D:Fibroadenoma

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Disease Term
Synonyms Fibroadenomas
Documents 82
Hot Single Events 14
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Fibroadenoma. They are ordered first by their relevance to Fibroadenoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT184527 Binding of DUS2L and HEPACAM 1 0.00 0.86 0.13 70.80
2 INT173058 INCENP Positive_regulation of Gene_expression of VEGFA 1 0.03 1.48 0.08 26.64
3 INT173057 Positive_regulation of HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.24 1.49 0.08 24.96
4 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
5 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19 5.00
6 INT182368 IgG Regulation of Cast 1 0.01 0.99 0.11 5.00
7 INT182367 IgG Regulation of Vim 1 0.00 0.99 0.11 5.00
8 INT213421 Binding of CXCL2 and SET 1 0.11 0.17 0.1 5.00
9 INT213417 Binding of CCL7 and SET 1 0.11 0.17 0.1 5.00
10 INT213414 Binding of CXCL1 and SET 1 0.10 0.17 0.1 5.00
11 INT213415 Binding of CCL8 and SET 1 0.11 0.17 0.1 5.00
12 INT213420 Binding of IL6 and SET 1 0.10 0.17 0.1 5.00
13 INT213416 Binding of CCL2 and SET 1 0.11 0.17 0.1 5.00
14 INT173061 Binding of HIF1A and LILRA3 1 0.03 1.24 0.09 5.00
15 INT173062 Binding of HIF1A and VHLL 1 0.04 1.26 0.09 5.00
16 INT213418 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of VCAM1 1 0.29 0.15 0.08 5.00
17 INT173106 VEGFA Positive_regulation of Fos 1 0.44 0.64 0.08 5.00
18 INT213419 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of HGF 1 0.25 0.15 0.08 5.00
19 INT173052 Binding of LILRA3 and VHLL 1 0.01 0.62 0.05 5.00
20 INT173053 Binding of VEGFA and NRP2 3 0.12 1.36 0.04 5.00
21 INT173060 Negative_regulation of VHLL Positive_regulation of Positive_regulation of HIF1A 1 0.04 0.66 0.04 5.00
22 INT173056 Binding of NRP2 and NRP1 2 0.24 0.61 0.04 5.00
23 INT173051 Binding of VEGFA and NRP1 16 0.44 1.29 0.04 5.00
24 INT183614 Binding of ESR1 and TMED4 2 0.02 0.13 0.03 5.00
25 INT213422 MITF Negative_regulation of PROC 1 0.00 0.52 0.03 5.00
26 INT173055 Binding of VEGFA and NCOR2 1 0.02 0.34 0.03 5.00
27 INT178638 Gh1 Regulation of Gene_expression of ESR1 1 0.01 0.47 0 5.00
28 INT173054 NRP1 Positive_regulation of KDR 1 0.08 0.34 0 5.00
29 INT178639 Binding of ESR1 and Igf1 1 0.02 0.39 0 5.00
30 INT178637 Igf1 Positive_regulation of ESR1 1 0.03 0.17 0 5.00
31 INT173050 Binding of VEGFA and NRP1 Positive_regulation of KDR 1 0.08 0.35 0 5.00
32 INT178628 Igf1 Regulation of Gene_expression of Pgr 1 0.24 0.19 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Fibroadenoma. They are ordered first by their pain relevance and then by number of times they were reported in Fibroadenoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT122449 Localization of SMUG1 10 0.67 7.97 1.47 98.04
2 INT214025 Negative_regulation of INVS 4 0.07 3.36 0 93.32
3 INT184530 Regulation of SMUG1 4 0.52 3.54 0.16 90.96
4 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 88.76
5 INT122330 Negative_regulation of Negative_regulation of TAM 1 0.27 0.66 0.1 88.72
6 INT122331 Negative_regulation of TAM 1 0.27 0.66 0.1 88.52
7 INT211700 Negative_regulation of Mri1 5 0.29 2.06 1.04 86.04
8 INT237246 Negative_regulation of Fus 1 0.32 0.9 0.24 86.04
9 INT153853 Positive_regulation of Fus 7 0.42 8.43 1.59 85.28
10 INT211701 Positive_regulation of Mri1 20 0.34 20.64 6.69 84.96
11 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68 82.00
12 INT89765 Positive_regulation of NR4A1 12 0.69 8.13 1.23 81.28
13 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 81.04
14 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72 81.04
15 INT184531 Regulation of DUS2L 1 0.01 1.24 0.09 76.08
16 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 75.68
17 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 75.20
18 INT175995 Gene_expression of HEPACAM 12 0.28 12.45 0.58 70.80
19 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 68.96
20 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 68.08
21 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57 68.08
22 INT204170 Binding of Mri1 5 0.22 4.45 1.11 67.00
23 INT93596 Binding of Fus 2 0.31 3.88 0.84 67.00
24 INT60765 Gene_expression of LAMB2 28 0.49 13.93 2.38 65.92
25 INT102249 Binding of HIF1A 39 0.36 30.47 1.04 61.12
26 INT46777 Localization of FECD7 1 0.61 2.09 0.16 60.52
27 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 56.16
28 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 56.08
29 INT158 Localization of Prl 2431 0.81 378.96 952.2 55.56
30 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08 53.28
31 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 51.88
32 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02 50.16
33 INT86370 Regulation of CDH1 10 0.54 13.89 0.7 48.16
34 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 47.76
35 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 47.60
36 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88 47.60
37 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 42.80
38 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 42.16
