D:Fibroma

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Disease Term
Synonyms Fibromas, Fibromatoses, FIBROMATOSIS, Fibromyxoma, Fibromyxomas, Myxofibroma, Myxofibromas
Documents 357
Hot Single Events 64
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Fibroma. They are ordered first by their relevance to Fibroma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 92.40
2 INT320492 KRT7 Positive_regulation of Pip 1 0.00 1.02 0.2 86.00
3 INT286113 Binding of Fap and Rpe65 1 0.04 1.97 0 83.64
4 INT286110 Binding of Rpe65 and Gopc 1 0.01 1.97 0 83.64
5 INT272012 Binding of TSC1 and Lsamp 1 0.03 2.1 0.08 79.52
6 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 11.68
7 INT228055 WNT1 Positive_regulation of CTNND2 1 0.54 1.75 0.42 5.00
8 INT272006 Binding of YWHAQ and Tsc2 1 0.27 0.39 0.1 5.00
9 INT355542 Binding of XRCC3 and BCC1 1 0.00 1.19 0.07 5.00
10 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07 5.00
11 INT341680 Binding of DES and Vim 1 0.02 0.59 0.06 5.00
12 INT272009 Binding of YWHAQ and Tsc1 1 0.37 0.14 0.03 5.00
13 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0 5.00
14 INT271990 Tsc1 Positive_regulation of Tsc2 1 0.36 0.31 0 5.00
15 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0 5.00
16 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0 5.00
17 INT286111 Binding of Rpa3 and Mutyh 1 0.30 0 0 5.00
18 INT271991 Tsc1 Regulation of Tsc2 1 0.23 0.15 0 5.00
19 INT272015 Pkd1 Positive_regulation of Localization of TSC1 1 0.18 0.65 0 5.00
20 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0 5.00
21 INT272017 TBC1D7 Positive_regulation of Protein_catabolism of Tsc1 1 0.08 0.46 0 5.00
22 INT286115 Binding of APEX1 and Mutyh 1 0.10 0 0 5.00
23 INT271982 Binding of Skp2 and Psmd9 1 0.01 0.68 0 5.00
24 INT272013 Binding of OGG1 and Tsc2 1 0.09 0.67 0 5.00
25 INT272010 Tsc2 Negative_regulation of OGG1 1 0.17 0.6 0 5.00
26 INT271966 Phosphorylation of Rasa1 Positive_regulation of Tsc2 1 0.01 0.31 0 5.00
27 INT272000 Binding of Skp2 and Hecw1 1 0.01 0.11 0 5.00
28 INT271985 Tsc1 Regulation of Cdkn1b 1 0.04 0.1 0 5.00
29 INT271979 Skp2 Positive_regulation of Protein_catabolism of Psmd9 1 0.01 0.35 0 5.00
30 INT272008 Tsc1 Negative_regulation of Binding of HERC1 1 0.01 0.32 0 5.00
31 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0 5.00
32 INT272014 Binding of RB1CC1 and Tsc1 1 0.05 0.44 0 5.00
33 INT272016 Mtor Negative_regulation of INS 1 0.00 0.61 0 5.00
34 INT242102 Nkx2-1 Regulation of Gene_expression of Ttf1 1 0.00 1.55 0 5.00
35 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0 5.00
36 INT271999 Binding of Fkbp1a and Positive_regulation of Negative_regulation of Mtor 1 0.00 0.18 0 5.00
37 INT271984 Binding of Tsc2 and Skp2 1 0.06 0.34 0 5.00
38 INT272011 Binding of RAB5A and Tsc2 1 0.02 0.16 0 5.00
39 INT272004 Binding of Hspa1b and Tsc2 1 0.01 0.45 0 5.00
40 INT271983 Binding of Tsc2 and Rap1a 1 0.02 0.16 0 5.00
41 INT271994 Binding of Fkbp1a and Mtor 1 0.00 0.22 0 5.00
42 INT272005 Phosphorylation of Tsc1 Regulation of Binding of Cdk1 and Plk1 1 0.02 0.3 0 5.00
43 INT286109 Binding of Pcna and Mutyh 1 0.30 0 0 5.00
44 INT271989 Binding of Tsc2 and Psmd9 1 0.02 0.47 0 5.00
45 INT272007 Binding of Tsc2 and SCPEP1 1 0.27 0.46 0 5.00
46 INT271998 Cdk1 Positive_regulation of Phosphorylation of Tsc1 1 0.17 0.3 0 5.00
47 INT271978 Positive_regulation of Racgap1 Regulation of Mtor 1 0.00 0.54 0 5.00
48 INT271987 Tsc2 Regulation of Skp2 1 0.10 0.28 0 5.00
49 INT271986 Tsc1 Regulation of Skp2 1 0.13 0.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Fibroma. They are ordered first by their pain relevance and then by number of times they were reported in Fibroma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT83590 Positive_regulation of Gene_expression of Col6a6 2 0.03 1.82 1.12 99.90
2 INT6231 Gene_expression of Col6a6 5 0.26 2.56 1.78 99.70
3 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 99.32
4 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 99.32
5 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 99.04
6 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 98.84
7 INT95636 Gene_expression of ACTG2 23 0.44 19.87 1.75 98.84
8 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 98.04
9 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 98.04
10 INT151343 Gene_expression of UBE2D1 2 0.56 3.48 0.15 97.92
11 INT49610 Positive_regulation of Gene_expression of CTS 7 0.43 7.45 3.58 97.64
12 INT19763 Gene_expression of CTs 69 0.78 32.92 18.87 97.48
13 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 97.40
14 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 97.40
15 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 97.40
16 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 97.40
17 INT36797 Regulation of Mki67 13 0.24 8.76 0.3 97.24
18 INT51066 Binding of S100B 24 0.48 13.5 0.97 96.72
19 INT105021 Binding of GOPC 187 0.40 60.39 20.38 96.40
20 INT37216 Binding of SMN1 11 0.36 6.66 1.86 96.28
21 INT18156 Gene_expression of Fap 18 0.73 27.02 1.46 96.20
22 INT188741 Binding of ACTG2 3 0.20 3.27 0 96.08
23 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29 95.92
24 INT55740 Gene_expression of Timp1 53 0.75 28.63 13.85 95.40
25 INT97334 Positive_regulation of Gene_expression of Timp1 11 0.49 7.44 4.14 95.40
26 INT55743 Gene_expression of Timp2 25 0.31 8.95 4.3 94.96
27 INT55742 Positive_regulation of Gene_expression of Timp2 2 0.08 1.81 0.82 94.96
28 INT92916 Gene_expression of Acta2 50 0.74 17.52 6.11 94.56
29 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 93.36
30 INT425 Localization of PRL 455 0.81 189.64 144.8 93.32
31 INT56032 Positive_regulation of NCAM1 38 0.49 26.01 4.68 92.48
32 INT68564 Binding of Fap 6 0.32 6.75 0.65 92.48
33 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 92.40
34 INT76477 Positive_regulation of CD99 14 0.50 14.77 1.42 92.00
35 INT79432 Positive_regulation of Calb2 7 0.23 6.59 0.61 91.52
36 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 91.32
37 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14 90.88
38 INT167181 Localization of Aktip 1 0.59 0.39 0.2 89.52
39 INT335179 Negative_regulation of Sftpd 1 0.21 2.61 0.06 89.28
40 INT124643 Binding of DYNLL1 3 0.36 0.9 0.23 88.40
41 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 87.96
42 INT83593 Localization of Col6a3 1 0.51 1.28 0.32 87.88
43 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 86.52
44 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 85.60
45 INT83212 Positive_regulation of Gene_expression of Mki67 21 0.55 17.53 0.39 84.88
46 INT181792 Positive_regulation of Gene_expression of MIB1 3 0.27 3.3 0.03 84.88
47 INT179524 Negative_regulation of Pip 7 0.38 4.49 0.29 84.80
48 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 84.48
49 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 84.24
50 INT194343 Gene_expression of ABCC8 8 0.65 8.15 0.77 83.84
51 INT17511 Negative_regulation of PRTN3 19 0.41 12 3.3 83.76
52 INT286108 Negative_regulation of Afap1 1 0.08 3.35 0.18 83.52
53 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 83.12
54 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 82.84
55 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 82.40
56 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 82.08
57 INT2836 Positive_regulation of PAEP 51 0.67 26.69 4.57 81.88
58 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 81.88
59 INT2792 Gene_expression of Mb 91 0.76 41.56 10.25 81.88
60 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 81.88
61 INT64700 Binding of Nf1 14 0.45 15.24 2.29 81.68
62 INT180497 Binding of MRI1 45 0.42 28.35 14.77 81.60
63 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 81.20
64 INT145328 Negative_regulation of Scrib 25 0.16 26.79 2.66 80.64
65 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26 77.44
66 INT242264 Binding of ACAT1 3 0.12 1.05 0.06 77.12
67 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 76.28
68 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 76.28
69 INT83592 Gene_expression of Col6a3 6 0.70 4.27 1.17 75.56
70 INT219752 Localization of EXOSC1 4 0.78 6.92 1.19 75.00
71 INT260174 Gene_expression of Rpe65 29 0.78 4.2 0.19 70.56
72 INT73627 Binding of Fap 8 0.36 11.14 0.4 68.88
73 INT78319 Binding of EPCAM 8 0.36 10.12 1.14 67.20
74 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67 67.20
75 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 66.24
76 INT99176 Positive_regulation of Fap 4 0.13 7.5 0.22 65.44
77 INT320500 Gene_expression of CA5A 4 0.58 3.45 0.28 64.88
78 INT36354 Localization of CTs 26 0.64 20.84 9.31 64.08
79 INT97331 Positive_regulation of Timp1 20 0.45 13.32 8.57 62.00
80 INT113268 Positive_regulation of Positive_regulation of Timp1 3 0.15 3.23 1.43 62.00
81 INT95164 Localization of NCAM1 13 0.78 6.06 2.62 59.44
82 INT74046 Localization of Calb2 12 0.80 2.05 2.24 59.44
83 INT134223 Localization of CD99 4 0.73 4.42 0.16 59.44
84 INT83591 Regulation of Gene_expression of Col6a3 1 0.39 0.48 0.12 58.28
85 INT23598 Binding of SCN5A 32 0.40 16 5.35 55.64
86 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 53.36
87 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 52.64
88 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 50.00
89 INT11235 Positive_regulation of IFNA2 27 0.69 15.32 2.57 50.00
90 INT116836 Binding of FAP 6 0.37 6.76 1.47 50.00
91 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81 50.00
92 INT156411 Gene_expression of Pdgfra 8 0.75 5.5 0.3 50.00
93 INT156410 Positive_regulation of Pdgfra 3 0.08 1.51 0.25 50.00
94 INT159231 Positive_regulation of PDGFRA 3 0.47 2.39 0.18 50.00
95 INT225029 Gene_expression of TRERF1 3 0.53 1.62 0.08 50.00
96 INT187628 Gene_expression of KRT14 15 0.75 11.54 0.1 48.16
97 INT171716 Regulation of Fap 4 0.27 4.05 0.23 47.56
98 INT187627 Gene_expression of KRT4 5 0.37 4.54 0 40.96
99 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 38.64
100 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 37.84
101 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14 37.00
102 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 36.32
103 INT242822 Transcription of Fap 1 0.18 1.2 0 34.88
104 INT11506 Binding of MUC16 20 0.48 22.89 1.03 32.56
105 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 32.04
106 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 31.92
107 INT1647 Negative_regulation of FSHR 54 0.45 13.44 8.87 31.72
108 INT15610 Localization of GOPC 223 0.65 68.26 28.7 31.28
109 INT183933 Binding of CD68 8 0.31 8.74 1.06 26.00
110 INT56955 Binding of MYOG 5 0.27 2.92 0.73 25.28
111 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 25.00
112 INT59784 Binding of DES 22 0.47 19.48 2.27 23.28
