D:Feminization

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Disease Term
Synonyms Feminizations
Documents 39
Hot Single Events 26
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Feminization. They are ordered first by their relevance to Feminization and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT291546 St8sia2 Positive_regulation of Sec22b 1 0.02 0.35 0.11 76.96
2 INT291550 St8sia2 Positive_regulation of Pik3cb 1 0.05 0.36 0.11 76.96
3 INT291547 Binding of St8sia2 and Positive_regulation of Sec22b 1 0.02 0.35 0.11 76.96
4 INT324570 Binding of ANTXR2 and Kiss1 1 0.42 0.06 0 61.36
5 INT324559 Atp6v1e1 Positive_regulation of Localization of Kiss1 1 0.16 0.52 0.06 23.28
6 INT291552 Binding of Dlat and Sec22b 1 0.01 0.95 0.67 5.00
7 INT291548 Binding of Gper and Sec22b 1 0.02 0.94 0.67 5.00
8 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5 5.00
9 INT100726 TNF Positive_regulation of Gene_expression of F2RL1 2 0.27 1.9 0.46 5.00
10 INT291545 Binding of Dlat and St8sia2 1 0.14 0.44 0.37 5.00
11 INT291555 Binding of ESR1 and Dlat 1 0.01 0.6 0.35 5.00
12 INT193784 ITIH4 Positive_regulation of YWHAZ 1 0.04 1.21 0.34 5.00
13 INT291554 Binding of ESR1 and St8sia2 1 0.01 0.49 0.33 5.00
14 INT291543 Binding of Dlat and Gper 1 0.15 0.37 0.33 5.00
15 INT312726 AASS Positive_regulation of FGD1 1 0.02 0.08 0.24 5.00
16 INT88310 ITIH4 Positive_regulation of CXCR4 2 0.27 1.98 0.23 5.00
17 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19 5.00
18 INT193779 Positive_regulation of ITIH4 Positive_regulation of CXCR4 1 0.19 0.83 0.15 5.00
19 INT324560 Binding of Kiss1r and Kiss1 1 0.35 0 0.14 5.00
20 INT193789 SDF2L1 Positive_regulation of CDKN1A 1 0.00 0.68 0.13 5.00
21 INT193785 SDF2L1 Positive_regulation of Gene_expression of CDKN1A 1 0.00 0.68 0.13 5.00
22 INT193781 SDF2L1 Positive_regulation of Localization of TNF 1 0.03 1.5 0.11 5.00
23 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1 5.00
24 INT193776 ITIH4 Positive_regulation of CXCR4 Positive_regulation of Phosphorylation of APAF1 1 0.03 0.42 0.08 5.00
25 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07 5.00
26 INT193790 ITIH4 Regulation of Gene_expression of MDM2 1 0.06 0.45 0.07 5.00
27 INT218009 AHR Positive_regulation of CYP27B1 1 0.16 0.06 0.05 5.00
28 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05 5.00
29 INT218010 EE Positive_regulation of CYP27B1 1 0.05 0 0.04 5.00
30 INT218011 AHR Positive_regulation of Transcription of CYP27B1 1 0.16 0 0.04 5.00
31 INT193778 ITIH4 Positive_regulation of CASP3 1 0.03 0.98 0.03 5.00
32 INT324569 Tpt1 Positive_regulation of Tpt1 Positive_regulation of Kiss1 1 0.04 0.86 0 5.00
33 INT324561 Hmgb1 Positive_regulation of Gene_expression of Arc 1 0.18 0.65 0 5.00
34 INT324564 Atp6v1e1 Positive_regulation of Kiss1 1 0.15 0.21 0 5.00
35 INT324567 S100a10 Positive_regulation of Gene_expression of Kiss1 1 0.28 0 0 5.00
36 INT324565 Tpt1 Positive_regulation of Kiss1 1 0.13 0.77 0 5.00
37 INT324566 Binding of Arc and Gnrh1 1 0.27 0.51 0 5.00
38 INT324563 Tpt1 Positive_regulation of Arc 1 0.11 0.84 0 5.00
39 INT218012 EE Positive_regulation of ESR1 1 0.03 0 0 5.00
40 INT324558 Hmgb1 Positive_regulation of Gene_expression of Kiss1 1 0.24 0.65 0 5.00
41 INT324562 Binding of Arc and Kiss1 1 0.24 0.51 0 5.00
