D:Foot Deformities

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Disease Term
Synonyms Cavus Deformities, CAVUS DEFORMITY, DEFORMITIES CAVUS, Deformities Foot, Deformities Metatarsal, Deformity Cavus, DEFORMITY FOOT, Deformity Metatarsal, FOOT DEFORMITY, METATARSAL DEFORMITIES, Metatarsal Deformity
Documents 261
Hot Single Events 20
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Foot Deformities. They are ordered first by their relevance to Foot Deformities and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT28816 Binding of TRPV4 and MND1 1 0.27 0.52 0.1 94.28
2 INT164249 Binding of MPZ and Mpz 1 0.06 2.13 0.24 80.88
3 INT283544 Binding of GARS and Bscl2 1 0.01 1.74 0 65.20
4 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1 5.00
5 INT110835 Binding of SPTLC2 and SPTLC1 2 0.42 1.36 0.68 5.00
6 INT110834 Binding of AGXT and SPTLC2 2 0.27 0.71 0.36 5.00
7 INT229785 Binding of RAB7A and SPTLC1 1 0.40 1.5 0.27 5.00
8 INT266006 Binding of COL5A2 and SGCG 1 0.00 0.89 0.23 5.00
9 INT266005 Binding of DIO3 and SGCG 1 0.00 0.86 0.22 5.00
10 INT266003 Binding of COL5A2 and DIO3 1 0.01 0.43 0.11 5.00
11 INT283539 Binding of Litaf and Mad2l1bp 1 0.00 0.67 0.11 5.00
12 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
13 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
14 INT307665 Binding of Mpz and Pmp22 1 0.34 0.39 0.08 5.00
15 INT307666 Binding of Pmp22 and Gjb1 1 0.31 0.38 0.08 5.00
16 INT307663 Binding of Pmp22 and Egr2 1 0.33 0.39 0.08 5.00
17 INT307664 Binding of Pmp22 and LOC689781 1 0.03 0.39 0.08 5.00
18 INT246539 EGF Negative_regulation of Gene_expression of PDGFA 1 0.06 0.38 0.07 5.00
19 INT246538 PDGFA Negative_regulation of Gene_expression of EGF 1 0.06 0.38 0.07 5.00
20 INT194324 Binding of MPZ and MAD2L1BP 1 0.02 0.62 0.04 5.00
21 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
22 INT283543 Binding of GARS and Setx 1 0.01 3.71 0 5.00
23 INT329013 Binding of LITAF and Nedd4 1 0.15 1.4 0 5.00
24 INT238270 Binding of VMO1 and MSLNL 1 0.11 0.42 0 5.00
25 INT194333 Binding of MFN2 and Racgap1 1 0.01 0.38 0 5.00
26 INT283542 Binding of SPG19 and Setx 1 0.06 3.69 0 5.00
27 INT329004 Binding of MPZ and RNF123 1 0.00 0.7 0 5.00
28 INT329012 Binding of MPZ and Nedd4 1 0.03 0.7 0 5.00
29 INT329008 Binding of LITAF and RNF123 1 0.01 1.39 0 5.00
30 INT308030 Binding of Mpz and ASPM 1 0.02 0.55 0 5.00
31 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00
32 INT329005 Binding of TSG101 and LITAF 1 0.04 1.41 0 5.00
33 INT308029 ASPM Positive_regulation of Regulation of Mpz 1 0.02 0.55 0 5.00
34 INT251822 Binding of POLG and C10orf2 1 0.42 0.29 0 5.00
35 INT283533 Binding of GARS and SPG19 1 0.00 1.72 0 5.00
36 INT329007 Binding of MPZ and TSG101 1 0.01 0.71 0 5.00
37 INT210285 Ccrs1 Regulation of RAI1 1 0.00 0.37 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Foot Deformities. They are ordered first by their pain relevance and then by number of times they were reported in Foot Deformities. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT283534 Negative_regulation of Ncs1 2 0.25 0.79 0.17 98.64
2 INT81955 Positive_regulation of SPTLC1 12 0.70 10.25 3.12 97.96
3 INT283541 Binding of GARS 1 0.01 3.33 0.04 97.60
4 INT144380 Gene_expression of SYNE1 12 0.58 6.99 1.55 94.56
5 INT68216 Binding of NF1 40 0.48 51.24 4.59 94.44
6 INT28817 Binding of TRPV4 6 0.39 3.92 2.59 94.28
7 INT199641 Regulation of Transcription of Fxn 1 0.29 1.89 0.04 92.28
8 INT199648 Regulation of Fxn 1 0.29 2.14 0.04 92.28
9 INT199646 Transcription of Fxn 2 0.67 4.78 0.08 91.60
10 INT308024 Negative_regulation of Icmt 1 0.06 0.59 0.05 90.08
11 INT228409 Localization of DSP 5 0.73 2.39 0.11 88.80
12 INT240786 Binding of Bcl2a1c 10 0.18 9.47 0.12 88.00
13 INT242911 Localization of Bcl2a1c 2 0.36 1.48 0.11 86.44
14 INT26273 Negative_regulation of RYR1 18 0.43 7.64 3.11 86.16