113 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 19.44
114 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 16.08
115 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 15.60
116 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 10.32
117 INT162666 Gene_expression of ST3 5 0.67 5.66 1.73 6.36
118 INT216123 Negative_regulation of Cd68 2 0.41 1.96 1.48 5.72
119 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
120 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
121 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
122 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
123 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
124 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
125 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
126 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
127 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
128 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
129 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
130 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
131 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
132 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 5.00
133 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
134 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
135 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
136 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
137 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
138 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
139 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
140 INT122041 Binding of Ppara 308 0.48 189.17 51.48 5.00
141 INT5793 Binding of CTS 110 0.48 63.91 40.62 5.00
142 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
143 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
144 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
145 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63 5.00
146 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
147 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
148 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
149 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
150 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 5.00
151 INT67610 Positive_regulation of Pparg 53 0.70 31.91 25.2 5.00
152 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 5.00
153 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
154 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
155 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
156 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 5.00
157 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
158 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
159 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
160 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
161 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 5.00
162 INT20632 Gene_expression of TNC 72 0.78 30.43 13.16 5.00
163 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
164 INT194462 Localization of Ppara 94 0.78 68.33 12.09 5.00
165 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
166 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66 5.00
167 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 5.00
168 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 5.00
169 INT68960 Gene_expression of Ptger4 42 0.67 15.75 9.64 5.00
170 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96 5.00
171 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 5.00
172 INT70896 Gene_expression of PDGFB 48 0.65 33.55 8.39 5.00
173 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 5.00
174 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 5.00
175 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 5.00
176 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41 5.00
177 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06 5.00
178 INT26585 Gene_expression of Vim 117 0.77 39.97 6 5.00
179 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7 5.00
180 INT115370 Gene_expression of PSIP1 22 0.65 9.45 5.68 5.00
181 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
182 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
183 INT10504 Localization of Pla2g1b 18 0.65 8.19 5.05 5.00
184 INT181186 Binding of Rxra 78 0.35 14.93 4.87 5.00
185 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21 5.00
186 INT115889 Binding of Fas 27 0.36 28.87 4.08 5.00
187 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91 5.00
188 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79 5.00
189 INT123411 Gene_expression of Sp1 15 0.69 4.2 3.79 5.00
190 INT70897 Positive_regulation of Gene_expression of PDGFB 15 0.57 13.04 3.52 5.00
191 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47 5.00
192 INT5345 Positive_regulation of BRD2 14 0.67 6.72 3.43 5.00
193 INT124579 Localization of BAX 35 0.78 30.31 3.43 5.00
194 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 5.00
195 INT192450 Gene_expression of CLTC 26 0.55 18.82 3.26 5.00
196 INT175449 Gene_expression of Sftpd 30 0.55 25.7 3.15 5.00
197 INT134795 Positive_regulation of Scrib 30 0.22 36.91 2.81 5.00
198 INT61231 Gene_expression of SULT1A1 14 0.75 3.01 2.76 5.00
199 INT79476 Gene_expression of HLA-DMA 23 0.38 9.5 2.76 5.00
200 INT27935 Binding of Vim 21 0.36 15.65 2.61 5.00
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