D:Focal Cartilage Defect

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Disease Term
Synonyms Articular Cartilage Defect, Articular Cartilage Defects, Cartilage Defect, Focal Cartilage Defects, Focal Chondral Defect, Focal Defect Of The Cartilage, Focal Defects In Joint Cartilage, Focal Degenerative Cartilage Defect, Focal Degenerative Cartilage Defects, Torn Cartilage
Documents 134
Hot Single Events 42
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Focal Cartilage Defect. They are ordered first by their relevance to Focal Cartilage Defect and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT251006 ICAM1 Positive_regulation of SELL 1 0.02 0.56 0 98.10
2 INT251005 VCAM1 Positive_regulation of SELL 1 0.03 0.56 0 97.94
3 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11 79.52
4 INT319042 Negative_regulation of Binding of Fgf7 and Fig4 1 0.07 0.2 0 53.68
5 INT319043 Binding of Fgf7 and Fig4 1 0.06 0.26 0 53.68
6 INT251803 PTH1R Positive_regulation of PTH 1 0.08 0.06 0.05 6.40
7 INT170992 Binding of FN1 and MMRN1 3 0.01 2.13 0.73 5.00
8 INT275320 Binding of Adamts5 and Adamts4 1 0.02 0.6 0.17 5.00
9 INT275318 Binding of Gpr143 and Adamts4 1 0.00 0.6 0.17 5.00
10 INT275319 Tg(Ngf)47Kma Positive_regulation of Gpr143 1 0.00 0.59 0.17 5.00
11 INT275317 Binding of Gpr143 and Adamts5 1 0.01 0.61 0.17 5.00
12 INT173660 Map2k6 Positive_regulation of MAPK8 1 0.15 0.27 0.07 5.00
13 INT173659 Map2k3 Positive_regulation of MAPK8 1 0.15 0.28 0.07 5.00
14 INT220081 Binding of COL1A1 and MMRN1 1 0.00 0.36 0.05 5.00
15 INT173612 FGFR1 Positive_regulation of INCENP 1 0.00 0.28 0.03 5.00
16 INT173613 BMP2 Positive_regulation of INCENP 1 0.00 0.28 0.03 5.00
17 INT354566 F2 Positive_regulation of PRNP 1 0.00 0.05 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Focal Cartilage Defect. They are ordered first by their pain relevance and then by number of times they were reported in Focal Cartilage Defect. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 99.76
2 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 99.76
3 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 99.68
4 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 99.68
5 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05 99.68
6 INT173116 Regulation of VCAM1 14 0.33 11.85 1.92 99.64
7 INT56448 Regulation of ICAM1 52 0.60 55.1 10.96 99.64
8 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 99.32
9 INT88810 Positive_regulation of Gene_expression of FGF2 17 0.50 12.62 2.98 99.32
10 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 99.14
11 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 99.14
12 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44 99.04
13 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05 99.04
14 INT188448 Negative_regulation of SQSTM1 4 0.53 3.75 0.55 98.96
15 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 98.60
16 INT12157 Positive_regulation of SELL 16 0.67 14.54 5.74 97.72
17 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 96.60
18 INT62829 Positive_regulation of VCAM1 39 0.70 38.42 9.15 96.28
19 INT225131 Negative_regulation of Binding of Fig4 5 0.19 1.43 0.08 96.06
20 INT174844 Binding of Fig4 81 0.41 18.03 12.87 95.48
21 INT63338 Regulation of Gene_expression of ICAM1 42 0.62 28.26 9.06 95.00
22 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08 94.96
23 INT183182 Negative_regulation of FGFR2 2 0.29 1.25 0.84 94.96
24 INT303555 Negative_regulation of Gene_expression of FGFR2 2 0.41 0.31 0 94.96
25 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45 94.32
26 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54 94.32
27 INT251812 Positive_regulation of SOX5 1 0.36 0.09 0.05 94.32
28 INT251811 Positive_regulation of IHH 1 0.29 0.09 0.05 94.32
29 INT251813 Positive_regulation of COL10A1 2 0.11 0.15 0 94.32
30 INT99708 Gene_expression of Fgf7 7 0.76 7.42 0.7 94.24
31 INT319039 Negative_regulation of Fgf7 1 0.42 0.18 0 94.24
32 INT319038 Negative_regulation of Gene_expression of Fgf7 1 0.42 0.18 0 94.24
33 INT113041 Gene_expression of IHH 9 0.78 5.83 2.87 93.52
34 INT250989 Gene_expression of SOX5 4 0.46 0.61 0.14 93.52
35 INT207426 Gene_expression of COL10A1 27 0.65 12.02 3.85 93.52
36 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 93.52
37 INT89126 Regulation of BMP7 7 0.45 2.5 0.58 91.92
38 INT220992 Protein_catabolism of Col2a1 8 0.40 5.55 1.64 89.04
39 INT275310 Positive_regulation of Protein_catabolism of Col2a1 1 0.16 0.88 0.22 89.04
40 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42 88.80
41 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 82.36
42 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 82.36
43 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85 78.52
44 INT233812 Gene_expression of PTH1R 32 0.77 18.15 6.15 78.40
45 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2 77.52
46 INT184219 Gene_expression of SOX6 4 0.59 0.13 0.03 77.04
47 INT99716 Transcription of FGFR2 2 0.34 0.22 0 76.88
48 INT124375 Gene_expression of Wnt2 67 0.56 38.03 4.67 76.60
49 INT99714 Transcription of Fgf7 2 0.67 0.22 0 76.16
50 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58 76.08
51 INT173651 Gene_expression of GDF6 3 0.42 0.3 0 67.96
52 INT169643 Binding of Ods 3 0.18 2.89 1.15 67.84
53 INT80302 Binding of TFAP2A 7 0.39 1.67 0.38 64.72
54 INT173627 Negative_regulation of Binding of TFAP2A 1 0.08 0.28 0 64.72
55 INT109699 Regulation of BMP2 5 0.43 2.21 0.23 64.40
56 INT173635 Negative_regulation of TFAP2A 3 0.34 2.93 0.33 63.76
57 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62 60.16
58 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 56.28
59 INT65261 Regulation of Col7a1 18 0.55 8.7 1.33 55.12
60 INT207429 Positive_regulation of Gene_expression of COL10A1 8 0.42 4.16 1.34 50.60
61 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 50.00
62 INT48555 Binding of SP1 30 0.46 11.38 6.53 48.24
63 INT20981 Binding of HRAS 42 0.48 24.49 4.23 48.00
64 INT220872 Regulation of UCN2 1 0.02 0.39 0 47.12
65 INT158136 Binding of FGFR2 9 0.26 4.5 0.63 46.60
66 INT62683 Negative_regulation of HRAS 19 0.57 7.93 2.65 43.60
67 INT37715 Positive_regulation of MSC 34 0.48 10.52 2.92 43.28
68 INT265899 Regulation of Binding of IGF1 2 0.22 0.94 0.22 40.04
69 INT326978 Regulation of Binding of FGF2 1 0.21 0.06 0.13 40.04
70 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 38.40
71 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 38.40
72 INT16130 Binding of IGF1 67 0.48 27.43 2.95 38.12
73 INT24671 Binding of FGF2 14 0.35 8.73 1.43 38.12
74 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66 30.64
75 INT106402 Positive_regulation of TFAP2A 2 0.13 0.35 0.35 28.40
76 INT173648 Regulation of Binding of TFAP2A 1 0.03 0.32 0 28.40
77 INT173631 Negative_regulation of Positive_regulation of TFAP2A 1 0.05 0.27 0 28.40
78 INT173642 Transcription of TFAP2A 1 0.09 0.27 0 28.40
79 INT173645 Regulation of TFAP2A 1 0.02 0.33 0 28.40
80 INT173630 Positive_regulation of Transcription of TFAP2A 1 0.06 0.54 0 28.40
81 INT48554 Positive_regulation of SP1 12 0.49 3.64 1.2 27.68
82 INT126899 Regulation of SP1 5 0.43 2.53 0.57 27.68
83 INT166959 Positive_regulation of Positive_regulation of SP1 3 0.46 2.23 0.35 27.68
84 INT173632 Transcription of SP1 7 0.41 1.42 0.09 27.68
85 INT173637 Negative_regulation of Positive_regulation of SP1 1 0.05 0.27 0 27.68
86 INT173623 Positive_regulation of Transcription of SP1 3 0.30 0.95 0 27.68
87 INT141150 Localization of BMP7 4 0.56 2.84 0.76 21.40
88 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 20.88
89 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 17.20
90 INT172592 Positive_regulation of PTH1R 9 0.28 6.25 2.5 12.96
91 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
92 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
93 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
94 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
95 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
96 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
97 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
98 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 5.00
99 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
100 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
101 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
102 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
103 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
104 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
105 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
106 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
107 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 5.00
108 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
109 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6 5.00
110 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
111 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
112 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 5.00
113 INT10799 Localization of ENG 63 0.78 18.67 27.28 5.00
114 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
115 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
116 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
117 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83 5.00
118 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68 5.00
119 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 5.00
120 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
121 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
122 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
123 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
124 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
