D:Fibrodysplasia Ossificans Progressiva

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Diffuse Progressive Ossifying Polymyositis, Fibrodysplasia Ossificans, Fibrodysplasia Ossificans Congenita, Fop Fibrodysplasia Ossificans Progressiva, Muenchmeyer S Syndrome, MUNCHMEYER DISEASE, MYOSITIS OSSIFICANS, Myositis Ossificans Progressiva, Progressive Myositis Ossificans, PROGRESSIVE OSSIFYING MYOSITIS
Documents 179
Hot Single Events 50
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Fibrodysplasia Ossificans Progressiva. They are ordered first by their relevance to Fibrodysplasia Ossificans Progressiva and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0 77.60
2 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0 77.60
3 INT265230 Binding of APC and FKBP1A Regulation of APC 1 0.01 0.41 0 77.60
4 INT265234 Binding of FKBP1A and SGCG 1 0.03 0.35 0 67.88
5 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0 67.60

Single Events

The table below shows the top 200 pain related interactions that have been reported for Fibrodysplasia Ossificans Progressiva. They are ordered first by their pain relevance and then by number of times they were reported in Fibrodysplasia Ossificans Progressiva. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT265243 Binding of FGFR1OP 1 0.20 0.74 0 100.00
2 INT265241 Regulation of FGFR1OP 1 0.33 0.88 0.05 100.00
3 INT319132 Binding of Fgfr1op 1 0.11 0.72 0 100.00
4 INT265238 Positive_regulation of FGFR1OP 1 0.26 0.76 0.04 100.00
5 INT265239 Gene_expression of FGFR1OP 1 0.36 0.41 0 100.00
6 INT319129 Regulation of Regulation of Fgfr1op 1 0.14 0.97 0.13 100.00
7 INT319130 Regulation of Fgfr1op 1 0.14 0.96 0.13 100.00
8 INT265247 Regulation of Gene_expression of FGFR1OP 1 0.24 0.21 0 100.00
9 INT339665 Gene_expression of Fgfr1op 1 0.09 0.87 0 100.00
10 INT339666 Positive_regulation of Gene_expression of Fgfr1op 1 0.07 0.88 0 100.00
11 INT265240 Regulation of Gene_expression of ACVR1 1 0.45 0.47 0 99.80
12 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 99.78
13 INT339670 Positive_regulation of Acvr1 1 0.24 0.47 0 99.56
14 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 99.40
15 INT158803 Gene_expression of ACVR1 2 0.67 1.27 0.19 99.20
16 INT265237 Negative_regulation of Gene_expression of ACVR1 1 0.43 0.47 0 99.20
17 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8 99.16
18 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 97.40
19 INT101163 Gene_expression of we 1 0.00 1.13 0.4 96.44
20 INT265248 Gene_expression of ST6GALNAC1 2 0.65 0.27 0 95.12
21 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 92.60
22 INT75504 Gene_expression of CDK4 9 0.72 7.43 0.3 92.60
23 INT43160 Gene_expression of EOS 3 0.65 5.03 0.81 92.48
24 INT155833 Gene_expression of Cma1 9 0.58 15.28 2.04 92.36
25 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73 92.08
26 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21 92.08
27 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 91.64
28 INT116529 Binding of HMOX1 10 0.47 15.38 1.04 91.16
29 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16 91.04
30 INT183910 Negative_regulation of Gene_expression of Lbp 10 0.35 9.78 6.15 91.04
31 INT265249 Positive_regulation of ACVR1 1 0.50 0.97 0 90.96
32 INT185009 Negative_regulation of BMP4 2 0.56 1.04 0.25 90.00
33 INT158801 Regulation of Acvr1 1 0.59 0.63 0.19 89.60
34 INT158802 Regulation of ACVR1 1 0.60 0.63 0.19 89.32
35 INT194462 Localization of Ppara 94 0.78 68.33 12.09 87.60
36 INT73972 Gene_expression of Bmpr1a 4 0.78 1.95 0.55 87.20
37 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 85.92
38 INT75975 Gene_expression of Grem1 3 0.59 2.22 0.18 85.04
39 INT159212 Positive_regulation of Gene_expression of BMP4 2 0.66 0.91 0.28 84.28
40 INT159213 Gene_expression of BMP4 8 0.74 2.1 0.28 84.28
41 INT265244 Positive_regulation of Phosphorylation of MLLT10 1 0.13 0.55 0.03 84.08
