D:Focal Segmental Glomerulosclerosis

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Disease Term
Synonyms FOCAL GLOMERULOSCLEROSIS, Focal Sclerosing Glomerulonephritides, FOCAL SCLEROSING GLOMERULONEPHRITIS, Glomerular Hyalinosis Segmental, Glomerulonephritides Focal Sclerosing, Glomerulonephritis Focal Sclerosing, GLOMERULOSCLEROSIS FOCAL, Hyalinosis Segmental, HYALINOSIS SEGMENTAL GLOMERULAR, Sclerosing Glomerulonephritides Focal, SCLEROSING GLOMERULONEPHRITIS FOCAL
Documents 61
Hot Single Events 48
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Focal Segmental Glomerulosclerosis. They are ordered first by their relevance to Focal Segmental Glomerulosclerosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT257665 Binding of Nphs1 and Pard3 1 0.39 0.67 0.09 99.52
2 INT333396 CFD Positive_regulation of Bcl2l1 1 0.05 0.98 0.13 64.80
3 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92 55.04
4 INT333398 CFD Negative_regulation of Gene_expression of Pdgfa 1 0.02 0.64 0.3 5.00
5 INT312726 AASS Positive_regulation of FGD1 1 0.02 0.08 0.24 5.00
6 INT333394 CFD Negative_regulation of Gene_expression of Cat 1 0.03 0.79 0.22 5.00
7 INT333397 CFD Negative_regulation of Gene_expression of Nos2 1 0.04 0.8 0.22 5.00
8 INT333393 CFD Positive_regulation of Gene_expression of Timp1 1 0.07 0.82 0.16 5.00
9 INT244328 ELF3 Negative_regulation of Positive_regulation of SH3GL3 3 0.20 1.26 0.04 5.00
10 INT352175 USE1 Regulation of NAGA 1 0.01 0.33 0 5.00
11 INT279241 Binding of ELF3 and GLA 1 0.20 0.53 0 5.00
12 INT257662 Binding of Mbp and Nphs1 1 0.11 0 0 5.00
13 INT257663 Binding of Nck1 and Nphs1 1 0.09 0 0 5.00
14 INT279242 Negative_regulation of Binding of GLA and SH3GL3 1 0.08 1.22 0 5.00
15 INT333395 Binding of CFD and Aes 1 0.03 0.24 0 5.00
16 INT340379 Binding of Rabep1 and Ocrl 1 0.08 0.62 0 5.00
17 INT340380 Binding of Cfl1 and Clcn4-2 1 0.13 0.82 0 5.00
18 INT279240 Binding of GLA and SH3GL3 1 0.07 1.21 0 5.00
19 INT257666 Binding of Mgst1 and Pard3 1 0.05 0 0 5.00
20 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 5.00
21 INT257664 Regulation of Binding of Nphs1 and Pard3 1 0.36 0 0 5.00
22 INT279239 ELF3 Regulation of SH3GL3 1 0.11 0.44 0 5.00
23 INT340378 Binding of Cfl1 and Clcn5 1 0.15 0.82 0 5.00
24 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0 5.00
25 INT340377 Binding of Clcn4-2 and Clcn5 1 0.35 0.82 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Focal Segmental Glomerulosclerosis. They are ordered first by their pain relevance and then by number of times they were reported in Focal Segmental Glomerulosclerosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT111298 Gene_expression of ACTN4 12 0.70 9.42 2.6 100.00
2 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 99.84
3 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 99.30
4 INT147438 Gene_expression of Nox4 5 0.65 2.97 0.47 98.20
5 INT170853 Positive_regulation of Gene_expression of CFD 7 0.23 9.89 1.41 97.36
6 INT164306 Regulation of Gene_expression of Trpc6 1 0.62 1.67 0.17 97.08
7 INT340359 Binding of Clcn5 1 0.48 1.91 0 96.96
8 INT143780 Positive_regulation of Positive_regulation of Trpc6 2 0.47 0.72 0.41 96.88
9 INT160437 Gene_expression of Trpc6 24 0.78 9.09 4.75 96.72
10 INT143779 Positive_regulation of Trpc6 3 0.70 2.22 0.9 96.36
11 INT103886 Negative_regulation of Negative_regulation of Agtr2 5 0.31 2.16 0.71 96.16
12 INT257639 Binding of Pard3 1 0.35 0.4 0.04 96.12
13 INT257641 Binding of Nphs1 1 0.46 0.33 0.04 96.12
14 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 95.84
15 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56 95.68
16 INT10585 Localization of NAGLU 53 0.80 23.32 12.75 92.96
17 INT3163 Gene_expression of NAGLU 28 0.75 15.23 4.98 92.96
18 INT38008 Positive_regulation of Gene_expression of NAGLU 6 0.44 6.64 2 92.96
19 INT14619 Positive_regulation of Localization of NAGLU 18 0.62 7.73 3.94 92.96
20 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 92.56
21 INT1973 Positive_regulation of NAGLU 36 0.65 14.78 7 92.44
22 INT160438 Positive_regulation of Gene_expression of Trpc6 6 0.70 3.44 1.29 90.12
23 INT164304 Negative_regulation of Gene_expression of Trpc6 1 0.59 0.81 0.07 89.40
24 INT164307 Regulation of Trpc6 2 0.31 0.85 0.11 89.36
25 INT129848 Negative_regulation of CD5 3 0.42 3.01 0.67 88.68
26 INT156201 Negative_regulation of Gene_expression of MTOR 6 0.58 7.7 0.36 88.32
27 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44 87.84
28 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 87.68
29 INT257647 Localization of Nphs1 1 0.71 0.34 0.05 87.36
30 INT164305 Positive_regulation of Nox4 2 0.42 1.6 0.53 86.88
31 INT164302 Positive_regulation of Gene_expression of Nox4 2 0.42 1.18 0.1 86.88
32 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 86.16
33 INT46221 Positive_regulation of Gene_expression of IgG 46 0.53 33.66 7.7 86.16
34 INT156207 Negative_regulation of Phosphorylation of MTOR 5 0.58 2.33 0.25 85.92
35 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 85.44
36 INT44717 Gene_expression of TNFSF14 12 0.75 13.44 3.72 85.44
37 INT156204 Phosphorylation of MTOR 15 0.82 3.99 0.21 85.08
38 INT126030 Regulation of CFD 4 0.21 3.92 0.83 84.24
39 INT257643 Regulation of Nphs1 1 0.26 0.62 0 84.24
40 INT545 Binding of GC 15 0.45 10.74 3.47 83.16
41 INT257638 Positive_regulation of Nphs1 1 0.66 0.22 0 82.92
42 INT158083 Gene_expression of FGD1 24 0.67 6.82 2.83 82.16
43 INT156205 Negative_regulation of Binding of CRTC2 1 0.02 0.38 0.09 81.60
44 INT156206 Negative_regulation of Gene_expression of CRTC2 1 0.02 0.38 0.09 81.60
45 INT156209 Positive_regulation of Gene_expression of CRTC2 1 0.03 0.38 0.09 81.00
46 INT156208 Gene_expression of CRTC2 2 0.03 1.17 0.09 81.00
47 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07 80.80
48 INT156202 Binding of CRTC2 1 0.02 0.38 0.09 80.40
49 INT156203 Positive_regulation of Phosphorylation of NEK3 1 0.08 0.38 0.09 79.68
50 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04 79.12
51 INT156200 Negative_regulation of Phosphorylation of NEK3 1 0.07 0.38 0.09 79.08
52 INT126948 Phosphorylation of NEK3 3 0.09 1.89 0.22 78.76
53 INT56916 Positive_regulation of Mir125b-1 3 0.10 1.14 3.22 78.36
54 INT1138 Positive_regulation of IgG-2a 16 0.68 5.59 8.11 78.36
55 INT101592 Gene_expression of TRPM8 82 0.78 70.61 22.89 76.64
56 INT130246 Negative_regulation of Gene_expression of TRPM8 4 0.59 3.35 1.14 76.64
57 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 75.00
58 INT7678 Localization of Alb 142 0.81 80.93 22.49 75.00
59 INT19847 Positive_regulation of Localization of Alb 21 0.70 13.89 4.16 75.00
60 INT56917 Positive_regulation of Positive_regulation of Mir125b-1 1 0.09 0.15 1.02 73.76
61 INT257653 Negative_regulation of Binding of Pard3 1 0.32 0.07 0 73.60
62 INT56914 Gene_expression of Mir125b-1 2 0.14 0.47 1.36 71.56
63 INT116655 Binding of NAA50 3 0.36 1.93 0.78 70.40
64 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 68.80
65 INT188774 Binding of RAPGEF5 12 0.29 13.55 1.04 67.76
66 INT217507 Localization of Tjp1 5 0.57 1.65 0.13 64.24
67 INT257636 Positive_regulation of Pard6a 1 0.18 0.06 0 64.08
68 INT56915 Positive_regulation of Positive_regulation of IgG-2a 1 0.09 0.13 1.09 63.72
69 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94 61.28
70 INT120004 Transcription of Tp53 8 0.72 4.92 1.48 61.28
71 INT248227 Protein_catabolism of CFD 4 0.46 2.48 0.77 60.08
72 INT167153 Gene_expression of A4GALT 10 0.49 10.45 1.71 55.96
73 INT257632 Binding of Kirrel 1 0.06 0.06 0 55.12
74 INT257650 Gene_expression of Nxf1 1 0.02 0.44 0 54.96
75 INT257642 Gene_expression of Nphs1 4 0.66 0.96 0 50.80
76 INT312738 Regulation of UGT2B17 1 0.45 1.04 0.94 46.32
77 INT192056 Binding of Pbx1 2 0.31 0.46 0.13 41.24
78 INT192051 Binding of Hoxa9 1 0.26 0.27 0.1 41.24
79 INT192063 Binding of Hoxa7 1 0.30 0.27 0.1 41.24
80 INT192059 Binding of Hoxa10 2 0.33 1.53 0.1 41.24
81 INT192062 Binding of Hoxa11 1 0.26 0.27 0.1 41.24
82 INT192053 Binding of Hoxa13 1 0.26 0.27 0.1 41.24
83 INT312731 Negative_regulation of UGT2B15 1 0.36 0.38 0.94 40.80
84 INT2544 Localization of PTH 39 0.81 30.55 2.22 24.32
85 INT192808 Negative_regulation of Localization of PTH 6 0.59 7.31 0.45 24.32
86 INT340373 Negative_regulation of Rbp4 1 0.17 1.96 0.16 23.84
87 INT101105 Positive_regulation of FUT1 62 0.30 55.96 9.28 21.12
88 INT161974 Regulation of UGT2B15 2 0.26 0.31 0.99 16.32
89 INT175558 Positive_regulation of CASR 5 0.47 3.55 0.6 16.24
90 INT258920 Regulation of CASR 3 0.22 2.02 0.18 16.24
91 INT322288 Positive_regulation of Regulation of CASR 1 0.38 0.95 0.14 16.24
92 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 15.60
93 INT150476 Positive_regulation of ELF3 32 0.56 13.61 2.39 15.52
94 INT312740 Localization of UGT2B17 1 0.75 0.15 0.47 14.64
95 INT312734 Localization of UGT2B15 1 0.62 0.15 0.47 14.64
96 INT233570 Gene_expression of Rbp4 4 0.66 3.4 0.17 10.64
97 INT218315 Gene_expression of RBP4 25 0.76 18.19 0.85 10.24
98 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
99 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
100 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
101 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
102 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
103 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
104 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
105 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
106 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
107 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
108 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
109 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
110 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
111 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
112 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
113 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 5.00
114 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
115 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
116 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
117 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 5.00
118 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
119 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
120 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 5.00
121 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 5.00
122 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
123 INT14306 Positive_regulation of Gal 36 0.70 21.66 18.51 5.00
124 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
125 INT14587 Positive_regulation of Cl 44 0.20 20.37 16.72 5.00
126 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
127 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76 5.00
128 INT96775 Gene_expression of Pdgfa 42 0.54 29.78 15.46 5.00
129 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
130 INT55740 Gene_expression of Timp1 53 0.75 28.63 13.85 5.00
131 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
132 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
133 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
134 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
135 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 5.00
136 INT48956 Negative_regulation of Positive_regulation of Nos2 34 0.46 13.15 11.15 5.00
137 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 5.00
138 INT2036 Localization of EGF 42 0.77 21.5 9.74 5.00
139 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14 5.00
140 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
141 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
142 INT51165 Binding of Gal 10 0.48 2.56 8.41 5.00
143 INT113987 Localization of IK 29 0.23 16.73 8.25 5.00
144 INT56223 Positive_regulation of MPO 35 0.70 43 8.2 5.00
145 INT16131 Negative_regulation of GBE1 37 0.30 10.32 8.15 5.00
146 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11 5.00
147 INT94082 Regulation of Gene_expression of IK 19 0.23 10.03 7.93 5.00
148 INT78226 Gene_expression of Mbp 43 0.75 22.14 7.79 5.00
149 INT52180 Binding of Aes 38 0.42 23.16 6.7 5.00
150 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
151 INT31598 Gene_expression of Mgst1 41 0.78 6.44 6.3 5.00
152 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
153 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14 5.00
154 INT96778 Positive_regulation of Pdgfa 22 0.46 12.7 5.31 5.00
155 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26 5.00
156 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 5.00
157 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
158 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77 5.00
159 INT26477 Regulation of ACE 26 0.45 16.31 4.33 5.00
160 INT5219 Negative_regulation of DBP 43 0.57 23.35 4.26 5.00
161 INT55741 Negative_regulation of Timp1 15 0.51 8.12 4.09 5.00
162 INT183207 Negative_regulation of USE1 14 0.18 10.97 4 5.00
163 INT15724 Negative_regulation of Fn1 15 0.53 5.61 3.87 5.00
164 INT175555 Gene_expression of CASR 17 0.78 14.83 3.73 5.00
165 INT185246 Gene_expression of Psmd1 26 0.50 8.89 3.73 5.00
166 INT14880 Positive_regulation of Car3 14 0.65 9.19 3.73 5.00
167 INT16723 Regulation of GBE1 16 0.11 4.3 3.7 5.00
168 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45 5.00
169 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 5.00
170 INT122051 Negative_regulation of ROM1 17 0.48 9.11 3.38 5.00
171 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 5.00
172 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 5.00
173 INT22375 Localization of PDGFA 21 0.75 15.46 3.25 5.00
174 INT117348 Regulation of EGFR 75 0.61 47.73 3.09 5.00
175 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
176 INT197446 Localization of Psmd1 10 0.56 3.78 2.79 5.00
177 INT142724 Negative_regulation of A4GALT 11 0.53 8.23 2.61 5.00
178 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 5.00
179 INT95898 Gene_expression of CAPG 14 0.39 10.51 2.33 5.00
180 INT94835 Localization of NUDT6 13 0.52 11.57 2 5.00
181 INT68829 Binding of ELF3 14 0.47 7.96 2 5.00
182 INT88701 Gene_expression of MMD 15 0.44 6.04 1.94 5.00
183 INT26364 Positive_regulation of CS 12 0.30 4.99 1.89 5.00
184 INT65545 Localization of EGFR 35 0.79 20.8 1.88 5.00
185 INT118511 Gene_expression of Pard3 5 0.57 0.76 1.86 5.00
186 INT46605 Positive_regulation of NAA50 17 0.49 6.33 1.76 5.00
187 INT145884 Negative_regulation of SH3GL3 19 0.43 12.67 1.72 5.00
188 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 5.00
189 INT121513 Positive_regulation of A4GALT 21 0.63 16.06 1.59 5.00
190 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 5.00
191 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52 5.00
192 INT103799 Positive_regulation of CAPG 8 0.34 5.16 1.52 5.00
193 INT147788 Regulation of FUT1 11 0.12 7.72 1.44 5.00
194 INT125980 Binding of CFD 8 0.42 10.96 1.39 5.00
195 INT210060 Localization of SH3GL3 4 0.59 6.61 1.37 5.00
196 INT8667 Localization of HSD11B1 22 0.73 22.74 1.25 5.00
197 INT118196 Gene_expression of ROM1 18 0.66 4.81 1.19 5.00
198 INT23199 Binding of LDLR 22 0.47 17.08 1.16 5.00
199 INT36179 Regulation of GLA 11 0.44 6.56 1.12 5.00
200 INT159775 Negative_regulation of Gene_expression of Timp1 9 0.37 4.36 1.08 5.00
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