D:Flatfoot

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pChart

Disease Term
Synonyms Feet Flat, Flat Feet, Flat Foot, Flatfeet, FOOT FLAT, Pes Planus
Documents 285
Hot Single Events 8
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Flatfoot. They are ordered first by their relevance to Flatfoot and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1 5.00
2 INT174104 Binding of HSPG2 and Ache 1 0.16 0.98 0.09 5.00
3 INT327451 HTN1 Positive_regulation of Adra1a 1 0.00 1.36 0.03 5.00
4 INT238270 Binding of VMO1 and MSLNL 1 0.11 0.42 0 5.00
5 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00
6 INT332159 Gh Positive_regulation of Gene_expression of Igfbp3 1 0.07 1.11 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Flatfoot. They are ordered first by their pain relevance and then by number of times they were reported in Flatfoot. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT79115 Binding of Tap1 12 0.47 4.21 0.95 99.52
2 INT219618 Regulation of Gene_expression of Tpe1 1 0.02 1.21 0.17 92.84
3 INT219617 Negative_regulation of Positive_regulation of Tap1 1 0.27 1.03 0.07 91.88
4 INT219619 Gene_expression of Tpe1 1 0.03 1.2 0.17 91.84
5 INT140449 Positive_regulation of Tap1 5 0.68 1.84 0.74 91.56
6 INT189092 Gene_expression of Tap1 56 0.76 14.09 1.33 89.24
7 INT219620 Gene_expression of F11R 3 0.65 2.8 0.14 89.24
8 INT84375 Regulation of COL1A2 6 0.44 8.75 1.72 82.12
9 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 73.04
10 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 69.64
11 INT164465 Negative_regulation of Sbp 12 0.33 10.31 0.56 69.52
12 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 69.52
13 INT269104 Positive_regulation of AOX1 1 0.19 4.25 0.4 62.92
14 INT233102 Regulation of VMO1 4 0.34 2.7 2.25 61.04
15 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06 57.44
16 INT196324 Localization of Cyp2b10 5 0.73 2.81 0.13 54.32
17 INT269102 Binding of AOX1 1 0.21 1.99 0.35 47.04
18 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16 39.56
19 INT70756 Gene_expression of Adm 28 0.77 13.33 4.22 36.88
20 INT212536 Negative_regulation of COL3A1 2 0.57 3.53 0.21 34.44
21 INT158540 Negative_regulation of HTN1 4 0.34 7.25 1.22 31.52
22 INT298013 Binding of MNS1 1 0.35 1.14 0.13 18.08
23 INT265814 Localization of Runx2 1 0.75 0.84 0 15.24
24 INT196714 Binding of VMO1 4 0.30 1.51 1.46 11.92
25 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 11.52
26 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 5.00
27 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 5.00
28 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 5.00
29 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
30 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
31 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 5.00
32 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
33 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
34 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
35 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
36 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
37 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
38 INT6058 Localization of Fos 73 0.81 16.7 30.84 5.00
39 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 5.00
40 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
41 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 5.00
42 INT39712 Binding of pad 82 0.48 110.92 10.33 5.00
43 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 5.00
44 INT200874 Positive_regulation of Localization of Gopc 27 0.38 5.69 7.5 5.00
45 INT75382 Negative_regulation of HSPG2 20 0.57 15.18 7.03 5.00
46 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 5.00
47 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 5.00
48 INT134966 Localization of Col7a1 23 0.42 16.4 5.24 5.00
49 INT135436 Gene_expression of Hspa9 31 0.62 14.75 5.2 5.00
50 INT112883 Gene_expression of Hspg2 22 0.65 6.54 4.95 5.00
51 INT17312 Binding of HSPG2 30 0.41 33.01 4.88 5.00
52 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 5.00
53 INT30031 Gene_expression of Hba-a1 7 0.60 7.46 4.41 5.00
54 INT107771 Localization of HSPG2 10 0.78 8.47 4.3 5.00
55 INT227519 Positive_regulation of Hspa9 22 0.55 16.38 3.83 5.00
56 INT157805 Negative_regulation of Gene_expression of Col7a1 22 0.34 12.85 3.51 5.00
57 INT227523 Localization of Hspa9 9 0.60 5.26 3.18 5.00
58 INT37811 Negative_regulation of SERPINB6 8 0.47 4.65 3.15 5.00
59 INT196710 Positive_regulation of VMO1 9 0.64 3.49 3.08 5.00
60 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 5.00
61 INT105993 Gene_expression of IDS 26 0.78 10.83 2.41 5.00
62 INT3590 Positive_regulation of AVL9 7 0.40 7.94 2.36 5.00
63 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 5.00
64 INT49082 Gene_expression of MPZ 15 0.65 31.26 2.24 5.00
65 INT164248 Positive_regulation of MPZ 18 0.67 24.54 2.16 5.00
66 INT108710 Gene_expression of HAL 36 0.58 14.75 2.16 5.00
67 INT114330 Binding of MPZ 21 0.32 25.58 2.14 5.00
68 INT37809 Gene_expression of SERPINB6 7 0.77 6.58 2.12 5.00
69 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02 5.00
70 INT131263 Negative_regulation of MPZ 12 0.49 7.11 1.94 5.00
71 INT37810 Positive_regulation of Negative_regulation of SERPINB6 2 0.41 1.84 1.78 5.00
72 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 5.00
73 INT142637 Positive_regulation of Gene_expression of PRTN3 8 0.46 6.23 1.75 5.00
74 INT38574 Binding of Ache 9 0.47 3.64 1.74 5.00
75 INT171997 Gene_expression of ERAL1 5 0.25 4.97 1.67 5.00
76 INT110201 Positive_regulation of Sbp 10 0.49 5.25 1.55 5.00
77 INT164512 Regulation of MPZ 12 0.30 8.38 1.53 5.00
78 INT93956 Binding of HBM 20 0.35 8.86 1.48 5.00
79 INT140245 Binding of Gli3 3 0.36 2.65 1.46 5.00
80 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44 5.00
81 INT61068 Gene_expression of Igfbp3 15 0.75 8.48 1.41 5.00
82 INT2824 Positive_regulation of HTN1 10 0.40 10.41 1.4 5.00
83 INT65261 Regulation of Col7a1 18 0.55 8.7 1.33 5.00
84 INT200463 Regulation of SERPINB6 9 0.25 3.46 1.25 5.00
85 INT221213 Negative_regulation of Hspa9 7 0.34 2.79 1.18 5.00
86 INT147213 Negative_regulation of Gene_expression of Dbp 5 0.34 2.88 1.16 5.00
87 INT198406 Localization of C2 5 0.65 1.42 1.01 5.00
88 INT200462 Binding of IDS 13 0.31 4.95 1 5.00
89 INT43484 Binding of Runx2 7 0.37 3.22 0.95 5.00
90 INT97174 Positive_regulation of SERPINB6 5 0.50 3.74 0.91 5.00
91 INT238271 Binding of WSN 2 0.04 2.61 0.81 5.00
92 INT318945 Gene_expression of AA467197 1 0.30 1.44 0.79 5.00
93 INT227522 Regulation of Hspa9 4 0.39 1.85 0.66 5.00
94 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65 5.00
95 INT246642 Binding of CLTCL1 3 0.17 1.32 0.63 5.00
96 INT196713 Gene_expression of VMO1 2 0.54 1.11 0.59 5.00
97 INT187090 Positive_regulation of Localization of Col7a1 4 0.07 3.16 0.51 5.00
98 INT269105 Localization of AOX1 1 0.31 2.16 0.5 5.00
99 INT142550 Binding of Sis 3 0.31 1.98 0.47 5.00
100 INT269103 Gene_expression of AOX1 2 0.26 1.97 0.46 5.00
101 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44 5.00
102 INT318951 Positive_regulation of Gene_expression of AA467197 1 0.22 0.87 0.41 5.00
103 INT200467 Binding of SERPINB6 2 0.30 0.14 0.31 5.00
104 INT318952 Positive_regulation of Slc9a3r2 1 0.05 0.76 0.3 5.00
105 INT200465 Negative_regulation of Regulation of SERPINB6 1 0.35 1.37 0.25 5.00
106 INT200461 Negative_regulation of PHF13 1 0.01 0.67 0.23 5.00
107 INT174101 Protein_catabolism of Ache 3 0.66 2.45 0.22 5.00
108 INT142117 Regulation of Runx2 6 0.61 2.75 0.22 5.00
109 INT129762 Binding of HTN1 5 0.03 5.68 0.19 5.00
110 INT202591 Regulation of AVL9 2 0.02 1.58 0.19 5.00
111 INT171614 Positive_regulation of Runx2 13 0.63 3.04 0.19 5.00
112 INT318949 Localization of Slc9a3r2 1 0.08 0.2 0.17 5.00
113 INT257840 Negative_regulation of Gene_expression of UBA1 1 0.35 0.4 0.17 5.00
114 INT318948 Negative_regulation of Gene_expression of AA467197 1 0.19 0.2 0.17 5.00
115 INT257841 Gene_expression of UBA1 1 0.56 0.4 0.16 5.00
116 INT200466 Positive_regulation of Negative_regulation of MPZ 1 0.42 0.19 0.14 5.00
117 INT259244 Negative_regulation of TNXB 1 0.42 2.15 0.13 5.00
118 INT195744 Gene_expression of XIST 3 0.65 1.61 0.12 5.00
119 INT318950 Gene_expression of Slc9a3r2 2 0.09 0.2 0.1 5.00
120 INT211942 Transcription of Runx2 3 0.69 2.46 0.08 5.00
121 INT318953 Positive_regulation of AA467197 1 0.22 0.17 0.08 5.00
122 INT318946 Negative_regulation of Slc9a3r2 1 0.05 0.12 0.06 5.00
123 INT165394 Regulation of HTN1 2 0.00 2.43 0.05 5.00
124 INT241221 Localization of MBS1 1 0.40 0.09 0.04 5.00
125 INT200464 Localization of MPZ 3 0.63 3.83 0.03 5.00
126 INT332156 Positive_regulation of Ppib 1 0.05 0.3 0 5.00
127 INT192611 Negative_regulation of Gene_expression of Hba-a1 1 0.07 0.86 0 5.00
128 INT318947 Negative_regulation of AA467197 1 0.19 0 0 5.00
129 INT192615 Localization of Atrx 1 0.74 0.1 0 5.00
130 INT192609 Negative_regulation of Gene_expression of Atrx 1 0.37 0.28 0 5.00
131 INT192616 Negative_regulation of Atrx 1 0.43 1.04 0 5.00
132 INT192608 Regulation of Atrx 1 0.39 0.67 0 5.00
133 INT192610 Positive_regulation of Atrx 1 0.50 0.78 0 5.00
134 INT192613 Positive_regulation of Binding of Atrx 1 0.69 0.09 0 5.00
135 INT315136 Gene_expression of TSIX 1 0.19 0.52 0 5.00
136 INT192619 Regulation of SMARCA2 1 0.06 0.3 0 5.00
137 INT350895 Transcription of PRTN3 2 0.58 0.15 0 5.00
138 INT265823 Binding of WHSC1 1 0.08 1.17 0 5.00
139 INT320210 Gene_expression of RRH 1 0.65 0.32 0 5.00
140 INT241220 Gene_expression of MBS1 2 0.36 0.38 0 5.00
141 INT332158 Positive_regulation of Crtap 1 0.49 0.3 0 5.00
142 INT192617 Binding of Atrx 1 0.48 0.58 0 5.00
143 INT192620 Regulation of BTAF1 1 0.06 0.3 0 5.00
144 INT192612 Regulation of Gene_expression of Hba-a1 1 0.07 0.99 0 5.00
145 INT142118 Regulation of Gene_expression of Runx2 2 0.61 2.92 0 5.00
146 INT265813 Regulation of Binding of Runx2 1 0.27 0.19 0 5.00
147 INT192614 Gene_expression of Atrx 1 0.77 1.75 0 5.00
148 INT192607 Transcription of Atrx 1 0.68 0.4 0 5.00
149 INT332157 Positive_regulation of Lepre1 1 0.17 0.3 0 5.00
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