D:Fat Necrosis

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Disease Term
Synonyms Fat Necroses, NECROSIS FAT, Steatonecroses, Steatonecrosis
Documents 198
Hot Single Events 30
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Fat Necrosis. They are ordered first by their relevance to Fat Necrosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4 53.00
2 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13 23.76
3 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87 5.00
4 INT352521 Cnn1 Positive_regulation of Cp 1 0.00 1.45 0.5 5.00
5 INT182771 ROS1 Positive_regulation of NFKB1 Positive_regulation of CRP 1 0.00 3.83 0.28 5.00
6 INT182772 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL1B 1 0.00 1.89 0.14 5.00
7 INT182773 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL6 1 0.00 1.9 0.14 5.00
8 INT182780 NFKB1 Positive_regulation of IL1B 1 0.00 1.8 0.14 5.00
9 INT330467 IL12A Positive_regulation of Localization of TH1L 1 0.16 0.3 0.14 5.00
10 INT182782 NFKB1 Positive_regulation of IL6 1 0.00 1.8 0.14 5.00
11 INT184527 Binding of DUS2L and HEPACAM 1 0.00 0.86 0.13 5.00
12 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12 5.00
13 INT182775 Binding of PTH and ROS1 1 0.04 1.73 0.04 5.00
14 INT182784 IGF1 Positive_regulation of Gene_expression of INS 1 0.02 1.87 0 5.00
15 INT182804 Binding of ETV3 and T2DM 1 0.10 2.62 0 5.00
16 INT182778 IGF1 Positive_regulation of Gene_expression of ETV3 1 0.03 1.89 0 5.00
17 INT182774 Binding of ETV3 and SAE1 1 0.00 1.17 0 5.00
18 INT182783 INS Positive_regulation of Gene_expression of ETV3 1 0.01 1.89 0 5.00
19 INT182777 IAPP Positive_regulation of Gene_expression of ETV3 1 0.06 1.88 0 5.00
20 INT182776 IAPP Positive_regulation of Gene_expression of INS 1 0.03 1.87 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Fat Necrosis. They are ordered first by their pain relevance and then by number of times they were reported in Fat Necrosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3414 Positive_regulation of Negative_regulation of Alb 4 0.44 1.91 1.09 98.00
2 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 97.48
3 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 97.44
4 INT92388 Gene_expression of ALK 16 0.78 22.46 2.26 97.12
5 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 96.68
6 INT62331 Gene_expression of TNFRSF8 26 0.72 17.75 2.08 96.56
7 INT184604 Negative_regulation of Pla2g3 2 0.02 1.85 0.39 95.04
8 INT102251 Positive_regulation of Positive_regulation of Crp 24 0.58 29.62 7.5 93.92
9 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 93.76
10 INT13948 Positive_regulation of Amy1a 2 0.44 2.1 0.91 93.00
11 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 92.28
12 INT12243 Positive_regulation of PRSS1 91 0.70 52.87 19.48 91.72
13 INT6196 Regulation of Nppa 83 0.62 30.31 30.18 88.84
14 INT43948 Localization of PLA2G1B 17 0.78 6.92 2.99 87.36
15 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 87.20
16 INT69304 Negative_regulation of Il10 47 0.59 36.88 19.79 87.20
17 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 86.16
18 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89 86.16
19 INT43946 Gene_expression of UGT2A2 3 0.06 1.08 0.61 84.32
20 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 83.84
21 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 83.84
22 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 83.84
23 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 83.84
24 INT110980 Gene_expression of CTSB 17 0.45 8.02 2.69 83.84
25 INT59135 Positive_regulation of CTSB 15 0.67 7.53 2.53 83.84
26 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 83.48
27 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 81.20
28 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 81.04
29 INT103327 Gene_expression of F8 45 0.71 32.5 2.12 80.92
30 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86 80.60
31 INT24278 Gene_expression of FUT4 33 0.75 26.7 4.29 80.00
32 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 79.72
33 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 79.40
34 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 79.00
35 INT68447 Positive_regulation of PDP1 11 0.64 5.69 0.83 77.60
36 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 74.84
37 INT182794 Gene_expression of CPLX1 1 0.06 5.57 0.17 73.80
38 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 71.44
39 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 69.84
40 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 68.96
41 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 68.60
42 INT38672 Binding of KRT20 69 0.39 48.01 6.31 64.36
43 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 64.24
44 INT70860 Binding of SNRPB 17 0.35 7 1.46 60.88
