D:Gauchers Disease

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Disease Term
Synonyms Acute Neuronopathic Gaucher Disease, Cerebroside Lipidosis Syndrome, Cerebroside Lipidosis Syndromes, Chitotriosidase Deficiency, Chronic Gaucher Disease, DEFICIENCY DISEASE GLUCOCEREBROSIDASE, DEFICIENCY DISEASE GLUCOSYLCERAMIDE BETA GLUCOSIDASE, Deficiency Diseases Glucocerebrosidase, Disease Acute Neuronopathic Gaucher, Disease Chronic Gaucher, Disease Gaucher Acute Neuronopathic
Documents 128
Hot Single Events 113
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Gauchers Disease. They are ordered first by their relevance to Gauchers Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT322931 Binding of MOCS1 and Litaf 1 0.00 0.82 0 100.00
2 INT241793 NBL1 Negative_regulation of B4GALNT1 1 0.00 0.83 0 99.92
3 INT277890 Binding of Ids and Tas2r111-ps2 1 0.08 0.5 0.09 97.16
4 INT277889 Regulation of Binding of Ids and Tas2r111-ps2 1 0.09 0.5 0.09 97.16
5 INT347806 Binding of MOCS1 and SMAP2 1 0.00 0.48 0.12 66.96
6 INT346598 Negative_regulation of Binding of Mapk3 and Sh2d1b2 1 0.22 0.2 0 63.76
7 INT346595 Binding of Mapk3 and Sh2d1b2 1 0.19 0.2 0 63.24
8 INT333978 Binding of ELF3 and TRAP 1 0.15 0.06 0 59.28
9 INT296867 Binding of B4galnt2 and Mtor 1 0.00 0.51 0 37.16
10 INT307305 Gene_expression of COMP Positive_regulation of Positive_regulation of CALR 1 0.27 0.41 0 10.68
11 INT307306 Gene_expression of COMP Positive_regulation of CALR 1 0.27 0.99 0 10.32
12 INT347807 GLA Positive_regulation of Positive_regulation of A4GALT 1 0.05 1.57 0.13 5.00
13 INT223088 Binding of ELF3 and NAGLU 1 0.14 0.84 0.09 5.00
14 INT223089 Binding of IDS and NAGLU 1 0.26 0.72 0.09 5.00
15 INT339583 Binding of ABCA1 and RPE 1 0.03 1.38 0.05 5.00
16 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
17 INT339587 Positive_regulation of Binding of ABCA1 and RPE 1 0.04 1.38 0.05 5.00
18 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
19 INT244328 ELF3 Negative_regulation of Positive_regulation of SH3GL3 3 0.20 1.26 0.04 5.00
20 INT296868 Binding of B4galnt2 and Map1lc3a 1 0.04 0.69 0.03 5.00
21 INT277892 IDS Regulation of Ids 1 0.18 0.41 0 5.00
22 INT352175 USE1 Regulation of NAGA 1 0.01 0.33 0 5.00
23 INT339582 AMD1 Regulation of C1QTNF5 1 0.07 2 0 5.00
24 INT244329 ELF3 Positive_regulation of Gene_expression of SH3GL3 1 0.27 0.66 0 5.00
25 INT346596 Sh2d1b2 Negative_regulation of Umod 1 0.23 0 0 5.00
26 INT339581 Binding of TIMP1 and TIMP3 1 0.30 0.54 0 5.00
27 INT268445 Olr1 Positive_regulation of Positive_regulation of Lipa 1 0.01 0.87 0 5.00
28 INT339580 TIMP3 Positive_regulation of ABCA1 1 0.16 0.73 0 5.00
29 INT268459 Binding of LDLR and Olr1 1 0.00 0.78 0 5.00
30 INT339585 Binding of AMD1 and MDM1 1 0.06 2.02 0 5.00
31 INT307307 COMP Positive_regulation of EREG 1 0.01 0.46 0 5.00
32 INT320848 Binding of Npc1 and Npc2 1 0.39 0 0 5.00
33 INT277891 Binding of TPBG and M6pr-ps 1 0.02 0.06 0 5.00
34 INT346597 Binding of Sh3gl3 and Sh2d1b2 1 0.09 0 0 5.00