39 INT78281 Gene_expression of Krt7 28 0.70 26.77 0.97 41.84
40 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66 41.08
41 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 41.08
42 INT213446 Regulation of Gene_expression of SRF 1 0.22 0.71 0 37.12
43 INT45489 Gene_expression of SRF 5 0.77 3.29 0.71 36.60
44 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 36.48
45 INT143443 Localization of HIF1A 14 0.78 10.93 1.49 36.48
46 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 35.84
47 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 35.08
48 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 33.16
49 INT159190 Gene_expression of KRT5 31 0.65 26.67 0.56 29.84
50 INT184528 Negative_regulation of DUS2L 1 0.01 1.67 0.16 28.04
51 INT88947 Positive_regulation of Gene_expression of Pgr 22 0.64 7 4.39 27.72
52 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 26.20
53 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 26.20
54 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 25.00
55 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 25.00
56 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 24.96
57 INT100381 Positive_regulation of Positive_regulation of HIF1A 12 0.49 12.05 2.17 24.96
58 INT105392 Positive_regulation of Binding of HIF1A 5 0.45 3.83 0.1 22.20
59 INT93399 Gene_expression of Ccnd1 38 0.58 21 3.65 21.28
60 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 21.24
61 INT78199 Gene_expression of Neu1 65 0.75 62.88 7.16 19.52
62 INT80174 Positive_regulation of Gene_expression of Neu1 23 0.37 17.82 1.12 19.52
63 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 12.00
64 INT155352 Phosphorylation of HIF1A 3 0.79 3.34 0.83 8.80
65 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
66 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
67 INT876 Localization of Gh1 843 0.80 67.75 340.82 5.00
68 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
69 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
70 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
71 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
72 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
73 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
74 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
75 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
76 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
77 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 5.00
78 INT874 Positive_regulation of Gh1 244 0.70 27.17 97.98 5.00
79 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
80 INT881 Negative_regulation of Localization of Gh1 164 0.58 15.1 75.28 5.00
81 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
82 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 5.00
83 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 5.00
84 INT1781 Negative_regulation of Gh1 127 0.59 16.94 51.77 5.00
85 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 5.00
86 INT873 Gene_expression of Gh1 130 0.76 26.15 46.75 5.00
87 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
88 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
89 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 5.00
90 INT2296 Positive_regulation of Gene_expression of Prl 137 0.70 36.96 35.39 5.00
91 INT118343 Positive_regulation of Eae1 121 0.39 136.06 34.87 5.00
92 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
93 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
94 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 5.00
95 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
96 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
97 INT94388 Gene_expression of GDF15 124 0.77 79.48 31.42 5.00
98 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
99 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27 5.00
100 INT6855 Binding of NCOR2 71 0.41 15.64 28.96 5.00
101 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
102 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
103 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
104 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
105 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
106 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
107 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
108 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
109 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23 5.00
110 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
111 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54 5.00
112 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
113 INT137767 Gene_expression of Eae1 74 0.34 89.32 20.48 5.00
114 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 5.00
115 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
116 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
117 INT1261 Localization of Adh1 63 0.81 19.36 16.09 5.00
118 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15 5.00
119 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91 5.00
