D:Gastrinoma

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Disease Term
Synonyms GASTRIN PRODUCING TUMOR, Gastrin Producing Tumors, Gastrinomas, ISLET CELL TUMOR ULCEROGENIC, Tumor Gastrin Producing, Tumors Gastrin Producing, Ulcerogenic Islet Cell Tumor
Documents 120
Hot Single Events 51
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Gastrinoma. They are ordered first by their relevance to Gastrinoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT30905 SST Negative_regulation of Localization of GCG 2 0.12 1.56 1.04 98.36
2 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96 98.36
3 INT303656 SST Negative_regulation of Localization of GAST 1 0.12 1.45 0.82 98.36
4 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3 96.72
5 INT229634 GOPC Positive_regulation of GAST 1 0.09 0.47 0.19 83.28
6 INT303659 SSTR2 Negative_regulation of Gene_expression of SST 1 0.30 0.94 0.16 65.20
7 INT303657 Gene_expression of SSTR2 Negative_regulation of Gene_expression of SST 1 0.30 0.94 0.16 65.20
8 INT39935 Gast Regulation of Gene_expression of Sct 1 0.15 1.15 0.06 62.04
9 INT212080 Eno2 Regulation of Localization of SYP 1 0.03 0.51 0.07 51.64
10 INT212071 Eno2 Regulation of Localization of Afp 1 0.01 0.52 0.07 51.64
11 INT212079 SYP Regulation of Localization of Afp 1 0.10 0.52 0.07 51.64
12 INT212078 Eno2 Regulation of Localization of EPHB6 1 0.03 0.52 0.07 51.64
13 INT212063 CHGA Regulation of Localization of SYP 1 0.49 0.51 0.07 51.64
14 INT212077 CHGA Regulation of Localization of Afp 1 0.10 0.52 0.07 51.64
15 INT212070 ENO2 Regulation of Localization of AFP 1 0.49 0.52 0.07 51.64
16 INT212064 ENO2 Regulation of Localization of SYP 1 0.49 0.51 0.07 51.64
17 INT212068 CHGA Regulation of Localization of EPHB6 1 0.49 0.52 0.07 51.64
18 INT212076 ENO2 Regulation of Localization of Afp 1 0.10 0.52 0.07 51.64
19 INT212069 SYP Regulation of Localization of EPHB6 1 0.49 0.52 0.07 51.64
20 INT212067 CHGA Regulation of Localization of AFP 1 0.49 0.52 0.07 51.64
21 INT212081 Eno2 Regulation of Localization of AFP 1 0.03 0.52 0.07 51.64
22 INT212062 SYP Regulation of Localization of AFP 1 0.49 0.52 0.07 51.64
23 INT212066 ENO2 Regulation of Localization of EPHB6 1 0.49 0.52 0.07 51.64
24 INT39934 Sct Regulation of Gast 1 0.08 1 0.09 45.64
25 INT303652 Binding of SST and SSTR2 1 0.26 0.46 0.57 5.00
26 INT303654 Binding of SST and SSTR5 1 0.22 0.46 0.57 5.00
27 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54 5.00
28 INT303651 Binding of SSTR2 and SSTR5 1 0.24 0.23 0.45 5.00
29 INT263917 Binding of SST and Sstr5 2 0.02 0.56 0.45 5.00
30 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41 5.00
31 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4 5.00
32 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
33 INT197811 Binding of SMS and SST 1 0.00 0.98 0.21 5.00
34 INT263901 Binding of Ighg1 and Slc3a2 1 0.00 0.89 0.16 5.00
35 INT197808 Binding of MEN1 and NME1 1 0.00 1.81 0 5.00
36 INT197809 Binding of MEN1 and VIM 1 0.04 0.52 0 5.00
37 INT197810 Binding of MEN1 and MUC1 1 0.06 0.47 0 5.00
38 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0 5.00
39 INT197816 Binding of MEN1 and NFKB1 1 0.05 0.07 0 5.00
40 INT197813 Binding of AMBP and MEN1 1 0.00 0.51 0 5.00
41 INT197812 Binding of AMBP and RDBP 1 0.00 0.51 0 5.00
42 INT197817 Binding of JUND and MEN1 1 0.18 0.14 0 5.00
43 INT263918 Binding of PTPRC and Cea 1 0.00 0.37 0 5.00
44 INT197844 Binding of MEN1 and Nfkb1 1 0.06 0.26 0 5.00
45 INT197815 Binding of MEN1 and TGFB1 1 0.16 0.13 0 5.00
46 INT263899 Binding of PTPRC and TMED7-TICAM2 1 0.00 0.85 0 5.00
47 INT197814 Binding of MEN1 and RELA 1 0.42 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Gastrinoma. They are ordered first by their pain relevance and then by number of times they were reported in Gastrinoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT90 Localization of Gast 400 0.81 137.67 113 99.92
2 INT2243 Localization of GAST 67 0.81 34.54 16.19 99.84
3 INT13733 Localization of SSTR1 8 0.65 3.11 2.49 99.80
4 INT136531 Binding of Men1 8 0.47 9.62 0.65 99.76
