D:Functional Bowel Disorder

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Disease Term
Synonyms Colonic Dysmotility, Colonic Hypermotility, Colonic Motility Disorder, Functional Abdominal Bloating, Functional Bowel Disease, Functional Constipation, FUNCTIONAL GASTROINTESTINAL DISORDER, GASTROINTESTINAL DYSMOTILITY, Gastrointestinal Hypermotility, GASTROINTESTINAL MOTILITY DISORDER, INTESTINAL DYSMOTILITY
Documents 5603
Hot Single Events 200
Hot Interactions 18

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Functional Bowel Disorder. They are ordered first by their relevance to Functional Bowel Disorder and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT32030 Binding of CEL and ERLEC1 1 0.08 0.42 0.1 97.60
2 INT153026 Binding of HTR3A and INSRR 1 0.13 0.29 0.1 96.48
3 INT153027 Binding of HTR3A and KCNMA1 1 0.18 0.29 0.1 96.48
4 INT153028 Binding of INSRR and KCNMA1 1 0.06 0.29 0.1 96.24
5 INT140667 IFNG Regulation of Gene_expression of SLC6A4 1 0.40 0.41 0.34 96.20
6 INT118136 Binding of HTR1A and HTR2A 1 0.36 0.77 0.45 96.00
7 INT140666 TNF Regulation of Gene_expression of SLC6A4 1 0.40 0.41 0.34 95.64
8 INT224404 Binding of GYPC and PYY 1 0.04 1.48 1.42 94.68
9 INT118239 Binding of CCKAR and CYP2B6 1 0.32 0.19 0.29 94.60
10 INT55901 Negative_regulation of Alox5 Negative_regulation of Localization of Ptafr 1 0.01 0.35 0.24 91.60
11 INT55902 Negative_regulation of Pla2g1b Negative_regulation of Localization of Ptafr 1 0.11 0.35 0.24 91.60
12 INT55903 Negative_regulation of Mthfs Negative_regulation of Localization of Ptafr 1 0.01 0.35 0.24 91.60
13 INT35691 IGHG3 Positive_regulation of Gene_expression of SUPT7L 1 0.26 0.18 0.09 91.48
14 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03 91.00
15 INT144107 Binding of SLC6A2 and SLC6A4 1 0.00 0.18 0.62 91.00
16 INT202160 Binding of ARSD and CSF1R 1 0.16 1.69 0.59 88.20
17 INT114414 TF Regulation of INS 1 0.18 0.09 0.09 85.04
18 INT116966 TNF Negative_regulation of Localization of CCL20 1 0.30 1.49 0.28 84.12
19 INT116369 Binding of Calca and Atp8a2 1 0.02 0.38 0.56 79.68
20 INT128684 Binding of TGM1 and RETNLB 1 0.00 2.46 0.72 78.12
21 INT137416 Binding of SDC1 and Tnf 1 0.00 1.19 0.47 75.28
22 INT167139 Binding of Ghrl and Mln 1 0.04 0.56 0.65 75.00
23 INT81267 Negative_regulation of Binding of MLN and NCOR2 1 0.02 0.28 0.56 75.00
24 INT81265 Binding of MLN and NCOR2 1 0.02 0.23 0.51 75.00
25 INT154329 Binding of S100A8 and S100A12 1 0.41 0.5 0.19 74.08
26 INT277192 SUGT1 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.86 1.04 73.44
27 INT341534 INSRR Positive_regulation of F2RL1 1 0.00 1.4 0.7 69.92
28 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84 69.36
29 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84 69.12
30 INT301079 Binding of GNAT1 and INPP5E 1 0.00 0.59 0.89 67.04
31 INT316889 Binding of Cd19 and Cr2 1 0.07 1.7 0.61 66.56
32 INT316882 Binding of Cd22 and Cr2 1 0.02 1.71 0.61 66.56
33 INT316883 Positive_regulation of Binding of Cd19 and Cd22 1 0.02 0.86 0.31 66.56
34 INT316884 Positive_regulation of Binding of Cr2 and Bcr 1 0.06 0.86 0.31 66.56
35 INT316886 Positive_regulation of Binding of Cd22 and Cr2 1 0.02 0.86 0.31 66.56
36 INT316881 Positive_regulation of Binding of Cd19 and Bcr 1 0.08 0.86 0.31 66.56
37 INT316887 Binding of Cd19 and Cd22 1 0.02 0.85 0.31 66.56
38 INT316885 Binding of Cr2 and Bcr 1 0.06 0.85 0.3 66.56
39 INT316888 Binding of Cd19 and Bcr 1 0.08 0.85 0.3 66.56
40 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93 66.40
41 INT158877 PRS Positive_regulation of Gene_expression of Fos 1 0.09 5.14 1.54 57.08
42 INT246360 Binding of Cea and Muc6 1 0.00 1.09 0.12 55.72
43 INT246362 Binding of MUC2 and Cea 1 0.00 1.08 0.12 55.72
44 INT137248 Slc6a14 Negative_regulation of Gene_expression of Ptgs2 1 0.19 1.32 0.58 53.72
45 INT137247 Slc6a14 Negative_regulation of Ptgs2 2 0.19 1.38 0.58 53.72
46 INT163410 CRX Positive_regulation of Gene_expression of Crhr2 1 0.02 0.94 0.05 53.20
47 INT163411 CRX Negative_regulation of Gene_expression of Crhr2 1 0.02 0.94 0.05 53.20
48 INT137246 Slc6a14 Negative_regulation of Gene_expression of Fos 1 0.10 1.24 0.54 51.52
49 INT159837 Trim2 Negative_regulation of Transcription of Fos 1 0.10 1.92 1.22 50.92
50 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92 50.00
51 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73 50.00
52 INT258858 CTSB Positive_regulation of Gene_expression of IL8 1 0.00 0.64 0.28 50.00
53 INT164736 MIR29A Regulation of Glul 1 0.59 0.06 0 50.00
54 INT66724 Mln Regulation of Localization of Cck 1 0.21 0 0 50.00
55 INT341531 F2RL1 Regulation of CD55 1 0.33 0.41 0.18 46.48
56 INT158878 CRX Positive_regulation of Gene_expression of Fos 1 0.02 1.49 0.41 46.20
57 INT270316 Binding of AMBP and NHS 1 0.20 0.91 0 41.60
58 INT288497 Binding of Tlr7 and Tlr9 1 0.21 0.97 0.27 40.80
59 INT100084 Binding of CRH and CRHR2 1 0.32 1.11 0.19 35.24
60 INT224406 INS Regulation of Localization of PYY 1 0.11 0.27 0.27 34.08
61 INT224405 INS Regulation of Localization of CCK 1 0.12 0.27 0.27 33.52
62 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 31.04
63 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5 26.40
64 INT122710 GUCA2A Positive_regulation of RTCA 1 0.03 0.16 0.05 25.00
65 INT122713 Guca2b Positive_regulation of RTCA 1 0.03 0.16 0.05 25.00
66 INT290377 NOD2 Negative_regulation of Positive_regulation of TLR2 1 0.24 0.95 0.23 18.80
67 INT290378 NOD2 Negative_regulation of TLR2 1 0.27 0.83 0.23 13.84
68 INT126335 Binding of Pax3 and Tac1 6 0.07 6.22 5.27 5.00
69 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
70 INT1151 Binding of CCK and GAST 7 0.49 0.73 3.08 5.00
71 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
72 INT329451 Binding of Oprd1 and Tacr1 1 0.05 0.23 1.41 5.00
73 INT329452 Binding of Tac1 and Oprd1 1 0.01 0.23 1.4 5.00
74 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29 5.00
75 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21 5.00
76 INT203016 CCK Positive_regulation of Localization of PYY 3 0.68 1.19 1.17 5.00
77 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11 5.00
78 INT230594 Binding of Hrh1 and Hrh2 1 0.24 0.99 1.02 5.00
79 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96 5.00
80 INT107001 F2 Positive_regulation of PAR1 4 0.05 2.15 0.92 5.00
81 INT185417 Binding of ALOX5 and PLA2G2A 4 0.16 3.13 0.9 5.00
82 INT126268 Tpsab1 Positive_regulation of F2rl1 2 0.35 1.65 0.88 5.00
83 INT224403 Binding of CCK and GYPC 1 0.04 0.83 0.77 5.00
84 INT224463 TPSAB1 Positive_regulation of F2RL1 2 0.03 1.49 0.76 5.00
85 INT313778 Gene_expression of Crhq1 Negative_regulation of Localization of Crh 1 0.05 0.66 0.71 5.00
86 INT171901 Binding of TNF and Il1 2 0.18 1.07 0.7 5.00
87 INT261517 Binding of HTR2A and USH1C 1 0.01 0 0.66 5.00
88 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63 5.00
89 INT230595 Binding of TNF and Tecr 1 0.03 1 0.62 5.00
90 INT181491 Tryptase Positive_regulation of HTR1A 1 0.02 0.93 0.61 5.00
91 INT185358 Binding of MCS and PCS 7 0.22 3.34 0.57 5.00
92 INT307016 IGKV1-17 Positive_regulation of Gene_expression of IL6 1 0.00 1.01 0.56 5.00
93 INT187222 Binding of Vip and Vipr2 2 0.19 1.82 0.56 5.00
94 INT202157 Binding of CSF1R and SLC6A4 1 0.08 0.9 0.54 5.00
95 INT66438 Tac2 Regulation of Binding of TAC1 1 0.01 0.12 0.47 5.00
96 INT280189 Binding of Cbs and P2rx3 1 0.01 1.03 0.47 5.00
97 INT280188 Binding of Cbs and Trpv1 1 0.26 1.03 0.47 5.00
98 INT312813 Binding of F2rl1 and Tpsab1 1 0.01 0.26 0.46 5.00
99 INT312814 TNF Positive_regulation of Spg21 1 0.00 0.6 0.45 5.00
100 INT189197 RASGRP1 Positive_regulation of JUN 1 0.07 1.26 0.43 5.00
101 INT327562 Binding of MCS and AKR1B10 1 0.00 0.5 0.41 5.00
102 INT290821 CRX Positive_regulation of Cort 1 0.14 0.51 0.41 5.00
103 INT350814 Negative_regulation of TNF Positive_regulation of Gene_expression of Cpox 1 0.06 1.33 0.37 5.00
104 INT350816 TNF Positive_regulation of Gene_expression of Cpox 1 0.05 1.33 0.37 5.00
105 INT307017 LBR Positive_regulation of Gene_expression of TNF 1 0.02 0.58 0.32 5.00
106 INT280190 Cbs Regulation of Gene_expression of Hist1h1t 1 0.04 0.58 0.32 5.00
107 INT307014 LBR Positive_regulation of Gene_expression of IL6 1 0.01 0.58 0.32 5.00
108 INT307008 MT1JP Positive_regulation of Gene_expression of IL6 1 0.02 0.27 0.32 5.00
109 INT307019 MT1JP Positive_regulation of Gene_expression of IL10 1 0.03 0.58 0.32 5.00
110 INT307018 MT1JP Positive_regulation of Gene_expression of CD69 1 0.05 0.83 0.29 5.00
111 INT264782 Binding of CRH and CRHR1 1 0.02 0.06 0.28 5.00
112 INT189200 Binding of CA2 and ITPR3 3 0.03 1.9 0.27 5.00
113 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27 5.00
114 INT307009 MT1JP Positive_regulation of Gene_expression of LAMP1 1 0.03 0.58 0.26 5.00
115 INT341515 C1QL1 Positive_regulation of Binding of TRGC1 and C1QL1 1 0.03 0.21 0.25 5.00
116 INT304582 IL12A Positive_regulation of Gene_expression of TH1L 1 0.21 0.83 0.25 5.00
117 INT304580 IL12A Regulation of Gene_expression of TH1L 1 0.19 0.82 0.25 5.00
118 INT341541 Binding of C1R and C1QL1 1 0.09 0.21 0.25 5.00
119 INT341536 Binding of TRGC1 and C1QL1 1 0.04 0.21 0.25 5.00
120 INT341513 C1R Positive_regulation of Binding of TRGC1 and C1QL1 1 0.02 0.21 0.25 5.00
121 INT341512 C1QL1 Positive_regulation of Binding of C1R and TRGC1 1 0.02 0.21 0.25 5.00
122 INT341532 Binding of C1R and TRGC1 1 0.04 0.21 0.25 5.00
123 INT341514 C1R Positive_regulation of Binding of C1R and TRGC1 1 0.02 0.21 0.25 5.00
124 INT290376 Binding of CSF1R and MEFV 1 0.29 0.31 0.24 5.00
125 INT307011 MT1JP Regulation of IL2 1 0.01 0 0.24 5.00
126 INT341538 F2 Positive_regulation of F2RL1 1 0.02 0.68 0.24 5.00
127 INT66437 Tac2 Regulation of TAC1 1 0.01 0.06 0.23 5.00
128 INT307013 MT1JP Negative_regulation of Binding of ROS1 1 0.02 0.64 0.23 5.00
129 INT189199 JUN Positive_regulation of KRT16 1 0.31 0.58 0.22 5.00
130 INT189196 RASGRP1 Positive_regulation of SP1 1 0.05 0.63 0.21 5.00
131 INT312815 IL1B Positive_regulation of Localization of Il6 1 0.00 0.33 0.2 5.00
132 INT340447 Negative_regulation of IRF6 Positive_regulation of RELA 1 0.00 0.87 0.18 5.00
133 INT340448 IRF6 Positive_regulation of RELA 1 0.00 0.86 0.17 5.00
134 INT261518 Binding of DLG4 and HTR4 1 0.01 0 0.16 5.00
135 INT350815 Negative_regulation of Binding of TNF and Il1 1 0.05 0.37 0.16 5.00
136 INT261521 Binding of ADCY1 and GLUL 1 0.01 0.09 0.15 5.00
137 INT261520 Binding of DLG4 and HTR2A 1 0.06 0 0.14 5.00
138 INT326605 Binding of HTR1A and KCNH2 1 0.00 0.45 0.14 5.00
139 INT343027 Binding of CYP3A4 and Azi1 1 0.02 0.75 0.14 5.00
140 INT185455 MUC1 Negative_regulation of Timp1 1 0.06 0.84 0.13 5.00
141 INT243308 Binding of LAMP2 and BBC3 1 0.08 0.59 0.13 5.00
142 INT261519 Binding of HTR4 and USH1C 1 0.00 0 0.13 5.00
143 INT243319 Binding of ATP6V0A1 and BBC3 1 0.07 0.59 0.13 5.00
144 INT185454 IGHG1 Negative_regulation of Timp1 1 0.04 0.85 0.13 5.00
145 INT185416 MUC1 Negative_regulation of TIMP1 1 0.18 0.84 0.13 5.00
146 INT185418 IGHG1 Negative_regulation of TIMP1 1 0.11 0.84 0.13 5.00
147 INT311399 Binding of Celf1 and Uts2r 1 0.08 0.26 0.12 5.00
148 INT319735 Positive_regulation of Binding of IL6 and IL8 1 0.01 1.35 0.11 5.00
149 INT341529 PRSS1 Positive_regulation of Gene_expression of F2RL1 1 0.06 0 0.11 5.00
150 INT307012 MT1JP Regulation of IL4 1 0.01 0 0.11 5.00
151 INT341543 PRSS1 Positive_regulation of Transcription of F2RL1 1 0.06 0 0.11 5.00
152 INT201348 Binding of Il4 and Ik 1 0.01 0.67 0.09 5.00
153 INT304581 IL4 Positive_regulation of Gene_expression of IGHE 1 0.17 0.35 0.09 5.00
154 INT307010 MT1JP Regulation of IL6 1 0.01 0 0.09 5.00
155 INT189195 Binding of C4A and C4B 1 0.14 2.45 0.09 5.00
156 INT201349 Binding of Hand2 and Il4 1 0.17 0.67 0.09 5.00
157 INT243309 TNFAIP1 Positive_regulation of Localization of TNF 1 0.07 0.71 0.08 5.00
158 INT243313 TNFAIP1 Positive_regulation of TNF 1 0.31 0.71 0.08 5.00
159 INT261556 Binding of USH1C and Olr1746 1 0.01 0 0.06 5.00
160 INT189202 Binding of C4B and HAS2 1 0.02 1.25 0.05 5.00
161 INT333847 Binding of E2f5 and Mir17 1 0.03 0.52 0.05 5.00
162 INT333849 Binding of Mcm4 and Mir17 1 0.03 0.52 0.05 5.00
163 INT333846 Binding of Wee1 and Mir17 1 0.03 0.52 0.05 5.00
164 INT333840 Binding of Cables1 and Mir17 1 0.03 0.52 0.05 5.00
165 INT243359 Binding of TNF and Tnfrsf14 1 0.01 0.86 0.05 5.00
166 INT333851 Binding of Ccna1 and Mir17 1 0.04 0.52 0.05 5.00
167 INT341542 Binding of DUSP4 and MAPK8 1 0.04 0.28 0.05 5.00
168 INT264780 Binding of ADRA2B and Regulation of MRGPRX1 1 0.00 0 0.05 5.00
169 INT307015 MT1JP Positive_regulation of IL6 1 0.03 0 0.05 5.00
170 INT297121 Binding of GNB3 and Eps8l3 1 0.00 0.81 0.05 5.00
171 INT280738 Mpl Positive_regulation of gr 1 0.01 0 0.05 5.00
172 INT307007 MT1JP Positive_regulation of Localization of LBR 1 0.01 0 0.05 5.00
173 INT341533 DUSP4 Regulation of MAPK8 1 0.03 0.28 0.05 5.00
174 INT333841 Binding of Rad51 and Mir17 1 0.02 0.52 0.05 5.00
175 INT341535 F2RL1 Positive_regulation of Gene_expression of THBS1 1 0.28 0.75 0.04 5.00
176 INT333839 Binding of Ccna1 and Tpt1 1 0.07 0.48 0.04 5.00
177 INT333852 Binding of Ccna1 and Cdk2 1 0.20 0.48 0.04 5.00
178 INT189198 Binding of C4A and SERPINF1 1 0.12 1.17 0.04 5.00
179 INT333844 Binding of Ccna1 and E2f2 1 0.00 0.48 0.04 5.00
180 INT333848 Binding of Ccna1 and Rb1 1 0.04 0.48 0.04 5.00
181 INT341537 F2RL1 Positive_regulation of TSC1 1 0.01 0.76 0.03 5.00
182 INT264801 Binding of Crhr2 and UCN2 1 0.00 0 0.03 5.00
183 INT272517 Binding of Ccnd1 and Celf1 3 0.08 0.07 0 5.00
184 INT352175 USE1 Regulation of NAGA 1 0.01 0.33 0 5.00
185 INT311390 Mbnl1 Positive_regulation of Celf1 1 0.26 0.48 0 5.00
186 INT311387 Binding of Celf1 and Mbnl1 1 0.20 0.25 0 5.00
187 INT311405 CCND3 Regulation of Celf1 1 0.41 0.14 0 5.00
188 INT333853 Binding of SOD1 and Gtf3a 1 0.00 0 0 5.00
189 INT234357 GRHPR Regulation of MRT5 1 0.00 0.05 0 5.00
190 INT260578 Binding of IGHG3 and SGSM3 1 0.00 1.07 0 5.00
191 INT333842 Hnf1a Positive_regulation of Mir194-1 1 0.02 0.18 0 5.00
192 INT311404 Binding of CDKN2A and Celf1 1 0.32 0.07 0 5.00
193 INT243318 MAPK3 Negative_regulation of FOS 1 0.04 0.14 0 5.00
194 INT299946 Binding of Tlr4 and Synj2bp 1 0.00 0.28 0 5.00
195 INT243315 MTTP Regulation of Gene_expression of CD1A 1 0.02 0.12 0 5.00
196 INT189203 CHGB Regulation of CA2 1 0.04 0.95 0 5.00
197 INT144261 CRH Positive_regulation of SEMA6A 1 0.56 0 0 5.00
198 INT311389 Positive_regulation of Binding of Celf1 and Eif2s2 1 0.17 0.59 0 5.00
199 INT333843 Ccne1 Regulation of Regulation of Mir103-2 1 0.06 0 0 5.00
200 INT311381 Phosphorylation of Akt1 Regulation of Celf1 1 0.10 0.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Functional Bowel Disorder. They are ordered first by their pain relevance and then by number of times they were reported in Functional Bowel Disorder. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 100.00
2 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 100.00
3 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 100.00
4 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 100.00
5 INT59165 Binding of fc 67 0.36 37.51 8.68 100.00
6 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4 100.00
7 INT2406 Gene_expression of CCK 85 0.78 28.04 46.67 100.00
8 INT85226 Gene_expression of JBS 2 0.38 0.94 0.97 100.00
9 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68 100.00
10 INT738 Regulation of POMC 459 0.62 111.19 243.74 100.00
11 INT88278 Binding of Kit 33 0.37 24.45 4.13 100.00
12 INT154664 Regulation of Positive_regulation of RETNLB 1 0.00 0.4 0.58 100.00
13 INT156752 Positive_regulation of JBS 1 0.32 0.29 0.38 100.00
14 INT146040 Regulation of JBS 1 0.02 1.43 1.04 100.00
15 INT73599 Negative_regulation of Gene_expression of Cpox 47 0.55 19.89 17.26 100.00
16 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 100.00
17 INT85227 Positive_regulation of Gene_expression of JBS 1 0.30 0.45 0.5 100.00
18 INT156290 Binding of JBS 1 0.00 0.45 0.45 100.00
19 INT157725 Gene_expression of ACLS 2 0.13 2.89 0.17 100.00
20 INT64827 Binding of Il2ra 5 0.36 6.57 0.79 100.00
21 INT2336 Negative_regulation of Lct 51 0.58 33.79 13.73 99.96
22 INT46060 Regulation of Negative_regulation of Lct 1 0.27 0.96 0.45 99.96
23 INT107012 Binding of EPRS 5 0.30 2.92 1.63 99.96
24 INT129053 Regulation of EPRS 3 0.17 2.79 1.6 99.96
25 INT130405 Regulation of Binding of EPRS 1 0.05 0.44 0.22 99.96
26 INT182720 Binding of SHE 18 0.26 9.15 2.24 99.92
27 INT1898 Regulation of Crh 220 0.62 61.33 102.64 99.84
28 INT24166 Localization of Mln 40 0.80 9.11 10.32 99.84
29 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 99.84
30 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59 99.84
31 INT164937 Protein_catabolism of occludin 1 0.36 0.61 0.51 99.84
32 INT164935 Positive_regulation of Protein_catabolism of occludin 1 0.25 0.47 0.51 99.84
33 INT147372 Gene_expression of Ginf1 1 0.01 0.19 0.37 99.84
34 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 99.76
35 INT126223 Binding of Nos2 17 0.37 6 3.22 99.76
36 INT189249 Localization of BGN 2 0.08 2.14 0.8 99.76
37 INT287 Localization of Cck 518 0.81 86.84 364.04 99.68
38 INT147554 Gene_expression of Birc2 11 0.75 10.93 0.6 99.68
39 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64 99.60
40 INT8824 Regulation of Vip 95 0.62 15.7 43.63 99.48
41 INT154334 Localization of S100A12 9 0.80 9.32 2.89 99.48
42 INT114862 Gene_expression of BEST1 16 0.65 12.14 1.53 99.48
43 INT72759 Transcription of Cpox 40 0.39 17.26 10 99.48
44 INT15584 Binding of S100A12 14 0.48 15.14 3 99.48
45 INT62510 Positive_regulation of MCS 32 0.60 11.79 5.45 99.46
46 INT9012 Localization of Vip 283 0.81 31.71 106.16 99.44
47 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 99.44
48 INT11525 Negative_regulation of Localization of Vip 42 0.49 6.91 18.04 99.44
49 INT61953 Transcription of Nos2 101 0.72 46.64 25.49 99.42
50 INT54099 Protein_catabolism of Trpm8 1 0.54 0.17 0.17 99.40
51 INT14513 Localization of Ghrl 52 0.78 29.26 11.63 99.36
52 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85 99.36
53 INT110 Regulation of Adrb3 33 0.60 8.09 13.84 99.34
54 INT132326 Positive_regulation of Negative_regulation of MCS 3 0.28 1.83 0.51 99.34
55 INT91817 Positive_regulation of RETNLB 22 0.34 21.4 13.12 99.28
56 INT35251 Regulation of Ghrl 21 0.60 8.26 2.6 99.28
57 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 99.24
58 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 99.24
59 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03 99.24
60 INT16277 Regulation of CHGA 16 0.44 11.31 4.43 99.22
61 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 99.20
62 INT30961 Binding of HTR2A 33 0.47 11.44 12.86 99.20
63 INT149027 Positive_regulation of C1s 8 0.36 4.27 0.51 99.18
64 INT47909 Binding of CPP 32 0.48 24.9 13.79 99.16
65 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72 99.16
66 INT19420 Positive_regulation of Positive_regulation of RIPK2 1 0.49 0.59 0.5 99.16
67 INT934 Regulation of Gtf3a 25 0.35 11.35 6.34 99.16
68 INT53949 Positive_regulation of Gene_expression of Cpox 82 0.65 38.12 25.93 99.14
69 INT62511 Negative_regulation of MCS 20 0.50 6.77 2.35 99.14
70 INT8725 Gene_expression of Mln 32 0.77 14.9 12.22 99.12
71 INT95481 Regulation of Gene_expression of TRPV1 48 0.62 29.3 26.28 99.08
72 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 99.08
73 INT53948 Regulation of Gene_expression of Cpox 40 0.51 20.97 13.87 99.08
74 INT115858 Positive_regulation of PRSS3 5 0.50 2.06 1.72 99.08
75 INT74286 Regulation of Il10 42 0.44 28.06 19.44 99.08
76 INT32032 Gene_expression of DMBT1 3 0.04 2.43 0.2 99.06
77 INT32031 Gene_expression of LOH19CR1 2 0.65 1.66 0.64 99.06
78 INT87470 Gene_expression of SDC1 27 0.78 24.86 5.81 99.04
79 INT116970 Gene_expression of CCL20 50 0.78 70.54 15.78 99.04
80 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 99.04
81 INT116975 Transcription of CCL20 4 0.69 7.15 2.03 99.04
82 INT116979 Negative_regulation of Gene_expression of CCL20 1 0.43 1.46 0.31 99.04
83 INT116969 Negative_regulation of CCL20 1 0.43 1.46 0.31 99.04
84 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.02
85 INT123142 Gene_expression of DEFB4A 54 0.76 36.14 10.02 99.02
86 INT6891 Binding of TTR 72 0.48 22.81 6.51 99.00
87 INT55658 Binding of HTR4 8 0.47 2.14 2.19 99.00
88 INT53871 Gene_expression of Socs1 32 0.71 22.83 6.21 99.00
89 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28 98.96
90 INT8634 Gene_expression of Nfasc 23 0.68 9.16 14.96 98.96
91 INT947 Regulation of Mln 20 0.59 4.09 5.87 98.92
92 INT48688 Positive_regulation of HTR4 12 0.67 1.94 2.81 98.88
93 INT62881 Positive_regulation of Positive_regulation of HTR4 2 0.49 0.96 0.59 98.88
94 INT183932 Localization of S100A9 13 0.47 14.99 4.21 98.86
95 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 98.80
96 INT5509 Positive_regulation of Localization of Crh 91 0.70 30.65 53.92 98.80
97 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41 98.72
98 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6 98.72
99 INT7584 Gene_expression of Crh 112 0.78 39.15 25.33 98.72
100 INT8075 Localization of Crh 64 0.81 25.41 19.45 98.72
101 INT152223 Binding of BEST1 10 0.29 6.67 1.46 98.72
102 INT146693 Gene_expression of Mbl1 17 0.59 10.99 3.13 98.68
103 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 98.68
104 INT1562 Localization of Crh 499 0.81 126.74 236.68 98.66
105 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 98.64
106 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 98.64
107 INT116973 Negative_regulation of Gene_expression of CCR6 5 0.40 7 2.44 98.64
108 INT116977 Transcription of CCR6 2 0.50 3.98 0.97 98.64
109 INT116971 Negative_regulation of CCR6 2 0.40 2.95 0.51 98.64
110 INT4798 Gene_expression of Nts 169 0.77 29.56 86.04 98.60
111 INT946 Negative_regulation of Nts 60 0.57 4.61 34.44 98.60
112 INT162453 Positive_regulation of IBD9 1 0.14 2.28 0.7 98.56
113 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 98.48
114 INT74134 Localization of FCGR2A 1 0.04 0.75 0.38 98.48
115 INT74136 Localization of IGHA1 1 0.63 0.54 0.3 98.48
116 INT10286 Positive_regulation of Positive_regulation of Cck 20 0.70 4.05 18.46 98.48
117 INT12082 Localization of IL6 365 0.81 241.78 105.78 98.48
118 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 98.48
119 INT111016 Gene_expression of F2rl1 11 0.73 3.58 2.37 98.48
120 INT74135 Localization of FCGR2C 1 0.02 0.27 0.15 98.48
121 INT42479 Positive_regulation of Negative_regulation of Lct 2 0.50 1 0.89 98.44
122 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 98.40
123 INT57256 Gene_expression of HLA-DQA2 52 0.55 23.87 6.27 98.40
124 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 98.40
125 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47 98.36
126 INT121678 Gene_expression of SRY 15 0.68 5.61 0.06 98.36
127 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 98.32
128 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09 98.28
129 INT54840 Localization of HTR4 6 0.73 2.67 3.42 98.28
130 INT62848 Negative_regulation of GER 8 0.57 3.89 0.93 98.24
131 INT44066 Gene_expression of Ltf 20 0.77 15.09 4.57 98.24
132 INT53402 Gene_expression of Htr7 7 0.75 1.13 3.02 98.16
133 INT142738 Gene_expression of Aqp8 13 0.78 4.46 0.71 98.00
134 INT178002 Positive_regulation of CSF1R 2 0.37 6.52 2.74 98.00
135 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46 97.96
136 INT157506 Gene_expression of Ly96 10 0.30 1.69 0.86 97.96
137 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52 97.92
138 INT12474 Regulation of INSRR 18 0.29 6.29 4.81 97.92
139 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22 97.86
140 INT118516 Positive_regulation of Positive_regulation of F2RL1 7 0.49 4.63 6.33 97.86
141 INT85631 Positive_regulation of Tyrp1 40 0.64 18.73 10.84 97.84
142 INT158168 Positive_regulation of CLCA2 1 0.04 0.74 0.22 97.84
143 INT326607 Positive_regulation of STC1 1 0.20 3 0.2 97.80
144 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52 97.72
145 INT75713 Positive_regulation of Mcpt2 9 0.69 5.93 2.16 97.72
146 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42 97.64
147 INT16569 Negative_regulation of HTR3A 14 0.57 6.91 4.42 97.56
148 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 97.52
149 INT15849 Gene_expression of FRTS 27 0.58 7.14 5.14 97.52
150 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06 97.48
151 INT14600 Positive_regulation of Tpsab1 51 0.68 22.1 7.7 97.48
152 INT10188 Positive_regulation of Il2ra 19 0.45 11.6 3.37 97.48
153 INT50740 Positive_regulation of SPG21 18 0.67 8.3 1.65 97.48
154 INT18894 Gene_expression of CPP 44 0.77 23.05 23.05 97.40
155 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 97.34
156 INT19430 Positive_regulation of IGHA1 10 0.67 6.42 2.58 97.34
157 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 97.34
158 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 97.34
159 INT19426 Positive_regulation of FCGR2A 4 0.07 1.68 0.85 97.34
160 INT74132 Positive_regulation of FCGR2C 2 0.13 0.72 0.23 97.34
161 INT944 Negative_regulation of Mln 14 0.43 3.39 4.96 97.32
162 INT13134 Binding of ADRA2C 11 0.46 0.73 3.86 97.32
163 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 97.28
164 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 97.28
165 INT13790 Binding of HTR1A 52 0.47 18.83 17.59 97.12
166 INT67637 Positive_regulation of PKM 2 0.49 2.39 1.46 97.12
167 INT80161 Positive_regulation of Crhr1 13 0.67 9.66 7.33 96.96
168 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 96.96
169 INT157664 Positive_regulation of DEFB4A 15 0.56 10.87 3.8 96.96
170 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 96.92
171 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 96.88
172 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18 96.88
173 INT55899 Positive_regulation of Ptafr 6 0.63 4.7 1.34 96.88
174 INT546 Binding of ALB 311 0.48 85.98 60.14 96.84
175 INT8713 Regulation of Tac1 56 0.60 25.29 45.94 96.80
176 INT74726 Negative_regulation of Slc6a4 61 0.59 21.01 27.84 96.68
177 INT9231 Binding of Htr3a 27 0.47 7.29 13.04 96.68
178 INT39212 Binding of Ttr 14 0.48 9.62 2.31 96.64
179 INT3637 Positive_regulation of Localization of Trh 33 0.70 2.13 10.55 96.56
180 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 96.52
181 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 96.52
182 INT15202 Regulation of Tacr1 26 0.60 9.65 16.48 96.48
183 INT9996 Positive_regulation of Localization of IGHE 8 0.49 1.95 1.8 96.44
184 INT132325 Positive_regulation of Localization of SYK 1 0.49 0.56 0.54 96.44
185 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 96.44
186 INT18898 Positive_regulation of CHGA 38 0.67 28.99 4.86 96.40
187 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 96.40
188 INT153972 Positive_regulation of HTR3B 1 0.47 0.37 0.23 96.36
189 INT9230 Gene_expression of Htr3a 43 0.78 10.54 18.81 96.28
190 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 96.28
191 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24 96.24
192 INT403 Localization of Trh 241 0.81 28.55 81.45 96.16
193 INT54602 Regulation of MCS 22 0.24 10.41 5.75 96.12
194 INT8388 Positive_regulation of Vip 142 0.70 39.72 67.61 96.08
195 INT350364 Negative_regulation of ITM2B 1 0.27 10.5 3.42 96.04
196 INT140670 Negative_regulation of Gene_expression of SLC6A4 4 0.51 2.7 3.88 95.96
197 INT48896 Positive_regulation of Gene_expression of Il10 73 0.70 43.14 35.5 95.92
198 INT5045 Regulation of VIP 26 0.62 7.15 11.61 95.88
199 INT49266 Positive_regulation of Arigg4 37 0.47 53.79 11.2 95.84
200 INT122675 Negative_regulation of Gene_expression of Slc6a4 14 0.59 6.4 4.69 95.80
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