15 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74 83.56
16 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 80.96
17 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 80.96
18 INT114330 Binding of MPZ 21 0.32 25.58 2.14 80.88
19 INT308025 Positive_regulation of Gdap1 1 0.39 1.05 0.14 80.52
20 INT49082 Gene_expression of MPZ 15 0.65 31.26 2.24 80.24
21 INT257840 Negative_regulation of Gene_expression of UBA1 1 0.35 0.4 0.17 79.96
22 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 79.84
23 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 79.84
24 INT308023 Gene_expression of Gdap1 1 0.65 1.13 0.14 78.68
25 INT257841 Gene_expression of UBA1 1 0.56 0.4 0.16 78.44
26 INT251827 Regulation of POLG 3 0.59 2.94 0.04 77.04
27 INT39690 Positive_regulation of DIO3 2 0.02 0.48 0.06 76.96
28 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48 76.60
29 INT164248 Positive_regulation of MPZ 18 0.67 24.54 2.16 75.36
30 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 75.04
31 INT114911 Positive_regulation of Mpz 3 0.23 1.46 0.8 74.96
32 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 72.88
33 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36 69.88
34 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 69.20
35 INT58857 Positive_regulation of Positive_regulation of CHKB 5 0.43 2.77 0.19 69.20
36 INT108968 Regulation of Mpz 6 0.54 2.9 0.7 66.84
37 INT257288 Regulation of Gene_expression of COL5A2 7 0.21 2.52 0.36 65.00
38 INT251831 Positive_regulation of C10orf2 1 0.50 1.23 0.08 64.52
39 INT251829 Positive_regulation of POLG 1 0.53 1.5 0.08 63.04
40 INT172411 Regulation of SV2A 3 0.22 0.93 0.61 62.64
41 INT233102 Regulation of VMO1 4 0.34 2.7 2.25 62.24
42 INT242910 Positive_regulation of Positive_regulation of Bcl2a1c 2 0.05 2.24 0.06 59.80
43 INT240787 Positive_regulation of Bcl2a1c 12 0.22 9.79 0.06 58.76
44 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 58.40
45 INT200465 Negative_regulation of Regulation of SERPINB6 1 0.35 1.37 0.25 57.96
46 INT200463 Regulation of SERPINB6 9 0.25 3.46 1.25 57.36
47 INT115304 Regulation of SNAP25 7 0.60 1.24 0.95 57.36
48 INT164512 Regulation of MPZ 12 0.30 8.38 1.53 57.04
49 INT85624 Gene_expression of GJB1 5 0.78 3.03 0.93 50.96
50 INT283537 Binding of Bscl2 1 0.36 0.48 0.09 49.16
51 INT246642 Binding of CLTCL1 3 0.17 1.32 0.63 47.12
52 INT93956 Binding of HBM 20 0.35 8.86 1.48 46.80
53 INT320805 Gene_expression of SLC26A2 1 0.57 1.1 0.19 45.04
54 INT251828 Negative_regulation of C10orf2 3 0.37 2.87 0.41 41.40
55 INT105993 Gene_expression of IDS 26 0.78 10.83 2.41 39.40
56 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 37.80
57 INT13218 Gene_expression of Litaf 2 0.52 0.8 0.09 36.16
58 INT283538 Regulation of Gene_expression of Litaf 1 0.24 0.43 0 36.16
59 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23 35.20
60 INT84248 Gene_expression of MPEG1 5 0.48 3.38 0.66 34.80
61 INT307661 Regulation of Mfn2 1 0.39 0.47 0.08 34.16
62 INT39060 Gene_expression of Mpz 45 0.77 21.55 4.3 32.88
63 INT200467 Binding of SERPINB6 2 0.30 0.14 0.31 28.00
64 INT307660 Positive_regulation of Pmp22 1 0.42 0.06 0 26.08
65 INT63164 Negative_regulation of Cst7 51 0.50 18.48 20.3 24.68
66 INT91099 Gene_expression of MFN2 2 0.67 1.32 0.07 19.20
67 INT196714 Binding of VMO1 4 0.30 1.51 1.46 13.12
68 INT213672 Positive_regulation of LRFN2 1 0.01 0.59 0.03 12.40
69 INT70895 Localization of PDGFB 20 0.52 8.98 3.4 11.44
70 INT22375 Localization of PDGFA 21 0.75 15.46 3.25 11.44
71 INT213671 Positive_regulation of COX4I1 1 0.00 0.58 0.03 11.28
72 INT213669 Positive_regulation of COL4A3 2 0.00 1.24 0.23 10.80
73 INT213673 Negative_regulation of ATP6V1A 1 0.02 0.49 0 10.32
74 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 9.40
75 INT173592 Binding of COL5A2 32 0.33 9.14 2.48 8.96