35 INT296869 Mtor Positive_regulation of Gene_expression of B4galnt2 1 0.01 1.56 0 5.00
36 INT307309 Binding of CALR and EREG 1 0.00 0.83 0 5.00
37 INT346599 Sh2d1b2 Negative_regulation of Sh3gl3 1 0.10 0 0 5.00
38 INT339586 TIMP3 Positive_regulation of RPE 1 0.16 0.72 0 5.00
39 INT268446 Cdk5 Positive_regulation of Cdk5r1 1 0.02 0.58 0 5.00
40 INT307310 Binding of CALR and COMP 1 0.28 0.82 0 5.00
41 INT307308 Binding of COMP and EREG 1 0.01 0.41 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Gauchers Disease. They are ordered first by their pain relevance and then by number of times they were reported in Gauchers Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5864 Localization of IL36RN 19 0.44 14.5 6.87 100.00
2 INT134946 Localization of GBA 3 0.75 2.49 0.24 100.00
3 INT352686 Positive_regulation of Positive_regulation of FOSB 1 0.03 0.53 0 99.98
4 INT241802 Regulation of GBA 2 0.39 2.27 0.3 99.92
5 INT69478 Negative_regulation of GBA 16 0.55 7.9 0.59 99.88
6 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 99.88
7 INT27534 Negative_regulation of Gba 10 0.57 6.23 0.38 99.88
8 INT55529 Negative_regulation of Gba 13 0.59 7.91 2.1 99.76
9 INT181781 Positive_regulation of FOSB 6 0.39 4.77 0.34 99.74
10 INT154448 Negative_regulation of FOSB 3 0.41 2.11 0.16 99.74
11 INT125227 Positive_regulation of CHIT1 5 0.21 3.52 0.33 99.68
12 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 99.68
13 INT39513 Positive_regulation of TRAP 14 0.48 5.11 1.67 99.68
14 INT65089 Positive_regulation of ACP5 4 0.50 1.67 0.57 99.68
15 INT3731 Negative_regulation of Neu1 17 0.39 8.35 5.67 99.64
16 INT150476 Positive_regulation of ELF3 32 0.56 13.61 2.39 99.52
17 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66 99.28
18 INT241800 Negative_regulation of Positive_regulation of GBA 2 0.36 1.05 0.24 99.26
19 INT311174 Binding of Sh2d1b2 2 0.26 2.42 0.37 99.16
20 INT346572 Regulation of Binding of Sh2d1b2 1 0.27 1.14 0.06 99.16
21 INT143143 Positive_regulation of Gene_expression of Gba 3 0.44 1.83 0.16 98.70
22 INT143141 Positive_regulation of Gene_expression of Gaa 1 0.03 1.57 0.15 98.70
23 INT241797 Gene_expression of CHIT1 10 0.24 9.75 0.69 98.60
24 INT322929 Positive_regulation of Gene_expression of CHIT1 1 0.07 6.12 0.83 98.60
25 INT241798 Negative_regulation of Gene_expression of CHIT1 4 0.15 2.07 0.1 98.52
26 INT143142 Negative_regulation of Gene_expression of Gba 3 0.43 1.78 0.2 98.50
27 INT134944 Gene_expression of MOCS1 37 0.06 10.76 2.17 98.46
28 INT134943 Localization of MOCS1 7 0.07 4.23 0.34 98.44
29 INT241803 Positive_regulation of GBA 6 0.70 2.41 0.3 98.34
30 INT131123 Gene_expression of Gba 22 0.78 3.74 3.14 98.30
31 INT37467 Gene_expression of Gaa 2 0.17 1.71 0.22 98.30
32 INT241799 Negative_regulation of CHIT1 13 0.42 4.37 0.44 98.24
33 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 98.24
34 INT69480 Protein_catabolism of GBA 2 0.89 0.38 0 98.14
35 INT186200 Negative_regulation of Gene_expression of SCARB2 2 0.22 1.02 0.04 98.10
36 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26 98.04
37 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 97.88
38 INT209387 Negative_regulation of Ugcg 9 0.25 7.61 0.9 97.80
39 INT183753 Regulation of HBM 24 0.39 13.13 1.79 97.68
40 INT186197 Gene_expression of SCARB2 7 0.40 2.93 0.13 97.66
41 INT352685 Positive_regulation of Gene_expression of SCARB2 1 0.11 0.51 0 97.66
42 INT200462 Binding of IDS 13 0.31 4.95 1 97.64
43 INT277878 Binding of Ids 4 0.34 0.8 0.24 97.64
44 INT139664 Gene_expression of CCL18 83 0.76 37.05 21.95 97.48
45 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 97.48
46 INT215117 Gene_expression of Ctsa 14 0.33 8.66 1.18 96.96
47 INT240423 Regulation of Ctsa 5 0.25 5.27 0.89 96.96
48 INT296846 Regulation of Gene_expression of Ctsa 1 0.18 1.35 0 96.96
49 INT346581 Gene_expression of Sh3gl3 1 0.25 4.08 0.11 96.88
50 INT296845 Regulation of B4galnt2 1 0.05 4.76 0.08 96.84
51 INT128755 Protein_catabolism of Esr1 10 0.57 4.61 0.9 96.80
52 INT146808 Positive_regulation of CCL18 25 0.69 11.98 5.71 96.76
53 INT234263 Negative_regulation of ELF3 6 0.39 3.9 0.04 96.64
54 INT346566 Negative_regulation of Positive_regulation of Sh3gl3 1 0.14 0.69 0 96.36
55 INT37296 Binding of Esr1 117 0.43 62.51 27.33 96.24
56 INT217723 Regulation of IDS 15 0.25 2.12 0.49 96.24
57 INT288384 Binding of CHIT1 2 0.15 2.04 0.22 96.12
58 INT8792 Gene_expression of GBA 20 0.78 14.73 1.98 96.08
59 INT346565 Positive_regulation of Sh3gl3 1 0.26 2.93 0.42 96.00
60 INT27446 Negative_regulation of CTSA 11 0.57 5.58 3.08 95.84
61 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 95.36
62 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 95.24
63 INT210058 Regulation of ELF3 11 0.29 7.93 2.51 95.20
64 INT82648 Positive_regulation of Gene_expression of GBA 1 0.50 2.77 0.08 95.04
65 INT244330 Localization of ELF3 8 0.56 2.71 0.18 93.92
66 INT39736 Protein_catabolism of Gba 1 0.52 0.48 0 93.80
67 INT68829 Binding of ELF3 14 0.47 7.96 2 93.56
68 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 92.84
69 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 92.64
70 INT346567 Negative_regulation of Sh3gl3 1 0.19 2.25 0.03 92.44
71 INT134945 Binding of GBA 3 0.37 3.69 0.24 91.72
72 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 91.16
73 INT191807 Gene_expression of CD24 75 0.78 53.92 3.34 90.40
74 INT206440 Binding of MOCS1 13 0.01 3.76 0.35 90.08
75 INT93532 Regulation of Tnfsf11 14 0.42 10.75 2.39 89.76
76 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59 89.24
77 INT296864 Negative_regulation of cma 1 0.20 1.22 0 88.88
78 INT9500 Negative_regulation of Ceacam1 26 0.58 6.89 3.91 88.52
79 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 87.48
80 INT8772 Positive_regulation of Gene_expression of HBG1 16 0.68 6.93 0.95 87.48
81 INT58590 Protein_catabolism of IFNG 2 0.84 0.75 0.1 87.48
82 INT296862 Positive_regulation of Gene_expression of Ctsa 1 0.20 1.35 0 86.84
83 INT8052 Negative_regulation of COMP 46 0.58 13.73 2.22 86.08
84 INT112459 Localization of Gba 12 0.80 1.45 6.4 85.92
