D:Frontotemporal Dementia

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Disease Term
Synonyms Dementia Frontotemporal, Dementia Frontotemporal Lobe Fldem, Dementia Frontotemporal With Parkinsonism, Dementia Hereditary Dysphasic Disinhibition, DEMENTIA UBIQUITIN POSITIVE FRONTOTEMPORAL, Dementias Frontotemporal, Dementias Frontotemporal Lobe Fldem, Dementias Ubiquitin Positive Frontotemporal, FRONTOTEMPORAL DEMENTIA UBIQUITIN POSITIVE, Frontotemporal Dementia With Parkinsonism, Frontotemporal Dementias
Documents 62
Hot Single Events 80
Hot Interactions 10

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Frontotemporal Dementia. They are ordered first by their relevance to Frontotemporal Dementia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT217486 Binding of PDB1 and Sqstm1 1 0.03 1.19 0.08 100.00
2 INT306677 Binding of Mapt and Atxn3 1 0.07 0.49 0 100.00
3 INT325429 Mapt Positive_regulation of Csf2 1 0.13 1.29 0 97.36
4 INT335742 Binding of PDB1 and Dpyd 1 0.02 1.75 0.09 95.12
5 INT335743 Binding of PDB1 and Salpa1 1 0.01 1.66 0.09 90.40
6 INT303337 Binding of SOD1 and Igfals 1 0.06 1.27 0.08 86.00
7 INT174133 Binding of Igfals and Sod1 3 0.19 3 0.08 83.76
8 INT325431 Positive_regulation of Binding of Csf2 and Mapt 1 0.18 1.49 0 83.32
9 INT325433 Binding of Csf2 and Mapt 1 0.12 4.41 0 82.92
10 INT254906 Binding of Igfals and Chmp2b 1 0.02 0.85 0 81.80
11 INT325428 Csf2 Regulation of Mapt 1 0.08 1.47 0 75.28
12 INT316060 Binding of Erbb4 and Ncor2 1 0.12 0.41 0.03 65.04
13 INT316056 Binding of Ncor2 and Tab2 1 0.12 0.41 0.03 65.04
14 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17 64.76
15 INT316055 Binding of Erbb4 and Tab2 1 0.23 0.4 0.03 62.96
16 INT316061 Positive_regulation of Binding of Erbb4 and Nrg1 1 0.03 0.38 0.03 54.96
17 INT316057 Binding of Erbb4 and Nrg1 2 0.03 0.38 0.03 54.96
18 INT325432 Vsnl1 Positive_regulation of Csf2 1 0.19 1.07 0 54.32
19 INT325430 Vsnl1 Positive_regulation of Vhl-ps1 1 0.03 1.01 0 53.44
20 INT209400 Binding of F13A1 and FGG 1 0.01 1.72 0.09 43.04
21 INT320400 Binding of Vcp and Khdrbs1 1 0.01 0.07 0 31.12
22 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11 14.16
23 INT179566 Binding of C1qa and Ywhaq 1 0.00 0.56 0.26 11.56
24 INT316054 Eif1 Positive_regulation of Il6 1 0.00 0.78 0.21 8.52
25 INT316062 Ps Positive_regulation of Il6 1 0.04 0.77 0.21 8.52
26 INT316063 Ps Positive_regulation of IL8 1 0.09 1.33 0.41 7.52
27 INT316065 Eif1 Positive_regulation of IL8 1 0.01 1.34 0.41 7.52
28 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11 5.00
29 INT316064 Binding of RBPJ and Csl 1 0.16 0.33 0.2 5.00
30 INT282708 Binding of MAPT and Y301C7L 1 0.00 0.54 0.16 5.00
31 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15 5.00
32 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15 5.00
33 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15 5.00
34 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15 5.00
35 INT257937 Binding of CSF2 and INVS 1 0.04 1.1 0.14 5.00
36 INT340744 CSF2 Regulation of BDNF 1 0.13 1.45 0.14 5.00
37 INT340742 Positive_regulation of CSF2 Regulation of BDNF 1 0.22 1.46 0.14 5.00