120 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 5.00
121 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
122 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
123 INT91817 Positive_regulation of RETNLB 22 0.34 21.4 13.12 5.00
124 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
125 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55 5.00
126 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
127 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
128 INT21632 Positive_regulation of Adh1 32 0.70 15.67 11.65 5.00
129 INT1708 Gene_expression of OXTR 56 0.78 6.92 10.69 5.00
130 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66 5.00
131 INT10184 Regulation of EDN1 44 0.62 23.78 10.06 5.00
132 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98 5.00
133 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
134 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
135 INT80420 Gene_expression of IFI27 145 0.78 63.61 8.83 5.00
136 INT22481 Gene_expression of CADM1 28 0.65 30.26 8.5 5.00
137 INT29229 Regulation of NCOR2 20 0.42 5.75 8.08 5.00
138 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98 5.00
139 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
140 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
141 INT167052 Gene_expression of Cr2 43 0.56 25.7 7.76 5.00
142 INT162393 Gene_expression of SMUG1 58 0.75 38.78 7.7 5.00
143 INT4299 Positive_regulation of Gene_expression of Gh1 27 0.50 5.24 7.31 5.00
144 INT6210 Binding of Nppa 39 0.47 14.35 7.21 5.00
145 INT127691 Gene_expression of CXCL1 23 0.66 18.11 7.04 5.00
146 INT104979 Gene_expression of MITF 51 0.62 54.83 6.91 5.00
147 INT15012 Regulation of Gpi1 18 0.60 11.64 6.91 5.00
148 INT2111 Gene_expression of LIF 34 0.77 16.82 6.76 5.00
149 INT110987 Transcription of ESR1 45 0.71 24.16 6.72 5.00
150 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
151 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45 5.00
152 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 5.00
153 INT86805 Localization of HGF 49 0.71 28.48 6.35 5.00
154 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26 5.00
155 INT24042 Gene_expression of MUC5AC 98 0.77 74.99 6.18 5.00
156 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1 5.00
157 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 5.00
158 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88 5.00
159 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88 5.00
160 INT8916 Regulation of Igf1 45 0.60 13.06 5.81 5.00
161 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51 5.00
162 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 5.00
163 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 5.00
164 INT100059 Gene_expression of MUC4 30 0.75 31.58 4.95 5.00
165 INT21650 Regulation of OXTR 29 0.61 5.99 4.91 5.00
166 INT62821 Negative_regulation of Gene_expression of VCAM1 21 0.54 12.24 4.41 5.00
167 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
168 INT49360 Localization of Igf1 22 0.76 6.96 4.26 5.00
169 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
170 INT231240 Gene_expression of Fus 2 0.56 20.05 3.9 5.00
171 INT84809 Positive_regulation of Gene_expression of MUC1 39 0.70 36.42 3.75 5.00
172 INT81695 Gene_expression of OSM 14 0.75 7.29 3.58 5.00
173 INT73463 Positive_regulation of Gene_expression of TSC1 20 0.38 14.59 3.53 5.00
174 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47 5.00
175 INT5345 Positive_regulation of BRD2 14 0.67 6.72 3.43 5.00
176 INT124579 Localization of BAX 35 0.78 30.31 3.43 5.00
177 INT116645 Regulation of Pik3cb 11 0.41 3.78 3.43 5.00
178 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4 5.00
179 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36 5.00
180 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05 5.00
181 INT8103 Binding of TP53 46 0.44 40.2 2.96 5.00
182 INT61231 Gene_expression of SULT1A1 14 0.75 3.01 2.76 5.00
183 INT79476 Gene_expression of HLA-DMA 23 0.38 9.5 2.76 5.00
184 INT50268 Gene_expression of FBN1 13 0.65 10.73 2.72 5.00
185 INT174727 Positive_regulation of Positive_regulation of ESR1 14 0.44 6.3 2.7 5.00
186 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 5.00
187 INT108555 Positive_regulation of HK2 5 0.29 4.91 2.62 5.00
188 INT72165 Gene_expression of CXCL6 8 0.52 4.76 2.6 5.00
189 INT39414 Gene_expression of SNRPB 37 0.59 14.07 2.52 5.00
190 INT97902 Gene_expression of AGGF1 17 0.11 13.45 2.51 5.00
191 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
192 INT66544 Binding of Igf1 23 0.46 8.33 2.44 5.00
193 INT33895 Positive_regulation of LIF 9 0.67 2.47 2.34 5.00
194 INT178632 Regulation of Gene_expression of Pgr 11 0.35 1.56 2.26 5.00
195 INT22605 Regulation of Pgr 22 0.62 7.1 2.26 5.00
196 INT27644 Gene_expression of BRD2 23 0.65 6.97 2.23 5.00
197 INT237252 Localization of Mri1 7 0.45 4.42 2.23 5.00
198 INT156694 Binding of SET 10 0.36 3.77 2.21 5.00
199 INT60279 Gene_expression of VHL 70 0.78 75.21 2.21 5.00
200 INT173090 Regulation of INCENP 24 0.09 9.45 2.16 5.00
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