D:Focal Dystonia

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Disease Term
Synonyms Adult Onset Dystonia, Adult Onset Dystonias, Adult Onset Idiopathic Focal Dystonias, Adult Onset Idiopathic Torsion Dystonias, AUTOSOMAL DOMINANT FAMILIAL DYSTONIA, AUTOSOMAL RECESSIVE FAMILIAL DYSTONIA, Childhood Onset Dystonia, Childhood Onset Dystonias, Dystonia Adult Onset, Dystonia Childhood Onset, Dystonia Disorder
Documents 152
Hot Single Events 23
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Focal Dystonia. They are ordered first by their relevance to Focal Dystonia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT340110 MAOB Positive_regulation of Ltp 1 0.02 0.59 0.49 50.80
2 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64 5.00
3 INT236835 Binding of CISH and CSF2 1 0.06 1.43 1.25 5.00
4 INT326586 SLC18A2 Negative_regulation of DDC 1 0.28 0.91 0.66 5.00
5 INT236832 CSF2 Regulation of CXCL13 1 0.09 0.34 0.45 5.00
6 INT326587 GYPA Regulation of DDC 1 0.08 0.83 0.33 5.00
7 INT326583 GYPA Negative_regulation of Binding of GYPA and SLC6A3 1 0.03 0.22 0.22 5.00
8 INT348970 Binding of MOG and HAND1 1 0.03 1.28 0.2 5.00
9 INT236833 Binding of CD19 and SDC1 1 0.26 0.54 0.15 5.00
10 INT340111 Chrna7 Regulation of CYSLTR1 1 0.00 0.25 0.15 5.00
11 INT236834 Binding of CD19 and CSF2 1 0.17 0.53 0.14 5.00
12 INT340109 GOPC Positive_regulation of Ltp 1 0.01 0.19 0.14 5.00
13 INT348971 Binding of MOG and CARTPT 1 0.06 0.73 0.08 5.00
14 INT348972 Binding of CSF2 and MOG 1 0.21 0.41 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Focal Dystonia. They are ordered first by their pain relevance and then by number of times they were reported in Focal Dystonia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT69350 Gene_expression of RAC1 23 0.77 12.16 5.54 99.92
2 INT27627 Binding of Rac1 41 0.41 22.88 13.68 99.36
3 INT79034 Negative_regulation of GPI 7 0.58 3.94 0.66 99.16
4 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 99.02
5 INT138997 Gene_expression of Dyt1 2 0.67 1.91 0.37 98.64
6 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 95.80
7 INT24020 Positive_regulation of HPS1 6 0.44 6.14 1.08 95.60
8 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 94.32
9 INT24196 Positive_regulation of Binding of Chrna7 8 0.45 0.79 2.13 93.44
10 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 91.92
11 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 91.76
12 INT177968 Negative_regulation of Transcription of CSF2 3 0.37 2.8 0.55 91.76
13 INT348975 Negative_regulation of Transcription of ALB 1 0.04 2.2 0.37 91.76
14 INT12484 Binding of Drd2 45 0.48 15.17 24.72 91.44
15 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 91.36
16 INT23330 Binding of Chrna7 79 0.48 10.06 35.5 89.44
17 INT163613 Transcription of CSF2 16 0.60 12.98 1.62 89.32
18 INT127291 Transcription of ALB 7 0.67 4.26 0.55 89.04
19 INT47425 Localization of Chrna7 11 0.81 6.7 1.86 87.68
20 INT32118 Regulation of Mcf2l 6 0.39 3.05 1.34 87.52
21 INT173912 Negative_regulation of LRP2 5 0.57 6.22 0.42 85.28
22 INT7134 Localization of KNG1 127 0.79 65.73 67.97 84.76
23 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 81.76
24 INT10980 Gene_expression of GYPA 40 0.78 15.32 5.51 79.56
25 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 77.92
26 INT127203 Positive_regulation of Mcf2l 14 0.43 9.84 7.03 70.52
27 INT63137 Regulation of Pd 10 0.12 4.01 0.81 66.56
28 INT232667 Binding of Pd 17 0.16 20.76 3.58 66.12
