D:Frailty

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Disease Term
Synonyms AGE RELATED MUSCLE LOSS, Atrophy, Bed Rest Atrophy, Bedrest, CACHEXIA CANCER CACHEXIA, Congestive Heart Failure, GLUCOCORTICOID INDUCED MUSCLE LOSS, Hip Fracture, IMMOBILIZATION INDUCED ATROPHY, Joint Replacement, MUSCLE WASTING
Documents 6781
Hot Single Events 200
Hot Interactions 152

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Frailty. They are ordered first by their relevance to Frailty and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT266445 Binding of HEY1 and GOPC 1 0.00 2.92 0.04 100.00
2 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35 100.00
3 INT322201 Binding of OAP and SLC34A1 1 0.01 1.49 0.77 100.00
4 INT266452 Binding of Acot1 and GOPC 1 0.02 1.23 0.04 100.00
5 INT266454 Binding of HEY1 and Acot1 1 0.00 1.19 0.04 100.00
6 INT146964 Negative_regulation of TCF19 Negative_regulation of Nfkb1 1 0.12 1.3 0.31 100.00
7 INT146963 TCF19 Negative_regulation of Nfkb1 1 0.12 1.3 0.31 100.00
8 INT146962 TCF19 Regulation of Nfkb1 1 0.07 1.17 0.24 100.00
9 INT146961 TCF19 Regulation of Gene_expression of Nfkb1 1 0.12 1.17 0.24 100.00
10 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17 100.00
11 INT136408 Binding of Fkrp and LGMD2I 1 0.10 0.7 0 100.00
12 INT277315 Binding of Insr and Mbnl1 1 0.18 1.1 0 100.00
13 INT277310 Binding of Tnnt2 and Mbnl1 1 0.18 1.1 0 100.00
14 INT161048 Nrm Positive_regulation of Prdm4 1 0.56 1.47 0.86 100.00
15 INT65185 Binding of ATRX and Ssr1 1 0.03 1.68 0.49 100.00
16 INT65184 Binding of CSCI and Ssr1 1 0.04 1.67 0.48 100.00
17 INT95125 Binding of KCNA6 and SGCG 1 0.40 2.73 0.18 100.00
18 INT79985 Gdnf Negative_regulation of Negative_regulation of GAD1 1 0.04 0.46 0.04 100.00
19 INT79986 Gdnf Negative_regulation of Gene_expression of GAD1 1 0.03 0.46 0.04 100.00
20 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41 99.92
21 INT317128 Gene_expression of Ncs1 Negative_regulation of Csn 1 0.04 0.44 0 99.76
22 INT178576 CNTN2 Positive_regulation of DPYD 1 0.05 2.18 0.76 99.66
23 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75 99.66
24 INT178577 CNTN2 Positive_regulation of IL2RA 1 0.03 2.16 0.75 99.66
25 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75 99.66
26 INT178575 CNTN2 Positive_regulation of PTHLH Positive_regulation of Positive_regulation of PTHLH 1 0.26 2.16 0.75 99.66
27 INT148437 Binding of Bdnf and Ngf 2 0.32 1.9 1.17 99.48
28 INT148436 Binding of Gdnf and Ngf 1 0.35 1.14 0.4 99.48
29 INT148438 Binding of Bdnf and Ntf3 1 0.33 1.14 0.4 99.48
30 INT148435 Binding of Bdnf and Gdnf 2 0.35 1.9 1.17 99.48
31 INT266453 SNRNP70 Regulation of Acot1 1 0.00 0.53 0 99.36
32 INT171976 Il18 Positive_regulation of Gene_expression of IFNA1 1 0.01 1.37 0.64 99.36
33 INT90079 Ass1 Positive_regulation of Casp1 1 0.02 0.99 0.43 99.24
34 INT69709 NPL Positive_regulation of Localization of POMC 2 0.36 1.22 1.51 98.84
35 INT283543 Binding of GARS and Setx 1 0.01 3.71 0 98.68
36 INT283542 Binding of SPG19 and Setx 1 0.06 3.69 0 98.68
37 INT161769 Cck Regulation of Cckar 1 0.27 0.53 0.92 98.56
38 INT301311 GPR17 Negative_regulation of Binding of CYSLTR1 1 0.04 0.46 0.08 98.44
39 INT301303 GPR17 Negative_regulation of Binding of CYSLTR1 and CYSLTR1 1 0.03 0.46 0.08 98.44
40 INT301309 GPR17 Negative_regulation of CYSLTR1 1 0.04 0.46 0.08 98.44
41 INT301308 GPR17 Negative_regulation of Positive_regulation of CYSLTR1 1 0.04 0.46 0.08 98.44
42 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 98.24
43 INT327829 Aqp1 Regulation of Binding of Csf2 1 0.11 1 0.14 98.12
