D:Freckles

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Chloasma, Chloasmas, Ephelides, FRECKLE, Melanism, Melanoses, Melanosis, Melasma, Melasmas, Xeroderma Pigmentosum
Documents 141
Hot Single Events 56
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Freckles. They are ordered first by their relevance to Freckles and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT260070 Binding of PHF2 and SPTLC1 1 0.17 1.93 0.1 89.64
2 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78 87.76
3 INT276283 Atrn Positive_regulation of Binding of Mc1r and a 1 0.38 0.26 0.8 87.76
4 INT276282 Binding of Atrn and Mc1r 1 0.32 0.41 1.29 86.88
5 INT355542 Binding of XRCC3 and BCC1 1 0.00 1.19 0.07 81.60
6 INT227830 CSH1 Regulation of ERCC6 1 0.11 0 0 43.60
7 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24 40.96
8 INT227838 Binding of ERCC6 and PGBD3 1 0.40 0.23 0 33.84
9 INT227836 Binding of ERCC6 and GPER 1 0.21 0.27 0.08 32.12
10 INT252549 ATM Positive_regulation of Positive_regulation of CHEK2 1 0.02 0 0 24.24
11 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
12 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
13 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
14 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2 5.00
15 INT286476 Binding of App and Itm2b 1 0.47 5.24 0.14 5.00
16 INT326605 Binding of HTR1A and KCNH2 1 0.00 0.45 0.14 5.00
17 INT184704 Binding of Prrx2 and Sr1 1 0.21 1.65 0.13 5.00
18 INT351032 Binding of CD80 and CD96 1 0.01 0.36 0.09 5.00
19 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
20 INT351031 Binding of CD28 and CD96 1 0.02 0.36 0.09 5.00
21 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
22 INT323392 SERPINH1 Negative_regulation of BCHE 1 0.02 0.52 0.04 5.00
23 INT323395 Binding of BCHE and SERPINH1 1 0.02 0.74 0.03 5.00
24 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
25 INT200211 Gh Positive_regulation of Localization of Igf1 1 0.38 2.05 0 5.00
26 INT227837 Positive_regulation of Binding of CSH1 and ERCC6 1 0.20 0.15 0 5.00
27 INT260071 Binding of FANCC and XPA 1 0.24 0.76 0 5.00
28 INT260066 Binding of PHF2 and XPA 1 0.20 1.04 0 5.00
29 INT351029 AGK Regulation of VEGFA 1 0.00 0.82 0 5.00
30 INT227829 CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0 5.00
31 INT323393 Positive_regulation of Binding of SERPINH1 and VRK1 1 0.01 0 0 5.00
32 INT260069 Binding of FANCC and PHF2 1 0.28 0.37 0 5.00
33 INT325375 Binding of Tp53 and Positive_regulation of Positive_regulation of PARP1 1 0.05 0.59 0 5.00
34 INT227832 Binding of CSH1 and ERCC6 1 0.15 0.15 0 5.00
35 INT323394 Binding of SERPINH1 and VRK1 1 0.00 0 0 5.00
36 INT227841 PGBD1 Positive_regulation of ERCC6 1 0.44 0.29 0 5.00
37 INT227833 Positive_regulation of CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0 5.00
38 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0 5.00
39 INT247427 CDKN2A Negative_regulation of Negative_regulation of RB1 1 0.07 1.16 0 5.00
40 INT227840 Binding of ERCC2 and ERCC6 1 0.11 0.66 0 5.00
41 INT237461 Binding of UTS2R and TTPA 1 0.01 0.63 0 5.00
42 INT260073 Binding of FANCC and PTCH1 1 0.33 0.49 0 5.00
43 INT227831 Binding of ERCC2 and PGBD3 1 0.07 0.23 0 5.00
44 INT260067 Binding of PTCH1 and XPA 1 0.26 1.08 0 5.00
45 INT227843 Binding of ERCC6 and MLL 1 0.00 0.34 0 5.00
46 INT351030 AGK Regulation of ARAF 1 0.00 0.82 0 5.00
47 INT260072 Binding of BRCA2 and FANCC 1 0.37 0.63 0 5.00
48 INT237460 Binding of TTPA and ADAMTS3 1 0.01 0.63 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Freckles. They are ordered first by their pain relevance and then by number of times they were reported in Freckles. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT52973 Gene_expression of Ercc3 1 0.78 5.82 0.43 100.00
2 INT58755 Binding of PAM 6 0.34 3.09 0.97 100.00
3 INT52972 Gene_expression of TelXp 1 0.04 1.14 0.08 100.00
4 INT4785 Gene_expression of PAM 6 0.58 3.47 0.64 100.00
5 INT178261 Positive_regulation of Gene_expression of a 23 0.55 14.67 4.07 99.98
6 INT55251 Gene_expression of a 142 0.67 81.21 23.03 99.80
7 INT21737 Binding of MC1R 129 0.48 45.45 56.54 99.76
8 INT71030 Binding of Mc1r 39 0.48 10.27 12.02 99.76
9 INT94652 Binding of a 15 0.48 4.18 5.4 99.76
10 INT84712 Regulation of MC1R 36 0.62 9.34 16.91 99.64
11 INT52974 Transcription of Ercc3 1 0.53 1.24 0.09 99.50
12 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52 99.44
13 INT276280 Regulation of Localization of a 1 0.37 0.33 0.09 99.32
14 INT178255 Localization of a 4 0.65 0.72 1.1 99.32
15 INT211708 Regulation of a 4 0.42 1.92 3.15 99.26
16 INT178246 Negative_regulation of Gene_expression of a 8 0.43 4.27 2.19 99.16
17 INT52971 Binding of Ercc3 1 0.48 0.96 0.07 99.06
18 INT276281 Regulation of Atrn 1 0.21 0.73 0.68 99.04
19 INT178260 Positive_regulation of a 6 0.50 3.09 2.08 98.88
20 INT85632 Regulation of Mc1r 14 0.61 3.22 6.5 98.82
21 INT211707 Positive_regulation of Transcription of a 2 0.51 0.27 0.55 98.68
22 INT178252 Transcription of a 3 0.67 0.73 0.9 98.68
23 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 98.32
24 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 97.88
25 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76 97.52
26 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 97.40
27 INT117116 Positive_regulation of Positive_regulation of MC1R 7 0.49 1.57 1.91 97.22
28 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 96.60
29 INT200205 Regulation of Ercc6 1 0.08 1.65 0.05 95.16
30 INT1643 Regulation of CSH1 10 0.26 2.45 2.53 95.16
31 INT200188 Regulation of Ercc5 1 0.19 1.64 0.05 95.16
32 INT200132 Regulation of Ercc2 2 0.36 4.56 0.05 95.16
33 INT200135 Regulation of Ercc3 2 0.34 3.47 0.05 95.16
34 INT176212 Transcription of Nr1h2 5 0.29 2.92 0.15 94.96
35 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01 94.16
36 INT135727 Positive_regulation of Gene_expression of Mc1r 18 0.69 8.69 4.92 94.16
37 INT326607 Positive_regulation of STC1 1 0.20 3 0.2 91.36
38 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49 91.12
39 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 90.96
40 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 90.92
41 INT738 Regulation of POMC 459 0.62 111.19 243.74 89.88
42 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 89.68
43 INT259109 Negative_regulation of STK11 2 0.54 2.11 0 89.68
44 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 89.48
45 INT342883 Gene_expression of Ots1 1 0.03 0.35 0 89.04
46 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 88.68
47 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 88.28
48 INT195206 Binding of BCC1 15 0.41 21.3 0.62 87.68
49 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22 87.64
50 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 87.08
51 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 85.40
52 INT141563 Regulation of ERCC6 6 0.59 2.54 0 84.96
53 INT323401 Negative_regulation of VRK1 1 0.15 2.64 0 83.04
54 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 82.72
55 INT142717 Positive_regulation of Negative_regulation of MC1R 1 0.47 0.36 0.28 82.04
56 INT66347 Gene_expression of MLL 29 0.65 14.82 3.18 81.36
57 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09 79.44
58 INT29636 Localization of PAM 5 0.73 2.1 0.87 79.36
59 INT107467 Binding of Atrn 3 0.43 0.35 0.75 79.00
60 INT213681 Gene_expression of TYMS 9 0.33 8.96 2.45 78.88
61 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95 78.72
62 INT172808 Positive_regulation of Positive_regulation of ROS1 35 0.40 31.39 2.27 78.72
63 INT13063 Binding of RHCE 16 0.38 6.54 1.22 78.28
64 INT28546 Regulation of SHBG 23 0.54 16.35 3.88 78.24
65 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 78.24
66 INT40059 Regulation of Positive_regulation of SHBG 1 0.45 1.19 0.19 78.24
67 INT292735 Regulation of Gene_expression of Pheo 1 0.11 0.08 0.94 78.16
68 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 77.60
69 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 76.92
70 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 76.68
71 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 76.08
72 INT252552 Positive_regulation of Phosphorylation of CHEK2 1 0.23 0.26 0.08 76.00
73 INT230296 Positive_regulation of Phosphorylation of H2AFX 3 0.18 0.15 0.04 76.00
74 INT199146 Gene_expression of Pheo 3 0.18 3.57 1.63 75.12
75 INT188018 Phosphorylation of H2AFX 11 0.64 0.94 0.13 75.04
76 INT15777 Gene_expression of Pvalb 66 0.78 25.97 26.13 75.00
77 INT69075 Regulation of Calb1 6 0.02 2.43 2.31 75.00
78 INT122933 Negative_regulation of Regulation of Calb1 1 0.02 1.12 1.27 75.00
79 INT99270 Negative_regulation of Gene_expression of Pvalb 5 0.08 5.74 3.15 75.00
80 INT30317 Regulation of TH 14 0.43 7.27 5.38 75.00
81 INT22142 Gene_expression of Calb1 9 0.58 1.84 2.93 75.00
82 INT122934 Negative_regulation of Regulation of TH 1 0.03 0.56 0.63 75.00
83 INT70273 Gene_expression of CALB2 9 0.75 7.85 2.54 75.00
84 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 74.56
85 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26 73.76
86 INT260080 Negative_regulation of Gene_expression of PTCH1 1 0.58 2.09 0 73.76
87 INT252551 Phosphorylation of CHEK2 4 0.48 4.73 0.08 73.28
88 INT233453 Gene_expression of Itm2b 8 0.74 8.45 0.99 73.16
89 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 72.76
90 INT84765 Positive_regulation of Mc1r 24 0.70 5.95 8.01 71.76
91 INT695 Binding of POMC 304 0.48 56.66 126.85 70.64
92 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93 68.12
93 INT44558 Positive_regulation of PDXP 6 0.35 3.65 1.22 67.88
94 INT323403 Localization of VRK1 1 0.17 0.13 0 67.88
95 INT323397 Regulation of VRK1 1 0.06 0.84 0.05 67.80
96 INT136531 Binding of Men1 8 0.47 9.62 0.65 66.72
97 INT323396 Positive_regulation of VRK1 1 0.12 0.77 0.09 66.40
98 INT80339 Gene_expression of PHF2 3 0.73 2.3 0.26 66.40
99 INT158754 Gene_expression of XPA 3 0.57 4.24 0.2 66.40
100 INT238184 Gene_expression of FANCC 6 0.60 2.92 0.19 66.40
101 INT204257 Gene_expression of RTL1 3 0.08 3.09 0 65.60
102 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 62.40
103 INT67890 Positive_regulation of Gene_expression of SGCG 26 0.67 9.91 6.41 62.40
104 INT542 Gene_expression of Fshb 14 0.75 5.22 3.24 61.52
105 INT10070 Negative_regulation of Fshb 13 0.42 3.48 2.5 61.52
106 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44 61.44
107 INT141562 Negative_regulation of ERCC6 11 0.50 3.04 0 60.56
108 INT335616 Positive_regulation of RASL12 1 0.08 0.9 0 60.44
109 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 60.08
110 INT158452 Negative_regulation of GIT1 3 0.22 1.16 2.13 59.76
111 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33 59.36
112 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 58.88
113 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23 58.88
114 INT2981 Negative_regulation of Gene_expression of CGA 14 0.42 3.41 1.05 58.88
115 INT45275 Gene_expression of CSH1 39 0.62 9.39 5.85 57.84
116 INT247307 Negative_regulation of Msx1 3 0.22 0.11 0.42 57.04
117 INT205968 Negative_regulation of PTCH1 2 0.58 2.35 0 56.88
118 INT32921 Positive_regulation of Msx1 4 0.47 0.99 0.57 54.64
119 INT108559 Gene_expression of Pol 46 0.45 30.07 1.14 54.08
120 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 50.72
121 INT227875 Protein_catabolism of ERCC6 1 0.65 0.81 0 50.64
122 INT62424 Transcription of Mc1r 8 0.71 3.67 4.54 50.00
123 INT227879 Regulation of Protein_catabolism of ERCC6 1 0.27 0.38 0 49.52
124 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 45.44
125 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 45.20
126 INT189346 Positive_regulation of ERCC6 6 0.60 3.37 0.23 44.64
127 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 44.00
128 INT323977 Phosphorylation of PTGFRN 1 0.01 0.81 0.22 43.28
129 INT36943 Binding of CHKB 14 0.37 4.09 2.75 37.56
130 INT51066 Binding of S100B 24 0.48 13.5 0.97 37.56
131 INT91209 Binding of VIM 15 0.36 12.02 0.53 37.56
132 INT234012 Binding of MEPE 1 0.02 1.35 0 37.56
133 INT234010 Binding of KLF9 1 0.36 1.39 0 37.56
134 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74 36.00
135 INT29 Negative_regulation of Gast 74 0.59 24.85 24.96 34.92