29 INT326597 Negative_regulation of Localization of GYPA 1 0.16 1.51 0.1 62.88
30 INT15744 Localization of GYPA 12 0.64 7.19 2.61 61.20
31 INT15508 Negative_regulation of nt 8 0.36 3.4 2.26 60.96
32 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 60.44
33 INT173910 Gene_expression of LRP2 24 0.75 19.99 4.09 58.64
34 INT179523 Binding of Pip 4 0.14 2.61 0.64 40.80
35 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 40.48
36 INT110961 Binding of GYPA 14 0.36 6.66 2.03 39.12
37 INT237229 Gene_expression of Amt 1 0.07 2.58 0.1 37.40
38 INT200373 Binding of Omd 7 0.34 7.03 0.34 36.68
39 INT59680 Binding of Lynx1 10 0.12 1.53 2.19 25.00
40 INT40578 Gene_expression of Lynx1 4 0.04 0.66 0.71 25.00
41 INT348978 Positive_regulation of MOG 6 0.49 4.2 0.63 15.52
42 INT231128 Gene_expression of HAND1 4 0.40 1.32 0.25 8.80
43 INT10261 Negative_regulation of Pd 16 0.42 5.55 7.4 6.32
44 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
45 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
46 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
47 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 5.00
48 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
49 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 5.00
50 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
51 INT13277 Regulation of Positive_regulation of Ltp 83 0.52 19.68 55.78 5.00
52 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
53 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
54 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
55 INT12608 Regulation of CNR1 62 0.60 24.36 36.02 5.00
56 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
57 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
58 INT99610 Localization of MMP9 126 0.79 48.46 32.67 5.00
59 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
60 INT57192 Binding of Ltp 43 0.41 17.48 24.96 5.00
61 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
62 INT49774 Binding of DRD2 48 0.48 17.42 20.73 5.00
63 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
64 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
65 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
66 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
67 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
68 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
69 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
70 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
71 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
72 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24 5.00
73 INT182240 Gene_expression of CXCL13 25 0.59 22.77 11.96 5.00
74 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
75 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8 5.00
76 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69 5.00
77 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 5.00
78 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
79 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
80 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96 5.00
81 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86 5.00
82 INT18391 Positive_regulation of GYPA 41 0.40 16.47 8.69 5.00
83 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
84 INT18190 Regulation of DRD2 11 0.60 9.01 7.63 5.00
85 INT143996 Positive_regulation of CISH 28 0.49 17.31 7.17 5.00
86 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55 5.00
87 INT2513 Binding of Napa 80 0.42 4.29 6.51 5.00
88 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 5.00