5 INT7253 Negative_regulation of Localization of Gast 70 0.59 21.06 20.06 99.74
6 INT2244 Positive_regulation of Localization of GAST 7 0.68 5.28 0.73 99.68
7 INT140542 Gene_expression of SSTR2 18 0.65 13.58 3.94 99.64
8 INT243480 Gene_expression of SSTR5 1 0.55 4.25 0.85 99.60
9 INT624 Positive_regulation of GAST 28 0.70 15.61 4.73 99.42
10 INT197832 Localization of MEN1 1 0.80 11.01 0.63 99.40
11 INT19220 Transcription of Gast 7 0.71 2.03 3.41 99.32
12 INT138872 Gene_expression of SPINK5 21 0.58 30.11 4.12 99.16
13 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 99.04
14 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 99.04
15 INT24724 Positive_regulation of Gene_expression of SST 11 0.67 7.51 6.12 99.04
16 INT2093 Gene_expression of GAST 50 0.78 32.32 7.98 98.86
17 INT3173 Negative_regulation of Localization of Sct 28 0.55 6.46 12.11 98.80
18 INT686 Negative_regulation of Sct 35 0.59 9.59 11.32 98.80
19 INT5118 Regulation of SST 97 0.62 34.35 51.74 98.76
20 INT288 Positive_regulation of Sct 88 0.70 32.83 24.5 98.72
21 INT397 Localization of SST 232 0.81 58.05 101.19 98.36
22 INT2364 Localization of Sct 134 0.80 26.21 41.47 98.32
23 INT158766 Localization of GRN 2 0.73 1.59 0.28 98.12
24 INT4075 Positive_regulation of Gene_expression of Gast 24 0.68 19.99 4.02 97.96
25 INT197827 Regulation of PHPT1 1 0.03 2.54 0.08 97.84
26 INT8154 Positive_regulation of Positive_regulation of Gast 13 0.54 6.59 3.49 97.80
27 INT29 Negative_regulation of Gast 74 0.59 24.85 24.96 97.68
28 INT30 Gene_expression of Gast 158 0.78 99 41.45 97.56
29 INT91 Positive_regulation of Localization of Gast 96 0.70 23.22 29.36 97.20
30 INT2278 Regulation of Localization of Gast 81 0.62 16.93 30.64 97.20
31 INT812 Localization of INS 1026 0.81 515.6 145.31 97.12
32 INT628 Negative_regulation of GAST 10 0.58 4.44 2.08 95.96
33 INT252 Localization of GH1 529 0.80 227.4 122.05 95.96
34 INT286 Positive_regulation of Positive_regulation of Sct 8 0.49 3.42 2.66 95.88
35 INT300623 Positive_regulation of Men1 1 0.35 10.65 0.57 94.84
36 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 93.08
37 INT18898 Positive_regulation of CHGA 38 0.67 28.99 4.86 92.88
38 INT17625 Localization of GCG 210 0.80 55.69 24.97 92.60
39 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 92.12
40 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 91.76
41 INT28642 Gene_expression of CXCR2 60 0.78 38.69 18.11 91.68
42 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 91.36
43 INT695 Binding of POMC 304 0.48 56.66 126.85 89.36
44 INT219879 Positive_regulation of SPINK5 4 0.30 7.64 1.16 87.84
45 INT197842 Gene_expression of PHPT1 1 0.06 5.89 0.16 87.28
46 INT164833 Transcription of Men1 1 0.53 1.25 0.14 87.24
47 INT152437 Localization of SPINK5 4 0.54 3.97 0.69 83.72
48 INT8725 Gene_expression of Mln 32 0.77 14.9 12.22 83.20
49 INT40753 Gene_expression of GLI1 9 0.75 5.98 0.33 82.40
50 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 82.00
51 INT691 Binding of SST 67 0.48 24.66 32.67 81.28
52 INT263872 Localization of Adra1d 1 0.01 2.5 0.11 79.92
53 INT197828 Negative_regulation of MEN1 1 0.43 5.06 0.06 78.68
54 INT197839 Negative_regulation of PHPT1 1 0.04 2.88 0.06 78.68
55 INT216011 Regulation of TSC2 2 0.26 3.31 0 77.24
56 INT1636 Gene_expression of Sct 58 0.77 16.14 11.57 77.12
57 INT7362 Gene_expression of Sst 185 0.78 41.73 111.37 76.32
58 INT197835 Positive_regulation of Gene_expression of PHPT1 1 0.04 3.17 0.07 76.08
59 INT158764 Binding of SPINK5 7 0.35 8.84 0.37 75.92
60 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 75.84
61 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2 75.80
62 INT61102 Gene_expression of MEN1 12 0.78 17.7 0.43 75.76
63 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 75.76
64 INT197836 Positive_regulation of Gene_expression of MEN1 1 0.50 3.16 0.07 75.76
65 INT118350 Negative_regulation of Chga 2 0.42 1.64 0.71 75.48
66 INT14930 Regulation of Gene_expression of SST 12 0.45 6.86 3.89 75.28
67 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 75.20
68 INT4853 Regulation of Hrh2 42 0.45 22.34 16.65 75.00
69 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46 74.72
70 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 73.76
71 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 73.76
72 INT31576 Transcription of SST 5 0.69 0.89 0.68 70.28
73 INT124407 Gene_expression of SSTR1 4 0.55 5.55 1.41 66.48
74 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 66.32
75 INT41555 Gene_expression of GRN 8 0.52 10.94 0.69 62.72
76 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 62.56
77 INT263879 Positive_regulation of Adra1d 1 0.00 0.47 0.04 62.16
78 INT233 Binding of Gast 31 0.42 17.07 5.21 62.04
79 INT249 Localization of GHRH 215 0.80 78.02 51.87 59.48
80 INT237247 Regulation of Mri1 6 0.27 4.64 1.2 56.80
81 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 53.84
82 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 52.72
83 INT303678 Regulation of Gene_expression of SSTR1 1 0.19 0.84 0.18 51.68
84 INT16277 Regulation of CHGA 16 0.44 11.31 4.43 51.64
85 INT56817 Regulation of Eno2 16 0.61 10.64 1.99 51.64
86 INT132885 Regulation of SYP 4 0.44 3.92 0.44 51.64
87 INT24890 Localization of SYP 5 0.73 2.22 2.23 51.16
88 INT8225 Localization of CHGA 26 0.78 13.52 9.4 50.56
89 INT29635 Localization of Eno2 9 0.76 6.05 1.35 49.84
90 INT160606 Localization of AFP 6 0.74 3.39 1.29 48.28
91 INT50950 Localization of Afp 9 0.50 5.04 0.18 48.28
92 INT212074 Localization of EPHB6 1 0.73 0.31 0.07 48.28
93 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 39.20
94 INT443 Localization of POMC 1020 0.81 284.52 443.17 38.80
95 INT1893 Localization of Gh 1041 0.79 340.23 256.58 38.80
96 INT425 Localization of PRL 455 0.81 189.64 144.8 38.80
97 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 36.48
98 INT158 Localization of Prl 2431 0.81 378.96 952.2 36.04
99 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 29.76
100 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 27.92
101 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 26.88
102 INT197 Gene_expression of Hrh2 24 0.63 12.35 8.37 25.00
103 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 20.76
104 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 20.32
105 INT49769 Binding of SSTR2 4 0.48 1.39 2.14 20.20
106 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 20.12
107 INT239095 Negative_regulation of PTTG1 2 0.32 8.24 0.09 19.12
108 INT266810 Negative_regulation of Binding of SST 1 0.22 0.56 0.41 17.60
109 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 13.96
110 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 9.28
111 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 7.44
112 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
113 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
114 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
115 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
116 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
117 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
118 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
119 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
120 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
121 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
122 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
123 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
124 INT129686 Gene_expression of FSCN1 46 0.15 18.91 34.47 5.00
125 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
126 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
127 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
128 INT28 Regulation of Gast 106 0.62 26.37 29.85 5.00
129 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 5.00
130 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
131 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
132 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
133 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
134 INT693 Negative_regulation of Localization of SST 46 0.59 8.57 21.75 5.00
135 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