136 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 34.80
137 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 34.80
138 INT207421 Positive_regulation of Gene_expression of GPT 9 0.49 5.62 0.83 34.80
139 INT8571 Gene_expression of B3GAT1 54 0.75 36.85 15.98 34.56
140 INT234011 Gene_expression of KLF9 1 0.65 2.71 0 34.44
141 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74 33.68
142 INT335620 Localization of RASL12 1 0.13 0.32 0 32.64
143 INT69439 Regulation of ROS1 46 0.45 31.22 6.94 31.04
144 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78 31.04
145 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 30.48
146 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 29.96
147 INT185295 Gene_expression of RASL12 2 0.13 2.02 0 29.72
148 INT10553 Regulation of GPER 13 0.15 2.12 3.02 28.56
149 INT68179 Gene_expression of Nf1 9 0.78 8.87 0.68 27.32
150 INT252554 Positive_regulation of ATR 1 0.13 0 0 27.28
151 INT244704 Gene_expression of ARG1 65 0.75 37.74 1.9 27.04
152 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 25.00
153 INT125413 Regulation of Regulation of MC1R 1 0.45 0.09 0.78 25.00
154 INT158641 Positive_regulation of CHEK2 5 0.35 4.15 0.37 24.24
155 INT252553 Positive_regulation of Positive_regulation of CHEK2 1 0.17 0 0 24.24
156 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 23.68
157 INT323398 Negative_regulation of Positive_regulation of SERPINH1 1 0.02 0.23 0 23.64
158 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 23.44
159 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 23.44
160 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39 22.64
161 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 22.24
162 INT323402 Positive_regulation of Positive_regulation of SERPINH1 1 0.02 0.46 0 20.16
163 INT309533 Negative_regulation of BCC1 3 0.25 2.62 0.03 18.96
164 INT237463 Regulation of Gene_expression of TYMS 1 0.12 0.51 0.06 17.84
165 INT130385 Gene_expression of ERCC6 7 0.77 8.36 0.63 17.44
166 INT160776 Positive_regulation of Positive_regulation of ATM 2 0.43 0.94 0.53 16.80
167 INT237466 Regulation of Transcription of TYMS 1 0.26 0.5 0.06 15.12
168 INT147148 Transcription of TYMS 2 0.30 0.5 0.06 15.12
169 INT182408 Localization of ERCC6 4 0.72 2.31 0.14 10.16
170 INT227860 Localization of PGBD3 1 0.71 0.34 0 10.16
171 INT33845 Binding of GPER 20 0.36 5.61 1.81 10.12
172 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24 8.44
173 INT477 Localization of Avp 813 0.81 131.58 300.4 5.00
174 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
175 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 5.00
176 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
177 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 5.00
178 INT90 Localization of Gast 400 0.81 137.67 113 5.00
179 INT12569 Localization of Oprd1 94 0.81 23.81 104.56 5.00
180 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
181 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
182 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66 5.00
183 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
184 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 5.00
185 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
186 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
187 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
188 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
189 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 5.00
190 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
191 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
192 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
193 INT5743 Localization of NA 104 0.59 14.35 35.29 5.00
194 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
195 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
196 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
197 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
198 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
199 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
200 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox