D:Friedreich Ataxia

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Disease Term
Synonyms Ataxia Freidreich S, Ataxia Friedreich, Ataxia Friedreich Familial, Ataxia Friedreich Hereditary, Ataxia Friedreich S, Ataxia Friedreich S Familial, ATAXIA FRIEDREICH S HEREDITARY, Ataxia Friedreich Spinocerebellar, Ataxias Friedreich, Ataxias Friedreich S Hereditary, Disease Friedreich
Documents 10
Hot Single Events 21
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Friedreich Ataxia. They are ordered first by their relevance to Friedreich Ataxia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT315543 NARFL Regulation of Gene_expression of HIF1A 1 0.01 0.63 0 33.36
2 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
3 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
4 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
5 INT196406 Car2 Positive_regulation of Ros1 1 0.00 0.69 0 5.00
6 INT315541 ACO1 Negative_regulation of Gene_expression of ALAS2 1 0.17 0.18 0 5.00
7 INT315534 Binding of ACO1 and ERN1 1 0.01 0.18 0 5.00
8 INT315535 Binding of ABCB7 and FECH 1 0.28 0.7 0 5.00
9 INT315533 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of ALAS2 1 0.38 1.06 0 5.00
10 INT315532 Binding of NFS1 and ISCU 1 0.19 0.37 0 5.00
11 INT315538 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Friedreich Ataxia. They are ordered first by their pain relevance and then by number of times they were reported in Friedreich Ataxia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74 100.00
2 INT199641 Regulation of Transcription of Fxn 1 0.29 1.89 0.04 100.00
3 INT199646 Transcription of Fxn 2 0.67 4.78 0.08 100.00
4 INT199648 Regulation of Fxn 1 0.29 2.14 0.04 100.00
5 INT199643 Phosphorylation of Fxn 1 0.40 1.04 0.08 100.00
6 INT199655 Negative_regulation of Gene_expression of Fxn 2 0.47 3.34 0.07 100.00
7 INT199642 Positive_regulation of Fxn 3 0.41 3.6 0.14 99.84
8 INT199640 Positive_regulation of Positive_regulation of Fxn 2 0.41 2.97 0.14 99.84
9 INT199654 Positive_regulation of Gene_expression of Fxn 3 0.64 2.95 0.05 99.66
10 INT199644 Positive_regulation of Gene_expression of H2-Q10 3 0.37 2.6 0.15 99.64
11 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 99.56
12 INT82177 Negative_regulation of H2-Q10 5 0.58 5.83 0.45 99.28
13 INT94563 Gene_expression of H2-Q10 7 0.42 7 0.88 99.28
14 INT199652 Negative_regulation of Fxn 3 0.54 12.37 0.11 98.60
15 INT199651 Binding of Fxn 3 0.30 1.45 0.03 97.92
16 INT315562 Gene_expression of GLRX5 1 0.69 4.92 0 95.20
17 INT315561 Regulation of ISCU 2 0.35 1.1 0 92.48
18 INT199653 Positive_regulation of Tfrc 2 0.13 1.57 0 86.72
19 INT174848 Gene_expression of ISCU 2 0.59 2.79 0.08 83.16
20 INT199656 Binding of Pnkp 1 0.07 1.36 0.07 81.92
21 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 80.04
22 INT2843 Gene_expression of Epo 100 0.78 62.01 14.66 78.36
23 INT3098 Positive_regulation of Epo 46 0.70 28.27 7 78.36
24 INT115300 Negative_regulation of Napa 7 0.23 1 2.68 74.84
25 INT194794 Binding of TTPA 7 0.08 2.56 0.57 73.88
26 INT199661 Negative_regulation of TTPA 2 0.04 1.84 0 71.04
27 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52 69.92
28 INT15798 Positive_regulation of Gene_expression of TFRC 9 0.46 4.99 1.42 69.92
29 INT315552 Negative_regulation of GLRX5 1 0.38 2.17 0 65.48
30 INT315549 Negative_regulation of Binding of WNT2 1 0.08 0.65 0 63.04
31 INT315579 Binding of WNT2 1 0.07 0.65 0 63.04
32 INT1727 Gene_expression of Cndp2 22 0.74 4.28 3.34 59.96
33 INT315556 Positive_regulation of Binding of ALAS2 1 0.43 1.05 0 59.96
