D:Fetal Alcohol Syndrome

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Disease Term
Synonyms Alcohol Affecting Fetus, Alcohol Affecting Fetus Newborn Via Placenta Breast Milk, Alcohol Affecting Foetus, ALCOHOL AFFECTING FOETUS NEWBORN VIA PLACENTA BREAST MILK, Alcohol Affecting Newborn, Alcohol Related Birth Defects, Alcoholic Embryopathy, Arbd, Dysmorphic Fetal Alcohol Syndrome, Dysmorphic Foetal Alcohol Syndrome, Embryofetal Alcohol Syndrome
Documents 53
Hot Single Events 10
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Fetal Alcohol Syndrome. They are ordered first by their relevance to Fetal Alcohol Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT176290 Fasl Positive_regulation of Pcna 1 0.02 0.44 0 35.44
2 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03 5.00
3 INT344923 Binding of CEBPZ and GOPC 1 0.06 0.24 0.33 5.00
4 INT176257 Positive_regulation of p53-ps Positive_regulation of Gene_expression of Fas 1 0.04 0.32 0.06 5.00
5 INT219230 Binding of Ecm1 and Ighv10-3 1 0.00 0.26 0.04 5.00
6 INT176283 Fasl Positive_regulation of Fas 1 0.21 0.3 0.03 5.00
7 INT176254 Fasl Positive_regulation of Fas Negative_regulation of Gene_expression of PCNA 1 0.02 0.3 0.03 5.00
8 INT176286 Fasl Positive_regulation of Gene_expression of Pcna 1 0.02 0.81 0.03 5.00
9 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03 5.00
10 INT176253 Fasl Positive_regulation of Fas Positive_regulation of Gene_expression of PCNA 1 0.02 0.3 0.03 5.00
11 INT176259 p53-ps Positive_regulation of Transcription of Fas 1 0.04 0.35 0 5.00
12 INT186999 Binding of KIT and Gtf3a 1 0.00 0.25 0 5.00
13 INT176289 Pcna Positive_regulation of Phosphorylation of Esr1 1 0.01 0.67 0 5.00
14 INT176292 Fasl Regulation of Gene_expression of CDKN1A 1 0.34 0.84 0 5.00
15 INT176288 Binding of Cdk2 and Pcna 1 0.01 0.66 0 5.00
16 INT176291 Fasl Regulation of Gene_expression of Pcna 1 0.01 0.31 0 5.00
17 INT176284 Binding of E2f1 and p53-ps 1 0.02 0.28 0 5.00
18 INT219229 Binding of Col7a1 and Ighv10-3 1 0.00 0.46 0 5.00
19 INT176258 p53-ps Regulation of Fas 1 0.03 0.06 0 5.00
20 INT176282 Binding of Pcna and p53-ps 1 0.00 0.69 0 5.00
21 INT176285 Fasl Regulation of Gene_expression of Cdc2b 1 0.03 0.34 0 5.00
22 INT176256 p53-ps Positive_regulation of Localization of Fas 1 0.04 0.35 0 5.00
23 INT176287 Cdk2 Positive_regulation of Phosphorylation of Esr1 1 0.05 0.67 0 5.00
24 INT176293 Fasl Positive_regulation of Gene_expression of CDKN1A 1 0.35 0.42 0 5.00
25 INT186989 Binding of Akt1 and Tert 1 0.00 0.61 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Fetal Alcohol Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Fetal Alcohol Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 100.00
2 INT95048 Negative_regulation of ADHD1 61 0.51 56.01 5.62 98.64
3 INT797 Regulation of Penk 812 0.62 111.13 542.24 98.54
4 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 87.04
5 INT5198 Negative_regulation of Vta1 21 0.59 4.78 18.07 85.28
6 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 84.64
7 INT172853 Positive_regulation of Localization of Cyct 14 0.67 10.48 2.65 83.60
8 INT219224 Gene_expression of Ighv10-3 1 0.03 12.91 0.07 82.96
9 INT176269 Phosphorylation of p53-ps 1 0.12 4.3 0.31 82.24
10 INT172852 Localization of Cyct 28 0.78 21.42 3.34 80.96
11 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 74.08
12 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 73.72
13 INT77621 Regulation of Gene_expression of Fas 10 0.56 7.62 2.08 72.88
14 INT115307 Gene_expression of Abcg2 3 0.75 1.37 0.88 72.60
15 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61 71.84
16 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 71.48
17 INT12440 Regulation of Gpr156 11 0.45 3.2 6.07 68.04
18 INT134375 Gene_expression of Cflar 14 0.58 8.4 2.66 64.64
19 INT161355 Transcription of Nes 2 0.18 0.7 0.26 64.12
20 INT186979 Regulation of Nes 2 0.26 0.64 0.12 61.40
21 INT186975 Regulation of Transcription of Nes 1 0.16 0.18 0.09 61.40
22 INT84820 Negative_regulation of Negative_regulation of Ngf 5 0.59 2.5 1.79 61.32
23 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 60.80
24 INT17493 Binding of Ar 14 0.48 3.62 0.6 48.96
25 INT129837 Gene_expression of Nes 44 0.75 8.05 1.19 48.08
26 INT139366 Gene_expression of PROM1 98 0.77 67.84 3.39 41.84
27 INT186981 Gene_expression of Atxn1 7 0.05 0.73 0.21 41.84
28 INT6158 Transcription of Ppia 2 0.70 0.35 0.22 26.96
29 INT143482 Negative_regulation of Gene_expression of Fas 20 0.41 8.3 0.79 26.00
30 INT6157 Positive_regulation of Ppia 4 0.68 1.24 0.75 25.52
31 INT186972 Negative_regulation of Atxn1 1 0.03 0.15 0.13 25.40
32 INT186977 Gene_expression of Tert 1 0.36 1.49 0.05 23.44
33 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 22.88
34 INT173744 Positive_regulation of Positive_regulation of Esr1 10 0.43 7.05 0.52 22.88
35 INT176246 Regulation of Cdk2 6 0.30 3.31 0.15 18.32
36 INT186980 Transcription of Tert 1 0.34 0.34 0.11 18.24
37 INT176250 Positive_regulation of Pcna 6 0.13 3.52 0 11.36
38 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
39 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
40 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 5.00
41 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
42 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
43 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
44 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37 5.00
45 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 5.00
46 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77 5.00
47 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
48 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
49 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
50 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
51 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
52 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
53 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 5.00
54 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
55 INT605 Regulation of Acot1 61 0.62 10.7 26.34 5.00
56 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
57 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64 5.00
58 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
59 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
60 INT8518 Localization of Ifng 53 0.81 36.68 24.13 5.00
61 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
62 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 5.00
63 INT89805 Gene_expression of Prkaca 45 0.77 11.03 20.77 5.00
64 INT26116 Gene_expression of Gpr156 31 0.78 13.97 20.59 5.00
65 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
66 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8 5.00
67 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
68 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
69 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
70 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 5.00
71 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78 5.00
72 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
73 INT13716 Positive_regulation of TH 33 0.68 19.11 16 5.00
74 INT47742 Binding of Flvcr2 26 0.42 3.28 15.87 5.00
75 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
76 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
77 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
78 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
79 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
80 INT93620 Positive_regulation of Gene_expression of Fasl 51 0.66 59.45 12.04 5.00
81 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 5.00
82 INT79556 Gene_expression of GRIN3B 16 0.77 7.71 10.75 5.00
83 INT65058 Binding of Nfkb1 36 0.45 19.87 10.02 5.00
84 INT88020 Positive_regulation of Fas 32 0.70 19.78 9.97 5.00
85 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84 5.00
86 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32 5.00
87 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28 5.00
88 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37 5.00
89 INT142526 Positive_regulation of Gene_expression of Prkaca 12 0.46 2.48 8.05 5.00
90 INT98178 Localization of Casp3 32 0.65 21.01 7.77 5.00
91 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 5.00
92 INT88014 Positive_regulation of Gene_expression of Fas 29 0.50 14.84 7.47 5.00
93 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91 5.00
94 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
95 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41 5.00
96 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 5.00
97 INT22901 Negative_regulation of Gene_expression of Esr1 30 0.42 20.92 6.29 5.00
98 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 5.00
99 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
100 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88 5.00
101 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84 5.00
102 INT116277 Transcription of Gpr156 7 0.53 2.53 5.61 5.00
103 INT35536 Negative_regulation of CAT 26 0.57 14.39 5.38 5.00
104 INT113516 Negative_regulation of Fas 16 0.51 8.37 5.32 5.00
105 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
106 INT10171 Binding of Gtf3a 33 0.36 19.84 5.1 5.00
107 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 5.00
108 INT2848 Localization of ABCA1 23 0.70 10.64 4.73 5.00
109 INT113517 Binding of Fas 16 0.37 15.86 4.62 5.00
110 INT96504 Negative_regulation of SLC18A2 5 0.36 2.07 4.62 5.00
111 INT143218 Binding of Gpr156 6 0.48 0.41 4.5 5.00
112 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44 5.00
113 INT134968 Localization of Ecm1 20 0.32 27.27 4.31 5.00
114 INT115889 Binding of Fas 27 0.36 28.87 4.08 5.00
115 INT123752 Regulation of Bax 19 0.60 16.45 4 5.00
116 INT121171 Negative_regulation of Gene_expression of Ngfr 6 0.58 3.46 3.89 5.00
117 INT120742 Negative_regulation of Gene_expression of Prkaca 6 0.24 3.76 3.86 5.00
118 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 5.00
119 INT85288 Gene_expression of Gabbr2 5 0.76 2.39 3.41 5.00
120 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33 5.00
121 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 5.00
122 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07 5.00
123 INT275367 Positive_regulation of Gene_expression of Gpr156 3 0.26 2.15 2.85 5.00
124 INT87340 Negative_regulation of BCAR1 8 0.38 6.96 2.63 5.00
125 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61 5.00
126 INT73592 Positive_regulation of p53-ps 19 0.10 7.85 2.56 5.00
127 INT68792 Gene_expression of p53-ps 14 0.75 6.81 2.47 5.00
128 INT142741 Gene_expression of Atp6v1e1 28 0.31 9.41 2.34 5.00
129 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3 5.00
130 INT88017 Regulation of Fas 12 0.62 8.27 2.29 5.00
131 INT35359 Negative_regulation of LCT 23 0.59 9.13 2.29 5.00
132 INT93341 Localization of Prkaca 7 0.59 2.04 2.28 5.00
133 INT101572 Negative_regulation of Gene_expression of PCNA 24 0.53 13.87 2.21 5.00
134 INT112868 Gene_expression of Pcna 21 0.75 8.6 2.15 5.00
135 INT98176 Positive_regulation of Localization of Casp3 7 0.33 6.85 2.12 5.00
136 INT73591 Positive_regulation of Positive_regulation of p53-ps 4 0.07 2.74 2.08 5.00
137 INT86671 Negative_regulation of Positive_regulation of Bcl2 6 0.57 3.83 2.03 5.00
138 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94 5.00
139 INT11136 Positive_regulation of Localization of Ifng 4 0.49 3.13 1.89 5.00
140 INT201232 Binding of CEBPZ 7 0.31 1.73 1.7 5.00
141 INT157720 Localization of ADHD1 15 0.64 15.84 1.69 5.00