125 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 5.00
126 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
127 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 5.00
128 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
129 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
130 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 5.00
131 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
132 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 5.00
133 INT72127 Protein_catabolism of MMRN1 68 0.52 56 14.13 5.00
134 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 5.00
135 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36 5.00
136 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96 5.00
137 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 5.00
138 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
139 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
140 INT4047 Binding of F13A1 105 0.43 66.54 11.81 5.00
141 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
142 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 5.00
143 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
144 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 5.00
145 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 5.00
146 INT86729 Positive_regulation of CDCP1 37 0.07 18.74 10.76 5.00
147 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41 5.00
148 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 5.00
149 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09 5.00
150 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 5.00
151 INT18185 Gene_expression of Tyr 32 0.76 12.52 8.17 5.00
152 INT95133 Gene_expression of FASLG 38 0.75 44.09 7.51 5.00
153 INT15490 Negative_regulation of Gene_expression of COL7A1 40 0.58 25.97 7.18 5.00
154 INT121752 Gene_expression of IL11 54 0.62 18.05 7.16 5.00
155 INT83531 Gene_expression of KITLG 54 0.65 26 7.07 5.00
156 INT170381 Transcription of Gopc 59 0.60 15.96 6.82 5.00
157 INT2111 Gene_expression of LIF 34 0.77 16.82 6.76 5.00
158 INT173639 Positive_regulation of INCENP 40 0.14 20.97 6.7 5.00
159 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 5.00
160 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 5.00
161 INT14258 Regulation of TSPO 32 0.60 10.16 6.24 5.00
162 INT250048 Positive_regulation of Gpr143 12 0.43 5.85 6.1 5.00
163 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39 5.00
164 INT49801 Positive_regulation of SELP 21 0.48 21.34 5.25 5.00
165 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72 5.00
166 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
167 INT96492 Gene_expression of NGFR 24 0.00 12.3 4.59 5.00
168 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51 5.00
169 INT113107 Phosphorylation of Hist1h3f 21 0.51 8.01 4.45 5.00
170 INT51898 Binding of PECAM1 26 0.36 18.87 4.22 5.00
171 INT48518 Gene_expression of ANPEP 51 0.78 22.88 4.18 5.00
172 INT117921 Positive_regulation of Positive_regulation of MAPK14 9 0.44 9.93 4.18 5.00
173 INT88545 Localization of MMRN1 21 0.78 16.67 4.01 5.00
174 INT45147 Gene_expression of C2 21 0.58 6.18 3.98 5.00
175 INT6513 Positive_regulation of Gene_expression of BGLAP 24 0.67 11.69 3.96 5.00
176 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94 5.00
177 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 5.00
178 INT98944 Gene_expression of ACTA2 14 0.59 11 3.7 5.00
179 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 5.00
180 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 5.00
181 INT171233 Binding of Ecm1 25 0.07 12.41 3.36 5.00
182 INT28094 Binding of PTH 29 0.37 13.57 3.09 5.00
183 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02 5.00
184 INT115317 Transcription of FGF2 14 0.62 12.79 3 5.00
185 INT143841 Positive_regulation of Mtpn 17 0.17 5.46 2.68 5.00
186 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 5.00
187 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45 5.00
188 INT87287 Phosphorylation of CDCP1 20 0.04 5.62 2.43 5.00
189 INT102659 Gene_expression of CSF3 32 0.77 21.93 2.39 5.00
190 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15 5.00
191 INT109908 Localization of MAPK8 10 0.73 3.86 2.14 5.00
192 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12 5.00
193 INT173647 Positive_regulation of Gene_expression of MAPK14 15 0.39 7.54 2.05 5.00
194 INT109906 Localization of MAPK1 12 0.54 1.68 2.01 5.00
195 INT113717 Negative_regulation of Gene_expression of COL1A1 21 0.41 6.14 2.01 5.00
196 INT167203 Binding of PRNP 25 0.48 20.09 1.84 5.00
197 INT173641 Regulation of MSC 13 0.39 2.85 1.82 5.00
198 INT164407 Negative_regulation of Gene_expression of Col2a1 6 0.39 4 1.78 5.00
199 INT99444 Positive_regulation of Proc 15 0.45 9.18 1.75 5.00
200 INT44637 Positive_regulation of Slc9a3r2 18 0.55 7.27 1.72 5.00
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