34 INT94423 Binding of ALAS2 4 0.32 2.1 0.61 59.20
35 INT315580 Negative_regulation of Localization of SLC40A1 1 0.25 0.64 0 59.20
36 INT315558 Negative_regulation of SLC40A1 1 0.25 0.63 0 59.20
37 INT243268 Gene_expression of SLC40A1 6 0.60 4.18 0.13 57.68
38 INT315565 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.73 0 57.68
39 INT296387 Localization of SLC40A1 2 0.44 0.94 0 57.68
40 INT241863 Binding of SLC40A1 4 0.28 3.86 0.22 57.16
41 INT162467 Gene_expression of ERN1 10 0.56 5.11 1.26 56.20
42 INT315631 Protein_catabolism of IREB2 1 0.44 0.4 0 46.08
43 INT315632 Positive_regulation of Protein_catabolism of IREB2 1 0.22 0.4 0 46.08
44 INT252722 Binding of IREB2 2 0.16 1.31 0 42.32
45 INT131139 Binding of ACO1 3 0.27 1.81 0.1 36.96
46 INT95756 Gene_expression of ACO1 3 0.27 2.49 0.1 35.84
47 INT315621 Gene_expression of CIAO1 1 0.34 4.11 0 35.44
48 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 30.84
49 INT114519 Gene_expression of Hcm 10 0.57 13.01 0.57 27.32
50 INT315588 Regulation of ACO1 1 0.18 0.57 0 20.72
51 INT315630 Gene_expression of FXN 8 0.64 20.05 0.05 7.00
52 INT166958 Gene_expression of LYRM4 4 0.18 2.9 0.27 6.24
53 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
54 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
55 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
56 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
57 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
58 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
59 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 5.00
60 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45 5.00
61 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
62 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 5.00
63 INT17962 Regulation of Car2 124 0.41 33.98 22.71 5.00
64 INT16794 Binding of App 103 0.48 64.87 19.79 5.00
65 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
66 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 5.00
67 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13 5.00
68 INT16266 Gene_expression of Chat 80 0.67 16.14 15.01 5.00
69 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38 5.00
70 INT100821 Localization of Ros1 59 0.60 45.26 11.92 5.00
71 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56 5.00
72 INT3982 Gene_expression of Acot1 53 0.56 7.61 10.46 5.00
73 INT158863 Negative_regulation of Ros1 84 0.35 40.3 10.14 5.00
74 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75 5.00
75 INT56292 Negative_regulation of Gene_expression of Ros1 70 0.38 36.14 9.17 5.00
76 INT170504 Positive_regulation of Gene_expression of Car2 60 0.41 19.1 8.45 5.00
77 INT3983 Positive_regulation of Acot1 30 0.68 5.83 8.34 5.00
78 INT143357 Binding of Ros1 48 0.36 27.76 6 5.00
79 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 5.00
80 INT170516 Negative_regulation of Gene_expression of Car2 35 0.35 9.4 5.48 5.00
81 INT42312 Negative_regulation of Chat 14 0.54 6.13 5.44 5.00
82 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 5.00
83 INT120511 Positive_regulation of Gene_expression of Cat 26 0.69 19.82 5.2 5.00
84 INT80486 Gene_expression of FECH 13 0.54 10.42 4.8 5.00
85 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 5.00
86 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
87 INT3722 Negative_regulation of Acot1 19 0.42 4.88 4.21 5.00
88 INT79723 Positive_regulation of Sod2 34 0.70 24.61 3.92 5.00
89 INT160828 Regulation of Gene_expression of Ros1 29 0.21 13.97 3.75 5.00
90 INT44015 Binding of Cd86 16 0.31 5.92 3.58 5.00
91 INT76468 Regulation of Positive_regulation of Car2 13 0.29 4.54 3.46 5.00
92 INT15801 Positive_regulation of TFRC 11 0.33 6.35 3.3 5.00
93 INT19393 Gene_expression of Gfm1 31 0.51 18.9 3.2 5.00
94 INT32852 Negative_regulation of FECH 18 0.57 10.59 3.08 5.00
95 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05 5.00
96 INT243496 Positive_regulation of Gene_expression of FECH 4 0.40 4.02 2.34 5.00
97 INT53567 Positive_regulation of FECH 14 0.45 11.03 1.82 5.00
98 INT163666 Localization of Cat 8 0.80 5.84 1.57 5.00
99 INT19181 Gene_expression of Bche 35 0.68 16.93 1.52 5.00
100 INT302084 Negative_regulation of WNT2 2 0.09 0.83 1.26 5.00
101 INT158831 Phosphorylation of Gfm1 10 0.58 5.99 1.19 5.00
102 INT196393 Negative_regulation of Cd86 9 0.22 4.24 1.17 5.00
103 INT115264 Binding of FECH 9 0.41 7.93 1.1 5.00
104 INT162471 Positive_regulation of ERN1 7 0.34 3.02 1.08 5.00
105 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08 5.00
106 INT25451 Negative_regulation of Gfm1 13 0.27 8.22 1.06 5.00
107 INT15310 Gene_expression of DLEU1 8 0.67 20.57 0.96 5.00
108 INT4436 Gene_expression of ABCB7 7 0.65 9.26 0.93 5.00
109 INT45082 Protein_catabolism of Acot1 4 0.20 1.15 0.92 5.00
110 INT196392 Negative_regulation of Positive_regulation of Ros1 7 0.17 4.94 0.88 5.00
111 INT167607 Positive_regulation of Binding of App 8 0.50 2.97 0.86 5.00
112 INT132662 Binding of Hcm 11 0.31 14.41 0.73 5.00
113 INT158136 Binding of FGFR2 9 0.26 4.5 0.63 5.00
114 INT649 Positive_regulation of Afp 10 0.55 6.5 0.62 5.00
115 INT38252 Positive_regulation of Hcm 7 0.40 9.96 0.59 5.00
116 INT196398 Protein_catabolism of Chat 1 0.24 2.1 0.47 5.00
117 INT302086 Gene_expression of WNT2 3 0.14 0.97 0.38 5.00
118 INT3321 Positive_regulation of ALAS2 10 0.51 3.08 0.32 5.00
119 INT221496 Localization of ISCA1 4 0.73 2.12 0.23 5.00
120 INT243267 Positive_regulation of SLC40A1 4 0.41 2.72 0.22 5.00
121 INT3323 Gene_expression of ALAS2 10 0.58 7.51 0.21 5.00
122 INT236980 Gene_expression of ISCA1 9 0.53 2.43 0.19 5.00
123 INT196397 Binding of Zfp263 1 0.07 0.44 0.17 5.00
124 INT196387 Negative_regulation of Zfp263 1 0.08 0.44 0.17 5.00
125 INT170629 Negative_regulation of Gene_expression of ABCB7 2 0.37 1.32 0.17 5.00
126 INT156639 Localization of Hcm 5 0.64 7.65 0.16 5.00
127 INT315643 Negative_regulation of Gene_expression of FECH 1 0.29 0.71 0.1 5.00
128 INT52411 Regulation of Negative_regulation of Bche 3 0.20 1.47 0.1 5.00
129 INT315554 Localization of NFS1 1 0.43 0.28 0.07 5.00
130 INT196386 Localization of Cisd1 1 0.00 0.42 0.07 5.00
131 INT315622 Protein_catabolism of FECH 1 0.77 0.49 0.07 5.00
132 INT315598 Localization of FXN 1 0.43 1.04 0.07 5.00
133 INT315626 Localization of DLEU1 2 0.35 4.17 0.07 5.00
134 INT168028 Gene_expression of Mcat 6 0.57 3.51 0.06 5.00
135 INT196391 Transcription of Cd86 2 0.44 0.78 0.05 5.00
136 INT196394 Positive_regulation of Transcription of Cd86 2 0.43 0.79 0.05 5.00
137 INT199650 Negative_regulation of Phyh 1 0.42 2.2 0.04 5.00
138 INT196396 Positive_regulation of Msra 2 0.36 1.09 0.04 5.00
139 INT196407 Binding of HSD17B10 2 0.21 0.58 0.03 5.00
140 INT315624 Positive_regulation of Gene_expression of ISCU 1 0.38 0.23 0.03 5.00
141 INT315583 Positive_regulation of Binding of NFS1 1 0.25 0 0 5.00
142 INT315551 Negative_regulation of Gene_expression of ALAS2 1 0.37 1.11 0 5.00
143 INT315585 Localization of SLC25A37 1 0.13 0.47 0 5.00
144 INT315581 Positive_regulation of Phosphorylation of ISCU 1 0.44 0.33 0 5.00
145 INT315617 Positive_regulation of Gene_expression of SLC25A37 1 0.10 0.39 0 5.00
