D:Fever Of Unknown Origin

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Disease Term
Synonyms Unknown Origin Fever, Unknown Origin Fevers
Documents 216
Hot Single Events 16
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Fever Of Unknown Origin. They are ordered first by their relevance to Fever Of Unknown Origin and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT198307 IL10 Positive_regulation of Gene_expression of IGHG3 2 0.01 1.21 0.15 38.60
2 INT185092 CRP Positive_regulation of ESR1 1 0.06 2.83 0.28 5.00
3 INT174820 IL6 Positive_regulation of VEGFA 1 0.20 3.32 0.12 5.00
4 INT174821 VEGFA Positive_regulation of Gene_expression of IL6 1 0.20 3.13 0.12 5.00
5 INT228229 Binding of Cd4 and Ntm 1 0.02 1.03 0.03 5.00
6 INT346971 Binding of IL4 and IL10 1 0.12 0.16 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Fever Of Unknown Origin. They are ordered first by their pain relevance and then by number of times they were reported in Fever Of Unknown Origin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 99.20
2 INT160961 Gene_expression of Fth1 4 0.28 3.89 0.63 98.48
3 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 96.92
4 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 96.24
5 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 96.24
6 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 95.52
7 INT1721 Negative_regulation of HP 148 0.42 86.82 16.89 90.24
8 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 88.04
9 INT174100 Gene_expression of YWHAE 14 0.31 12.42 0.08 87.44
10 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 86.56
11 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 86.28
12 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 85.64
13 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85 84.36
14 INT61501 Transcription of FN1 6 0.68 4.6 0.39 84.12
15 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 82.96
16 INT266505 Protein_catabolism of rsm1 1 0.62 0.85 0 80.88
17 INT79121 Binding of CHSY1 2 0.27 2.39 0.58 77.04
18 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 75.00
19 INT107924 Localization of Tnfrsf1a 5 0.70 3.86 1.37 75.00
20 INT60528 Negative_regulation of TNFRSF1A 6 0.42 4.86 1.45 74.92
21 INT255212 Localization of IRS4 1 0.08 0.93 0.08 73.48
22 INT255215 Gene_expression of IRS4 1 0.19 0.92 0.08 71.92
23 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 66.96
24 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 66.20
25 INT157884 Positive_regulation of HPLH1 1 0.02 1.79 0.22 63.88
26 INT19944 Negative_regulation of IFNG 39 0.58 22.35 10.91 63.36
27 INT140637 Negative_regulation of IFI27 11 0.40 9.48 0.69 63.36
28 INT346983 Negative_regulation of ISG15 1 0.19 3.69 0.35 63.36
29 INT19399 Gene_expression of Rf 43 0.36 33.39 13.53 63.20
30 INT190337 Negative_regulation of IFI44 2 0.23 2.02 0.18 62.56
31 INT346980 Negative_regulation of IFIT2 1 0.13 1.83 0.17 62.56
32 INT346978 Negative_regulation of IFIT1 1 0.13 1.83 0.17 62.56
33 INT213965 Gene_expression of rsm1 7 0.54 4.18 1.29 60.88
34 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 54.72
35 INT20205 Binding of IgG 108 0.46 66.68 8.57 53.24
36 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 52.64
37 INT89925 Gene_expression of NR1I2 22 0.75 9.63 4.21 50.00
38 INT135133 Binding of NR1I2 7 0.42 1.7 0.29 50.00
39 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 47.44
40 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 47.12
41 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 45.08
42 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 38.48
43 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 33.16
44 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 31.64
45 INT52937 Gene_expression of Cd68 37 0.67 31.33 7.54 31.64
46 INT83295 Positive_regulation of Cd68 21 0.39 14.55 2.46 25.72
47 INT255213 Gene_expression of DUH 1 0.06 0.68 0 16.28
48 INT62386 Negative_regulation of Gene_expression of IGHG3 12 0.20 7.94 3.62 16.20
49 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 14.08
50 INT95636 Gene_expression of ACTG2 23 0.44 19.87 1.75 14.08
51 INT264435 Positive_regulation of Gene_expression of IL1R2 2 0.10 2.46 0.69 12.80
52 INT146971 Gene_expression of IL1R2 3 0.67 2.69 0.69 12.80
53 INT66606 Gene_expression of CXCR1 34 0.75 27.79 11.36 11.44
