 Positive_regulation of Cd69 19 0.60 17.75 6.07 5.00
64 INT13418 Positive_regulation of Lpp 8 0.54 0.55 5.84 5.00
65 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44 5.00
66 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 5.00
67 INT20200 Positive_regulation of Serpinc1 25 0.68 17.08 4.98 5.00
68 INT114311 Negative_regulation of Gene_expression of Gpt 33 0.38 17.83 4.94 5.00
69 INT39000 Regulation of pr 24 0.44 12.51 4.36 5.00
70 INT98357 Binding of Gnas 11 0.41 1.87 4.35 5.00
71 INT48518 Gene_expression of ANPEP 51 0.78 22.88 4.18 5.00
72 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17 5.00
73 INT28546 Regulation of SHBG 23 0.54 16.35 3.88 5.00
74 INT185246 Gene_expression of Psmd1 26 0.50 8.89 3.73 5.00
75 INT57252 Negative_regulation of PGR 22 0.43 12.95 3.33 5.00
76 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64 5.00
77 INT177998 Binding of RUNX1 7 0.35 7.12 2.08 5.00
78 INT27878 Gene_expression of FCGR1B 22 0.26 20.62 2.04 5.00
79 INT96764 Positive_regulation of Gene_expression of SOD1 36 0.61 16.55 1.99 5.00
80 INT23148 Gene_expression of RUNX1 10 0.10 6.58 1.71 5.00
81 INT12942 Regulation of ITGAL 8 0.35 3.29 1.57 5.00
82 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48 5.00
83 INT73938 Gene_expression of Cd36 20 0.76 12.27 1.35 5.00
84 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34 5.00
85 INT89928 Gene_expression of CSF2RA 19 0.75 6.78 1.27 5.00
86 INT191253 Negative_regulation of DDR1 13 0.25 10.05 1.05 5.00
87 INT172529 Negative_regulation of Gene_expression of PGR 24 0.48 16.69 1.04 5.00
88 INT83835 Positive_regulation of CEACAM6 3 0.24 1.53 1.01 5.00
89 INT124090 Gene_expression of Gadd45a 9 0.63 3.25 0.99 5.00
90 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 5.00
91 INT151815 Localization of RUNX1 3 0.68 1.87 0.81 5.00
92 INT1869 Negative_regulation of SLC17A5 12 0.42 5.51 0.75 5.00
93 INT124093 Negative_regulation of Gene_expression of Gadd45a 2 0.35 1.52 0.71 5.00
94 INT75311 Gene_expression of Cd79a 5 0.77 5.13 0.58 5.00
95 INT217083 Gene_expression of Rrm2 10 0.47 4.16 0.47 5.00
96 INT214985 Localization of FANCC 6 0.55 1.43 0.43 5.00
97 INT214981 Binding of FANCC 3 0.33 2.71 0.38 5.00
98 INT261227 Gene_expression of Impact 3 0.20 2.38 0.37 5.00
99 INT260086 Negative_regulation of MSRA 3 0.41 2.36 0.33 5.00
100 INT146792 Negative_regulation of Nf2 2 0.59 3.49 0.3 5.00
101 INT260079 Transcription of FANCC 2 0.62 1.55 0.26 5.00
102 INT35719 Gene_expression of Atm 34 0.78 15.75 0.24 5.00
103 INT214984 Regulation of FANCC 2 0.40 3.19 0.23 5.00
104 INT199642 Positive_regulation of Fxn 3 0.41 3.6 0.14 5.00
105 INT199640 Positive_regulation of Positive_regulation of Fxn 2 0.41 2.97 0.14 5.00
106 INT282824 Regulation of PML 3 0.44 2.66 0.09 5.00
107 INT260083 Regulation of PTCH1 11 0.27 4.46 0.09 5.00
108 INT234175 Regulation of Fam89b 1 0.01 0.59 0.08 5.00
109 INT199646 Transcription of Fxn 2 0.67 4.78 0.08 5.00
110 INT83483 Regulation of Regulation of ITGAL 2 0.01 0.3 0.04 5.00
111 INT191252 Localization of DDR1 4 0.45 3.15 0.04 5.00
112 INT291510 Gene_expression of Pmaip1 1 0.29 0.5 0.04 5.00
113 INT183070 Transcription of PTCH1 2 0.68 0.95 0.04 5.00
114 INT356186 Positive_regulation of Regulation of PML 1 0.49 1.14 0.04 5.00
115 INT291517 Gene_expression of Sesn1 1 0.31 0.5 0.04 5.00
116 INT105948 Gene_expression of AURKA 5 0.65 4.26 0.03 5.00
117 INT105949 Positive_regulation of Gene_expression of AURKA 3 0.49 1.91 0.03 5.00
118 INT291518 Positive_regulation of Negative_regulation of Fxn 1 0.47 1.1 0.03 5.00
119 INT199651 Binding of Fxn 3 0.30 1.45 0.03 5.00
120 INT291511 Positive_regulation of Transcription of Fxn 1 0.47 0.09 0 5.00
121 INT260088 Negative_regulation of Transcription of PTCH1 1 0.43 0.4 0 5.00
122 INT291516 Negative_regulation of Transcription of Fxn 1 0.54 0.77 0 5.00
123 INT260090 Regulation of XPA 1 0.17 0.96 0 5.00
124 INT334184 Positive_regulation of Regulation of pr 1 0.02 0.53 0 5.00
125 INT260075 Binding of PHF2 1 0.32 0.75 0 5.00
126 INT260087 Regulation of Regulation of PHF2 1 0.23 0.19 0 5.00
127 INT260084 Negative_regulation of FANCC 1 0.39 0.44 0 5.00
128 INT291513 Positive_regulation of Ccar1 1 0.17 0.6 0 5.00
129 INT260081 Negative_regulation of Transcription of PHF2 1 0.37 0.63 0 5.00
130 INT291521 Positive_regulation of C10orf88 1 0.19 0.58 0 5.00
131 INT291519 Positive_regulation of Sgce 1 0.16 0.61 0 5.00
132 INT291514 Positive_regulation of Impact 1 0.14 0.59 0 5.00
133 INT260089 Localization of PTCH1 1 0.70 0.37 0 5.00
134 INT291522 Positive_regulation of DHFRL1 1 0.24 0.62 0 5.00
135 INT291509 Positive_regulation of Tbx3 1 0.14 0.6 0 5.00
136 INT260076 Binding of XPA 1 0.20 1.1 0 5.00
137 INT291508 Positive_regulation of Irx2 1 0.15 0.61 0 5.00
138 INT260077 Transcription of XPA 1 0.43 0.33 0 5.00
139 INT260085 Transcription of PHF2 1 0.60 1.36 0 5.00
140 INT291515 Positive_regulation of Adam23 1 0.16 0.61 0 5.00
141 INT291507 Regulation of Negative_regulation of Fxn 1 0.37 0.87 0 5.00
142 INT260078 Regulation of PHF2 1 0.23 1.65 0 5.00
143 INT291512 Regulation of Gene_expression of Fxn 1 0.37 0.06 0 5.00
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