D:Frontotemporal Lobar Degeneration

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Disease Term
Synonyms DEGENERATION FRONTOTEMPORAL LOBAR, Degenerations Frontotemporal Lobar, Dementia Semantic, Dementias Semantic, Frontotemporal Lobar Degenerations, Ftld, FTLDS, LOBAR DEGENERATION FRONTOTEMPORAL, Lobar Degenerations Frontotemporal, Semantic Dementia, SEMANTIC DEMENTIAS
Documents 13
Hot Single Events 48
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Frontotemporal Lobar Degeneration. They are ordered first by their relevance to Frontotemporal Lobar Degeneration and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT303815 Binding of Igfals and Tdp1 1 0.11 1.68 0.1 96.52
2 INT264679 IGFALS Positive_regulation of CTSC 1 0.02 1.68 0 36.48
3 INT264683 Binding of VAPB and ALS2 1 0.29 1.1 0 31.40
4 INT264678 Binding of SETX and KRT20 1 0.00 2.17 0 30.80
5 INT264682 Binding of VAPB and SETX 1 0.28 1.09 0 30.36
6 INT303337 Binding of SOD1 and Igfals 1 0.06 1.27 0.08 5.00
7 INT174133 Binding of Igfals and Sod1 3 0.19 3 0.08 5.00
8 INT303333 MAPK1 Positive_regulation of Mknk2 1 0.04 0.14 0 5.00
9 INT303331 Mtor Positive_regulation of Rps6kb1 1 0.07 0.07 0 5.00
10 INT303332 ras Positive_regulation of Raf1 1 0.02 0.07 0 5.00
11 INT303822 Tdp1 Regulation of TREH 1 0.02 0.92 0 5.00
12 INT303334 Binding of SOS1 and Grb2 1 0.00 0.11 0 5.00
13 INT303257 MAPK1 Positive_regulation of NEK4 1 0.05 0.14 0 5.00
14 INT303336 MAPKAPK2 Positive_regulation of Hspb2 1 0.04 0.24 0 5.00
15 INT303335 Binding of Igfals and CHMP2B 1 0.05 1.3 0 5.00
16 INT303338 Binding of ULK1 and Atg13 1 0.07 0.73 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Frontotemporal Lobar Degeneration. They are ordered first by their pain relevance and then by number of times they were reported in Frontotemporal Lobar Degeneration. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT303799 Phosphorylation of Tdp1 1 0.82 22.84 0.71 100.00
2 INT303797 Phosphorylation of Igfals 1 0.21 1.61 0 100.00
3 INT191122 Localization of Igfals 2 0.20 2.16 0.5 100.00
4 INT203372 Positive_regulation of Igfals 10 0.40 9.24 1.11 100.00
5 INT191125 Gene_expression of Igfals 12 0.25 12.96 2.89 99.80
6 INT303805 Positive_regulation of Phosphorylation of Tdp1 1 0.50 3.27 0.09 99.72
7 INT303801 Positive_regulation of Tdp1 1 0.60 9.8 0.06 99.72
8 INT334211 Positive_regulation of Gene_expression of TARDBP 1 0.32 3.03 0 99.68
9 INT303796 Gene_expression of Tdp1 1 0.77 70.15 2.55 99.44
10 INT264685 Gene_expression of TARDBP 4 0.61 8.8 0.31 99.40
11 INT334213 Transcription of TARDBP 1 0.24 0.98 0 99.40
12 INT303295 Regulation of Tardbp 2 0.45 4.74 0 99.22
13 INT335733 Positive_regulation of Tardbp 8 0.69 28.41 0.41 99.20
14 INT303811 Binding of Tdp1 1 0.37 8.69 0.33 98.84
15 INT303804 Localization of Tdp1 1 0.80 11.71 0.59 98.64
16 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 98.32
17 INT292763 Localization of Tardbp 6 0.80 12.51 0.91 97.36
18 INT344992 Positive_regulation of Ranbp1 1 0.01 2.14 0 96.12
19 INT116432 Positive_regulation of Positive_regulation of SOD1 3 0.40 3.88 0.2 95.96
20 INT303810 Positive_regulation of Localization of Tdp1 1 0.46 0.67 0.03 94.64
21 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 94.56
22 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 93.84
23 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09 93.84
24 INT78297 Gene_expression of CD59 31 0.72 24.11 3.18 92.20
25 INT335724 Positive_regulation of Localization of Tardbp 3 0.47 4.9 0.25 91.20
26 INT344990 Binding of Tardbp 1 0.37 3.5 0.15 90.56
27 INT105569 Binding of IGFALS 13 0.25 17.31 1.36 90.32
28 INT118716 Positive_regulation of MAPT 4 0.49 7.25 0.54 89.88
29 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 89.52
30 INT303287 Gene_expression of Tardbp 4 0.77 44.78 1.09 88.32
31 INT56494 Localization of Ide 73 0.68 22.9 11.26 87.92
32 INT303795 Negative_regulation of Tdp1 1 0.43 1.71 0.08 87.48
33 INT344988 Positive_regulation of Gene_expression of Tardbp 1 0.47 3.29 0 87.44
34 INT264684 Regulation of Gene_expression of TARDBP 1 0.41 4.21 0.31 87.12
35 INT334210 Negative_regulation of Negative_regulation of DLEU1 1 0.09 1.14 0 87.00
36 INT49129 Positive_regulation of GFAP 35 0.69 28.78 10.38 86.68
37 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 86.08
38 INT334212 Negative_regulation of DLEU1 2 0.28 8.84 0.53 86.08
39 INT344986 Regulation of Positive_regulation of Tardbp 1 0.39 0.98 0 85.04
40 INT56497 Negative_regulation of Localization of Ide 12 0.44 5.34 1.42 84.92
41 INT191123 Positive_regulation of Igfals 3 0.18 2.89 0.68 84.80
42 INT283245 Gene_expression of MND1 2 0.11 1.94 0.07 84.72
43 INT264687 Binding of TARDBP 1 0.33 4.14 0.31 84.40
44 INT303806 Negative_regulation of Gene_expression of Tdp1 1 0.58 3.26 0.08 82.64
45 INT158146 Gene_expression of Ranbp1 2 0.04 3.09 0.09 81.60
46 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 80.44
47 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 80.24
48 INT163998 Gene_expression of CTSC 9 0.65 11.24 1.69 80.16
49 INT303808 Positive_regulation of Gene_expression of Tdp1 1 0.69 9.07 0.35 79.52
50 INT303284 Regulation of Gene_expression of Tardbp 2 0.45 6.82 0 76.20
51 INT344997 Regulation of Gene_expression of Rnrc 1 0.02 2.09 0 76.20
52 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11 75.56
53 INT329734 Gene_expression of Rnrc 2 0.04 7.78 0.16 74.12
54 INT344994 Regulation of Rnrc 1 0.01 1.01 0 72.32
55 INT303803 Transcription of Tdp1 1 0.53 0.56 0 69.68
56 INT303809 Positive_regulation of Lrrk2 1 0.39 1.25 0 68.44
57 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 64.12
58 INT303802 Binding of Tardbp 1 0.12 0.39 0 62.80
59 INT50080 Binding of APOE 38 0.45 29.61 2.67 62.00
60 INT23775 Regulation of S100B 24 0.62 16.75 2.57 59.12
61 INT58563 Negative_regulation of S100B 13 0.51 11.75 1.77 59.12
62 INT43085 Negative_regulation of Ide 28 0.39 19.96 3.45 51.64
63 INT284671 Binding of HOOK2 1 0.06 0.16 0 50.60
64 INT286615 Phosphorylation of Ide 7 0.31 5.22 0.7 47.20
65 INT59454 Regulation of Gene_expression of CSF2 22 0.52 19.67 2.69 45.72
66 INT303308 Negative_regulation of CHMP2B 1 0.33 0.85 0 42.16
67 INT292764 Negative_regulation of Tardbp 2 0.58 2.59 0.19 41.44
68 INT344991 Negative_regulation of Positive_regulation of Tardbp 1 0.43 0.81 0.05 41.44
69 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 36.44
70 INT303812 Regulation of Tdp1 1 0.45 3.32 0.19 27.84
71 INT224963 Gene_expression of Pdia6 6 0.22 4.51 0.28 24.72
72 INT240280 Gene_expression of IGFALS 14 0.42 20.38 0.95 21.76
73 INT344999 Protein_catabolism of Tardbp 1 0.66 1.18 0 11.84
74 INT344996 Negative_regulation of Gene_expression of Tardbp 1 0.43 0.73 0 8.60
75 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29 7.32
76 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 6.92
77 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 6.16
78 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
79 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
80 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
81 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
82 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
83 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
84 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
85 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
