D:Flank Pain

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Disease Term
Synonyms Flank Pain Left, Flank Pain Right, Flank Pains, Flank Pains Left, Flank Pains Right, Left Flank Pain, Left Flank Pains, Pain Flank, Pain Left Flank, Pain Right Flank, Pains Flank
Documents 1617
Hot Single Events 92
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Flank Pain. They are ordered first by their relevance to Flank Pain and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT137398 Binding of CD99 and Vim 2 0.02 2.36 0.09 89.16
2 INT137395 Binding of CD99 and S100B 1 0.17 1.04 0.09 89.16
3 INT137394 Binding of DES and CD99 1 0.17 1.04 0.09 89.16
4 INT118227 Binding of ACTG2 and CD34 1 0.15 1.17 0.06 61.40
5 INT315868 Vhl Positive_regulation of Transcription of PDGFA 1 0.00 1.39 0 29.52
6 INT315867 Vhl Positive_regulation of Transcription of VEGFA 1 0.01 1.39 0 29.52
7 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56 5.00
8 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 0.09 1.07 0.46 5.00
9 INT306731 Il22 Positive_regulation of Gene_expression of Il2 1 0.12 1.07 0.46 5.00
10 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22 5.00
11 INT306714 IL23A Positive_regulation of TNF 1 0.29 0.5 0.21 5.00
12 INT306746 Il12a Positive_regulation of TNF 1 0.24 0.5 0.21 5.00
13 INT320492 KRT7 Positive_regulation of Pip 1 0.00 1.02 0.2 5.00
14 INT306744 IL23A Positive_regulation of Il12a 1 0.13 0.59 0.2 5.00
15 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19 5.00
16 INT306747 IL23A Positive_regulation of Il17a 1 0.05 0.51 0.16 5.00
17 INT260342 Binding of Esr1 and Rcc1 1 0.05 0.99 0 5.00
18 INT337062 Binding of VEGFA and NMI 1 0.07 1.12 0 5.00
19 INT315856 FLT3 Positive_regulation of Gene_expression of PDGFA 1 0.01 1.15 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Flank Pain. They are ordered first by their pain relevance and then by number of times they were reported in Flank Pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 99.92
2 INT8670 Negative_regulation of Afp 27 0.58 19.85 2.87 99.76
3 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 99.74
4 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 99.50
5 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 99.08
6 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 99.04
7 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19 98.96
8 INT51150 Positive_regulation of HTC2 10 0.67 6.8 2.95 98.88
9 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 98.76
10 INT337064 Localization of NMI 1 0.13 0.93 0.19 98.56
11 INT35329 Positive_regulation of KRTAP19-9P 15 0.59 12.55 2.98 98.32
12 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 98.16
13 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 97.76
14 INT66061 Positive_regulation of Gene_expression of AFP 6 0.70 8.67 0.81 97.76
15 INT76732 Gene_expression of CGB7 4 0.63 4.14 0.37 97.76
16 INT150123 Positive_regulation of Gene_expression of CGB7 2 0.40 1.64 0.19 97.76
17 INT42994 Binding of BDNF-AS 21 0.35 14.17 4 97.56
18 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 97.40
19 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 97.40
20 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 97.40
21 INT28249 Positive_regulation of HLA-DRA 25 0.70 13.63 3.25 97.40
22 INT1925 Gene_expression of PLAT 47 0.75 34.76 7.88 97.28
23 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 97.20
24 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 97.20
25 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 97.12
26 INT5871 Binding of IFNA2 38 0.48 20.35 6.46 97.08
27 INT5180 Binding of Serpinc1 27 0.36 13.39 2.47 96.68
28 INT78937 Negative_regulation of Aprt 2 0.48 1.12 0.25 96.56
29 INT22383 Binding of IL2 59 0.48 39.06 8.56 96.36
30 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 96.32
31 INT76735 Positive_regulation of CGB7 3 0.38 2.91 0.28 96.24
32 INT118217 Regulation of Cuzd1 2 0.30 2.36 0.91 96.20
33 INT99095 Binding of COL4A4 7 0.37 3.51 0.29 95.56
34 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 95.48
35 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 95.36
36 INT260339 Positive_regulation of Gene_expression of Rcc1 1 0.11 2.28 0.15 95.32
37 INT260340 Gene_expression of Rcc1 4 0.58 5.36 0.21 94.88
38 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 94.68
39 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 94.68
40 INT23146 Negative_regulation of Aprt 8 0.56 7.53 0.71 94.32
41 INT1921 Gene_expression of CEACAM7 47 0.78 43.23 2.53 93.64
42 INT85829 Gene_expression of CA9 14 0.68 12.59 1.4 93.64
43 INT10207 Gene_expression of PADI4 22 0.75 23.49 1.74 93.64
44 INT85830 Positive_regulation of Gene_expression of CA9 4 0.41 5.47 1.02 93.64
45 INT1922 Positive_regulation of CEACAM7 32 0.70 33.31 2.72 93.24
46 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 93.20
47 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 93.16
48 INT85831 Positive_regulation of CA9 5 0.60 8.29 1.02 92.92
49 INT4873 Positive_regulation of FCGR3A 21 0.49 14.35 2.89 92.60
50 INT59121 Positive_regulation of MYOM2 2 0.17 1.51 0.09 92.60
51 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 92.24
52 INT55812 Positive_regulation of LOC259246 2 0.03 1.87 0.09 92.04
53 INT2792 Gene_expression of Mb 91 0.76 41.56 10.25 91.84
54 INT59120 Gene_expression of MYOM2 2 0.22 2.81 0.25 90.84
55 INT35328 Gene_expression of KRTAP19-9P 9 0.52 9.08 1.44 90.36
56 INT89445 Gene_expression of MEPE 17 0.58 18.07 1.55 89.96
57 INT120693 Positive_regulation of MEPE 7 0.50 8.22 0.79 89.96
58 INT127607 Gene_expression of EID1 4 0.63 5.57 1.6 89.96
59 INT143908 Positive_regulation of EID1 2 0.17 2.27 0.09 89.96
60 INT3286 Positive_regulation of Gpt 90 0.69 45.08 28.34 89.48
61 INT3288 Positive_regulation of Gene_expression of Gpt 9 0.49 5.55 1.1 89.48
62 INT3287 Gene_expression of Gpt 50 0.75 23.69 8.57 89.12
63 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 89.00
64 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 88.60
65 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 88.60
66 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 88.60
67 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 88.60
68 INT214073 Binding of TSC1 9 0.37 22 1.34 88.56
69 INT17489 Regulation of F13A1 28 0.45 15.79 4.93 87.72
70 INT39948 Binding of FLNA 45 0.42 58.05 4.27 87.12
71 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 86.80
72 INT182810 Gene_expression of Cuzd1 5 0.44 1.49 0.53 86.40
73 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 85.72
74 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 85.72
75 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 85.72
76 INT5118 Regulation of SST 97 0.62 34.35 51.74 85.56
77 INT41545 Negative_regulation of APRT 8 0.57 2.99 2.88 84.72
78 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 84.48
79 INT67379 Positive_regulation of Cd34 38 0.58 26.18 3.28 84.40
80 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7 83.92
81 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 83.48
82 INT63067 Localization of MYC 13 0.78 6.93 0.19 82.16
83 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 82.08
84 INT123443 Positive_regulation of WWOX 2 0.45 3.45 0.68 81.60
85 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 81.08
86 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 81.08
87 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 81.08
88 INT148288 Gene_expression of CCL15 9 0.25 6.53 3.41 81.08
89 INT148286 Gene_expression of FOXK1 1 0.02 1.76 0.43 81.08
90 INT95636 Gene_expression of ACTG2 23 0.44 19.87 1.75 81.08
91 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 80.56
92 INT17817 Binding of VUR 41 0.48 46.85 0.95 80.24
93 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 79.36
94 INT140175 Regulation of Kit 23 0.62 8.59 1.79 78.48
95 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 77.88
96 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36 77.68
97 INT50446 Binding of MRGPRF 3 0.31 3.05 0.08 77.64
98 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76 77.00
99 INT120519 Localization of XRCC1 15 0.78 17.03 1.51 76.56
100 INT119168 Negative_regulation of Cd34 8 0.37 4.91 0.96 75.72
101 INT166312 Negative_regulation of Vim 7 0.22 5.9 0.46 75.72
102 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 75.24
103 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 75.24
104 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 75.24
105 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 75.24
106 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 75.20
107 INT18897 Binding of CHGA 11 0.36 10.12 1.17 75.20
108 INT80329 Positive_regulation of THBD 12 0.47 20.96 2.45 75.12
109 INT13724 Positive_regulation of WT1 5 0.69 4.99 0.59 75.12
110 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 74.96
111 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 74.28
112 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 73.68
113 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 73.68
114 INT143850 Gene_expression of S100a1 19 0.73 9.52 1.54 73.68
115 INT22454 Regulation of Crp 213 0.62 160.67 49.24 72.76
116 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 72.76
117 INT55813 Regulation of LOC259246 1 0.03 1.01 0.07 72.76
118 INT80712 Gene_expression of PTGER4 21 0.65 13.08 5.03 72.40
119 INT15310 Gene_expression of DLEU1 8 0.67 20.57 0.96 72.40
120 INT102659 Gene_expression of CSF3 32 0.77 21.93 2.39 71.80
121 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 71.68
122 INT122813 Binding of Krt20 11 0.32 13.77 0.88 71.68
123 INT40583 Regulation of ALPI 4 0.45 1.87 0.48 71.56
124 INT109896 Negative_regulation of CA9 2 0.06 2.87 0.16 71.56
125 INT22891 Positive_regulation of Localization of ELANE 16 0.69 11.52 3.42 71.12
126 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 70.96
127 INT54912 Gene_expression of SKI 3 0.57 2.81 0.82 70.60
128 INT89289 Positive_regulation of Gene_expression of SKI 1 0.01 0.54 0.11 70.60
129 INT10147 Gene_expression of Serpinc1 28 0.76 17.73 5.77 69.12
130 INT60707 Transcription of CALB2 2 0.52 1.45 0.26 69.00
131 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 68.52
132 INT49625 Negative_regulation of Positive_regulation of Vim 1 0.22 1.33 0.07 68.00
133 INT2609 Localization of ELANE 111 0.81 50.22 26.63 67.68
134 INT106381 Negative_regulation of CEACAM7 8 0.38 7.45 0.5 67.64
135 INT99961 Positive_regulation of SYP 13 0.67 15.13 2.79 65.60
136 INT11386 Positive_regulation of RAE1 3 0.11 1.53 0.83 65.52
137 INT48217 Gene_expression of SLC4A3 22 0.75 21.12 2.17 65.40
138 INT48218 Gene_expression of KRIT1 16 0.75 7.59 1.8 65.40
139 INT48216 Gene_expression of Mak 2 0.58 1.89 0.34 65.40
140 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 65.08
141 INT74520 Positive_regulation of CD68 30 0.61 31.68 7.59 65.08
142 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 65.08
143 INT22092 Gene_expression of SERPINA3 17 0.75 11.57 3.16 65.08
144 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 65.08
145 INT56944 Positive_regulation of SERPINA3 8 0.67 6.56 1.32 65.08
146 INT148285 Positive_regulation of FOXK1 2 0.01 1.47 0.34 65.08
147 INT148287 Positive_regulation of CCL15 1 0.01 0.85 0.21 65.08
148 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 64.24
149 INT26585 Gene_expression of Vim 117 0.77 39.97 6 63.24
150 INT27935 Binding of Vim 21 0.36 15.65 2.61 62.92
151 INT263948 Positive_regulation of Binding of VUR 1 0.43 0.61 0.06 61.84
152 INT21682 Binding of CD34 18 0.47 13.19 1.47 61.40
153 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 59.88
154 INT56375 Positive_regulation of AMBP 25 0.60 21.24 2.22 59.60
155 INT101208 Positive_regulation of Gene_expression of Wt1 3 0.47 3.08 0.15 59.20
156 INT101212 Positive_regulation of Gene_expression of MTUS1 1 0.01 2.31 0.09 59.20
157 INT101213 Gene_expression of MTUS1 2 0.02 2.72 0.09 59.20
158 INT97446 Localization of Mki67 9 0.46 3.74 0.46 58.96
159 INT654 Localization of REN 250 0.81 75.12 47.86 58.88
160 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7 58.88
161 INT328097 Positive_regulation of MBOAT7 1 0.02 3.57 0.38 58.56
162 INT59784 Binding of DES 22 0.47 19.48 2.27 57.24
163 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 55.84
164 INT26583 Positive_regulation of Cd4 40 0.54 21.96 4.83 53.36
165 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 51.60
166 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 51.36
167 INT302533 Gene_expression of Mest 2 0.65 1.86 0.05 50.24
168 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 50.00
169 INT39500 Positive_regulation of Positive_regulation of Pth 14 0.48 9.75 1.28 50.00
170 INT18898 Positive_regulation of CHGA 38 0.67 28.99 4.86 49.68
171 INT16277 Regulation of CHGA 16 0.44 11.31 4.43 49.68
172 INT11920 Regulation of ENO2 18 0.55 11.51 2.89 49.68
173 INT34808 Binding of Ec 14 0.24 17.27 2.65 49.04
174 INT258473 Binding of TOP2A 3 0.05 1.65 0.05 48.84
175 INT105782 Positive_regulation of Krt20 9 0.20 9.62 0.53 48.76
176 INT179032 Negative_regulation of Cdcs1 1 0.04 1.39 0.06 48.52
177 INT93168 Gene_expression of Ttf1 24 0.63 17.18 1.14 47.60
178 INT22707 Positive_regulation of Eno2 36 0.69 27.31 5.07 47.20
179 INT149527 Positive_regulation of Positive_regulation of Eno2 1 0.31 0.8 0.06 47.20
180 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 46.52
181 INT184511 Positive_regulation of Negative_regulation of VEGFA 5 0.46 2.86 0.09 46.52
182 INT93941 Gene_expression of SSX2 5 0.75 5.32 0.45 46.40
183 INT197367 Positive_regulation of Tbs1 5 0.07 2.44 0.8 45.32
184 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 43.56
185 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 43.16
186 INT302534 Localization of Mest 1 0.28 1.81 0 41.04
187 INT237384 Positive_regulation of Localization of VUR 2 0.43 2.85 0 39.36
188 INT30 Gene_expression of Gast 158 0.78 99 41.45 38.72
189 INT237382 Localization of VUR 11 0.72 14.58 0.11 38.40
190 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 36.96
191 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 34.36
192 INT1116 Regulation of Ren 103 0.62 27.66 33.26 29.76
193 INT152060 Gene_expression of VUR 75 0.67 83.83 2.34 26.60
194 INT175770 Binding of Pnet-ps 1 0.00 4.91 0 26.08
195 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 25.80
196 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 25.80
197 INT98782 Gene_expression of Cdkn1b 70 0.75 36.43 1.9 25.80
198 INT123733 Gene_expression of Fhit 5 0.78 12.34 0.26 25.80
199 INT179036 Gene_expression of Fez1 1 0.70 13.28 0.11 25.80
200 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22 25.64
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