44 INT139619 Binding of Usp14 and Gm16381 1 0.04 1.01 0 98.00
45 INT144213 Nppa Positive_regulation of Localization of Calca 1 0.71 2.8 1.65 97.92
46 INT165568 Tnf Regulation of Gene_expression of Il1b 1 0.41 1.26 0.41 97.92
47 INT106154 Calca Positive_regulation of Nos1 1 0.29 0.2 0.68 97.68
48 INT187176 Binding of BSG and MMP1 1 0.09 1.18 1.08 97.56
49 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66 97.44
50 INT277308 Upf1 Regulation of Regulation of Celf1 1 0.00 1.05 0 97.32
51 INT240065 KCNIP3 Regulation of Transcription of PDYN 1 0.42 0.88 0.67 97.24
52 INT340563 Gopc Regulation of Phosphorylation of Mapk14 1 0.04 0.91 0 97.20
53 INT340565 Gopc Regulation of Phosphorylation of Mapk8 1 0.04 0.92 0 97.20
54 INT271717 Binding of Fut4 and Tlr4 1 0.01 0.3 0 97.16
55 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78 97.16
56 INT351076 IK Positive_regulation of Gene_expression of Ucp3 1 0.00 0.8 0.58 97.00
57 INT274864 Negative_regulation of Mapk1 Negative_regulation of Gene_expression of TNF 1 0.05 1.15 0.41 96.84
58 INT274867 Negative_regulation of Mapk1 Negative_regulation of TNF 1 0.03 1.15 0.41 96.84
59 INT189560 Binding of MBNL1 and CCNL1 1 0.12 0.22 0 96.72
60 INT108065 Negative_regulation of Binding of Ngf and IgG-2a 1 0.01 2.38 1.2 96.32
61 INT108067 Negative_regulation of Binding of NTRK1 and Ngf 1 0.06 2.38 1.2 96.32
62 INT303399 Binding of Jag1 and Myh3 1 0.50 0.85 0 95.16
63 INT303394 Binding of Myh3 and Mul1 1 0.04 0.38 0 95.00
64 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83 94.68
65 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91 94.68
66 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 94.40
67 INT328223 Mmp14 Regulation of Positive_regulation of Mmp13 1 0.07 0.69 0.29 94.24
68 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4 94.20
69 INT352518 Binding of FAT1 and Adipoq 1 0.01 2.79 0.2 94.12
70 INT352517 Binding of INS and Adipoq 1 0.09 1.32 0.07 94.12
71 INT320451 ECT Positive_regulation of Gene_expression of BDNF 1 0.05 1.21 0.49 93.94
72 INT108064 Binding of Ngf and IgG-2a 1 0.01 2.36 1.19 93.92
73 INT249479 Binding of Ephb1 and Grin2b 1 0.29 0.37 0.54 93.76
74 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66 93.60
75 INT165565 Tnf Regulation of Gene_expression of Sdf2l1 1 0.26 1.15 0.39 93.56
76 INT165567 Tnf Regulation of Gene_expression of Tgfb1 1 0.41 1.15 0.39 93.56
77 INT165566 Tnf Regulation of Gene_expression of Il6 1 0.32 1.15 0.39 93.56
78 INT328222 Mmp2 Regulation of Positive_regulation of Mmp13 1 0.05 0.69 0.28 93.40
79 INT327333 Binding of TNF and Fxr1 1 0.06 3.74 0.48 93.16
80 INT352500 Binding of FAT1 and INS 1 0.01 1.38 0.1 92.88
81 INT231116 Ros1 Positive_regulation of Protein_catabolism of Psmb8 1 0.00 1.14 0 92.48
82 INT283533 Binding of GARS and SPG19 1 0.00 1.72 0 92.48
83 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93 92.44
84 INT169477 TGFB3 Positive_regulation of Spink3 1 0.02 1.83 0.89 92.40
85 INT341479 Binding of SCN2A and SCN4A 1 0.37 1.29 0.98 92.24
86 INT341480 Binding of SCN1A and SCN4A 1 0.36 1.29 0.98 92.24
87 INT340566 Binding of Mstn and Mapk1 1 0.12 0.5 0 91.88
88 INT226209 Pik3cb Positive_regulation of Phosphorylation of Akt1 1 0.10 1.16 0.17 91.44
89 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48 90.92
90 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48 90.92
91 INT319963 Binding of IGFALS and Vcan 1 0.03 2.99 0.13 90.84
92 INT169478 TGFB3 Positive_regulation of Tgfa 1 0.01 0.9 0.44 90.32
93 INT299004 Binding of Il18 and Il1 1 0.04 1.16 0.58 90.16
94 INT340562 Mstn Positive_regulation of Mapk1 1 0.16 1.16 0.17 90.04
95 INT190775 Gene_expression of Il4 Negative_regulation of Positive_regulation of FOSL1 1 0.39 2.42 1.4 89.84
96 INT276887 MTOR Regulation of Ppargc1a 1 0.23 0.33 0 89.64
97 INT276868 MTOR Regulation of Gene_expression of MTUS1 1 0.01 0.33 0 89.64
98 INT321842 Binding of Ros1 and SCFV 1 0.01 1.34 0.54 89.60
99 INT171990 Binding of DMD and VDR 5 0.05 2.58 0.39 89.52
100 INT342265 Binding of VDR and HHIP 1 0.00 0.93 0 89.52
101 INT206619 Mtpn Positive_regulation of Igf1 1 0.04 0.17 0.05 89.28
102 INT130335 Binding of Mc4r and Nr3c2 1 0.06 1.87 0.5 89.16
103 INT169466 TGFB3 Positive_regulation of HRAS 1 0.03 0.89 0.43 88.96
104 INT169465 TGFB3 Positive_regulation of MTG1 1 0.03 0.89 0.43 88.96
105 INT187064 ARSD Negative_regulation of CYP19A1 1 0.22 0.7 0.35 88.72
106 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13 88.28
107 INT240069 KCNIP3 Regulation of Gene_expression of PDYN 1 0.25 0.75 0.59 88.24
108 INT299628 MSTN Negative_regulation of Gene_expression of MYOD1 1 0.09 0.15 0 88.16
109 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4 88.04
110 INT202620 Binding of Ppara and Rxra 15 0.09 2.63 1.11 87.80
111 INT215878 Eif2ak3 Positive_regulation of Localization of Ins1 1 0.04 0.96 0.06 87.72
112 INT261579 Serpinc1 Negative_regulation of Gene_expression of CYBB 1 0.00 1.69 0.18 87.52
113 INT303963 Lep Positive_regulation of Gene_expression of Il7 1 0.02 0.41 0 87.40
114 INT278693 ERAL1 Positive_regulation of CD4 1 0.05 1.1 0.31 87.32
115 INT278692 ERAL1 Positive_regulation of Positive_regulation of CD4 1 0.05 1.1 0.31 87.32
116 INT210263 Mtx1 Regulation of Gene_expression of LYZ 1 0.00 0.33 0.32 86.80
117 INT340568 Fgf1 Positive_regulation of Mapk1 1 0.06 1.02 0.04 86.68
118 INT352961 Ghrl Positive_regulation of Localization of GHSR 1 0.18 1.19 0.21 86.48
119 INT301306 Binding of GPR17 and CYSLTR1 1 0.04 0.42 0.16 86.44
120 INT301307 Binding of GPR17 and LTC4S 1 0.00 0.42 0.11 86.44
121 INT145908 Pdyn Regulation of Positive_regulation of Casp3 1 0.14 0.94 0.37 86.40
122 INT181168 Binding of CD79A and TAPBP 1 0.10 0.7 0.04 86.24
123 INT274865 Positive_regulation of Mapk1 Negative_regulation of Gene_expression of TNF 1 0.04 1.08 0.35 86.08
124 INT352501 PRKAB1 Positive_regulation of INS 1 0.04 1.36 0.12 86.04
125 INT311390 Mbnl1 Positive_regulation of Celf1 1 0.26 0.48 0 86.00
126 INT299626 Binding of IGF1 and IGFBP3 Positive_regulation of IGF1 1 0.02 0.39 0 85.52
127 INT340558 Gene_expression of Fst Positive_regulation of Akt1 1 0.09 0.41 0.03 84.96
128 INT340567 Jun Positive_regulation of Gene_expression of Ccnd1 1 0.05 0.27 0.07 84.76
129 INT60626 Crh Positive_regulation of Localization of Pomc 7 0.54 2.3 1.99 84.64
130 INT132318 Ghrl Positive_regulation of Localization of GH1 5 0.32 4.49 0.84 84.56
131 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3 84.24
132 INT340561 Mapk1 Negative_regulation of Gene_expression of Pax7 1 0.23 0.25 0 84.24
133 INT333893 Negative_regulation of HDAC9 Negative_regulation of Gene_expression of TNF 1 0.09 1.03 0.34 83.64
134 INT181084 Binding of S100a8 and S100a9 6 0.42 2.91 0.62 83.56
135 INT201747 Itpr3 Positive_regulation of Localization of Esr1 2 0.03 1.19 0.09 82.88
136 INT130839 Gfap Positive_regulation of S100B 1 0.51 1.9 1.56 82.52
137 INT130838 Gfap Positive_regulation of Aqp4 1 0.51 1.9 1.56 82.52
138 INT321714 Slc10a3 Positive_regulation of Binding of Akt1 1 0.08 0.22 0 82.44
139 INT277318 Upf1 Positive_regulation of Atxn8os 1 0.01 0.77 0.21 82.20
140 INT340564 Akt1 Regulation of Gene_expression of Fbxo32 1 0.05 0.52 0.07 82.16
141 INT226786 Scl1 Positive_regulation of Lbp 1 0.04 1.68 0.07 82.04
142 INT340553 Pik3r1 Regulation of Gene_expression of Fbxo32 1 0.04 0.52 0.07 81.84
143 INT181169 TAPBP Negative_regulation of MALT1 1 0.00 0.48 0 81.80
144 INT181167 TAPBP Negative_regulation of CD79A 1 0.11 0.48 0 81.80
145 INT154118 Binding of S100A8 and Shc2 1 0.13 0.66 0.2 81.68
146 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36 81.36
147 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36 81.36
148 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 81.36
149 INT226787 Trglyd Positive_regulation of Lbp 1 0.04 1.67 0.07 81.28
150 INT118786 Binding of KIAA0101 and NANS 1 0.28 4.67 0.3 81.04
151 INT232417 Binding of Mtx1 and Ifx 1 0.04 0.99 0.86 80.80
152 INT208554 Phosphorylation of YWHAQ Positive_regulation of Binding of YWHAQ and Akt1 1 0.32 1.04 0.08 80.40
153 INT213552 Gene_expression of Phox2a Positive_regulation of Gene_expression of Phox2b 1 0.45 0.17 0 79.44
154 INT333892 TNF Positive_regulation of Gene_expression of HDAC1 1 0.09 0.46 0.23 79.28
155 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35 79.12
156 INT355672 Il6 Negative_regulation of Transcription of TNF 1 0.05 0.98 0.46 79.08
157 INT208556 Binding of YWHAQ and Akt1 1 0.22 1.02 0.08 79.00
158 INT118519 Slc8a1 Negative_regulation of Positive_regulation of Nfkb1 1 0.16 0.59 0.42 78.88
159 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81 78.72
160 INT208555 YWHAQ Positive_regulation of Atxn1 1 0.77 1.02 0.08 78.52
161 INT110892 AWAT1 Positive_regulation of RS1 1 0.00 0.93 0.32 78.48
162 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73 78.40
163 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34 78.32
164 INT226207 Binding of Ins1 and Positive_regulation of Pik3cb 1 0.01 2.08 0 77.84
165 INT226190 Binding of Igf1 and Positive_regulation of Pik3cb 1 0.17 1.04 0 77.84
166 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78 77.80
167 INT220063 Binding of NTF3 and NTRK2 1 0.09 1.13 0.78 77.80
168 INT266038 Atp6v1e1 Positive_regulation of Positive_regulation of Mapk1 1 0.07 0.64 0.22 77.60
169 INT277319 Gene_expression of Celf1 Positive_regulation of Positive_regulation of Slc6a11 1 0.24 0.08 0.08 77.24
170 INT293627 GHRL Positive_regulation of EDNRA 1 0.00 0.96 0.1 76.92
171 INT94617 KNG1 Positive_regulation of Localization of Calca 1 0.00 0.75 1.7 76.80
172 INT340555 Igf1 Positive_regulation of Mapk1 1 0.24 0.65 0.09 76.64
173 INT349861 Gfra1 Negative_regulation of Ntrk1 1 0.01 0.36 0.15 76.52
174 INT349850 Gfra1 Negative_regulation of Adcyap1r1 1 0.15 0.36 0.15 76.52
175 INT349854 Gfra1 Negative_regulation of Ntrk1 1 0.12 0.36 0.15 76.52
176 INT226210 Akt1 Regulation of Mul1 1 0.04 0.6 0.1 76.40
177 INT349852 Gfra2 Negative_regulation of Ntrk1 1 0.27 0.3 0.15 76.24
178 INT349859 Gfra2 Negative_regulation of Ntrk1 1 0.02 0.3 0.15 76.24
179 INT349849 Gfra2 Negative_regulation of Adcyap1r1 1 0.33 0.31 0.15 76.24
180 INT349857 Gfra2 Negative_regulation of Gfra3 1 0.20 0.3 0.15 76.24
181 INT181165 TAPBP Regulation of Gene_expression of CD79A 1 0.07 0.35 0 76.20
182 INT226206 Gtf3a Positive_regulation of Akt1 1 0.00 1.02 0 76.16
183 INT226193 Gtf3a Positive_regulation of Pik3cb 1 0.00 1.02 0 76.16
184 INT220057 Binding of NTS and TNFRSF1B 1 0.08 1.23 0.76 76.12
185 INT120018 VEGFA Positive_regulation of CCL3 1 0.01 1 0.7 76.00
186 INT120017 CCL2 Positive_regulation of CCL3 1 0.01 0.99 0.7 76.00
187 INT120020 VEGFA Positive_regulation of CCL2 1 0.00 1 0.7 76.00
188 INT120035 CCL2 Positive_regulation of Prap1 1 0.00 0.99 0.7 76.00
189 INT120037 IL8 Positive_regulation of Prap1 1 0.00 0.99 0.7 76.00
190 INT120019 IL8 Positive_regulation of CCL3 1 0.02 0.99 0.7 76.00