38 INT255808 SMN2 Positive_regulation of SMN1 1 0.41 0.89 0.14 5.00
39 INT316059 Ps Regulation of Binding of Cd4 1 0.06 0.86 0.13 5.00
40 INT316058 Ps Regulation of Binding of Cd8a 1 0.02 0.86 0.13 5.00
41 INT217470 Traf6 Positive_regulation of Ngf 1 0.36 0.52 0.1 5.00
42 INT217476 Nup62 Positive_regulation of Ngf 1 0.37 0.52 0.1 5.00
43 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09 5.00
44 INT193963 App Regulation of Gene_expression of Ps 1 0.06 0.93 0.09 5.00
45 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08 5.00
46 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06 5.00
47 INT217472 Binding of Nup62 and Mul1 1 0.12 0 0.05 5.00
48 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05 5.00
49 INT316015 AIC Regulation of ERN1 1 0.08 0.1 0.05 5.00
50 INT331227 Binding of Becn1 and Pink1 1 0.03 1.13 0.05 5.00
51 INT320402 Binding of Usp14 and Psmb10 1 0.00 0 0.05 5.00
52 INT217468 Positive_regulation of Binding of Nup62 and Mul1 1 0.16 0 0.05 5.00
53 INT193966 AKT1 Negative_regulation of Gsk3b 1 0.05 0.75 0.05 5.00
54 INT193969 AKT1 Negative_regulation of Phosphorylation of Gsk3b 1 0.05 0.75 0.05 5.00
55 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05 5.00
56 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05 5.00
57 INT193964 Mapk1 Negative_regulation of Gsk3b 1 0.00 0.74 0.05 5.00
58 INT217467 Binding of Nup62 and Tnfrsf11a 1 0.31 0 0.05 5.00
59 INT320440 Binding of Adrm1 and Psmb10 1 0.00 0 0.04 5.00
60 INT320439 Binding of Uchl5 and Psmb10 1 0.00 0 0.04 5.00
61 INT217474 Tnfrsf11a Regulation of Gene_expression of Tnfsf11 1 0.41 1.2 0.04 5.00
62 INT254909 ARSH Regulation of Sumf1 1 0.00 0.9 0.04 5.00
63 INT254908 ARSH Regulation of Eef1a1 1 0.00 0.89 0.04 5.00
64 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0 5.00
65 INT335736 Binding of Map1lc3a and Map1lc3b 1 0.19 0.36 0 5.00
66 INT331234 Binding of Becn1 and Pik3c3 Positive_regulation of Pik3c3 1 0.00 0.47 0 5.00
67 INT331226 Binding of Becn1 and Pik3c3 1 0.02 0.47 0 5.00
68 INT331238 Binding of ULK1 and Pik3r1 1 0.09 0.48 0 5.00
69 INT331237 Negative_regulation of IMPA1 Negative_regulation of Itpr3 1 0.00 0.52 0 5.00
70 INT303333 MAPK1 Positive_regulation of Mknk2 1 0.04 0.14 0 5.00
71 INT193962 Binding of Psen1 and Ncstn 1 0.13 0.08 0 5.00
72 INT331232 Binding of Atg12 and Atg16l1 1 0.03 0.08 0 5.00
73 INT217473 Nup62 Regulation of Tnfrsf11a 1 0.38 0.66 0 5.00
74 INT217402 Binding of Bace1 and PSENEN 1 0.02 0.72 0 5.00
75 INT303331 Mtor Positive_regulation of Rps6kb1 1 0.07 0.07 0 5.00
76 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0 5.00
77 INT303332 ras Positive_regulation of Raf1 1 0.02 0.07 0 5.00
78 INT320399 Binding of Vcp and Psmb10 1 0.00 0.16 0 5.00
79 INT331222 Tsc1 Negative_regulation of Mtor 1 0.00 0.68 0 5.00
80 INT193949 Alph1 Positive_regulation of Notch1 1 0.01 0.08 0 5.00
81 INT217399 Binding of Bace1 and Ncstn 1 0.05 0.72 0 5.00
82 INT331235 RASA1 Positive_regulation of Mtor 1 0.00 0.32 0 5.00
83 INT193950 Alph1 Positive_regulation of Positive_regulation of Notch1 1 0.01 0.07 0 5.00
84 INT331225 Binding of Atg5 and Atg16l1 1 0.05 0.08 0 5.00