89 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93 5.00
90 INT236839 Positive_regulation of CXCL13 14 0.44 19.27 5.81 5.00
91 INT87470 Gene_expression of SDC1 27 0.78 24.86 5.81 5.00
92 INT156794 Gene_expression of CISH 41 0.58 23.09 5.03 5.00
93 INT96504 Negative_regulation of SLC18A2 5 0.36 2.07 4.62 5.00
94 INT135572 Negative_regulation of Slc18a2 9 0.43 1.25 4.52 5.00
95 INT170988 Positive_regulation of CYSLTR1 15 0.34 6.23 4.44 5.00
96 INT35744 Binding of MAOB 13 0.46 7.52 4.26 5.00
97 INT119053 Positive_regulation of SLC6A3 15 0.65 2.51 4 5.00
98 INT78619 Positive_regulation of RAC1 27 0.65 10.43 3.75 5.00
99 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 5.00
100 INT121967 Regulation of RAC1 9 0.45 6.14 3.41 5.00
101 INT122051 Negative_regulation of ROM1 17 0.48 9.11 3.38 5.00
102 INT122577 Regulation of SLC6A3 9 0.53 1.47 3.09 5.00
103 INT10443 Regulation of Gene_expression of CNR1 10 0.50 3.96 3.06 5.00
104 INT38814 Positive_regulation of Aspt1 9 0.63 6.89 3.06 5.00
105 INT93517 Binding of Slc18a2 6 0.48 0.31 3 5.00
106 INT172177 Protein_catabolism of INCENP 18 0.37 6.34 2.91 5.00
107 INT13634 Gene_expression of CYSLTR1 19 0.75 11.24 2.88 5.00
108 INT85885 Positive_regulation of SNAP25 8 0.69 2.74 2.84 5.00
109 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 5.00
110 INT15745 Negative_regulation of GYPA 18 0.43 8.01 2.74 5.00
111 INT143952 Regulation of Gene_expression of MMP9 14 0.53 10.16 2.73 5.00
112 INT63135 Transcription of Pd 5 0.04 1.91 2.59 5.00
113 INT193251 Binding of CYSLTR1 13 0.32 8.32 2.57 5.00
114 INT236842 Positive_regulation of Gene_expression of CXCL13 6 0.32 3.91 2.55 5.00
115 INT143316 Negative_regulation of Slc18a2 7 0.50 3.17 2.52 5.00
116 INT109559 Localization of Napa 16 0.61 1.3 2.42 5.00
117 INT182238 Binding of CXCL13 5 0.33 5.32 2.37 5.00
118 INT76515 Gene_expression of Slc18a1 3 0.50 0.55 2.31 5.00
119 INT14488 Regulation of MBP 5 0.25 5.17 2.25 5.00
120 INT70987 Binding of RAC1 14 0.37 12.14 2.13 5.00
121 INT133218 Binding of Slc18a2 2 0.48 2.96 1.99 5.00
122 INT50895 Regulation of GYPA 10 0.60 4.05 1.95 5.00
123 INT95904 Gene_expression of CD27 45 0.76 26.17 1.93 5.00
124 INT96588 Gene_expression of MOG 18 0.75 11.41 1.89 5.00
125 INT117980 Regulation of Rac1 10 0.45 3.72 1.88 5.00
126 INT115303 Localization of SNAP25 8 0.73 1.43 1.82 5.00
127 INT26318 Positive_regulation of CD19 7 0.67 5.61 1.8 5.00
128 INT167847 Positive_regulation of Gene_expression of Chrna7 7 0.49 3.02 1.57 5.00
129 INT49567 Regulation of DRD1 5 0.35 1.02 1.54 5.00
130 INT121136 Negative_regulation of DDC 4 0.57 2.98 1.32 5.00
131 INT214574 Positive_regulation of SDC1 4 0.32 3.24 1.28 5.00
132 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26 5.00
133 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99 5.00
134 INT115304 Regulation of SNAP25 7 0.60 1.24 0.95 5.00
135 INT326601 Gene_expression of SLC18A2 2 0.42 1.31 0.92 5.00
136 INT170238 Negative_regulation of Gene_expression of GYPA 5 0.42 1.74 0.88 5.00
137 INT175904 Localization of RAC1 7 0.41 5.05 0.86 5.00
138 INT236841 Negative_regulation of Gene_expression of CXCL13 3 0.27 2.17 0.83 5.00
139 INT264629 Localization of Rac1 8 0.72 5.7 0.79 5.00
140 INT63134 Regulation of Transcription of Pd 2 0.03 0.48 0.77 5.00
141 INT122578 Regulation of Gene_expression of SLC6A3 3 0.34 0.2 0.75 5.00
142 INT206664 Positive_regulation of Gene_expression of CISH 3 0.20 0.59 0.74 5.00
143 INT196238 Binding of MOG 4 0.36 4.19 0.73 5.00
144 INT326603 Regulation of Positive_regulation of DRD2 1 0.44 0.8 0.69 5.00
145 INT326602 Negative_regulation of Gene_expression of SLC18A2 1 0.25 0.93 0.67 5.00
146 INT340106 Negative_regulation of Positive_regulation of CYSLTR1 1 0.08 0.62 0.62 5.00
147 INT172411 Regulation of SV2A 3 0.22 0.93 0.61 5.00
148 INT63133 Gene_expression of Pd 13 0.18 5.31 0.61 5.00
149 INT236837 Regulation of Negative_regulation of CSF2 2 0.32 1.83 0.61 5.00
150 INT335968 Binding of Slc18a1 1 0.05 1 0.6 5.00
151 INT90362 Negative_regulation of Gene_expression of SDC1 3 0.59 2.88 0.59 5.00
152 INT200372 Positive_regulation of Omd 3 0.33 2.23 0.57 5.00
153 INT320849 Binding of CARTPT 5 0.14 1.85 0.54 5.00
154 INT119054 Negative_regulation of Binding of SLC6A3 2 0.43 0 0.54 5.00
155 INT326496 Regulation of Phb2 1 0.06 1.03 0.52 5.00
156 INT264585 Localization of Slc18a2 1 0.60 0.54 0.51 5.00
157 INT202581 Positive_regulation of Gene_expression of DRD2 2 0.49 0.81 0.47 5.00
158 INT231129 Positive_regulation of HAND1 5 0.30 2.73 0.45 5.00
159 INT165597 Positive_regulation of Htt 8 0.60 4.27 0.44 5.00
160 INT340755 Negative_regulation of CARTPT 2 0.30 2.08 0.4 5.00
161 INT18390 Positive_regulation of Positive_regulation of GYPA 2 0.40 1.42 0.39 5.00
162 INT272221 Gene_expression of BRS3 3 0.11 3.09 0.38 5.00
163 INT211361 Regulation of RENBP 5 0.08 2.8 0.38 5.00
164 INT132864 Binding of Htt 15 0.46 2.34 0.38 5.00
165 INT236846 Localization of CD19 3 0.68 1.55 0.36 5.00
166 INT264637 Localization of CLDN4 3 0.73 0.85 0.29 5.00
167 INT236843 Negative_regulation of CXCL13 1 0.27 0.24 0.29 5.00
168 INT315733 Gene_expression of Sqstm1 7 0.45 0.53 0.27 5.00
169 INT264582 Gene_expression of Slc18a2 1 0.62 0.26 0.25 5.00
170 INT326598 Negative_regulation of Negative_regulation of SLC6A3 1 0.28 0.65 0.24 5.00
171 INT334903 Positive_regulation of Localization of Chrna7 2 0.04 0.83 0.23 5.00
172 INT326600 Negative_regulation of Gene_expression of DRD2 1 0.53 0.35 0.23 5.00
173 INT38790 Regulation of CYSLTR1 3 0.18 0.25 0.2 5.00
174 INT340105 Negative_regulation of Gene_expression of BRS3 1 0.06 0.15 0.19 5.00
175 INT214569 Positive_regulation of Localization of CD27 3 0.49 2.16 0.19 5.00
176 INT236840 Positive_regulation of Localization of CD19 1 0.45 0.78 0.19 5.00
177 INT340104 Positive_regulation of Gene_expression of BRS3 1 0.08 0.15 0.19 5.00
178 INT163189 Localization of CD27 7 0.74 5.31 0.18 5.00
179 INT236845 Gene_expression of PTPRCAP 1 0.04 0.62 0.17 5.00
180 INT264583 Negative_regulation of Slc18a1 1 0.01 0.33 0.16 5.00
181 INT348980 Positive_regulation of Gene_expression of MOG 1 0.38 0.69 0.08 5.00
182 INT348977 Positive_regulation of Negative_regulation of CARTPT 1 0.08 0.69 0.08 5.00
183 INT236887 Positive_regulation of Gene_expression of Pd 4 0.13 1.24 0.07 5.00
184 INT203012 Regulation of ADRM1 5 0.11 1.79 0.07 5.00
185 INT348979 Regulation of MOG 1 0.24 1.54 0.06 5.00
186 INT326599 Positive_regulation of Binding of GYPA 1 0.14 0.88 0.03 5.00
187 INT236889 Transcription of ADRM1 1 0.11 0.8 0 5.00
188 INT304409 Negative_regulation of MOG 2 0.44 0.37 0 5.00
189 INT348976 Positive_regulation of CARTPT 1 0.08 0.61 0 5.00
190 INT246981 Gene_expression of DHDDS 2 0.10 0.6 0 5.00
191 INT124699 Regulation of Zbtb8b 1 0.03 0.1 0 5.00
192 INT249724 Binding of Sqstm1 4 0.25 0 0 5.00
193 INT348974 Transcription of MOG 1 0.60 0.41 0 5.00
194 INT236888 Negative_regulation of Transcription of Pd 1 0.03 0.64 0 5.00
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