142 INT73589 Positive_regulation of Gene_expression of p53-ps 4 0.49 3.51 1.66 5.00
143 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63 5.00
144 INT116275 Regulation of Gene_expression of Gpr156 2 0.62 0.95 1.62 5.00
145 INT86247 Gene_expression of Bcl2l10 14 0.34 12.21 1.61 5.00
146 INT142719 Binding of Col1a1 7 0.34 5.83 1.47 5.00
147 INT109512 Negative_regulation of Gene_expression of Bax 12 0.42 8.04 1.44 5.00
148 INT220177 Binding of Apc 21 0.37 15.34 1.37 5.00
149 INT171690 Transcription of Casp3 8 0.55 2.62 1.36 5.00
150 INT90491 Binding of Igf1 25 0.44 9.75 1.36 5.00
151 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 5.00
152 INT38964 Negative_regulation of Lsd 3 0.37 0.52 1.32 5.00
153 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31 5.00
154 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 5.00
155 INT186995 Gene_expression of RBFOX3 17 0.30 2.31 1.3 5.00
156 INT38916 Positive_regulation of Tert 3 0.33 1.92 1.28 5.00
157 INT11137 Negative_regulation of Localization of Ifng 3 0.38 2.45 1.26 5.00
158 INT167593 Gene_expression of Ly6a 5 0.75 3.07 1.22 5.00
159 INT21756 Regulation of Alb 15 0.43 8.21 1.19 5.00
160 INT162831 Regulation of ARSD 13 0.35 6.17 1.19 5.00
161 INT58211 Gene_expression of FURIN 7 0.57 0.62 1.15 5.00
162 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14 5.00
163 INT170321 Binding of Mmp13 3 0.36 2.54 1.09 5.00
164 INT183820 Regulation of BCAR1 4 0.39 3.27 1.06 5.00
165 INT81945 Negative_regulation of Binding of Esr1 3 0.32 0.55 1.06 5.00
166 INT50444 Negative_regulation of Gene_expression of Alb 11 0.39 7.63 1.06 5.00
167 INT326601 Gene_expression of SLC18A2 2 0.42 1.31 0.92 5.00
168 INT94546 Transcription of Fas 13 0.56 6.99 0.88 5.00
169 INT275366 Negative_regulation of Gene_expression of Gpr156 5 0.22 3.64 0.85 5.00
170 INT176261 Gene_expression of DDAH2 4 0.65 1.97 0.82 5.00
171 INT201233 Localization of CEBPZ 4 0.62 0.82 0.77 5.00
172 INT15783 Regulation of SMS 6 0.23 3.2 0.75 5.00
173 INT125526 Gene_expression of PRKDC 5 0.58 4 0.74 5.00
174 INT167178 Gene_expression of Cdc2b 4 0.78 2.4 0.66 5.00
175 INT143095 Positive_regulation of Gene_expression of Alb 8 0.40 1.53 0.66 5.00
176 INT68564 Binding of Fap 6 0.32 6.75 0.65 5.00
177 INT94548 Localization of Fas 9 0.77 5.15 0.65 5.00
178 INT174986 Gene_expression of AIRN 20 0.57 6.13 0.64 5.00
179 INT114879 Gene_expression of Cdk2 5 0.55 2.33 0.6 5.00
180 INT89100 Gene_expression of CNOT1 7 0.65 1.76 0.59 5.00
181 INT143219 Negative_regulation of Binding of Gpr156 2 0.37 0 0.59 5.00
182 INT173748 Phosphorylation of Esr1 11 0.77 5.7 0.55 5.00
183 INT176271 Negative_regulation of Positive_regulation of p53-ps 2 0.06 1.15 0.54 5.00
184 INT176242 Binding of Bax 10 0.42 10.18 0.52 5.00
185 INT176264 Binding of PCNA 21 0.21 9.08 0.51 5.00
186 INT84403 Localization of Prep 3 0.04 0 0.51 5.00
187 INT114672 Negative_regulation of p53-ps 3 0.09 0.51 0.48 5.00
188 INT128376 Binding of KIT 26 0.48 14.24 0.47 5.00
189 INT186998 Negative_regulation of Gene_expression of KIT 20 0.43 16.77 0.46 5.00
190 INT344929 Localization of AOC2 1 0.31 0.2 0.45 5.00
191 INT139399 Regulation of Gene_expression of PCNA 14 0.56 6.06 0.43 5.00
192 INT275368 Gene_expression of Cyct 5 0.65 3.21 0.37 5.00
193 INT275370 Positive_regulation of Gene_expression of Cyct 1 0.49 1.62 0.37 5.00
194 INT139391 Regulation of PCNA 10 0.60 3.12 0.33 5.00
195 INT129835 Negative_regulation of Gene_expression of Nes 6 0.57 2.22 0.32 5.00
196 INT225667 Transcription of Apc 3 0.52 3.73 0.32 5.00
197 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31 5.00
198 INT242816 Positive_regulation of GRINA 1 0.05 0.26 0.31 5.00
199 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29 5.00
200 INT169996 Positive_regulation of Negative_regulation of Fas 2 0.25 1.69 0.28 5.00
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