45 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 59.68
46 INT82685 Gene_expression of Pecam1 36 0.76 27.95 9.01 59.56
47 INT90021 Gene_expression of IGKV2D-40 6 0.13 3.07 1.31 59.56
48 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 59.12
49 INT67379 Positive_regulation of Cd34 38 0.58 26.18 3.28 57.92
50 INT94381 Negative_regulation of Col4a2 2 0.31 0.57 0.43 54.64
51 INT133057 Binding of TRAM1 8 0.41 1.62 0.64 54.40
52 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 53.36
53 INT288 Positive_regulation of Sct 88 0.70 32.83 24.5 51.44
54 INT222650 Gene_expression of Col4a2 6 0.19 1.84 0.19 50.00
55 INT43947 Localization of ASAP1 11 0.68 4.49 0.88 47.28
56 INT68448 Negative_regulation of Positive_regulation of PDP1 4 0.40 1.84 0.24 46.08
57 INT184530 Regulation of SMUG1 4 0.52 3.54 0.16 43.32
58 INT291134 Gene_expression of PDP1 4 0.62 0.64 0.26 42.72
59 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 37.28
60 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 34.80
61 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 33.36
62 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 20.56
63 INT6852 Localization of TNF 883 0.81 705.95 270.84 18.92
64 INT19511 Localization of Il6 212 0.81 118.17 67.67 18.92
65 INT55255 Positive_regulation of Localization of Il6 48 0.69 24.88 12.76 18.92
66 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 18.56
67 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 17.84
68 INT179523 Binding of Pip 4 0.14 2.61 0.64 13.76
69 INT106263 Gene_expression of R3hcc1 4 0.44 9.36 0.88 12.64
70 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
71 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
72 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
73 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
74 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
75 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
76 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
77 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
78 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
79 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 5.00
80 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
81 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
82 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
83 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
84 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
85 INT249 Localization of GHRH 215 0.80 78.02 51.87 5.00
86 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
87 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 5.00
88 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
89 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
90 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
91 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
92 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
93 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
94 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
95 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
96 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
97 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
98 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
99 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 5.00
100 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23 5.00
101 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54 5.00
102 INT89484 Gene_expression of TNFRSF11B 119 0.76 53.57 19.67 5.00
103 INT45142 Gene_expression of DCPS 109 0.56 84.71 16.87 5.00
104 INT2432 Positive_regulation of Cp 41 0.67 31.1 16.68 5.00
105 INT984 Positive_regulation of Localization of GHRH 58 0.70 12.66 16.51 5.00
106 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
107 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 5.00
108 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 5.00
109 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 5.00
110 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 5.00
111 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 5.00
112 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
113 INT159631 Positive_regulation of DCPS 60 0.27 43.23 10.3 5.00
114 INT94784 Binding of ROS1 113 0.40 71.57 10.26 5.00
115 INT69306 Negative_regulation of TH1L 28 0.57 24.81 9.74 5.00
116 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 5.00
117 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98 5.00
118 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 5.00
119 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 5.00
120 INT29229 Regulation of NCOR2 20 0.42 5.75 8.08 5.00
121 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 5.00
122 INT12010 Gene_expression of Cp 38 0.65 20.55 7.84 5.00
123 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 5.00
