D:Fragile X Syndrome

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Disease Term
Synonyms AUTISM FRAGILE X SYNDROME, Chromosome X Fragility Syndrome, Escalante Syndrome, Fra X 28 Syndrome, Fra X Q27 28 Syndrome, FRA X Q27 SYNDROME, FRA X SYNDROME, FRAGILE SITE MENTAL RETARDATION 1, Fragile X Mental Retardation Syndrome, FRAGILE X SYNDROMES, Fragile Xq Syndrome
Documents 7
Hot Single Events 15
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Fragile X Syndrome. They are ordered first by their relevance to Fragile X Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT287612 Binding of Fmr1 and Dnajc13 1 0.01 0.84 0 97.12
2 INT287613 Binding of Fmr1 and Cysltr1 1 0.01 0.18 0.04 50.00
3 INT287620 Fmr1 Regulation of Gene_expression of Fxr2 1 0.43 0 0 50.00
4 INT287609 Fmr1 Regulation of Protein_catabolism of Dlg4 1 0.05 0.06 0 50.00
5 INT287606 Binding of Fxr1 and Fxr2 1 0.32 0 0 50.00
6 INT287605 Binding of Fmr1 and Kdm5d 1 0.01 0 0 50.00
7 INT287610 Binding of Fmr1 and Fxr1 1 0.46 0 0 50.00
8 INT287616 Ap3b1 Regulation of Binding of Fmr1 1 0.01 0 0 50.00
9 INT287611 Fmr1 Regulation of Gene_expression of Fxr1 1 0.38 0 0 50.00
10 INT287615 Ap3b1 Regulation of Binding of Fxr1 1 0.00 0 0 50.00
11 INT287617 Ap3b1 Regulation of Fxr1 1 0.00 0 0 50.00
12 INT287619 Fmr1 Regulation of Dlg4 1 0.12 0.06 0 50.00
13 INT287614 Fxr2 Regulation of Gene_expression of Fxr1 1 0.24 0 0 50.00
14 INT287608 Binding of Fmr1 and Fxr2 1 0.52 0 0 50.00
15 INT352669 PRKDC Positive_regulation of Memor1 1 0.00 1.02 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Fragile X Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Fragile X Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT352662 Negative_regulation of Gene_expression of FMR1 1 0.31 1.05 0.03 99.44
2 INT34058 Gene_expression of FMR1 5 0.75 5.11 0.26 99.20
3 INT204463 Gene_expression of Fmr1 50 0.78 23.73 0.78 98.84
4 INT204468 Negative_regulation of Gene_expression of Fmr1 5 0.59 7.5 0.19 98.84
5 INT54527 Negative_regulation of Ap3b1 3 0.01 1.24 0.89 97.92
6 INT151540 Regulation of Fmr1 8 0.59 6.08 1.34 97.68
7 INT151543 Binding of Fmr1 56 0.48 19.4 1.65 97.60
8 INT151539 Negative_regulation of Fmr1 9 0.59 11.85 0.87 97.12
9 INT204467 Negative_regulation of Binding of Fmr1 3 0.57 1.43 0 97.12
10 INT287598 Binding of Dnajc13 1 0.00 0.83 0 97.12
11 INT204466 Negative_regulation of Regulation of Fmr1 2 0.43 0.97 0.08 96.52
12 INT151538 Positive_regulation of Fmr1 21 0.68 12.24 2.07 94.72
13 INT204452 Binding of Fxr1 10 0.40 4.48 0.45 91.36
14 INT36915 Gene_expression of Neo1 39 0.36 7.28 1.31 84.56
15 INT204460 Positive_regulation of Gene_expression of Fmr1 7 0.61 6.19 0.03 82.76
16 INT287580 Binding of Mex3c 1 0.00 0.29 0 78.88
17 INT287573 Negative_regulation of Binding of Mex3c 1 0.01 0.15 0 78.88
18 INT287592 Positive_regulation of Regulation of Fmr1 1 0.50 0.61 0 75.20
19 INT100383 Binding of FRA10AC1 2 0.01 1.2 0.42 75.00
20 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 74.72
21 INT287572 Positive_regulation of Fxr1 1 0.42 0.07 0.03 69.20
22 INT287578 Positive_regulation of Fxr2 1 0.47 0.07 0.03 69.20
