D:Femoral Fractures

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Disease Term
Synonyms FEMORAL FRACTURE, Fracture Femoral, FRACTURES FEMORAL
Documents 305
Hot Single Events 22
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Femoral Fractures. They are ordered first by their relevance to Femoral Fractures and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT351373 Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18 43.44
2 INT351377 Gene_expression of Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18 43.44
3 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 41.84
4 INT351378 Gene_expression of Ngf Positive_regulation of Ntrk1 1 0.35 0.41 1.18 41.84
5 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
6 INT351380 Ngf Regulation of TPM1 1 0.44 2.17 2.11 5.00
7 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31 5.00
8 INT351379 Ngf Positive_regulation of Binding of Ngf and Ntrk1 1 0.38 0.63 1.21 5.00
9 INT351374 Mir470 Negative_regulation of Ntrk3 1 0.00 1.55 0.7 5.00
10 INT351375 Mir470 Negative_regulation of Ntrk2 1 0.01 1.54 0.7 5.00
11 INT351376 Mir470 Negative_regulation of Ntrk1 1 0.01 1.54 0.7 5.00
12 INT339779 IGF1 Regulation of GHRH 1 0.08 0.38 0.05 5.00
13 INT339778 Binding of EDNRA and PTH 1 0.12 0.35 0.05 5.00
14 INT270775 PTH Regulation of DMD 1 0.09 0.64 0.03 5.00
15 INT174532 PTH Positive_regulation of Transcription of IGF1 1 0.06 0.51 0 5.00
16 INT278021 BMP2 Positive_regulation of Gene_expression of RUNX1T1 1 0.02 0.5 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Femoral Fractures. They are ordered first by their pain relevance and then by number of times they were reported in Femoral Fractures. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171585 Positive_regulation of INADL 3 0.40 0.61 0.75 99.88
2 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83 98.68
3 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 98.48
4 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 97.64
5 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43 91.52
6 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55 90.48
7 INT254332 Negative_regulation of Gene_expression of Bmpr2 3 0.22 2.41 0.07 90.48
8 INT112054 Negative_regulation of Negative_regulation of DMD 12 0.44 5.02 0.45 90.00
9 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 89.52
10 INT16165 Regulation of DMD 114 0.60 35.13 3.64 89.12
11 INT341693 Positive_regulation of Regulation of DMD 1 0.02 0.4 0 89.12
12 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 88.68
13 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 87.60
14 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 87.36
15 INT164066 Negative_regulation of SIL1 3 0.21 2.75 0.96 87.32
16 INT88870 Negative_regulation of PDXP 4 0.43 4.64 0.57 87.00
17 INT52689 Regulation of Ptgs2 27 0.60 12.76 10.6 85.68
18 INT149259 Gene_expression of RCT 38 0.67 15.73 3.87 85.68
19 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 83.52
20 INT10916 Positive_regulation of BDNF-AS 39 0.49 25.88 5.28 82.16
21 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 81.92
22 INT103779 Positive_regulation of MEMO1 2 0.01 3.77 0.3 81.76
23 INT174538 Transcription of RUNX2 1 0.26 0.59 0 78.96
24 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 77.76
25 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 77.76
26 INT73501 Negative_regulation of Localization of RETNLB 5 0.01 3.96 1.83 77.76
27 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 77.60
28 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 77.32
29 INT52722 Localization of RETNLB 54 0.38 48.63 27.98 77.04
30 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29 76.72
31 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 74.76
32 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 74.40
33 INT150331 Positive_regulation of Gene_expression of BMPR2 2 0.02 0.59 0.19 74.08
34 INT150330 Gene_expression of BMPR2 7 0.29 4.22 0.34 73.68
35 INT199005 Localization of KRT2 1 0.05 1.5 0 72.56
36 INT66040 Positive_regulation of Bdnf 114 0.69 67.67 51.81 72.08
37 INT199004 Gene_expression of ARMC9 43 0.58 17.72 1.32 69.76
38 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 68.40
39 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 68.40
40 INT16404 Regulation of CD4 54 0.61 33.05 10.29 63.80
41 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 63.20
42 INT105021 Binding of GOPC 187 0.40 60.39 20.38 60.00
43 INT99237 Gene_expression of Ntrk3 84 0.77 38.68 20.77 53.20
44 INT300893 Protein_catabolism of HSPG2 1 0.27 1.1 0.41 52.64
45 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 50.00
46 INT76857 Transcription of HSPG2 6 0.60 5.07 0.23 50.00
47 INT39624 Binding of DHS 3 0.31 1.8 0.41 49.64
48 INT178037 Gene_expression of Del(7)Tyr<c-23DVT>-p 18 0.22 23.44 4.07 48.24
49 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 44.88
50 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 43.44
51 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05 42.32
52 INT114664 Binding of BMP2 12 0.37 6.54 0.91 41.80
53 INT171998 Binding of DMD 58 0.47 38.13 3.35 38.64
54 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 38.00
55 INT148415 Positive_regulation of GALNT3 3 0.40 1.23 0.65 33.20
56 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 27.92
57 INT276088 Binding of Csn2 2 0.08 0.92 0 25.68
58 INT31117 Binding of Casp3 14 0.23 5.27 0.93 24.76
59 INT105065 Negative_regulation of Vit 3 0.35 1.23 0.38 24.60
60 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1 24.00
61 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 23.12
62 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 16.28
63 INT168418 Positive_regulation of RCT 32 0.55 20.2 4.07 9.44
64 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26 5.32
65 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98 5.32
66 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 5.00
67 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
68 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
69 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
70 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
71 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 5.00
72 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
73 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
74 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
75 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
76 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
77 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
78 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
79 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 5.00
80 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 5.00
81 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
82 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
83 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
84 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 5.00
85 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
86 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 5.00
87 INT102206 Regulation of Bdnf 37 0.62 28.54 28.78 5.00
88 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
89 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
90 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
91 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 5.00
92 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73 5.00
93 INT48240 Binding of Ngf 46 0.46 23.51 24.42 5.00
94 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 5.00
95 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
96 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 5.00
97 INT113925 Localization of Bdnf 59 0.79 24.03 22.76 5.00
98 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
99 INT30887 Negative_regulation of Ngf 56 0.59 32.96 20.86 5.00
100 INT89484 Gene_expression of TNFRSF11B 119 0.76 53.57 19.67 5.00
101 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
102 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
103 INT3364 Binding of SGCG 87 0.47 31.93 17.24 5.00
104 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
105 INT97871 Gene_expression of Ntf3 47 0.78 25.9 15.94 5.00
106 INT51014 Transcription of IL2 42 0.71 21.56 12.7 5.00
107 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 5.00
108 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
109 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
110 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27 5.00
111 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9 5.00
112 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09 5.00
113 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 5.00
114 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 5.00
115 INT97870 Positive_regulation of Gene_expression of Ntf3 19 0.70 9.56 7.8 5.00
116 INT50973 Negative_regulation of Gene_expression of Ntrk1 22 0.56 11.12 7.38 5.00
117 INT129020 Phosphorylation of Ntrk1 17 0.80 5.97 6.37 5.00
118 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 5.00
119 INT107103 Negative_regulation of Ntrk2 21 0.59 10.38 5.28 5.00
120 INT4864 Regulation of BGLAP 22 0.34 10.8 5.07 5.00
121 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 5.00
122 INT68260 Localization of BGLAP 34 0.78 16.04 4.63 5.00
123 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26 5.00
124 INT113282 Negative_regulation of TNFRSF11B 17 0.57 13.71 4.17 5.00
125 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
126 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46 5.00
127 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 5.00