146 INT196399 Transcription of Gfm1 2 0.01 0.89 0 5.00
147 INT196389 Gene_expression of Cisd1 3 0.01 0.44 0 5.00
148 INT315614 Negative_regulation of Transcription of FXN 1 0.25 0.82 0 5.00
149 INT315602 Binding of ISCA1 1 0.30 0 0 5.00
150 INT315587 Positive_regulation of Gene_expression of CIAO1 1 0.22 1.6 0 5.00
151 INT315591 Negative_regulation of Positive_regulation of SLC40A1 1 0.25 0.46 0 5.00
152 INT315620 Regulation of Gene_expression of GLRX5 1 0.40 0.5 0 5.00
153 INT315550 Transcription of GLRX5 1 0.53 0.66 0 5.00
154 INT315575 Transcription of SLC40A1 1 0.40 0.85 0 5.00
155 INT315637 Transcription of FXN 1 0.40 1.44 0 5.00
156 INT315563 Positive_regulation of Gene_expression of FXN 4 0.41 5.05 0 5.00
157 INT315634 Negative_regulation of Binding of ISCU 1 0.33 0.28 0 5.00
158 INT315597 Negative_regulation of ISCU 1 0.51 0.22 0 5.00
159 INT315600 Regulation of CIAO1 1 0.20 0.39 0 5.00
160 INT315571 Binding of NFS1 1 0.19 0 0 5.00
161 INT315613 Positive_regulation of WNT2 1 0.09 0.41 0 5.00
162 INT315627 Binding of GLRX5 1 0.33 0 0 5.00
163 INT315606 Regulation of Gene_expression of WNT2 1 0.08 0.84 0 5.00
164 INT315644 Negative_regulation of Transcription of DLEU1 1 0.21 0.64 0 5.00
165 INT315555 Binding of FXN 1 0.28 1.29 0 5.00
166 INT315605 Binding of ABCB7 1 0.33 1.84 0 5.00
167 INT315592 Positive_regulation of Gene_expression of SLC40A1 1 0.41 3.52 0 5.00
168 INT315640 Gene_expression of NUBP1 1 0.41 0.32 0 5.00
169 INT315567 Positive_regulation of Negative_regulation of CIAO1 1 0.22 1.29 0 5.00
170 INT315623 Positive_regulation of Localization of ACO1 1 0.20 0.79 0 5.00
171 INT315635 Positive_regulation of FXN 2 0.41 5.76 0 5.00
172 INT315608 Localization of NFU1 1 0.14 0 0 5.00
173 INT315596 Localization of ISCA2 1 0.11 0 0 5.00
174 INT315601 Positive_regulation of NFU1 1 0.22 0.13 0 5.00
175 INT315642 Negative_regulation of Gene_expression of NFU1 1 0.16 0.37 0 5.00
176 INT315636 Negative_regulation of ABCB7 1 0.38 0.17 0 5.00
177 INT196395 Transcription of Ros1 3 0.23 1.58 0 5.00
178 INT315570 Negative_regulation of Positive_regulation of TFRC 1 0.19 0.08 0 5.00
179 INT196400 Positive_regulation of Negative_regulation of Cd86 1 0.02 0.79 0 5.00
180 INT315573 Negative_regulation of Gene_expression of NFS1 1 0.24 0.74 0 5.00
181 INT315568 Regulation of Gene_expression of CIAO1 1 0.20 0.15 0 5.00
182 INT174850 Binding of ISCU 2 0.33 0.51 0 5.00
183 INT315638 Gene_expression of GLRX3 1 0.25 0 0 5.00
184 INT315564 Binding of NFU1 1 0.16 0 0 5.00
185 INT315619 Regulation of Gene_expression of NFS1 1 0.26 0.74 0 5.00
186 INT315607 Positive_regulation of Gene_expression of GLRX5 1 0.61 2.28 0 5.00
187 INT315593 Regulation of Transcription of SLC40A1 1 0.26 1.7 0 5.00
188 INT315641 Gene_expression of ISCA2 1 0.22 0 0 5.00
189 INT315590 Negative_regulation of Transcription of CIAO1 1 0.19 0.33 0 5.00
190 INT315612 Gene_expression of NFS1 1 0.39 1.68 0 5.00
191 INT315610 Transcription of DLEU1 1 0.25 0.64 0 5.00
192 INT315576 Positive_regulation of Binding of CIAO1 1 0.22 0.67 0 5.00
193 INT315615 Positive_regulation of ISCU 1 0.44 0.11 0 5.00
194 INT315589 Binding of CIAO1 1 0.16 0.67 0 5.00
195 INT199647 Regulation of Phyh 1 0.27 2.71 0 5.00
196 INT315599 Binding of ISCA2 1 0.12 0 0 5.00
197 INT315639 Localization of ISCU 1 0.66 0 0 5.00
198 INT315560 Gene_expression of SLC19A2 1 0.55 1.32 0 5.00
199 INT315629 Phosphorylation of ISCU 1 0.71 0.33 0 5.00
200 INT315586 Gene_expression of SLC25A38 1 0.52 0.51 0 5.00
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