85 INT331231 Binding of Bcl2 and Mapk8 1 0.01 0.77 0 5.00
86 INT340743 Negative_regulation of CSF2 Positive_regulation of ZNF807 1 0.00 1.77 0 5.00
87 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0 5.00
88 INT268445 Olr1 Positive_regulation of Positive_regulation of Lipa 1 0.01 0.87 0 5.00
89 INT331230 Binding of Mapk8 and Becn1 1 0.02 0.77 0 5.00
90 INT303334 Binding of SOS1 and Grb2 1 0.00 0.11 0 5.00
91 INT303257 MAPK1 Positive_regulation of NEK4 1 0.05 0.14 0 5.00
92 INT340745 CSF2 Positive_regulation of ZNF807 1 0.00 1.76 0 5.00
93 INT255809 Binding of SF1 and U2AF2 1 0.21 0.3 0 5.00
94 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0 5.00
95 INT217487 Binding of PDB1 and Tnfrsf11a 1 0.03 0.76 0 5.00
96 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0 5.00
97 INT331228 Atg5 Positive_regulation of Atg12 1 0.06 0.08 0 5.00
98 INT303336 MAPKAPK2 Positive_regulation of Hspb2 1 0.04 0.24 0 5.00
99 INT217480 Tnfsf11 Negative_regulation of Tnfrsf11a 1 0.39 0.75 0 5.00
100 INT320401 Dbn1 Regulation of Protein_catabolism of Snap25 1 0.02 0 0 5.00
101 INT331224 Binding of Akt1 and Tsc2 1 0.03 0.33 0 5.00
102 INT193968 Binding of PSEN1 and Ps 1 0.07 0.66 0 5.00
103 INT268459 Binding of LDLR and Olr1 1 0.00 0.78 0 5.00
104 INT320397 Tax1bp1 Regulation of Protein_catabolism of Snap25 1 0.04 0 0 5.00
105 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0 5.00
106 INT193958 Binding of Pld1 and Psen1 1 0.17 0 0 5.00
107 INT331223 Negative_regulation of Tsc1 Positive_regulation of Positive_regulation of Mtor 1 0.01 0.33 0 5.00
108 INT217396 Binding of Abca1 and App 1 0.26 0.83 0 5.00
109 INT193965 Binding of BCL2 and Ps 1 0.05 0.59 0 5.00
110 INT193953 Binding of Bcl2l1 and Psen1 1 0.07 0.66 0 5.00
111 INT193960 Binding of Bcl2l1 and Ps 1 0.01 0.6 0 5.00
112 INT193956 Binding of Psen1 and Rab6a 1 0.15 0 0 5.00
113 INT193957 Binding of Bcl2l1 and Psen2 1 0.07 0.66 0 5.00
114 INT255810 SLU7 Positive_regulation of Binding of SNRPA 1 0.01 0.23 0 5.00
115 INT331229 Rasa1 Positive_regulation of Mtor 1 0.00 0.32 0 5.00
116 INT331233 Binding of Mtor and Rasa1 1 0.00 0.32 0 5.00
117 INT193947 Notch1 Positive_regulation of Alph1 1 0.01 0.07 0 5.00
118 INT331236 Binding of RASA1 and Mtor 1 0.00 0.32 0 5.00
119 INT303335 Binding of Igfals and CHMP2B 1 0.05 1.3 0 5.00
120 INT193961 Alph1 Positive_regulation of Zglp1 1 0.01 0.08 0 5.00
121 INT303338 Binding of ULK1 and Atg13 1 0.07 0.73 0 5.00
122 INT268446 Cdk5 Positive_regulation of Cdk5r1 1 0.02 0.58 0 5.00
123 INT320398 Binding of Psmb10 and Psmf1 1 0.00 0.1 0 5.00
124 INT217397 Binding of Bace1 and Alph1 1 0.02 0.73 0 5.00
125 INT331221 Binding of Akt1 and Tsc1 1 0.03 0.33 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Frontotemporal Dementia. They are ordered first by their pain relevance and then by number of times they were reported in Frontotemporal Dementia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT61999 Gene_expression of MAPT 19 0.75 15.4 1.3 100.00
2 INT107341 Phosphorylation of MAPT 19 0.80 14 1.61 100.00
3 INT1753 Gene_expression of Ache 38 0.78 15.31 4.58 99.84
4 INT8777 Positive_regulation of Ache 25 0.68 7.77 3.18 99.84
5 INT93017 Binding of PDB1 8 0.36 6.36 0.51 99.80
6 INT75299 Binding of Atxn3 8 0.43 5.3 0.26 99.64
7 INT163544 Binding of Psen1 40 0.36 15.28 2.42 99.56
8 INT16794 Binding of App 103 0.48 64.87 19.79 99.56
9 INT303326 Gene_expression of CHMP2B 25 0.75 10.08 0.76 99.52
10 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 99.12
11 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 99.08
12 INT24458 Negative_regulation of PDB1 8 0.41 4.5 1.5 98.88
13 INT155775 Gene_expression of PDB1 12 0.65 10.18 0.41 98.88
14 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 98.48
15 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 98.48
16 INT335740 Negative_regulation of VCP 1 0.41 1 0.03 98.40
17 INT97254 Positive_regulation of Gap43 22 0.46 7.36 4.48 98.00
18 INT263689 Positive_regulation of Mapt 6 0.49 5.15 0.36 97.56
19 INT155200 Protein_catabolism of VCP 1 0.70 1.18 0.06 97.34
20 INT171959 Binding of Tnfrsf11a 15 0.34 11.03 3.02 97.24
21 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35 97.12
22 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27 97.12
23 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45 97.04
24 INT217438 Binding of Chuk 24 0.25 7.29 1.29 97.04
25 INT124774 Binding of Vcp 4 0.44 3.4 0.52 97.04
26 INT118264 Binding of Hmbs 6 0.37 4.87 0.33 97.04
27 INT316035 Negative_regulation of Eif1 1 0.01 2.24 0.27 96.56
28 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 96.28
29 INT255824 Regulation of Gene_expression of MAPT 2 0.44 2.62 0 96.12
30 INT287203 Negative_regulation of Gene_expression of Htt 7 0.37 5.08 0.07 95.72
31 INT331193 Negative_regulation of Gene_expression of Atxn3 1 0.17 0.73 0 95.72
32 INT75627 Gene_expression of Mapt 41 0.75 22.1 4.58 95.64
33 INT48390 Negative_regulation of Localization of CSF2 10 0.51 7.39 3.28 95.64
34 INT169628 Binding of SNCA 4 0.47 3.53 0.36 95.52
35 INT200189 Negative_regulation of Igfals 7 0.24 4.19 1.39 95.44
36 INT14690 Localization of CSF2 124 0.80 85.17 27.26 95.40
37 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 95.28
38 INT25394 Negative_regulation of Gene_expression of Csf2 22 0.52 13.18 5.84 95.28
39 INT335728 Positive_regulation of Dpyd 1 0.17 1.74 0.09 95.12
40 INT118716 Positive_regulation of MAPT 4 0.49 7.25 0.54 95.08
41 INT303303 Positive_regulation of Gene_expression of CHMP2B 2 0.49 0.97 0 94.92
42 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 94.92
43 INT80597 Negative_regulation of Ptcra 4 0.37 2.54 1.01 94.80
44 INT135045 Gene_expression of Atxn3 34 0.78 11.59 0.36 94.32
45 INT166776 Localization of HMGN4 2 0.32 1.14 0.12 94.32
46 INT166777 Regulation of HMGN4 1 0.19 1.01 0.14 93.68
47 INT179534 Localization of Sephs1 1 0.12 0.76 0.1 93.40
48 INT193878 Negative_regulation of Ps 4 0.10 8.39 2.77 91.84
49 INT59454 Regulation of Gene_expression of CSF2 22 0.52 19.67 2.69 91.24
50 INT15310 Gene_expression of DLEU1 8 0.67 20.57 0.96 91.20
51 INT63133 Gene_expression of Pd 13 0.18 5.31 0.61 91.20
52 INT335733 Positive_regulation of Tardbp 8 0.69 28.41 0.41 90.64
53 INT282705 Regulation of Mapt 1 0.25 2.64 0 90.64
54 INT237045 Positive_regulation of Vcp 7 0.62 6.96 0.12 90.64
55 INT255817 Positive_regulation of Positive_regulation of GNAS 1 0.01 0.85 0 90.64
56 INT193832 Localization of Ps 19 0.13 6.96 8.04 90.52
57 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 90.40
58 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 90.08
59 INT193869 Negative_regulation of Localization of Ps 2 0.05 1.13 1.03 90.04
60 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32 90.00
61 INT254888 Binding of Chmp2b 1 0.13 0.88 0 89.08
62 INT14301 Binding of CSF2 82 0.48 67.95 8.98 88.96
63 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 88.20
64 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 88.16
65 INT68789 Regulation of CFP 17 0.51 4.76 3.98 88.16
66 INT95328 Gene_expression of Gstp1 11 0.61 8.59 0.48 87.52
67 INT155201 Gene_expression of VCP 4 0.75 8.25 0.31 87.20
68 INT56494 Localization of Ide 73 0.68 22.9 11.26 85.80
69 INT315626 Localization of DLEU1 2 0.35 4.17 0.07 85.36
70 INT217442 Regulation of Sqstm1 3 0.59 3.86 0.65 85.00
71 INT65500 Gene_expression of App 605 0.78 429.94 98.31 84.36
72 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77 84.32
73 INT316039 Negative_regulation of Tauph 2 0.42 2.01 0.26 84.32
74 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83 82.92
75 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19 82.92
76 INT56497 Negative_regulation of Localization of Ide 12 0.44 5.34 1.42 82.80
77 INT340751 Binding of DLEU1 1 0.20 12.05 0.49 82.68
78 INT201692 Positive_regulation of Positive_regulation of GSK 2 0.49 1.54 0.18 81.44
79 INT95939 Positive_regulation of GSK 19 0.67 10 1.33 81.00
80 INT335724 Positive_regulation of Localization of Tardbp 3 0.47 4.9 0.25 80.16
81 INT335731 Gene_expression of Vcp 1 0.73 12.21 0.18 79.04
82 INT141936 Phosphorylation of Mapt 14 0.80 10.59 0.95 79.04
83 INT335732 Positive_regulation of Gene_expression of Vcp 1 0.57 0.87 0 79.04
84 INT254885 Gene_expression of Chmp2b 1 0.24 0.84 0 79.00
85 INT335738 Positive_regulation of VCP 1 0.06 1.88 0.06 78.84
86 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84 78.80
87 INT292763 Localization of Tardbp 6 0.80 12.51 0.91 78.40
88 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 78.32
89 INT264685 Gene_expression of TARDBP 4 0.61 8.8 0.31 77.60
90 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38 77.20
91 INT121117 Regulation of Protein_catabolism of App 10 0.62 6.41 1.78 77.20
92 INT200186 Binding of Igfals 5 0.19 4.46 1.52 77.20
93 INT63923 Binding of Mapt 4 0.47 6.28 1.19 77.08
94 INT6666 Negative_regulation of PENK 30 0.58 9.16 17.91 76.48
95 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 76.36
96 INT237038 Gene_expression of Becn1 18 0.36 13.68 0.31 76.24
97 INT282981 Positive_regulation of Gene_expression of Becn1 8 0.13 6.2 0.06 76.24
98 INT277161 Gene_expression of UFD1L 1 0.78 8.73 0.39 75.52
99 INT179307 Regulation of GNAS 7 0.01 1.93 0.05 75.52
100 INT65502 Regulation of App 77 0.62 52.05 19.44 74.00
101 INT24459 Positive_regulation of PDB1 7 0.46 7 0.5 73.20
102 INT303287 Gene_expression of Tardbp 4 0.77 44.78 1.09 71.76
103 INT335735 Binding of Atp13a3 2 0.03 1.17 0.24 71.16