76 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
77 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
78 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
79 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
80 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
81 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
82 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
83 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
84 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
85 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 5.00
86 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
87 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
88 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
89 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
90 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
91 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
92 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
93 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
94 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
95 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
96 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
97 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
98 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
99 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
100 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
101 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 5.00
102 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
103 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
104 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 5.00
105 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
106 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43 5.00
107 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
108 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
109 INT39712 Binding of pad 82 0.48 110.92 10.33 5.00
110 INT70896 Gene_expression of PDGFB 48 0.65 33.55 8.39 5.00
111 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 5.00
112 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
113 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
114 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
115 INT91100 Binding of SPTLC1 10 0.47 12.85 5.71 5.00
116 INT113112 Negative_regulation of CXCR4 39 0.58 28.28 5.36 5.00
117 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 5.00
118 INT10100 Binding of ELANE 22 0.47 15.32 5.19 5.00
119 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 5.00
120 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
121 INT30031 Gene_expression of Hba-a1 7 0.60 7.46 4.41 5.00
122 INT57273 Positive_regulation of Gene_expression of FN1 26 0.47 17.83 4.2 5.00
123 INT173910 Gene_expression of LRP2 24 0.75 19.99 4.09 5.00
124 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 5.00
125 INT78203 Gene_expression of PMP22 12 0.63 7.49 3.58 5.00
126 INT229788 Negative_regulation of SPTLC1 1 0.38 4.82 3.53 5.00
127 INT145520 Positive_regulation of Dss1 16 0.39 14.04 3.38 5.00
128 INT52839 Regulation of Racgap1 14 0.25 9.46 3.37 5.00
129 INT1727 Gene_expression of Cndp2 22 0.74 4.28 3.34 5.00
130 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 5.00
131 INT37811 Negative_regulation of SERPINB6 8 0.47 4.65 3.15 5.00
132 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 5.00
133 INT196710 Positive_regulation of VMO1 9 0.64 3.49 3.08 5.00
134 INT123466 Binding of T2dm2 21 0.37 34.87 2.91 5.00
135 INT14448 Localization of COL5A2 34 0.67 17.35 2.85 5.00
136 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
137 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 5.00
138 INT115300 Negative_regulation of Napa 7 0.23 1 2.68 5.00
139 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
140 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 5.00
141 INT64734 Positive_regulation of Mpz 17 0.67 6.81 2.55 5.00
142 INT18848 Localization of LMOD1 5 0.69 1 2.49 5.00
143 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26 5.00
144 INT57360 Gene_expression of STAR 31 0.66 12.72 2.24 5.00
145 INT96762 Gene_expression of RAI1 9 0.56 5.77 2.17 5.00
146 INT88464 Negative_regulation of CST7 11 0.31 5.33 2.17 5.00
147 INT37809 Gene_expression of SERPINB6 7 0.77 6.58 2.12 5.00
148 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12 5.00
149 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02 5.00
150 INT131263 Negative_regulation of MPZ 12 0.49 7.11 1.94 5.00
151 INT128030 Gene_expression of GJA1 23 0.75 7.81 1.88 5.00
152 INT37810 Positive_regulation of Negative_regulation of SERPINB6 2 0.41 1.84 1.78 5.00
153 INT122895 Transcription of DIO2 3 0.52 0.91 1.73 5.00
154 INT72870 Negative_regulation of SPTLC2 7 0.57 1.82 1.73 5.00
155 INT171997 Gene_expression of ERAL1 5 0.25 4.97 1.67 5.00
156 INT31616 Protein_catabolism of DNM2 5 0.75 1.61 1.63 5.00
157 INT309257 Transcription of LMOD1 3 0.36 1.71 1.57 5.00
158 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 5.00
159 INT25771 Regulation of DSP 8 0.10 3.67 1.55 5.00
160 INT140245 Binding of Gli3 3 0.36 2.65 1.46 5.00
161 INT58930 Negative_regulation of RAC1 14 0.55 7.55 1.4 5.00
162 INT113111 Regulation of CXCR4 14 0.61 12.81 1.39 5.00
163 INT189092 Gene_expression of Tap1 56 0.76 14.09 1.33 5.00
164 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 5.00
165 INT229794 Positive_regulation of RAB7A 2 0.65 11.68 1.31 5.00
166 INT110838 Regulation of AGXT 5 0.46 2.21 1.28 5.00
167 INT229791 Gene_expression of RAB7A 2 0.73 6.48 1.21 5.00
168 INT9205 Binding of DSP 12 0.44 9.9 1.21 5.00
169 INT86670 Negative_regulation of AGXT 6 0.57 2.24 1.18 5.00
170 INT229792 Negative_regulation of Positive_regulation of RAB7A 1 0.40 1.49 1.17 5.00
171 INT229793 Negative_regulation of Positive_regulation of SPTLC1 1 0.43 1.49 1.17 5.00
172 INT70825 Positive_regulation of NINJ1 2 0.70 1.71 1.11 5.00
173 INT64732 Positive_regulation of Gene_expression of Mpz 9 0.50 3.99 1.11 5.00
174 INT70826 Localization of NINJ1 4 0.75 2.17 1.1 5.00
175 INT66043 Regulation of SPTLC2 3 0.44 1.62 1.09 5.00
176 INT229787 Gene_expression of AGXT 4 0.16 0.94 1.08 5.00
177 INT200462 Binding of IDS 13 0.31 4.95 1 5.00
178 INT69134 Positive_regulation of MPEG1 9 0.26 5.95 0.97 5.00
179 INT79115 Binding of Tap1 12 0.47 4.21 0.95 5.00
180 INT21660 Regulation of CHM 14 0.61 8.51 0.93 5.00
181 INT97174 Positive_regulation of SERPINB6 5 0.50 3.74 0.91 5.00
182 INT188317 Positive_regulation of Gene_expression of PDGFA 15 0.46 12.7 0.91 5.00
183 INT94563 Gene_expression of H2-Q10 7 0.42 7 0.88 5.00
184 INT210276 Positive_regulation of Gene_expression of PMP22 3 0.46 1.58 0.88 5.00
185 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87 5.00
186 INT238271 Binding of WSN 2 0.04 2.61 0.81 5.00
187 INT80498 Gene_expression of DSP 15 0.75 7.06 0.79 5.00
188 INT50687 Gene_expression of Aldoc 6 0.78 0.17 0.78 5.00
189 INT69744 Gene_expression of CDT1 3 0.65 1.6 0.75 5.00
190 INT140449 Positive_regulation of Tap1 5 0.68 1.84 0.74 5.00
191 INT229789 Regulation of RAB7A 4 0.42 7.09 0.72 5.00
192 INT229786 Transcription of SPTLC1 1 0.60 0.78 0.71 5.00
193 INT79034 Negative_regulation of GPI 7 0.58 3.94 0.66 5.00
194 INT66042 Positive_regulation of SPTLC2 2 0.68 0.97 0.66 5.00
195 INT63064 Gene_expression of PRM1 7 0.50 2.66 0.65 5.00
196 INT649 Positive_regulation of Afp 10 0.55 6.5 0.62 5.00
197 INT70824 Gene_expression of NINJ1 4 0.78 2.67 0.61 5.00
198 INT52347 Negative_regulation of CHM 17 0.58 13.03 0.59 5.00
199 INT196713 Gene_expression of VMO1 2 0.54 1.11 0.59 5.00
200 INT309253 Negative_regulation of Transcription of LMOD1 1 0.03 0.2 0.57 5.00
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