54 INT346981 Positive_regulation of Gene_expression of CXCR1 1 0.05 1.18 0.22 11.44
55 INT3206 Positive_regulation of Got1 39 0.69 19.36 17.02 10.12
56 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 9.84
57 INT92388 Gene_expression of ALK 16 0.78 22.46 2.26 9.84
58 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 6.96
59 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 6.96
60 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
61 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
62 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
63 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
64 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
65 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
66 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
67 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
68 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
69 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
70 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
71 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
72 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12 5.00
73 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
74 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
75 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
76 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
77 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
78 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
79 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
80 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 5.00
81 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 5.00
82 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
83 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
84 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
85 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
86 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
87 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
88 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
89 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
90 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95 5.00
91 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 5.00
92 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
93 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 5.00
94 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
95 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 5.00
96 INT8798 Positive_regulation of Csrp1 61 0.69 63.86 14.14 5.00
97 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 5.00
98 INT4931 Localization of IFNG 53 0.78 33.25 13.65 5.00
99 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 5.00
100 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
101 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
102 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 5.00
103 INT65713 Localization of ICAM1 42 0.81 39.55 11.49 5.00
104 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
105 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 5.00
106 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
107 INT53590 Gene_expression of PRF1 33 0.58 23.46 10.02 5.00
108 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 5.00
109 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 5.00
110 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
111 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 5.00
112 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
113 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
114 INT60034 Positive_regulation of VWF 40 0.68 30.42 8.15 5.00
115 INT167052 Gene_expression of Cr2 43 0.56 25.7 7.76 5.00
116 INT91667 Localization of IL12A 39 0.74 25.51 7.36 5.00
117 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18 5.00
118 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
119 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 5.00
120 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 5.00
121 INT131378 Negative_regulation of FN1 20 0.35 33.98 5.85 5.00
122 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61 5.00
123 INT77146 Binding of IL4 23 0.36 13.69 5.39 5.00
124 INT187295 Gene_expression of Serpinb1a 6 0.58 13.73 5.05 5.00
125 INT142162 Binding of IL10 30 0.37 21.9 4.84 5.00
126 INT2065 Binding of BTG3 15 0.36 10.9 4.65 5.00
127 INT5870 Negative_regulation of IFNA2 20 0.49 12 4.3 5.00
128 INT57273 Positive_regulation of Gene_expression of FN1 26 0.47 17.83 4.2 5.00
129 INT48518 Gene_expression of ANPEP 51 0.78 22.88 4.18 5.00
130 INT14778 Gene_expression of FCGR3A 25 0.75 16.25 3.86 5.00
131 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 5.00
132 INT44631 Gene_expression of Ntm 14 0.64 4.87 3.35 5.00
133 INT61500 Binding of FN1 39 0.48 27.33 3.13 5.00
134 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 5.00
135 INT1631 Binding of Hdl1 42 0.36 49.22 2.92 5.00
136 INT24443 Gene_expression of PSMD2 20 0.54 7.29 2.77 5.00
137 INT8512 Gene_expression of PREP 17 0.65 7.98 2.5 5.00
138 INT70297 Gene_expression of NEFH 12 0.75 4.85 2.33 5.00
139 INT112784 Positive_regulation of Positive_regulation of IFNG 11 0.49 7.84 2.18 5.00
140 INT17747 Regulation of Cd4 14 0.41 10.02 2.12 5.00
141 INT173851 Localization of FN1 20 0.76 13.95 1.97 5.00
142 INT90584 Gene_expression of GZMB 15 0.14 13.81 1.86 5.00
143 INT15742 Negative_regulation of EPO 37 0.59 17.44 1.84 5.00
144 INT167692 Binding of NCAM1 11 0.36 6.73 1.59 5.00
145 INT61076 Gene_expression of RHD 9 0.65 3.52 1.39 5.00
146 INT181869 Gene_expression of ENAH 2 0.10 2 1.39 5.00
147 INT71782 Gene_expression of MAP2K1 7 0.68 3.17 1.37 5.00
148 INT247904 Localization of ICAM2 1 0.07 5.72 1.32 5.00
149 INT247903 Localization of ITGA1 1 0.06 5.69 1.32 5.00
150 INT66852 Gene_expression of Fcer2 15 0.14 9.74 1.27 5.00
151 INT114031 Gene_expression of ORM1 3 0.41 6.31 1.18 5.00
152 INT37679 Positive_regulation of HLA-DRB4 12 0.34 11.93 1.16 5.00
153 INT3512 Gene_expression of Igha 9 0.60 7.71 1.13 5.00
154 INT15527 Gene_expression of FFAR1 19 0.61 11.15 1.08 5.00
155 INT105543 Gene_expression of DNTT 11 0.65 4.63 1 5.00
156 INT88000 Gene_expression of LAP 15 0.55 6.94 0.91 5.00
157 INT36200 Gene_expression of S100A1 9 0.77 9.56 0.75 5.00
158 INT140297 Binding of ENAH 2 0.36 0.65 0.68 5.00
159 INT216291 Negative_regulation of BTK 4 0.42 4.9 0.67 5.00
160 INT44632 Localization of Ntm 2 0.45 4.95 0.65 5.00
161 INT28097 Negative_regulation of Wbc1 8 0.11 4.07 0.53 5.00
162 INT101739 Gene_expression of CACNA1E 2 0.25 0.43 0.49 5.00
163 INT96186 Gene_expression of MLF1IP 5 0.53 8.54 0.41 5.00
164 INT48721 Negative_regulation of Localization of SERPINE1 3 0.43 2.4 0.38 5.00
165 INT192071 Gene_expression of Carg1 10 0.13 9.4 0.36 5.00
166 INT73854 Transcription of ABL1 4 0.52 2.26 0.34 5.00
167 INT88374 Gene_expression of DPP3 3 0.75 1.2 0.32 5.00
168 INT130344 Gene_expression of APOH 3 0.34 2.87 0.32 5.00
169 INT157020 Negative_regulation of DDIT3 2 0.42 2.39 0.23 5.00
170 INT79719 Negative_regulation of VAPA 6 0.43 2.94 0.21 5.00
171 INT185093 Binding of H2AFB3 1 0.01 2.8 0.2 5.00
172 INT339173 Regulation of AREG 2 0.26 1.83 0.2 5.00
173 INT257837 Positive_regulation of Negative_regulation of BTK 1 0.08 2.01 0.17 5.00
174 INT76278 Binding of VAPA 4 0.48 3.32 0.16 5.00
175 INT257835 Negative_regulation of Btk 6 0.41 2.41 0.16 5.00
176 INT186837 Gene_expression of EBNA1BP2 9 0.64 8.66 0.13 5.00
177 INT320168 Regulation of APH1A 1 0.00 1.56 0.08 5.00
178 INT201062 Positive_regulation of Gene_expression of ENAH 1 0.04 0.47 0.07 5.00
179 INT268770 Positive_regulation of am 1 0.02 0.59 0.03 5.00
180 INT337670 Positive_regulation of DEFA3 7 0.42 10.51 0 5.00
181 INT266504 Negative_regulation of rsm1 1 0.30 0.53 0 5.00
182 INT346982 Positive_regulation of Gene_expression of ORM1 1 0.06 0.2 0 5.00
183 INT266508 Binding of rsm1 2 0.25 0.89 0 5.00
184 INT346979 Transcription of ORM1 1 0.06 0 0 5.00
185 INT214942 Gene_expression of Anxa6 2 0.04 0.19 0 5.00
186 INT255214 Gene_expression of RPA4 1 0.11 1.26 0 5.00
187 INT257839 Binding of BTK 1 0.06 2.84 0 5.00
188 INT257834 Gene_expression of Btk 7 0.65 3.45 0 5.00
189 INT266507 Localization of rsm1 1 0.52 0.53 0 5.00
190 INT257838 Negative_regulation of Binding of BTK 1 0.07 2.02 0 5.00
191 INT266506 Positive_regulation of rsm1 3 0.48 1.3 0 5.00
192 INT255650 Phosphorylation of FN1 1 0.52 2.58 0 5.00
193 INT315684 Gene_expression of DEFA3 2 0.54 1.46 0 5.00
194 INT337660 Positive_regulation of Positive_regulation of DEFA3 4 0.42 5.4 0 5.00
195 INT257827 Gene_expression of Stap1 1 0.01 1.01 0 5.00
196 INT268769 Gene_expression of am 1 0.02 0.19 0 5.00
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