104 INT286313 Transcription of Psen1 9 0.70 2.26 0.76 70.88
105 INT316041 Transcription of Psen2 1 0.64 1.1 0.45 70.88
106 INT335729 Gene_expression of Vmn1r155 1 0.01 2.54 0 70.56
107 INT217448 Regulation of Tnfrsf11a 1 0.42 2.31 0.14 69.84
108 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 69.48
109 INT320422 Regulation of Psmb10 1 0.00 1.11 0.21 69.36
110 INT319758 Localization of Dcx 2 0.73 0.87 0.1 69.24
111 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 68.44
112 INT258685 Regulation of Gene_expression of Notch1 2 0.40 1.45 0.3 67.92
113 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41 67.36
114 INT209403 Positive_regulation of MYL10 1 0.01 6.28 0.07 67.04
115 INT320415 Negative_regulation of Psmb10 1 0.00 1.18 0.56 66.76
116 INT134915 Binding of Aif1 4 0.36 1.72 1.72 66.48
117 INT335734 Binding of Sh2b1 1 0.06 0.83 0.13 66.48
118 INT254887 Negative_regulation of Lamp1 2 0.20 3.17 0 65.80
119 INT255827 Positive_regulation of Gene_expression of MAPT 3 0.49 2.63 0.1 65.68
120 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 65.12
121 INT316040 Localization of Ncor2 2 0.28 0.57 0.03 65.04
122 INT320411 Gene_expression of Vcp 1 0.18 0.92 0 64.48
123 INT157305 Gene_expression of Map1lc3a 47 0.75 18.04 1.93 64.00
124 INT246641 Gene_expression of YWHAQ 5 0.58 3 0.22 63.68
125 INT157302 Positive_regulation of Map1lc3a 27 0.66 11.31 0.79 63.64
126 INT108539 Gene_expression of Khdrbs1 3 0.12 0.9 0 63.52
127 INT320414 Negative_regulation of Khdrbs1 1 0.04 0.44 0 61.92
128 INT123752 Regulation of Bax 19 0.60 16.45 4 61.76
129 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 60.56
130 INT216110 Binding of AAVS1 13 0.36 3.24 0.3 60.24
131 INT303308 Negative_regulation of CHMP2B 1 0.33 0.85 0 60.04
132 INT118711 Positive_regulation of Binding of Om 1 0.05 1.12 0.13 59.68
133 INT237409 Localization of Erbb4 3 0.57 1.31 1.41 59.44
134 INT118710 Negative_regulation of Binding of Om 1 0.05 1.12 0.13 59.40
135 INT13790 Binding of HTR1A 52 0.47 18.83 17.59 59.20
136 INT30961 Binding of HTR2A 33 0.47 11.44 12.86 59.20
137 INT83654 Positive_regulation of Binding of HTR2A 2 0.49 2.08 0.24 59.20
138 INT18681 Gene_expression of Thy1 80 0.71 38.8 5.23 59.16
139 INT73067 Binding of Om 8 0.08 2.35 2.56 59.08
140 INT231584 Protein_catabolism of SIPA1L1 1 0.05 0.29 0 56.24
141 INT183761 Phosphorylation of Csf2 6 0.80 4.04 1.58 56.00
142 INT179533 Regulation of Gene_expression of C1qa 1 0.44 0.67 0.04 55.36
143 INT56053 Negative_regulation of Bdnf 77 0.58 64.4 26.83 55.12
144 INT168640 Positive_regulation of Gene_expression of Iba1 9 0.33 8.3 4.55 55.12
145 INT335723 Negative_regulation of Gene_expression of Iba1 2 0.47 1.97 0.98 55.12
146 INT190676 Binding of Fkbp1a 15 0.36 3.11 0.28 54.76
147 INT168641 Gene_expression of Iba1 24 0.63 12.21 6.7 54.72
148 INT116229 Gene_expression of C1qa 28 0.77 18.53 5.35 54.24
149 INT9695 Negative_regulation of Csf2 41 0.57 31.65 6.28 54.16
150 INT105784 Binding of Nrg1 7 0.37 1.29 1.52 53.04
151 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 52.48
152 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 51.12