124 INT167052 Gene_expression of Cr2 43 0.56 25.7 7.76 5.00
125 INT162393 Gene_expression of SMUG1 58 0.75 38.78 7.7 5.00
126 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 5.00
127 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51 5.00
128 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
129 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
130 INT81688 Binding of ras 32 0.41 30.13 4.02 5.00
131 INT63121 Binding of APC 29 0.41 23.02 3.8 5.00
132 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
133 INT16130 Binding of IGF1 67 0.48 27.43 2.95 5.00
134 INT133080 Gene_expression of GATA3 15 0.61 5.64 2.89 5.00
135 INT26996 Positive_regulation of Gene_expression of Crp 21 0.68 21.55 2.75 5.00
136 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
137 INT12618 Positive_regulation of IAPP 54 0.68 32.03 2.29 5.00
138 INT59784 Binding of DES 22 0.47 19.48 2.27 5.00
139 INT55291 Gene_expression of Slc2a1 20 0.68 11.46 2.16 5.00
140 INT152174 Negative_regulation of Samsn1 5 0.14 6.46 2.1 5.00
141 INT82166 Regulation of NOS3 14 0.54 7.57 2.08 5.00
142 INT59194 Gene_expression of STS 18 0.59 6.74 1.89 5.00
143 INT198568 Regulation of DCPS 17 0.34 16.26 1.86 5.00
144 INT122449 Localization of SMUG1 10 0.67 7.97 1.47 5.00
145 INT184529 Negative_regulation of SMUG1 8 0.49 7.06 1.46 5.00
146 INT184532 Binding of SMUG1 7 0.21 5.73 1.45 5.00
147 INT18844 Binding of IAPP 11 0.36 11.01 1.45 5.00
148 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 5.00
149 INT158540 Negative_regulation of HTN1 4 0.34 7.25 1.22 5.00
150 INT158542 Gene_expression of HTN1 10 0.75 10.69 1.07 5.00
151 INT197368 Gene_expression of Tbs1 6 0.10 3.56 1 5.00
152 INT32129 Gene_expression of Esrra 8 0.36 5.64 0.97 5.00
153 INT158541 Positive_regulation of Gene_expression of HTN1 3 0.40 5.88 0.97 5.00
154 INT99289 Localization of STS 8 0.79 6.5 0.92 5.00
155 INT221427 Positive_regulation of FOXP3 6 0.45 2.74 0.83 5.00
156 INT197367 Positive_regulation of Tbs1 5 0.07 2.44 0.8 5.00
157 INT190611 Gene_expression of Cnn1 13 0.56 5.87 0.75 5.00
158 INT182792 Regulation of STS 4 0.47 2.91 0.61 5.00
159 INT175995 Gene_expression of HEPACAM 12 0.28 12.45 0.58 5.00
160 INT158409 Gene_expression of T2DM 3 0.65 9.58 0.56 5.00
161 INT126119 Positive_regulation of TCN1 9 0.43 1.31 0.48 5.00
162 INT296947 Binding of ISM1 1 0.15 4.54 0.46 5.00
163 INT194993 Binding of RB1 15 0.37 10.96 0.4 5.00
164 INT173095 Positive_regulation of Gene_expression of NCOR2 3 0.39 2.83 0.39 5.00
165 INT119271 Positive_regulation of BCS1L 13 0.50 7.56 0.39 5.00
166 INT182790 Positive_regulation of SAE1 3 0.49 3.18 0.39 5.00
167 INT182787 Binding of ETV3 14 0.37 25.44 0.37 5.00
168 INT296949 Transcription of ISM1 1 0.21 1.92 0.36 5.00
169 INT182788 Gene_expression of ETV3 8 0.40 11.33 0.36 5.00
170 INT42244 Regulation of Gene_expression of PTH 5 0.45 3.95 0.34 5.00
171 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33 5.00
172 INT118243 Transcription of APC 4 0.45 3.33 0.33 5.00
173 INT143839 Negative_regulation of TCN1 2 0.27 0.28 0.33 5.00
174 INT131019 Binding of T2DM 6 0.47 6.97 0.31 5.00
175 INT182791 Binding of CPLX1 1 0.04 2.85 0.3 5.00
176 INT184526 Phosphorylation of Slc2a1 2 0.18 1.53 0.29 5.00
177 INT182752 Negative_regulation of T2DM 1 0.41 2.06 0.29 5.00
178 INT121834 Gene_expression of IAPP 24 0.66 20.96 0.26 5.00
179 INT151851 Positive_regulation of Regulation of TH1L 3 0.40 0.97 0.23 5.00
180 INT6604 Binding of ITGA3 3 0.14 3.37 0.22 5.00
181 INT165643 Regulation of TCN1 4 0.39 0.56 0.22 5.00
182 INT78386 Positive_regulation of GSTT2 4 0.32 0.94 0.21 5.00
183 INT129762 Binding of HTN1 5 0.03 5.68 0.19 5.00
184 INT184525 Phosphorylation of Slc2a3 1 0.03 1.47 0.17 5.00
185 INT184533 Negative_regulation of Gene_expression of C19orf48 1 0.41 0.92 0.16 5.00
186 INT184534 Gene_expression of C19orf48 1 0.75 0.91 0.16 5.00
187 INT184528 Negative_regulation of DUS2L 1 0.01 1.67 0.16 5.00
188 INT296948 Negative_regulation of ISM1 1 0.16 1.04 0.14 5.00
189 INT182800 Positive_regulation of ETV3 5 0.46 10.01 0.14 5.00
190 INT184531 Regulation of DUS2L 1 0.01 1.24 0.09 5.00
191 INT278654 Phosphorylation of SULT2A1 2 0.60 0.29 0.08 5.00
192 INT182785 Gene_expression of NHEJ1 1 0.01 1.08 0.06 5.00
193 INT182754 Positive_regulation of T2DM 1 0.67 4.5 0.03 5.00
194 INT182799 Positive_regulation of Gene_expression of CPLX1 1 0.04 1.49 0.03 5.00
195 INT182801 Positive_regulation of CPLX1 1 0.04 2.92 0.03 5.00
196 INT330470 Regulation of Positive_regulation of TCN1 1 0.17 0.23 0.03 5.00
197 INT182753 Positive_regulation of Binding of 1 0.49 1.88 0 5.00
198 INT178941 Transcription of Sdc1 1 0.67 0.92 0 5.00
199 INT182786 Positive_regulation of Binding of ETV3 1 0.12 1.88 0 5.00
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