23 INT287567 Negative_regulation of Negative_regulation of Fmr1 1 0.43 0.14 0 68.72
24 INT170988 Positive_regulation of CYSLTR1 15 0.34 6.23 4.44 65.52
25 INT339011 Negative_regulation of Positive_regulation of Fmr1 1 0.43 2.18 0 62.92
26 INT246552 Transcription of Fmr1 11 0.72 6.72 0.71 52.04
27 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52 50.00
28 INT33358 Gene_expression of Cysltr1 46 0.62 24.18 13.36 50.00
29 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 50.00
30 INT116163 Gene_expression of S1pr1 29 0.78 14.11 7.27 50.00
31 INT28424 Regulation of Cysltr1 17 0.41 7.33 6.34 50.00
32 INT183402 Positive_regulation of Gene_expression of Tbx15 7 0.49 4.87 1.62 50.00
33 INT165368 Positive_regulation of Gene_expression of Cysltr1 8 0.46 2.47 1.35 50.00
34 INT16854 Gene_expression of Uts2r 17 0.26 3.1 1.31 50.00
35 INT85168 Negative_regulation of Om 5 0.02 0.32 0.72 50.00
36 INT287566 Gene_expression of Sar1b 5 0.47 3.94 0.2 50.00
37 INT181059 Gene_expression of Rnase1 5 0.25 0.98 0.19 50.00
38 INT287577 Positive_regulation of Transcription of Fmr1 2 0.48 2.5 0.16 50.00
39 INT138871 Positive_regulation of Efemp2 2 0.18 1.12 0.15 50.00
40 INT198738 Protein_catabolism of Dlg4 5 0.97 0.06 0.12 50.00
41 INT204442 Regulation of Gene_expression of Fmr1 2 0.44 0.3 0.08 50.00
42 INT204457 Regulation of Binding of Fmr1 2 0.45 0.4 0.06 50.00
43 INT287587 Regulation of Negative_regulation of Fmr1 1 0.45 0.46 0.05 50.00
44 INT204443 Gene_expression of Fxr2 2 0.73 1.13 0.03 50.00
45 INT287584 Localization of Fxr2 1 0.71 0 0 50.00
46 INT287597 Binding of Mex3b 1 0.01 0 0 50.00
47 INT287589 Regulation of Binding of Fxr1 1 0.37 0 0 50.00
48 INT287594 Negative_regulation of Pkn1 1 0.01 0.12 0 50.00
49 INT287576 Binding of Nova1 1 0.47 0 0 50.00
50 INT287593 Binding of Fxr2 1 0.45 0 0 50.00
51 INT287591 Gene_expression of Fxr1 1 0.64 0 0 50.00
52 INT204446 Localization of Fmr1 5 0.79 1.12 0 50.00
53 INT287569 Positive_regulation of Gene_expression of Fxr2 1 0.47 0.61 0 50.00
54 INT287596 Negative_regulation of Fxr1 1 0.36 0 0 50.00
55 INT287582 Negative_regulation of Fxr2 1 0.41 0 0 50.00
56 INT287585 Regulation of Binding of Fxr2 1 0.42 0 0 50.00
57 INT287575 Localization of Fxr1 1 0.62 0 0 50.00
58 INT287579 Positive_regulation of Binding of Fmr1 1 0.50 0 0 50.00
59 INT38788 Negative_regulation of CYSLTR1 8 0.42 4.5 1.16 41.28
60 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 35.52
61 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 29.68
62 INT119132 Regulation of Grm5 8 0.48 2.66 5.46 28.12
63 INT349397 Positive_regulation of Transcription of CISH 1 0.03 0.05 0 8.68
64 INT206245 Transcription of CISH 1 0.14 1.64 0.26 8.04
65 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
66 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37 5.00
67 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 5.00
68 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
69 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
70 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
71 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6 5.00
72 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 5.00
73 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
74 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1 5.00
75 INT179753 Gene_expression of SLC1A2 28 0.59 13.72 8.71 5.00
76 INT165460 Gene_expression of SLC1A3 15 0.75 7.19 5.43 5.00
77 INT107390 Negative_regulation of Grm5 11 0.45 6 4.42 5.00
78 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 5.00
79 INT179756 Positive_regulation of Gene_expression of SLC1A2 8 0.38 2.95 3.06 5.00
80 INT250283 Positive_regulation of SLC1A2 5 0.53 3.22 2.29 5.00
81 INT82587 Positive_regulation of Gene_expression of GRIN1 8 0.67 3.66 2.18 5.00
82 INT165459 Positive_regulation of SLC1A3 3 0.49 1.08 1.73 5.00
83 INT84722 Regulation of Gene_expression of AR 20 0.61 7.73 1.69 5.00
84 INT179752 Positive_regulation of Gene_expression of SLC1A3 3 0.17 2.35 1.56 5.00
85 INT147873 Negative_regulation of Gene_expression of GRIN1 8 0.58 2.3 1.46 5.00
86 INT64065 Gene_expression of Btg3 5 0.65 12.62 1.41 5.00
87 INT82932 Transcription of AR 14 0.67 5.75 1.34 5.00
88 INT125525 Positive_regulation of PRKDC 7 0.45 2.72 1.21 5.00
89 INT322822 Regulation of GRIA3 4 0.61 1.19 1.11 5.00
90 INT207773 Negative_regulation of GRIA1 2 0.57 0.85 0.97 5.00
91 INT17574 Binding of CISH 23 0.31 4.3 0.93 5.00
92 INT170813 Gene_expression of Prdm6 11 0.65 4.35 0.88 5.00
93 INT352657 Transcription of SLC1A2 1 0.06 0.76 0.8 5.00
94 INT352660 Transcription of SLC1A3 1 0.05 0.76 0.8 5.00
95 INT125526 Gene_expression of PRKDC 5 0.58 4 0.74 5.00
96 INT322816 Transcription of GRIA3 2 0.71 0.75 0.7 5.00
97 INT188137 Regulation of CISH 7 0.04 0.97 0.6 5.00
98 INT352656 Positive_regulation of Transcription of SLC1A2 1 0.04 0.39 0.43 5.00
99 INT352659 Positive_regulation of Transcription of SLC1A3 1 0.04 0.39 0.43 5.00
100 INT352667 Positive_regulation of Transcription of GRIA3 1 0.08 0.39 0.42 5.00
101 INT352661 Positive_regulation of GRIA3 1 0.12 0.33 0.41 5.00
102 INT230973 Gene_expression of SLC25A12 2 0.36 1.7 0.4 5.00
103 INT322433 Regulation of CGF1 8 0.12 5.94 0.37 5.00
104 INT125524 Positive_regulation of Gene_expression of PRKDC 2 0.09 1 0.29 5.00
105 INT352664 Binding of SLC25A12 1 0.15 0.69 0.22 5.00
106 INT352654 Binding of BPTF 1 0.01 0.95 0.22 5.00
107 INT352655 Positive_regulation of Gene_expression of SLC25A12 1 0.32 0.74 0.18 5.00
108 INT263859 Gene_expression of WSN 5 0.08 2.1 0.18 5.00
109 INT352666 Regulation of PRKDC 1 0.01 0.36 0.09 5.00
110 INT317918 Gene_expression of MAPK8IP2 2 0.59 1.43 0.09 5.00
111 INT199320 Positive_regulation of MAPK8IP2 2 0.28 1.5 0.08 5.00
112 INT352648 Regulation of gri 1 0.01 0.36 0.08 5.00
113 INT68693 Regulation of Gene_expression of HTT 3 0.45 0.72 0.06 5.00
114 INT352665 Regulation of Gene_expression of WSN 1 0.01 0.63 0.05 5.00
115 INT352653 Positive_regulation of Positive_regulation of PRKDC 1 0.01 0.56 0.03 5.00
116 INT352658 Negative_regulation of PRKDC 1 0.01 0.33 0 5.00
117 INT349396 Gene_expression of HDAC11 1 0.75 0 0 5.00
118 INT349395 Positive_regulation of Gene_expression of HDAC11 1 0.49 0 0 5.00
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