86 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 5.00
87 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
88 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 5.00
89 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
90 INT16794 Binding of App 103 0.48 64.87 19.79 5.00
91 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 5.00
92 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68 5.00
93 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 5.00
94 INT2038 Localization of Esr1 104 0.79 40.12 13.27 5.00
95 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38 5.00
96 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35 5.00
97 INT3535 Regulation of CA2 61 0.32 16.48 10.8 5.00
98 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38 5.00
99 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 5.00
100 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.00
101 INT33220 Negative_regulation of ras 110 0.58 70.21 9.19 5.00
102 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
103 INT38173 Gene_expression of Ang 40 0.75 32.63 8.86 5.00
104 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 5.00
105 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
106 INT179744 Negative_regulation of SLC1A2 16 0.45 12.32 6.14 5.00
107 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 5.00
108 INT26919 Gene_expression of ITPR3 47 0.42 5.86 5.79 5.00
109 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 5.00
110 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
111 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06 5.00
112 INT90277 Negative_regulation of Ppp2ca 15 0.41 4.04 4.02 5.00
113 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 5.00
114 INT160251 Gene_expression of Myo5a 48 0.63 37.14 3.16 5.00
115 INT3463 Gene_expression of Igfals 21 0.39 21.1 2.93 5.00
116 INT91319 Positive_regulation of CD63 6 0.63 3.86 2.76 5.00
117 INT83642 Gene_expression of CD63 22 0.77 10.06 2.63 5.00
118 INT191974 Regulation of Ide 16 0.38 9.54 2.52 5.00
119 INT15201 Positive_regulation of CHRM1 8 0.54 2.14 2.35 5.00
120 INT26335 Binding of ITPR3 22 0.18 3.3 2.27 5.00
121 INT100622 Localization of CD68 16 0.73 6.58 2.2 5.00
122 INT119018 Gene_expression of TREH 22 0.65 12.44 1.95 5.00
123 INT157305 Gene_expression of Map1lc3a 47 0.75 18.04 1.93 5.00
124 INT120505 Negative_regulation of ITPR3 6 0.27 1.46 1.68 5.00
125 INT139247 Gene_expression of S100a10 13 0.67 2.35 1.57 5.00
126 INT200186 Binding of Igfals 5 0.19 4.46 1.52 5.00
127 INT117101 Gene_expression of Sod1 18 0.67 7.93 1.47 5.00
128 INT120543 Gene_expression of AP4B1 4 0.58 1.75 1.44 5.00
129 INT125796 Regulation of Gene_expression of APP 8 0.59 5.95 1.41 5.00
130 INT200189 Negative_regulation of Igfals 7 0.24 4.19 1.39 5.00
131 INT61999 Gene_expression of MAPT 19 0.75 15.4 1.3 5.00
132 INT235401 Negative_regulation of Gene_expression of ITPR3 4 0.20 1.69 1.24 5.00
133 INT128752 Negative_regulation of Localization of Esr1 11 0.43 4.8 1.23 5.00
134 INT50494 Phosphorylation of Pla2g1b 4 0.29 1.39 1.17 5.00
135 INT284669 Gene_expression of LRRK2 3 0.65 4.58 1.14 5.00
136 INT141360 Negative_regulation of AP1B1 2 0.21 0 1.06 5.00
137 INT72002 Negative_regulation of Gnaq 7 0.35 0.2 1.02 5.00
138 INT68217 Positive_regulation of CHRM3 9 0.39 1.36 0.99 5.00
139 INT141936 Phosphorylation of Mapt 14 0.80 10.59 0.95 5.00
140 INT192785 Regulation of Myo5a 4 0.05 9.05 0.93 5.00
141 INT38172 Regulation of Ang 8 0.31 4.13 0.9 5.00
142 INT157303 Positive_regulation of Gene_expression of Map1lc3a 15 0.53 4.12 0.85 5.00
143 INT157302 Positive_regulation of Map1lc3a 27 0.66 11.31 0.79 5.00
144 INT284852 Binding of S100a10 4 0.26 1.58 0.78 5.00
145 INT303326 Gene_expression of CHMP2B 25 0.75 10.08 0.76 5.00
146 INT139249 Negative_regulation of S100a10 4 0.42 1.21 0.75 5.00
147 INT702 Negative_regulation of TREH 3 0.36 1.01 0.75 5.00
148 INT90757 Gene_expression of Brp8 4 0.14 1.6 0.75 5.00
149 INT129630 Regulation of Sod1 6 0.44 4.94 0.73 5.00
150 INT127432 Gene_expression of Nup62 20 0.71 11.01 0.71 5.00
151 INT261203 Binding of HTs 5 0.32 3.01 0.71 5.00
152 INT160799 Regulation of IGFALS 11 0.29 9.09 0.7 5.00
153 INT133386 Positive_regulation of PNKD 2 0.45 1.71 0.69 5.00
154 INT240281 Positive_regulation of IGFALS 11 0.31 10.44 0.56 5.00
155 INT225462 Positive_regulation of Positive_regulation of APP 3 0.44 1.41 0.55 5.00
156 INT210539 Binding of Ide 11 0.29 6.09 0.52 5.00
157 INT83641 Binding of CD63 4 0.19 1 0.45 5.00
158 INT264689 Negative_regulation of IGFALS 10 0.33 12.58 0.45 5.00
159 INT125586 Gene_expression of Stmn1 13 0.75 8.28 0.42 5.00
160 INT96520 Gene_expression of PRPH 5 0.75 2.55 0.39 5.00
161 INT187472 Regulation of Gene_expression of Sod1 5 0.53 2.68 0.37 5.00
162 INT286614 Phosphorylation of Zfp422 1 0.01 1.51 0.36 5.00
163 INT303286 Localization of Nup62 1 0.08 0 0.35 5.00
164 INT236580 Regulation of Binding of Esr1 4 0.39 1.1 0.34 5.00
165 INT158697 Negative_regulation of Vti1b 2 0.42 0.45 0.3 5.00
166 INT123622 Negative_regulation of Vcp 5 0.42 2.51 0.3 5.00
167 INT251949 Negative_regulation of Gene_expression of PRNP 6 0.43 4.16 0.3 5.00
168 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 5.00
169 INT264686 Positive_regulation of Gene_expression of IGFALS 2 0.28 2.21 0.27 5.00
170 INT284851 Positive_regulation of Gene_expression of S100a10 2 0.25 0.73 0.27 5.00
171 INT226646 Protein_catabolism of Nxf1 4 0.64 1.59 0.25 5.00
172 INT166432 Positive_regulation of Atp2a2 5 0.44 0.45 0.24 5.00
173 INT344987 Gene_expression of Gm270 1 0.02 1.63 0.23 5.00
174 INT202756 Phosphorylation of Brp8 3 0.02 1.23 0.2 5.00
175 INT232830 Positive_regulation of Protein_catabolism of Nup62 3 0.39 0.75 0.15 5.00
176 INT345000 Binding of Olfr7 1 0.36 0.78 0.13 5.00
177 INT237045 Positive_regulation of Vcp 7 0.62 6.96 0.12 5.00
178 INT303807 Gene_expression of LOC100360075 1 0.08 2.7 0.1 5.00
179 INT286616 Phosphorylation of Phf1 3 0.39 1.08 0.1 5.00
180 INT125587 Positive_regulation of Gene_expression of Stmn1 9 0.67 4.2 0.08 5.00
181 INT160627 Positive_regulation of Slc8a1 2 0.22 0.27 0.07 5.00
182 INT286610 Phosphorylation of Htr7 1 0.02 0.44 0.07 5.00
183 INT232834 Protein_catabolism of Nup62 3 0.56 0.8 0.07 5.00
184 INT303278 Negative_regulation of Hspb2 2 0.27 1.53 0.05 5.00
185 INT303283 Gene_expression of Mknk2 1 0.39 0.33 0.05 5.00
186 INT286609 Gene_expression of Phf1 1 0.20 0.44 0.05 5.00
187 INT303306 Positive_regulation of CHMP2B 1 0.61 0.09 0.05 5.00
188 INT303281 Regulation of Mknk2 1 0.18 0.33 0.05 5.00
189 INT303290 Regulation of Gene_expression of Mknk2 1 0.18 0.33 0.05 5.00
190 INT286611 Phosphorylation of Gm270 1 0.01 0.67 0.04 5.00
191 INT286613 Phosphorylation of Pdia6 1 0.01 0.67 0.04 5.00
192 INT303305 Negative_regulation of LMNB1 1 0.04 0.82 0.04 5.00
193 INT284672 Gene_expression of ZFAND2B 1 0.11 1.03 0.04 5.00
194 INT303324 Negative_regulation of Gene_expression of CHMP2B 1 0.32 0 0.03 5.00
195 INT303320 Positive_regulation of VDAC3 1 0.12 0.27 0.03 5.00
196 INT344995 Binding of Gm270 1 0.01 0.67 0.03 5.00
197 INT303311 Negative_regulation of GNA11 1 0.01 0.2 0.03 5.00
198 INT303303 Positive_regulation of Gene_expression of CHMP2B 2 0.49 0.97 0 5.00
199 INT303319 Localization of CHMP2B 1 0.57 0.43 0 5.00
200 INT303322 Positive_regulation of Phosphorylation of EIF4A2 1 0.08 0.16 0 5.00
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