42 INT324557 Binding of Gnrh1 and Kiss1 1 0.48 0.51 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Feminization. They are ordered first by their pain relevance and then by number of times they were reported in Feminization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT4160 Gene_expression of Ces2a 3 0.17 2.64 1.1 99.62
2 INT44942 Positive_regulation of Localization of HSD11B1 5 0.49 4.18 0.31 98.46
3 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 98.10
4 INT8667 Localization of HSD11B1 22 0.73 22.74 1.25 98.10
5 INT283020 Binding of Afp 2 0.37 0.64 0 97.88
6 INT324550 Positive_regulation of Kiss1 1 0.69 7.03 0.45 95.44
7 INT324555 Positive_regulation of Gene_expression of Kiss1 1 0.69 12.97 0.48 95.24
8 INT278567 Gene_expression of Kiss1 2 0.78 36 1.3 94.64
9 INT30817 Gene_expression of Th 142 0.76 33.56 38.12 91.80
10 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 91.20
11 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 91.20
12 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58 91.20
13 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 90.80
14 INT197889 Binding of Sec22b 7 0.04 4.38 1.46 88.48
15 INT324500 Regulation of Positive_regulation of Atp6v1e1 1 0.06 0.17 0 88.16
16 INT142835 Regulation of Localization of Ptgs2 2 0.25 0.26 0.5 88.16
17 INT324494 Regulation of Localization of Atp6v1e1 1 0.10 0.09 0 88.16
18 INT112530 Localization of Ptgs2 13 0.70 7.77 5.86 87.76
19 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71 87.76
20 INT206913 Localization of Atp6v1e1 8 0.32 3.55 0.43 86.20
21 INT173926 Positive_regulation of Atp6v1e1 21 0.27 11.39 4.24 86.20
22 INT10787 Gene_expression of Gnrh1 64 0.78 23.06 6.76 85.60
23 INT193806 Positive_regulation of Positive_regulation of MAP3K4 1 0.03 1.03 0.04 85.40
24 INT193807 Positive_regulation of MAP3K4 2 0.13 1.12 0.07 84.96
25 INT324499 Gene_expression of Fut9 5 0.27 1.27 0 81.88
26 INT152 Negative_regulation of MBD2 31 0.38 3.95 11.31 80.24
27 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 79.72
28 INT23472 Binding of St8sia2 18 0.42 1.73 7.74 76.96
29 INT324548 Regulation of Gene_expression of Kiss1 1 0.62 4.65 0.06 73.68
30 INT182372 Regulation of Afp 2 0.45 0.44 0.04 72.44
31 INT61873 Gene_expression of Arc 128 0.78 128.25 52.24 70.28
32 INT159162 Binding of Gper 2 0.48 1.69 1.12 69.92
33 INT246723 Localization of Arc 10 0.63 7.27 1.92 69.64
34 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 68.64
35 INT324506 Regulation of 1810014F10Rik 1 0.34 0.23 0 68.12
36 INT120966 Positive_regulation of Pik3cb 34 0.68 15.15 16.59 66.44
37 INT312735 Localization of AASS 1 0.24 0.73 0 64.28
38 INT2085 Positive_regulation of LH 441 0.70 60.15 191.02 64.00
39 INT10595 Positive_regulation of Srd5a3 5 0.68 0.65 3.05 62.88
40 INT20164 Positive_regulation of B3gat2 8 0.55 1.36 2.11 62.48
41 INT324556 Regulation of Kiss1 1 0.27 3.35 0.12 61.84
42 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 57.84
43 INT2158 Negative_regulation of Positive_regulation of LH 41 0.58 4.52 17.75 57.84
44 INT15620 Positive_regulation of Negative_regulation of LH 13 0.69 2.23 5.08 57.84
45 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 54.40
46 INT324544 Positive_regulation of Positive_regulation of Kiss1 1 0.44 0.05 0 52.96
47 INT22065 Negative_regulation of B3gat2 2 0.51 0.52 0.91 52.48