153 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 50.88
154 INT325422 Protein_catabolism of Ncs1 1 0.02 0.99 0 50.56
155 INT340749 Positive_regulation of ZNF807 1 0.00 3.79 0 50.28
156 INT68297 Binding of MAPT 9 0.47 4.45 0.75 50.00
157 INT25381 Localization of Csf2 62 0.76 47.48 9.03 49.76
158 INT24142 Regulation of DLEU1 1 0.21 1.01 0.85 49.76
159 INT43085 Negative_regulation of Ide 28 0.39 19.96 3.45 49.52
160 INT78649 Binding of Psen2 7 0.36 5.9 0.73 49.36
161 INT126200 Negative_regulation of Bace1 73 0.58 50.19 7.44 49.24
162 INT316038 Positive_regulation of Erbb4 2 0.45 0.22 0.03 48.56
163 INT193891 Binding of Parl 1 0.13 0.63 0 48.32
164 INT254881 Negative_regulation of Atg7 9 0.34 5.69 0.32 48.08
165 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 47.84
166 INT306663 Negative_regulation of Atg5 1 0.10 0.28 0 47.36
167 INT325425 Positive_regulation of Localization of Gstp1 1 0.04 0.9 0.37 46.92
168 INT325423 Localization of Gstp1 1 0.06 0.85 0.37 46.52
169 INT306659 Negative_regulation of Crtc2 1 0.01 0.17 0 46.20
170 INT209402 Regulation of Gene_expression of FGG 1 0.16 1.79 0 46.00
171 INT209406 Gene_expression of FGG 2 0.45 2.93 0 46.00
172 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 45.60
173 INT134468 Gene_expression of Cdk5r1 26 0.48 27.09 5.2 45.52
174 INT209408 Regulation of FGG 1 0.09 1.79 0 45.44
175 INT286615 Phosphorylation of Ide 7 0.31 5.22 0.7 45.08
176 INT325411 Binding of Tm2d1 1 0.01 0.71 0.07 43.80
177 INT193602 Negative_regulation of HTT 7 0.41 1.8 0 43.28
178 INT85621 Regulation of PRNP 16 0.60 8.7 1.15 42.96
179 INT325414 Regulation of Regulation of PRNP 1 0.26 0.7 0.16 42.96
180 INT217465 Regulation of Positive_regulation of PDB1 1 0.04 0.69 0.05 41.72
181 INT320424 Binding of Khdrbs1 1 0.04 0.19 0 41.60
182 INT1728 Negative_regulation of Cndp2 36 0.57 3.76 25.39 39.84
183 INT13840 Negative_regulation of CPQ 19 0.57 1.25 8.36 39.84
184 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85 37.48
185 INT179547 Negative_regulation of Gene_expression of C1qa 2 0.41 0.64 0.1 36.80
186 INT193855 Binding of Ps 8 0.07 3.15 0.25 35.52
187 INT6661 Positive_regulation of Positive_regulation of Jun 31 0.50 7.12 3.89 35.24
188 INT217447 Positive_regulation of Positive_regulation of Nfatc1 4 0.46 3.34 2.2 35.24
189 INT11625 Localization of App 98 0.78 55.46 20.86 34.88
190 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 34.76
191 INT194748 Positive_regulation of Nfatc1 16 0.64 5.07 2.44 34.76
192 INT209407 Positive_regulation of FGG 1 0.24 1.59 0.03 34.56
193 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56 33.44
194 INT85297 Positive_regulation of Gene_expression of TNNI3 29 0.50 29.77 1.68 33.44
195 INT320418 Binding of Vcp 1 0.14 0.31 0 32.72
196 INT199762 Positive_regulation of Gstp1 2 0.55 2.02 0.32 31.76
197 INT316049 Regulation of Regulation of Notch1 1 0.03 0.92 0.23 31.08
198 INT139872 Regulation of Notch1 14 0.45 7.69 2.82 29.68
199 INT143612 Positive_regulation of AIC 13 0.70 2.95 6.15 29.12
200 INT282985 Negative_regulation of Becn1 11 0.20 7.72 0.04 28.96
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