42 INT265242 Positive_regulation of Binding of MLLT10 1 0.13 0.55 0.03 84.08
43 INT265235 Positive_regulation of MLLT10 1 0.12 0.55 0.03 84.08
44 INT265236 Binding of MLLT10 1 0.10 0.54 0.03 83.52
45 INT265245 Phosphorylation of MLLT10 1 0.22 0.54 0.03 83.52
46 INT332262 Positive_regulation of Gene_expression of Cma1 1 0.41 4.94 0.38 82.88
47 INT59357 Gene_expression of Fosb 36 0.78 7.81 9.68 81.20
48 INT265246 Negative_regulation of ACVR1 1 0.37 0.08 0 80.52
49 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 80.48
50 INT15756 Positive_regulation of Gene_expression of Jun 29 0.69 16.58 12.06 80.48
51 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 79.20
52 INT267187 Negative_regulation of Grem1 2 0.19 2.16 0.04 78.96
53 INT57062 Regulation of APC 24 0.58 14.3 0.7 77.60
54 INT339669 Regulation of Col2a1 1 0.01 1.02 0.05 76.80
55 INT280947 Gene_expression of Acvr1 3 0.40 2.73 0.26 76.40
56 INT339671 Positive_regulation of Gene_expression of Acvr1 1 0.36 1.67 0 76.40
57 INT332257 Localization of Cma1 1 0.36 1.06 0.04 76.40
58 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 75.68
59 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 74.48
60 INT339673 Regulation of Gene_expression of RUNX2 2 0.41 1.78 0.4 74.40
61 INT220211 Gene_expression of RUNX2 7 0.71 7.31 2 73.84
62 INT220203 Positive_regulation of Gene_expression of RUNX2 3 0.63 3.4 0.97 73.84
63 INT49488 Gene_expression of mMCP-7 37 0.75 26.11 7.68 69.52
64 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 68.64
65 INT165516 Regulation of MSX2 8 0.23 3.41 0.09 68.00
66 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63 67.96
67 INT3214 Localization of Ins1 527 0.80 196.9 79.26 66.08
68 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 66.00
69 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 66.00
70 INT332259 Positive_regulation of Positive_regulation of Fgf1 1 0.18 2.33 0.23 65.80
71 INT114704 Positive_regulation of Fgf1 13 0.50 8.89 0.89 65.24
72 INT332258 Positive_regulation of Localization of Fgf1 1 0.18 2.32 0.23 65.24
73 INT252961 Localization of Fgf1 3 0.27 5.91 0.35 64.12
74 INT126368 Gene_expression of MSX2 12 0.65 7.2 2.71 63.20
75 INT339668 Negative_regulation of Gene_expression of Acvr1 1 0.22 0.74 0 62.40
76 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07 61.44
77 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 61.04
78 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39 61.04
79 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 60.80
80 INT67610 Positive_regulation of Pparg 53 0.70 31.91 25.2 60.80
81 INT339672 Positive_regulation of Gene_expression of MSX2 1 0.16 0.98 0.05 60.16
82 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05 59.52
83 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59 59.52
84 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 58.72
85 INT12991 Negative_regulation of Gene_expression of PTGS1 28 0.41 13.39 8.9 58.72
86 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 50.00
87 INT122041 Binding of Ppara 308 0.48 189.17 51.48 50.00
88 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 50.00
89 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 50.00
90 INT181186 Binding of Rxra 78 0.35 14.93 4.87 50.00
91 INT215378 Protein_catabolism of Ppara 12 0.86 5.12 2.14 50.00
92 INT151588 Phosphorylation of Prkag1 48 0.73 15.62 1.38 50.00
93 INT197167 Positive_regulation of Localization of Ppara 18 0.67 9.51 1.21 50.00
94 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19 50.00
95 INT84511 Positive_regulation of Tfap2a 3 0.27 0.72 1.04 50.00
96 INT243974 Binding of Tfap2a 7 0.18 1.36 0.93 50.00
97 INT192156 Negative_regulation of Col1a1 6 0.39 3.92 0.8 50.00
98 INT69283 Gene_expression of PHEX 25 0.75 7.81 0.64 50.00
99 INT236564 Positive_regulation of Binding of Rxra 2 0.18 1.3 0.24 50.00
100 INT171614 Positive_regulation of Runx2 13 0.63 3.04 0.19 50.00
101 INT319133 Localization of Ahrr 2 0.02 0.48 0.06 50.00
102 INT319134 Phosphorylation of Psmd4 1 0.19 0.14 0.03 50.00
103 INT319135 Positive_regulation of Sp7 1 0.41 0.36 0.03 50.00
104 INT319131 Positive_regulation of Lrp5 1 0.43 0.36 0.03 50.00
105 INT319128 Positive_regulation of Binding of Tfap2a 1 0.23 0.5 0 50.00
106 INT4097 Localization of Pth 66 0.81 47.17 4.36 46.32
107 INT19395 Negative_regulation of Localization of Pth 11 0.58 10.16 0.55 46.32
108 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86 39.36
109 INT137609 Localization of Vegfa 22 0.78 14.67 3.01 33.92
110 INT137607 Positive_regulation of Localization of Vegfa 7 0.49 3.72 1.18 33.92
111 INT62570 Binding of Pth 48 0.48 26.45 4.85 33.84
112 INT233856 Regulation of SFTPC 4 0.60 2.25 0.19 30.72
113 INT339667 Localization of Bmp4 1 0.38 0.27 0 29.56
114 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 27.52
115 INT302312 Localization of Bmpr2 4 0.46 0.47 0 15.08
116 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 6.80
117 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31 6.80
118 INT39500 Positive_regulation of Positive_regulation of Pth 14 0.48 9.75 1.28 6.80
119 INT36770 Positive_regulation of Localization of Pth 14 0.70 10.42 0.46 6.40
120 INT1026 Binding of Lbp 207 0.48 150.96 119.16 5.00
121 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
122 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 5.00
123 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 5.00
124 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71 5.00
125 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
126 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 5.00
127 INT1030 Localization of Lbp 52 0.74 38.92 24.91 5.00
128 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 5.00
129 INT52179 Regulation of Lbp 39 0.61 25.4 18.32 5.00
130 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 5.00
131 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
132 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 5.00
133 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
134 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 5.00
135 INT19829 Negative_regulation of Gene_expression of Tbxa2r 32 0.56 12.78 8.3 5.00
136 INT45234 Binding of Ldha 20 0.37 9.8 8.18 5.00
137 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
138 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74 5.00
139 INT39900 Positive_regulation of Gene_expression of Ldha 36 0.50 20.35 5.22 5.00
140 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 5.00
141 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 5.00
142 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96 5.00
143 INT17963 Gene_expression of Ldha 11 0.75 6.53 2.48 5.00
144 INT99444 Positive_regulation of Proc 15 0.45 9.18 1.75 5.00
145 INT76477 Positive_regulation of CD99 14 0.50 14.77 1.42 5.00
146 INT56219 Gene_expression of KDM5D 16 0.53 5.59 1.23 5.00
147 INT118054 Regulation of ARMC9 23 0.34 11.32 1.06 5.00
148 INT76315 Gene_expression of Myog 15 0.41 6.79 0.6 5.00
149 INT181026 Positive_regulation of Cma1 3 0.40 2.76 0.43 5.00
150 INT212271 Binding of ARMC9 14 0.27 3.29 0.43 5.00
151 INT133874 Negative_regulation of Gene_expression of Fgf1 2 0.24 2.82 0.36 5.00
152 INT155832 Negative_regulation of Cma1 2 0.33 2.02 0.3 5.00
153 INT332263 Negative_regulation of Positive_regulation of Cma1 1 0.25 0.9 0.21 5.00
154 INT332260 Negative_regulation of Gene_expression of Cma1 1 0.25 0.9 0.21 5.00
155 INT193777 Negative_regulation of Fgf1 6 0.13 4.26 0.12 5.00
156 INT282122 Positive_regulation of Gene_expression of Ldha 3 0.11 1.58 0.1 5.00
157 INT200458 Positive_regulation of Tha1 3 0.15 0.78 0.03 5.00
158 INT208507 Binding of EOS 2 0.10 2.42 0 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox