D:Food Poisoning

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Disease Term
Synonyms Food Poisonings, Infectious Diarrhea, INFECTIOUS DIARRHOEA, Intestinal Infection, Intestinal Infections, Intestine Infection, Intestine Infections, Poisoning Food, POISONINGS FOOD
Documents 287
Hot Single Events 36
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Food Poisoning. They are ordered first by their relevance to Food Poisoning and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT96805 Binding of ST8SIA2 and A4GALT 1 0.01 1.31 0.07 90.12
2 INT299592 SQLE Regulation of RatNP-3b 1 0.01 0.99 0.22 88.60
3 INT299556 SQLE Regulation of CRS 1 0.00 0.77 0.03 76.60
4 INT323386 Negative_regulation of Binding of Lta and Coq10a 1 0.10 0.57 0 63.56
5 INT323385 Binding of Lta and Coq10a 1 0.09 0.56 0 62.40
6 INT217529 Dss1 Negative_regulation of Gene_expression of Tjp1 1 0.07 0.54 0.04 44.56
7 INT229820 Fos Positive_regulation of Gene_expression of Ghrl 1 0.02 0.05 0.05 31.56
8 INT355857 Binding of Span and SETBP1 1 0.00 0.17 0.04 30.24
9 INT272859 Binding of HRAS and M1 1 0.00 0.33 0 27.68
10 INT101591 Binding of RAC1 and RAC3 1 0.13 0.52 0 25.00
11 INT275850 Binding of NDUFAB1 and SNCA 1 0.00 3.78 3.16 5.00
12 INT275851 PES1 Negative_regulation of CP 1 0.01 1.96 1.83 5.00
13 INT185417 Binding of ALOX5 and PLA2G2A 4 0.16 3.13 0.9 5.00
14 INT275849 PES1 Positive_regulation of Gene_expression of TNFAIP1 1 0.01 1.28 0.42 5.00
15 INT258574 Cysltr1 Positive_regulation of Positive_regulation of Cnr1 1 0.01 0.07 0.32 5.00
16 INT299557 Binding of CRS and SQLE 1 0.00 0.7 0.29 5.00
17 INT217528 Binding of Tjp1 and Vapb 1 0.00 1.6 0.19 5.00
18 INT355829 Binding of SETBP1 and LIN9 1 0.00 0.06 0.17 5.00
19 INT185455 MUC1 Negative_regulation of Timp1 1 0.06 0.84 0.13 5.00
20 INT185454 IGHG1 Negative_regulation of Timp1 1 0.04 0.85 0.13 5.00
21 INT185416 MUC1 Negative_regulation of TIMP1 1 0.18 0.84 0.13 5.00
22 INT185418 IGHG1 Negative_regulation of TIMP1 1 0.11 0.84 0.13 5.00
23 INT217530 Binding of Tjp1 and Tjp2 1 0.10 0.91 0.1 5.00
24 INT320659 Vsig2 Positive_regulation of Transcription of Nos2 1 0.07 0.65 0.07 5.00
25 INT355828 Binding of MFGE8 and SEA 1 0.01 0.07 0.07 5.00
26 INT229822 Fos Positive_regulation of Gene_expression of Pyy 1 0.54 0 0.05 5.00
27 INT229823 Fos Positive_regulation of Gene_expression of Ppy 1 0.41 0 0.05 5.00
28 INT229808 Fos Positive_regulation of Gene_expression of Cck 1 0.39 0 0.05 5.00
29 INT229812 Fos Positive_regulation of Sec61a1 1 0.17 0.5 0.04 5.00
30 INT310041 Gtf3a Positive_regulation of Met 1 0.00 0.15 0.03 5.00
31 INT229811 Fos Positive_regulation of Fabp1 1 0.57 0.2 0.03 5.00
32 INT310040 Hgf Positive_regulation of Met 1 0.06 0.15 0.03 5.00
33 INT229815 Fos Regulation of Bad 1 0.09 0.31 0 5.00
34 INT310044 Binding of Hgf and Slc30a4 1 0.08 0.38 0 5.00
35 INT229825 Fos Positive_regulation of Mt2A 1 0.41 0.71 0 5.00
36 INT229818 Fos Positive_regulation of Hmox1 1 0.43 0.37 0 5.00
37 INT229813 Fos Positive_regulation of Glp1r 1 0.03 0 0 5.00
38 INT299946 Binding of Tlr4 and Synj2bp 1 0.00 0.28 0 5.00
39 INT310043 Binding of Met and Slc30a4 1 0.05 0.35 0 5.00
40 INT229814 Fos Positive_regulation of Pla2g1b 1 0.12 0.27 0 5.00
41 INT310042 Binding of Cdh1 and Lsr1 1 0.01 0.09 0 5.00
42 INT229827 Fos Positive_regulation of Mt1a 1 0.40 0.36 0 5.00
43 INT229824 Fos Regulation of Casp9 1 0.07 0.32 0 5.00
44 INT229821 Fos Positive_regulation of Bax 1 0.15 0.27 0 5.00
45 INT185453 Binding of PRKCB and Lhx1 1 0.35 1.99 0 5.00
46 INT229809 Fos Regulation of Casp3 1 0.06 0.32 0 5.00
47 INT229817 Fos Positive_regulation of Dnase1 1 0.23 0.27 0 5.00
48 INT229807 Fos Regulation of Casp2 1 0.04 0.32 0 5.00
49 INT229863 Fos Positive_regulation of GSTK1 1 0.03 0.37 0 5.00
50 INT229816 Fos Regulation of Bcl2 1 0.13 0.31 0 5.00
51 INT264936 Binding of TRGV9 and Ggt1 1 0.02 0.1 0 5.00
52 INT229826 Fos Positive_regulation of Sod1 1 0.42 0.38 0 5.00
53 INT229810 Fos Positive_regulation of Sod3 1 0.40 0.38 0 5.00
54 INT310039 Binding of Cdh1 and Slc30a4 1 0.04 0.46 0 5.00
55 INT291419 Binding of GSTM1 and Gopc 1 0.03 0.06 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Food Poisoning. They are ordered first by their pain relevance and then by number of times they were reported in Food Poisoning. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT191018 Positive_regulation of Gene_expression of Cd79a 12 0.26 8.01 1.05 99.98
2 INT95929 Binding of Cfp 6 0.27 7.12 0.74 99.90
3 INT355463 Gene_expression of SPRED1 1 0.56 6.96 0.24 99.84
4 INT8388 Positive_regulation of Vip 142 0.70 39.72 67.61 99.60
5 INT8724 Positive_regulation of Mln 21 0.66 14.12 6.17 99.60
6 INT243545 Positive_regulation of PSPH 3 0.14 1.05 0 99.54
7 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 99.52
8 INT243551 Negative_regulation of PSPH 1 0.04 0.97 0 99.48
9 INT63839 Binding of CRS 31 0.41 34.05 4.7 99.02
10 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 98.22
11 INT3364 Binding of SGCG 87 0.47 31.93 17.24 98.22
12 INT74375 Positive_regulation of Gene_expression of Cnr1 24 0.70 14.25 13.66 97.88
13 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7 97.48
14 INT275863 Phosphorylation of PES1 1 0.37 0.45 0 93.52
15 INT177778 Gene_expression of SQLE 28 0.40 16.42 2.08 91.08
16 INT82033 Gene_expression of Isyna1 2 0.12 0.95 1.33 90.64
17 INT113676 Gene_expression of NRP1 22 0.72 10.81 1.71 90.48
18 INT4931 Localization of IFNG 53 0.78 33.25 13.65 90.24
19 INT36338 Gene_expression of NRP2 29 0.67 6.47 2.4 90.16
20 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 89.84
21 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 89.84
22 INT14502 Gene_expression of BCHE 40 0.67 18.52 4.6 89.80
23 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 88.32
24 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 88.04
25 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 87.88
26 INT5286 Gene_expression of ANTXR2 46 0.75 21.06 3.41 87.60
27 INT93878 Positive_regulation of Lipc 4 0.47 3.09 0.11 84.16
28 INT20981 Binding of HRAS 42 0.48 24.49 4.23 83.88
29 INT152616 Gene_expression of SPECC1 8 0.66 8.43 4.32 82.72
30 INT153706 Gene_expression of CLDN7 5 0.49 3.02 1.26 80.76
31 INT310010 Gene_expression of Slc30a4 1 0.33 2.95 0.13 80.56
32 INT310003 Positive_regulation of Gene_expression of Slc30a4 1 0.21 0.85 0 80.56
33 INT246406 Binding of SETBP1 5 0.43 3.79 0.69 80.40
34 INT196182 Localization of NRP2 9 0.46 3.61 0.8 80.28
35 INT265800 Localization of NRP1 14 0.75 3.66 0.69 80.28
36 INT299578 Localization of RatNP-3b 1 0.07 0.77 0.08 80.28
37 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 79.36
38 INT75713 Positive_regulation of Mcpt2 9 0.69 5.93 2.16 78.96
39 INT7994 Gene_expression of Lta 113 0.67 69.81 19.59 78.20
40 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 77.76
41 INT191017 Localization of Cd79a 28 0.56 13.94 2.55 77.60
42 INT62044 Binding of Lta 16 0.30 7.49 1.01 76.56
43 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 76.08
44 INT23257 Regulation of CRP 127 0.62 100.05 21.87 76.08
45 INT355774 Negative_regulation of Regulation of CRP 1 0.15 0.64 0.15 76.08
46 INT344265 Regulation of CCL7 1 0.04 0.55 0.16 76.00
47 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 75.76
48 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 75.76
49 INT6058 Localization of Fos 73 0.81 16.7 30.84 75.64
50 INT114880 Negative_regulation of Cdk2 7 0.35 3.89 0.77 75.36
51 INT179860 Positive_regulation of Msts1 1 0.00 0.82 0 75.32
52 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 75.00
53 INT11773 Gene_expression of Tac1 56 0.77 10 25.72 75.00
54 INT24956 Gene_expression of Tacr3 22 0.74 7.21 13.37 75.00
55 INT191265 Gene_expression of PES1 2 0.30 2.5 1.35 73.44
56 INT258780 Regulation of Il23a 6 0.13 4.77 1.96 72.24
57 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 70.16
58 INT87976 Regulation of Gene_expression of Cnr1 9 0.58 6.87 7.51 67.44
59 INT92632 Gene_expression of Vsig2 48 0.50 19.93 3.04 65.92
60 INT50308 Binding of Cnr1 61 0.48 14.41 33.52 65.76
61 INT125446 Negative_regulation of Positive_regulation of CLDN4 2 0.59 2.14 1.3 65.16
62 INT125447 Positive_regulation of CLDN4 14 0.70 4.71 4.45 63.64
63 INT20228 Negative_regulation of Gene_expression of Lta 8 0.22 3.81 1.03 63.56
64 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 63.28
65 INT20212 Binding of Cd79a 10 0.23 3.96 0.17 61.96
66 INT299944 Regulation of Gene_expression of Synj2bp 1 0.01 1.31 0.32 61.88
67 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35 61.64
68 INT106939 Gene_expression of Zic3 1 0.00 0.14 0.69 61.64
69 INT299942 Gene_expression of Synj2bp 1 0.01 1.3 0.32 61.36
70 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 61.32
71 INT179859 Gene_expression of Msts1 2 0.09 0.57 0.06 60.40
72 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 59.44
73 INT204768 Regulation of Gene_expression of Il23a 3 0.11 1.25 0.41 59.44
74 INT119223 Gene_expression of EPHA1 3 0.55 2.59 0.06 59.20
75 INT62046 Negative_regulation of Lta 8 0.43 4.42 1.67 57.60
76 INT196158 Binding of NRP2 16 0.06 7.03 1.73 57.12
77 INT139205 Binding of NRP1 27 0.45 4.34 0.71 56.48
78 INT33661 Regulation of Tbpl1 7 0.44 5.36 3.26 53.76
79 INT43009 Gene_expression of Scn7a 45 0.68 7.85 10.29 53.56
80 INT37540 Localization of MSMB 5 0.60 1.17 0.68 52.40
81 INT355846 Negative_regulation of Binding of CES1 1 0.01 0.72 0.11 51.80
82 INT71418 Binding of CES1 42 0.40 29.78 5.01 51.36
83 INT355854 Binding of TARP 1 0.03 0.73 0.11 51.20
84 INT217503 Regulation of Gene_expression of Dss1 2 0.30 0.99 0.2 50.72
85 INT29821 Gene_expression of Serpina1 18 0.60 2.98 5.75 50.00
86 INT47885 Gene_expression of Max 5 0.65 0.54 1.84 50.00
87 INT217514 Gene_expression of Dss1 12 0.47 7.6 1.35 50.00
88 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 49.88
89 INT29832 Negative_regulation of Scn7a 20 0.37 5.91 3.63 49.76
90 INT267670 Regulation of Nexn 4 0.39 3.95 0.04 48.72
91 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 45.56
92 INT169561 Negative_regulation of Dss1 8 0.28 4.92 1.01 45.08
93 INT159141 Negative_regulation of Gene_expression of Tjp1 7 0.57 5.44 0.62 44.04
94 INT239068 Regulation of SEA 3 0.07 1.37 0.31 43.96
95 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 43.76
96 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 43.76
97 INT149031 Gene_expression of Tjp1 43 0.75 19.1 2.06 43.32
98 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 42.88
99 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84 41.08
100 INT75841 Binding of Trav6-3 66 0.47 29.14 7.63 39.72
101 INT28528 Gene_expression of MSMB 25 0.65 7.66 3.49 38.72
102 INT355851 Negative_regulation of SETBP1 1 0.52 0.5 0.21 36.80
103 INT102659 Gene_expression of CSF3 32 0.77 21.93 2.39 35.20
104 INT207496 Regulation of Gene_expression of Scn7a 8 0.04 1.1 0.89 33.76
105 INT117570 Positive_regulation of Gene_expression of Scn7a 7 0.43 1.4 0.77 33.76
106 INT217525 Gene_expression of SMPD2 9 0.75 1.9 0.35 33.76
107 INT217524 Regulation of Gene_expression of SMPD2 1 0.44 0.53 0.06 33.76
108 INT217526 Positive_regulation of Gene_expression of SMPD2 1 0.49 0.53 0.06 33.76
109 INT79711 Binding of M1 11 0.27 3.77 0.58 32.64
110 INT22875 Regulation of CRS 16 0.39 14.33 2.69 31.56
111 INT61893 Gene_expression of Ghrl 125 0.75 71.49 15.14 30.92
112 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 29.00
113 INT355843 Positive_regulation of Gene_expression of SETBP1 1 0.45 1.01 0.33 29.00
114 INT299579 Gene_expression of RatNP-3b 2 0.09 0.39 0.17 28.48
115 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 28.08
116 INT355844 Negative_regulation of Gene_expression of SETBP1 1 0.38 0.18 0.04 28.08
117 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 27.84
118 INT117546 Gene_expression of SETBP1 5 0.69 3.31 1.7 27.68
119 INT165871 Negative_regulation of Gene_expression of Vsig2 2 0.24 0.83 0.32 26.96
120 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 26.92
121 INT197 Gene_expression of Hrh2 24 0.63 12.35 8.37 25.00
122 INT23665 Gene_expression of St8sia2 14 0.58 6.74 1.08 25.00
123 INT177775 Negative_regulation of SQLE 7 0.06 5.97 0.04 24.84
124 INT294953 Negative_regulation of PPYR1 1 0.03 0.63 0.48 22.72
125 INT355849 Regulation of Gene_expression of SETBP1 1 0.40 0.58 0.04 22.32
126 INT103456 Positive_regulation of SMPD2 4 0.49 1.85 0.55 21.20
127 INT205215 Localization of Tjp1 2 0.29 0.95 0.35 20.28
128 INT63296 Positive_regulation of TRGV9 3 0.60 1.39 0.42 19.36
129 INT264935 Localization of TRGV9 3 0.64 0.65 0.09 13.92
130 INT25602 Positive_regulation of THPO 5 0.69 4.55 0.57 12.52
131 INT299574 Localization of SQLE 1 0.10 1.41 0.32 11.84
132 INT7147 Localization of Vsig2 7 0.49 4.42 0.86 8.40
133 INT159146 Regulation of Gene_expression of Tjp1 13 0.44 6.91 0.45 7.12
134 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 5.00
135 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
136 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 5.00
137 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
138 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 5.00
139 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
140 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
141 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
142 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 5.00
143 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
144 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
145 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
146 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 5.00
147 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
148 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
149 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
150 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9 5.00
151 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
152 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 5.00
153 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
154 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
155 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
156 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
157 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
158 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 5.00
159 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
160 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
161 INT5587 Regulation of Fos 191 0.62 40.81 99.7 5.00
162 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
163 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
164 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4 5.00
165 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 5.00
166 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
167 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
168 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
169 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
170 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
171 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
172 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
173 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
174 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
175 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
176 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
177 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
178 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
179 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
180 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 5.00
181 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
182 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 5.00
183 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 5.00
184 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
185 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
186 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
187 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 5.00
188 INT2463 Localization of CCK 101 0.81 37.54 47.59 5.00
189 INT2406 Gene_expression of CCK 85 0.78 28.04 46.67 5.00
190 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
191 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
192 INT935 Localization of Gtf3a 124 0.70 35.72 43.3 5.00
193 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
194 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
195 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
196 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
197 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
198 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
199 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
200 INT23330 Binding of Chrna7 79 0.48 10.06 35.5 5.00
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