136 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 5.00
137 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
138 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
139 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
140 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
141 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
142 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 5.00
143 INT987 Localization of TRH 37 0.78 10.53 11.1 5.00
144 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
145 INT2491 Regulation of Cea 38 0.61 26.18 10.95 5.00
146 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8 5.00
147 INT65058 Binding of Nfkb1 36 0.45 19.87 10.02 5.00
148 INT4494 Regulation of GCG 41 0.45 18.38 9.68 5.00
149 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48 5.00
150 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
151 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 5.00
152 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
153 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 5.00
154 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 5.00
155 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
156 INT3395 Negative_regulation of VIP 15 0.59 4.23 5.62 5.00
157 INT14681 Negative_regulation of GCG 31 0.57 13.55 4.98 5.00
158 INT67195 Negative_regulation of Gene_expression of SST 7 0.42 6.98 4.88 5.00
159 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 5.00
160 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 5.00
161 INT17182 Binding of Cea 25 0.48 14.98 4.16 5.00
162 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 5.00
163 INT48726 Gene_expression of IGFBP1 27 0.67 9.45 3.36 5.00
164 INT986 Negative_regulation of Localization of GHRH 16 0.58 8.57 3.16 5.00
165 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 5.00
166 INT16130 Binding of IGF1 67 0.48 27.43 2.95 5.00
167 INT99961 Positive_regulation of SYP 13 0.67 15.13 2.79 5.00
168 INT9473 Binding of MUC1 66 0.48 46.77 2.36 5.00
169 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 5.00
170 INT57018 Gene_expression of GANAB 9 0.08 3.76 1.79 5.00
171 INT104524 Localization of FSCN1 3 0.13 1.76 1.75 5.00
172 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73 5.00
173 INT48616 Positive_regulation of IGFBP1 14 0.43 5.62 1.56 5.00
174 INT44783 Gene_expression of Chga 3 0.75 1.72 1.45 5.00
175 INT212466 Regulation of EPHB1 7 0.37 5.72 1.42 5.00
176 INT303667 Regulation of BCL2L11 3 0.16 1.03 1.21 5.00
177 INT166261 Localization of SLN 2 0.66 1.23 1.07 5.00
178 INT86834 Positive_regulation of Tg 10 0.69 4.9 1.04 5.00
179 INT134822 Gene_expression of Gja1 18 0.72 4.2 1 5.00
180 INT263912 Positive_regulation of SLN 6 0.39 0.66 0.99 5.00
181 INT144461 Negative_regulation of SSTR2 2 0.49 1.03 0.98 5.00
182 INT192300 Positive_regulation of Gene_expression of IGFBP1 6 0.60 2.85 0.81 5.00
183 INT263905 Gene_expression of SLN 33 0.63 23.21 0.74 5.00
184 INT61910 Binding of Slc3a2 6 0.01 3 0.7 5.00
185 INT246036 Positive_regulation of GRN 3 0.17 2.04 0.69 5.00
186 INT158836 Positive_regulation of Localization of TRH 7 0.49 2.61 0.67 5.00
187 INT243477 Binding of SSTR1 3 0.26 3.49 0.65 5.00
188 INT115423 Gene_expression of Men1 4 0.47 14.08 0.64 5.00
189 INT178752 Binding of IGFBP1 8 0.15 4.58 0.61 5.00
190 INT214707 Gene_expression of Slc2a8 5 0.24 2.76 0.61 5.00
191 INT30629 Regulation of Positive_regulation of SST 2 0.37 1.35 0.59 5.00
192 INT202187 Regulation of GRN 3 0.09 1.47 0.53 5.00
193 INT303669 Regulation of SPINK5 1 0.24 0.65 0.53 5.00
194 INT91209 Binding of VIM 15 0.36 12.02 0.53 5.00
195 INT55047 Gene_expression of GNRHR 8 0.78 5.2 0.53 5.00
196 INT300621 Localization of Men1 1 0.56 4.63 0.52 5.00
197 INT303674 Positive_regulation of Regulation of BCL2L11 1 0.02 0.28 0.5 5.00
198 INT263904 Negative_regulation of Gene_expression of SLN 1 0.14 7.18 0.47 5.00
199 INT246502 Negative_regulation of Men1 2 0.30 8.9 0.33 5.00
200 INT303680 Negative_regulation of Positive_regulation of VIP 1 0.15 1.2 0.28 5.00
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