191 INT120036 VEGFA Positive_regulation of Prap1 1 0.00 1 0.7 76.00
192 INT303966 Lep Regulation of Il1 2 0.09 0.41 0.1 76.00
193 INT349862 Gfra3 Negative_regulation of Ntrk1 1 0.02 0.3 0.15 75.96
194 INT349851 Gfra3 Negative_regulation of Adcyap1r1 1 0.28 0.31 0.15 75.96
195 INT349856 Gfra3 Negative_regulation of Ntrk1 1 0.23 0.3 0.15 75.96
196 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3 75.92
197 INT141470 Glp2r Positive_regulation of Nts 1 0.22 0.08 0.16 75.84
198 INT141471 Glp2r Positive_regulation of Glp2r Positive_regulation of Nts 1 0.25 0.08 0.16 75.84
199 INT94618 KNG1 Positive_regulation of Calca 1 0.00 0.75 1.66 75.72
200 INT308175 Negative_regulation of Mapk14 Negative_regulation of Localization of TNF 1 0.03 0.89 0.61 75.60

Single Events

The table below shows the top 200 pain related interactions that have been reported for Frailty. They are ordered first by their pain relevance and then by number of times they were reported in Frailty. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT95877 Gene_expression of St13 24 0.49 11.18 3.95 100.00
2 INT178766 Negative_regulation of HHIP 19 0.28 11.1 0.43 100.00
3 INT176618 Gene_expression of HEY1 29 0.59 36 4.37 100.00
4 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68 100.00
5 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 100.00
6 INT244935 Binding of St13 6 0.35 4.77 0.61 100.00
7 INT121480 Positive_regulation of St13 10 0.50 4.51 1.39 100.00
8 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 100.00
9 INT266451 Regulation of Gene_expression of HEY1 1 0.02 2.03 0.09 100.00
10 INT194957 Binding of ASPN 5 0.27 2.95 1.09 100.00
11 INT121337 Negative_regulation of HEY1 7 0.20 12.91 1.89 100.00
12 INT125479 Positive_regulation of HHIP 38 0.44 12.39 3.75 100.00
13 INT125477 Gene_expression of HHIP 91 0.78 31.18 12.57 100.00
14 INT171252 Gene_expression of BMI1 21 0.70 26.98 4.11 100.00
15 INT187286 Binding of HEY1 17 0.32 31.21 4.52 100.00
16 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 100.00
17 INT350837 Positive_regulation of Binding of St13 1 0.36 1.9 0.19 100.00
18 INT12642 Gene_expression of TRIM47 3 0.54 1.18 2.49 100.00
19 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 100.00
20 INT148384 Positive_regulation of HEY1 19 0.43 29.76 5.89 100.00
21 INT97217 Gene_expression of Nenf 3 0.27 1.18 0.99 100.00
22 INT342268 Positive_regulation of Negative_regulation of HHIP 1 0.04 0.91 0 100.00
23 INT209299 Positive_regulation of Gene_expression of St13 8 0.36 1.72 1.13 100.00
24 INT337032 Negative_regulation of Fxc1 1 0.04 1.85 0.06 100.00
25 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 100.00
26 INT127645 Positive_regulation of CD200 3 0.39 1.97 0.58 100.00
27 INT109124 Positive_regulation of TIMP3 8 0.61 5.57 5.72 100.00
28 INT19342 Regulation of Insr 12 0.24 6.11 1.54 100.00
29 INT189629 Negative_regulation of TIMP3 14 0.48 7.63 3.91 100.00
30 INT194064 Regulation of Gene_expression of Gpx6 5 0.02 3.66 0.63 100.00
31 INT5838 Negative_regulation of Positive_regulation of Gfap 10 0.58 6.52 4.39 100.00
32 INT337031 Binding of Fxc1 1 0.04 2 0 100.00
33 INT231737 Localization of OAP 5 0.50 7.4 2.63 100.00
34 INT202008 Binding of OPA6 2 0.35 1.98 1.11 100.00
35 INT350836 Negative_regulation of St13 1 0.31 0.85 0 100.00
36 INT64821 Positive_regulation of SLPI 11 0.67 5.08 1.48 100.00
37 INT227216 Binding of TRIM47 2 0.30 1.11 0.34 100.00
38 INT140973 Negative_regulation of Binding of Ngf 2 0.43 1.93 1.17 100.00
39 INT148432 Negative_regulation of Binding of Bdnf 2 0.38 1.74 0.99 100.00
40 INT148433 Negative_regulation of Binding of Gdnf 1 0.41 1.14 0.4 100.00
41 INT148434 Negative_regulation of Binding of Ntf3 1 0.39 1.14 0.4 100.00
42 INT272511 Positive_regulation of DMPK 8 0.54 6.85 0.72 100.00
43 INT63958 Regulation of Tnnt2 7 0.45 5.36 0.7 100.00
44 INT322203 Negative_regulation of TRIM47 1 0.34 0.56 0.28 100.00
45 INT171254 Binding of OAP 7 0.39 8.04 3.42 100.00
46 INT165327 Binding of TCF19 1 0.36 0.97 0.33 100.00
47 INT211701 Positive_regulation of Mri1 20 0.34 20.64 6.69 100.00
48 INT39546 Regulation of Nenf 3 0.06 0.94 1.27 100.00
49 INT18636 Negative_regulation of OAP 9 0.37 5.05 2.13 100.00
50 INT121481 Localization of St13 4 0.54 1.7 1.3 100.00
51 INT90078 Negative_regulation of Positive_regulation of Casp1 2 0.42 1.38 0.53 100.00
52 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59 100.00
53 INT97219 Regulation of Gene_expression of Nenf 1 0.12 0.65 0.45 100.00
54 INT337022 Localization of SPESP1 1 0.26 1.14 0.64 100.00
55 INT337017 Positive_regulation of Localization of SPESP1 1 0.17 1.14 0.64 100.00
56 INT266450 Negative_regulation of Regulation of HEY1 1 0.02 0.72 0 100.00
57 INT187289 Regulation of HEY1 5 0.39 7.8 1.03 100.00
58 INT263358 Positive_regulation of Positive_regulation of St13 2 0.36 0.78 0.42 100.00
59 INT194066 Gene_expression of Omp 6 0.34 2.28 0.12 100.00
60 INT187288 Positive_regulation of Gene_expression of HEY1 5 0.17 8.42 0.89 100.00
61 INT18583 Positive_regulation of Gene_expression of Ins1 67 0.50 49.72 8.26 100.00
62 INT238674 Binding of Btc 1 0.31 0.51 0 100.00
63 INT287206 Regulation of Gene_expression of Htt 6 0.50 3.27 0.57 100.00
64 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 100.00
65 INT24081 Binding of tda1 1 0.01 0.54 0.26 100.00
66 INT176445 Protein_catabolism of Gopc 23 0.76 7.57 0.75 100.00
67 INT125480 Regulation of HHIP 17 0.38 6.16 2.16 100.00
68 INT269485 Positive_regulation of Gene_expression of HHIP 9 0.41 1.08 0.92 100.00
69 INT202006 Gene_expression of OPA6 1 0.58 0.68 0.35 100.00
70 INT213648 Phosphorylation of S100A6 2 0.30 1.43 0.36 100.00
71 INT194060 Negative_regulation of Gene_expression of Gpx6 3 0.04 0.8 0.16 100.00
72 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 100.00
73 INT311099 Positive_regulation of Negative_regulation of TIMP3 2 0.22 0.78 0.45 100.00
74 INT313229 Negative_regulation of Positive_regulation of SLPI 1 0.26 0.41 0.14 100.00
75 INT125005 Negative_regulation of SLPI 9 0.42 5.79 4.43 100.00
76 INT202007 Negative_regulation of OPA6 1 0.37 0.6 0.35 100.00
77 INT255122 Gene_expression of Mypop 2 0.11 1.78 0.06 100.00
78 INT337033 Localization of Fxc1 1 0.07 0.67 0 100.00
79 INT349060 Regulation of Negative_regulation of HHIP 1 0.10 1.33 0 100.00
80 INT297709 Positive_regulation of Gene_expression of Ucp3 5 0.56 4.67 1.28 100.00
81 INT246572 Positive_regulation of Negative_regulation of PGRMC1 1 0.06 0.28 0 100.00
82 INT49437 Gene_expression of OAP 25 0.54 20.12 7.34 100.00
83 INT90348 Regulation of Gast 2 0.61 1.41 0.42 100.00
84 INT214735 Gene_expression of IGHD1-7 5 0.57 3.28 0.14 100.00
85 INT78479 Negative_regulation of Localization of PENK 2 0.43 1.9 1.81 100.00
86 INT125870 Gene_expression of CD47 3 0.76 5.11 1.71 100.00
87 INT263523 Regulation of Binding of BMI1 1 0.34 3.01 1.3 100.00
88 INT160786 Regulation of Tada1 1 0.16 0.69 1.04 100.00
89 INT105221 Gene_expression of NOL3 5 0.75 0.78 0.73 100.00
90 INT161027 Negative_regulation of RPE 7 0.37 4.34 0.38 100.00
91 INT259031 Negative_regulation of Gene_expression of CADPS 1 0.07 3.04 0.35 100.00
92 INT178764 Negative_regulation of GET4 1 0.15 0.78 0.04 100.00
93 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 99.98
94 INT3948 Regulation of Cck 291 0.62 58.07 255.88 99.98
95 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26 99.98
96 INT184052 Localization of Socs1 3 0.59 4.07 1.54 99.98
97 INT112428 Positive_regulation of Gene_expression of P2rx4 12 0.68 12.67 9.57 99.98
98 INT173940 Positive_regulation of Negative_regulation of DMD 8 0.59 2.97 0.36 99.98
99 INT145922 Positive_regulation of Positive_regulation of CCL21 1 0.39 0.82 0.69 99.98
100 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 99.96
101 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 99.96
102 INT277289 Transcription of Atxn8os 1 0.68 3.3 0.26 99.96
103 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 99.96
104 INT100921 Positive_regulation of Positive_regulation of Grm1 2 0.47 1.01 1.24 99.96
105 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 99.96
106 INT122548 Negative_regulation of Localization of FGF2 3 0.41 1.01 0.22 99.96
107 INT130754 Gene_expression of Cast 21 0.78 11.6 2.08 99.96
108 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 99.96
109 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.92
110 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 99.92
111 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26 99.92
112 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 99.92
113 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 99.92
114 INT217658 Negative_regulation of MSTN 4 0.30 1.35 0.17 99.92
115 INT180497 Binding of MRI1 45 0.42 28.35 14.77 99.92
116 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78 99.92
117 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47 99.92
118 INT111514 Positive_regulation of Gene_expression of Mpo 20 0.49 15.13 3.88 99.92
119 INT19949 Regulation of Positive_regulation of Fos 36 0.60 6.11 22.05 99.92
120 INT47818 Positive_regulation of Homer1 48 0.70 11.11 24.05 99.92
121 INT82829 Gene_expression of COMP 104 0.78 57 9.81 99.92
122 INT82828 Positive_regulation of COMP 45 0.61 35.12 6.2 99.92
123 INT102746 Negative_regulation of Hmbs 11 0.59 8.35 0.77 99.92
124 INT231093 Negative_regulation of Fbxo32 3 0.41 0.55 0.12 99.92
125 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 99.90
126 INT1645 Negative_regulation of CSH1 20 0.42 1.71 3.7 99.90
127 INT17233 Positive_regulation of Localization of PDYN 9 0.69 2.84 10.06 99.90
128 INT18460 Positive_regulation of Transcription of PDYN 11 0.67 2.14 6.61 99.90
129 INT221448 Gene_expression of CREG1 8 0.05 27.44 10.87 99.88
130 INT217659 Regulation of Gene_expression of MSTN 4 0.31 1.15 0 99.88
131 INT9155 Gene_expression of Glul 60 0.77 17.97 23.95 99.88
132 INT264605 Negative_regulation of Binding of Htr3a 1 0.01 1.12 0.64 99.88
133 INT943 Negative_regulation of Cck 205 0.59 38.42 174.78 99.88
134 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 99.84
135 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 99.84
136 INT86437 Binding of IL6 154 0.48 121.22 29.3 99.84
137 INT240080 Negative_regulation of Transcription of KCNIP3 1 0.51 4.34 3.61 99.84
138 INT6481 Binding of TNF 624 0.48 510.2 214.82 99.84
139 INT194073 Gene_expression of Gpx6 22 0.09 10.02 1.62 99.84
140 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 99.84
141 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 99.84
142 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 99.84
143 INT140337 Negative_regulation of Cd8a 42 0.50 25.4 3.66 99.84
144 INT322202 Gene_expression of SLC34A1 1 0.04 1.01 0.45 99.84
145 INT21685 Gene_expression of ras 115 0.66 85.6 7.76 99.84
146 INT327824 Positive_regulation of Gene_expression of Aqp1 4 0.67 5.4 1.37 99.84
147 INT231091 Protein_catabolism of Psmb8 1 0.01 1.87 0 99.84
148 INT27325 Positive_regulation of Pyy 15 0.62 13.69 6.54 99.84
149 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 99.84
150 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8 99.84
151 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48 99.84
152 INT277061 Positive_regulation of COL11A1 2 0.43 1.56 0.28 99.84
153 INT91994 Regulation of Gene_expression of Gfra1 5 0.42 6 3.6 99.84
154 INT24079 Positive_regulation of Negative_regulation of Ngf 4 0.50 1.02 1.68 99.84
155 INT88425 Negative_regulation of DYSF 4 0.57 4.68 0.83 99.84
156 INT231103 Positive_regulation of Protein_catabolism of Psmb8 1 0.01 0.73 0 99.84
157 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 99.84
158 INT23564 Negative_regulation of Car2 103 0.50 27.28 21.86 99.84
159 INT303374 Negative_regulation of Jag1 2 0.48 0.9 0.23 99.84
160 INT93659 Positive_regulation of ITGAE 3 0.22 1.9 0.16 99.84
161 INT303367 Negative_regulation of Positive_regulation of Jag1 1 0.35 0.28 0 99.84
162 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 99.82
163 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68 99.82
164 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 99.82
165 INT119089 Regulation of Phosphorylation of Grin1 17 0.61 3.1 12.82 99.82
166 INT340544 Binding of Myog 1 0.16 0.81 0.04 99.82
167 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 99.80
168 INT108479 Positive_regulation of CCL21 18 0.67 19.93 10.76 99.80
169 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.80
170 INT102745 Positive_regulation of Hmbs 17 0.61 12.41 0.78 99.80
171 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29 99.80
172 INT171997 Gene_expression of ERAL1 5 0.25 4.97 1.67 99.80
173 INT61310 Negative_regulation of Binding of HTR1A 2 0.57 1.36 0.72 99.80
174 INT13790 Binding of HTR1A 52 0.47 18.83 17.59 99.80
175 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 99.80
176 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 99.80
177 INT277290 Regulation of Atxn8os 1 0.60 1.11 0.14 99.80
178 INT264337 Positive_regulation of NCOA5 4 0.03 4.28 1.23 99.80
179 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.78
180 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 99.78
181 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06 99.78
182 INT179257 Binding of SERPINA6 5 0.10 2.09 1.24 99.78
183 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 99.76
184 INT118254 Negative_regulation of Ppcs 4 0.39 2.49 0.79 99.76
185 INT287344 Regulation of NDUFB11 1 0.01 0.33 0 99.76
186 INT194061 Regulation of Binding of Gpx6 1 0.02 0.31 0.03 99.76
187 INT20129 Regulation of Il1 53 0.53 44.14 19.89 99.76
188 INT3275 Negative_regulation of Slco1c1 28 0.37 10.93 5.15 99.76
189 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.74
190 INT100920 Positive_regulation of Gene_expression of Grm1 7 0.70 5.88 4.87 99.74
191 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 99.74
192 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 99.74
193 INT58919 Localization of Gap43 10 0.78 3.53 4.61 99.74
194 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 99.74
195 INT177337 Localization of VDR 6 0.73 3.44 0.59 99.74
196 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 99.72
197 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 99.72
198 INT74745 Gene_expression of Grm8 30 0.68 9.85 14.52 99.72
199 INT11652 Gene_expression of Rara 30 0.58 24.96 6.98 99.72
200 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5 99.72
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