48 INT7590 Regulation of B3gat2 2 0.24 0.52 0.82 52.48
49 INT53482 Gene_expression of ITIH4 75 0.77 58.87 26.05 50.16
50 INT291542 Negative_regulation of Regulation of St8sia2 1 0.23 0.15 0.15 48.00
51 INT291534 Regulation of St8sia2 1 0.14 0.15 0.14 48.00
52 INT22799 Positive_regulation of Miox 1 0.19 0.16 0.08 46.88
53 INT64787 Regulation of ITIH4 7 0.38 5.61 1.82 46.00
54 INT291541 Negative_regulation of Gper 1 0.33 0.14 0.14 44.48
55 INT2165 Localization of Cga 41 0.80 4.02 19.53 40.88
56 INT8088 Regulation of Localization of Cga 28 0.60 2.37 13.91 40.88
57 INT324542 Negative_regulation of Positive_regulation of Kiss1 1 0.43 0.81 0.03 36.60
58 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21 32.28
59 INT139247 Gene_expression of S100a10 13 0.67 2.35 1.57 32.28
60 INT324498 Negative_regulation of Fut9 1 0.17 0.49 0 31.84
61 INT324493 Regulation of Localization of Afp 1 0.45 0.15 0.03 31.56
62 INT41804 Localization of Afp 3 0.81 0.28 0.27 30.24
63 INT324492 Protein_catabolism of Afp 1 0.65 0.15 0.03 29.72
64 INT50080 Binding of APOE 38 0.45 29.61 2.67 28.72
65 INT193810 Phosphorylation of APOE 2 0.27 1.13 0.2 25.28
66 INT22797 Regulation of Regulation of Shbg 2 0.32 0.75 0.18 25.00
67 INT324553 Localization of Kiss1 1 0.75 1.72 0.06 23.28
68 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61 16.60
69 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 16.44
70 INT88678 Gene_expression of CYP27B1 8 0.75 2.11 0.41 16.44
71 INT52980 Positive_regulation of Dlat 20 0.37 5.14 4.06 14.20
72 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59 8.12
73 INT10783 Negative_regulation of Gnrh1 24 0.59 7.9 6.2 5.92
74 INT324545 Negative_regulation of Kiss1 1 0.43 0.54 0.05 5.56
75 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 5.00
76 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
77 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
78 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
79 INT1562 Localization of Crh 499 0.81 126.74 236.68 5.00
80 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 5.00
81 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
82 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 5.00
83 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
84 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
85 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
86 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
87 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
88 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
89 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34 5.00
90 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
91 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 5.00
92 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
93 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
94 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6 5.00
95 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
96 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
97 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78 5.00
98 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
99 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
100 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45 5.00
101 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
102 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
103 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
104 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 5.00
105 INT4977 Binding of ITIH4 60 0.46 42.48 15.65 5.00
106 INT20966 Positive_regulation of Arc 30 0.70 24.38 15.62 5.00
107 INT18513 Binding of GRIN1 32 0.47 9.44 15.08 5.00
108 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15 5.00
109 INT7674 Regulation of ENG 42 0.30 11.41 14.44 5.00
110 INT121783 Positive_regulation of Gene_expression of Arc 30 0.70 29.22 13.02 5.00
111 INT49129 Positive_regulation of GFAP 35 0.69 28.78 10.38 5.00
112 INT102525 Gene_expression of CCR3 24 0.71 16.19 10 5.00
113 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37 5.00
114 INT97649 Gene_expression of Dlat 48 0.66 13.77 8.94 5.00
115 INT7673 Negative_regulation of ENG 31 0.42 7.9 8.61 5.00
116 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15 5.00
117 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
118 INT12334 Positive_regulation of CYP3A 34 0.70 6.77 7.85 5.00
119 INT171715 Gene_expression of Sema5b 46 0.31 6.46 7.48 5.00
120 INT117186 Positive_regulation of CXCR4 29 0.69 24.19 6.84 5.00
121 INT12333 Regulation of CYP3A 18 0.62 2.25 6.74 5.00
122 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36 5.00
123 INT107315 Negative_regulation of CCR5 22 0.57 13.82 6.11 5.00
124 INT22128 Positive_regulation of HIVEP1 61 0.43 70.52 6.07 5.00
125 INT34306 Localization of Gnrh1 43 0.81 4.86 6 5.00
126 INT135106 Positive_regulation of Sec22b 15 0.27 1.89 5.99 5.00
127 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93 5.00
128 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 5.00
129 INT165460 Gene_expression of SLC1A3 15 0.75 7.19 5.43 5.00
130 INT57293 Regulation of Gnrh1 21 0.62 7.29 5.41 5.00
131 INT113112 Negative_regulation of CXCR4 39 0.58 28.28 5.36 5.00
132 INT59891 Positive_regulation of GSTK1 46 0.67 17.66 5.33 5.00
133 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 5.00
134 INT60252 Binding of HIVEP1 59 0.32 65.12 5.06 5.00
135 INT86219 Negative_regulation of GSTK1 25 0.41 8.99 4.97 5.00
136 INT84057 Positive_regulation of Gene_expression of ITIH4 12 0.50 10.5 4.92 5.00
137 INT149093 Positive_regulation of TNFSF10 31 0.49 34.61 4.56 5.00
138 INT187346 Regulation of Dlat 12 0.29 1.82 4.28 5.00
139 INT57645 Gene_expression of GSTK1 54 0.62 21.05 4.2 5.00
140 INT39945 Binding of Dlat 27 0.32 14.95 3.88 5.00
141 INT17620 Positive_regulation of Gnrh1 23 0.70 9.77 3.79 5.00
142 INT5286 Gene_expression of ANTXR2 46 0.75 21.06 3.41 5.00
143 INT102901 Regulation of Gene_expression of Th 12 0.60 2.42 3.22 5.00
144 INT130784 Regulation of Gene_expression of Arc 4 0.54 4.9 2.84 5.00
145 INT158083 Gene_expression of FGD1 24 0.67 6.82 2.83 5.00
146 INT161942 Regulation of Gene_expression of F2RL1 12 0.62 4.84 2.73 5.00
147 INT62487 Localization of HIVEP1 35 0.73 36.24 2.72 5.00
148 INT76099 Positive_regulation of ITIH4 8 0.69 5.71 2.66 5.00
149 INT120483 Localization of ITIH4 11 0.69 12.05 2.51 5.00
150 INT184914 Negative_regulation of Gene_expression of Th 15 0.43 9.17 2.46 5.00
151 INT142741 Gene_expression of Atp6v1e1 28 0.31 9.41 2.34 5.00
152 INT57360 Gene_expression of STAR 31 0.66 12.72 2.24 5.00
153 INT71048 Transcription of CYP19A1 11 0.72 8.74 2.24 5.00
154 INT130785 Regulation of Arc 9 0.62 5.56 2.2 5.00
155 INT102752 Positive_regulation of Gene_expression of BCL2L1 14 0.67 13.8 2.19 5.00
156 INT95592 Positive_regulation of Gene_expression of CASP1 15 0.48 13.06 2.1 5.00
157 INT57923 Gene_expression of CYP3A 12 0.71 2.62 2 5.00
158 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98 5.00
159 INT65855 Localization of TP53 18 0.76 17.08 1.89 5.00
160 INT26080 Gene_expression of St8sia2 3 0.67 1.6 1.85 5.00
161 INT282317 Negative_regulation of Gene_expression of Arc 4 0.37 6.87 1.68 5.00
162 INT58931 Binding of NAGLU 11 0.34 4.47 1.63 5.00
163 INT155130 Gene_expression of IMPACT 14 0.58 3.43 1.61 5.00
164 INT193809 Regulation of Binding of ITIH4 2 0.31 1.82 1.59 5.00
165 INT179752 Positive_regulation of Gene_expression of SLC1A3 3 0.17 2.35 1.56 5.00
166 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 5.00
167 INT650 Gene_expression of Afp 13 0.78 7.44 1.47 5.00
168 INT127889 Regulation of Gene_expression of CYP19A1 11 0.62 6.7 1.41 5.00
169 INT158078 Gene_expression of Gper 7 0.67 1.13 1.26 5.00
170 INT193815 Regulation of Gene_expression of CXCR4 17 0.61 20.27 1.15 5.00
171 INT189287 Binding of Atp6v1e1 7 0.19 6.9 1.14 5.00
172 INT193816 Gene_expression of SYCP3 4 0.65 3.55 1.09 5.00
173 INT158077 Regulation of Gper 2 0.35 0.91 1.04 5.00
174 INT161974 Regulation of UGT2B15 2 0.26 0.31 0.99 5.00
175 INT71906 Regulation of Gene_expression of ESR1 22 0.41 11.01 0.98 5.00
176 INT175280 Binding of DBT 19 0.08 6.37 0.98 5.00
177 INT312731 Negative_regulation of UGT2B15 1 0.36 0.38 0.94 5.00
178 INT312738 Regulation of UGT2B17 1 0.45 1.04 0.94 5.00
179 INT114704 Positive_regulation of Fgf1 13 0.50 8.89 0.89 5.00
180 INT61874 Negative_regulation of Positive_regulation of Arc 2 0.27 1.16 0.79 5.00
181 INT161019 Positive_regulation of Gene_expression of Dlat 6 0.32 1.19 0.79 5.00
182 INT257400 Positive_regulation of Gene_expression of FGD1 3 0.50 0.79 0.78 5.00
183 INT193805 Negative_regulation of Gene_expression of ITIH4 3 0.42 3.98 0.76 5.00
184 INT17227 Gene_expression of 16S 11 0.75 2.65 0.76 5.00
185 INT324541 Transcription of Arc 2 0.54 3.34 0.58 5.00
186 INT193811 Localization of CXCR4 6 0.75 7.68 0.58 5.00
187 INT104935 Localization of AHR 6 0.74 2.54 0.53 5.00
188 INT161973 Binding of UGT2B17 1 0.47 0.62 0.51 5.00
189 INT312739 Negative_regulation of UGT2B17 1 0.59 0.22 0.5 5.00
190 INT34305 Positive_regulation of Localization of Gnrh1 5 0.70 0.64 0.48 5.00
191 INT312740 Localization of UGT2B17 1 0.75 0.15 0.47 5.00
192 INT312734 Localization of UGT2B15 1 0.62 0.15 0.47 5.00
193 INT193812 Negative_regulation of Localization of ITIH4 1 0.30 1.15 0.44 5.00
194 INT218020 Positive_regulation of CYP27B1 3 0.49 0.15 0.41 5.00
195 INT119271 Positive_regulation of BCS1L 13 0.50 7.56 0.39 5.00
196 INT193814 Positive_regulation of Positive_regulation of CXCR4 2 0.38 3.08 0.39 5.00
197 INT197603 Positive_regulation of Binding of Dlat 3 0.23 0.67 0.35 5.00
198 INT161877 Regulation of Esrra 2 0.33 0.62 0.34 5.00
199 INT209323 Positive_regulation of Transcription of CYP19A1 5 0.32 4.22 0.33 5.00
200 INT91420 Negative_regulation of Gene_expression of Gnrh1 5 0.43 0.07 0.32 5.00
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