128 INT28094 Binding of PTH 29 0.37 13.57 3.09 5.00
129 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07 5.00
130 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05 5.00
131 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99 5.00
132 INT64186 Positive_regulation of Gene_expression of TNFRSF11A 13 0.68 7.19 2.9 5.00
133 INT14448 Localization of COL5A2 34 0.67 17.35 2.85 5.00
134 INT68091 Localization of COL1A1 19 0.66 9.13 2.56 5.00
135 INT141367 Negative_regulation of Transcription of IL2 9 0.32 2.07 2.43 5.00
136 INT15654 Gene_expression of Tg 22 0.66 12.2 2.36 5.00
137 INT2544 Localization of PTH 39 0.81 30.55 2.22 5.00
138 INT139648 Localization of Ntf3 7 0.66 3.73 2.22 5.00
139 INT19131 Localization of CYP27A1 14 0.80 8.19 2.15 5.00
140 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12 5.00
141 INT122881 Negative_regulation of Ntrk3 10 0.51 5.52 2.04 5.00
142 INT160533 Gene_expression of NUDT6 24 0.20 18.6 1.7 5.00
143 INT66709 Transcription of IGF1 13 0.71 5.65 1.64 5.00
144 INT3343 Regulation of PTH 24 0.62 11.18 1.62 5.00
145 INT92311 Regulation of SIL1 7 0.44 6.2 1.61 5.00
146 INT126504 Regulation of Ntf3 5 0.39 4.3 1.54 5.00
147 INT129017 Negative_regulation of Phosphorylation of Ntrk1 3 0.41 1.5 1.42 5.00
148 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42 5.00
149 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 5.00
150 INT245532 Negative_regulation of Positive_regulation of Ntrk1 2 0.34 1.56 1.34 5.00
151 INT195060 Gene_expression of ALPL 9 0.73 4.82 1.3 5.00
152 INT124069 Localization of Ntrk1 9 0.59 3.32 1.13 5.00
153 INT209900 Negative_regulation of Gene_expression of TNFRSF11B 13 0.51 4.05 1.12 5.00
154 INT82214 Transcription of PTH 6 0.54 3.33 1.11 5.00
155 INT209895 Transcription of TNFRSF11A 4 0.52 2.56 1.09 5.00
156 INT13397 Localization of DMD 21 0.78 7.96 1.08 5.00
157 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04 5.00
158 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02 5.00
159 INT29788 Gene_expression of DNASE1L1 3 0.03 0.61 0.99 5.00
160 INT192686 Positive_regulation of Positive_regulation of DMD 8 0.41 4.66 0.93 5.00
161 INT207735 Negative_regulation of TPM1 3 0.57 2.77 0.83 5.00
162 INT62155 Positive_regulation of Gene_expression of DMD 17 0.67 6.17 0.82 5.00
163 INT114504 Positive_regulation of Scd1 10 0.48 3.77 0.8 5.00
164 INT171096 Transcription of PDGFA 5 0.47 4.42 0.79 5.00
165 INT125627 Gene_expression of TTF1 11 0.78 12.68 0.78 5.00
166 INT151217 Phosphorylation of SIGMAR1 2 0.04 0.41 0.72 5.00
167 INT139205 Binding of NRP1 27 0.45 4.34 0.71 5.00
168 INT174537 Positive_regulation of HEYL 7 0.39 3.07 0.68 5.00
169 INT4238 Negative_regulation of ALPI 7 0.58 3.31 0.62 5.00
170 INT174540 Positive_regulation of Localization of COL5A2 2 0.04 2.44 0.6 5.00
171 INT244679 Binding of Mmp2 4 0.30 3.75 0.54 5.00
172 INT85808 Localization of BMP2 7 0.77 1.94 0.51 5.00
173 INT180578 Regulation of HEYL 3 0.06 3.15 0.49 5.00
174 INT47311 Gene_expression of Sts 12 0.58 11.02 0.44 5.00
175 INT133316 Localization of CTSK 5 0.52 2.43 0.43 5.00
176 INT46615 Negative_regulation of Gene_expression of PTH 8 0.57 5.1 0.4 5.00
177 INT180145 Gene_expression of THOP1 15 0.28 5.94 0.36 5.00
178 INT201967 Positive_regulation of Bmpr2 4 0.31 1.24 0.34 5.00
179 INT251324 Binding of Bmpr2 5 0.23 2.99 0.34 5.00
180 INT87963 Regulation of Tg 3 0.45 2.7 0.32 5.00
181 INT215302 Gene_expression of PQBP1 15 0.53 3.93 0.31 5.00
182 INT351371 Negative_regulation of Mir470 1 0.01 0.34 0.25 5.00
183 INT62361 Negative_regulation of Positive_regulation of PTH 4 0.43 2.22 0.23 5.00
184 INT109699 Regulation of BMP2 5 0.43 2.21 0.23 5.00
185 INT44872 Localization of Sts 5 0.64 5.2 0.2 5.00
186 INT220839 Gene_expression of Cd244 7 0.29 3.2 0.19 5.00
187 INT13398 Regulation of Gene_expression of DMD 5 0.44 0.6 0.17 5.00
188 INT322091 Negative_regulation of Cd244 1 0.18 0.49 0.16 5.00
189 INT129832 Positive_regulation of Positive_regulation of PTH 5 0.50 3.4 0.14 5.00
190 INT211066 Negative_regulation of Positive_regulation of DMD 5 0.16 2.56 0.14 5.00
191 INT278037 Positive_regulation of Transcription of PDGFA 4 0.07 2.39 0.12 5.00
192 INT39866 Gene_expression of RUNX1T1 2 0.65 1.75 0.1 5.00
193 INT278036 Negative_regulation of BMP2 2 0.34 0.64 0.09 5.00
194 INT201962 Transcription of Bmpr2 6 0.37 3.51 0.09 5.00
195 INT53927 Positive_regulation of Localization of PTH 8 0.69 5.33 0.09 5.00
196 INT245157 Negative_regulation of Gene_expression of DMD 8 0.57 4.79 0.09 5.00
197 INT274020 Phosphorylation of PTH 2 0.71 1.39 0.08 5.00
198 INT72901 Negative_regulation of Il1rl1 2 0.27 0.59 0.06 5.00
199 INT191074 Negative_regulation of Gene_expression of THOP1 2 0.10 0.97 0.06 5.00
200 INT322090 Positive_regulation of Cd244 1 0.20 0.49 0.04 5.00
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