85 INT39512 Negative_regulation of TRAP 22 0.56 8.18 4.76 85.36
86 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 85.36
87 INT33096 Negative_regulation of Gene_expression of ACE 9 0.43 2.84 1.93 85.36
88 INT333986 Negative_regulation of Gene_expression of TRAP 3 0.32 0.77 0 85.36
89 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 85.12
90 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 85.12
91 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 85.12
92 INT71933 Positive_regulation of Gene_expression of F2 19 0.56 14.24 2.53 85.12
93 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 84.28
94 INT81578 Gene_expression of TRAP 25 0.72 9.75 2.82 84.08
95 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 84.08
96 INT254421 Negative_regulation of SLC25A24 1 0.42 2.37 0.2 84.08
97 INT315310 Gene_expression of CHIA 1 0.12 4.45 0.33 83.96
98 INT171610 Negative_regulation of Sh2d1b2 2 0.30 1.25 0.04 82.96
99 INT16964 Binding of IFNG 27 0.48 14.31 2.45 82.92
100 INT307328 Negative_regulation of Positive_regulation of FIBP 1 0.01 0.95 0.06 82.36
101 INT254419 Gene_expression of SLC25A24 1 0.65 2.28 0.2 82.32
102 INT254422 Positive_regulation of Gene_expression of SLC25A24 1 0.49 2.29 0.2 82.32
103 INT200984 Positive_regulation of FIBP 2 0.12 1.12 0.14 81.92
104 INT311177 Binding of Gba 1 0.48 0.44 0.06 81.72
105 INT137221 Gene_expression of Sh2d1b2 6 0.47 1.99 0.6 81.60
106 INT51244 Gene_expression of Umod 7 0.60 2.03 0.95 81.60
107 INT131126 Positive_regulation of Gba 2 0.50 0.65 1.4 81.52
108 INT254420 Positive_regulation of SLC25A24 1 0.45 2.27 0.2 81.36
109 INT277884 Binding of Tas2r111-ps2 1 0.09 0.95 0.19 81.04
110 INT26477 Regulation of ACE 26 0.45 16.31 4.33 81.00
111 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 81.00
112 INT296849 Positive_regulation of Positive_regulation of Mtor 1 0.05 1.24 0 81.00
113 INT277778 Regulation of AFD1 1 0.01 0.88 0.13 80.08
114 INT254881 Negative_regulation of Atg7 9 0.34 5.69 0.32 79.64
115 INT175455 Gene_expression of Hspb8 54 0.76 59.87 3.9 77.84
116 INT322930 Regulation of Gene_expression of GBA 1 0.39 0.26 0 77.44
117 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 77.40
118 INT346579 Regulation of Sh2d1b2 1 0.16 0.46 0 76.48
119 INT15699 Binding of Litaf 2 0.01 1.06 0.19 76.24
120 INT222089 Positive_regulation of Localization of Esr1 19 0.49 8.73 1.58 75.28
121 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 75.00
122 INT79234 Positive_regulation of CCL3 15 0.67 11.43 4.15 75.00
123 INT103441 Regulation of TRAP 5 0.26 3.01 0.32 75.00
124 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 75.00
125 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 75.00
126 INT4029 Positive_regulation of HYAL1 10 0.69 2 1.39 75.00
127 INT333987 Regulation of Regulation of TRAP 1 0.20 0.07 0 75.00
128 INT17561 Localization of Car2 303 0.79 60.95 44.52 74.64
129 INT2038 Localization of Esr1 104 0.79 40.12 13.27 74.28
130 INT282985 Negative_regulation of Becn1 11 0.20 7.72 0.04 73.48
131 INT333985 Regulation of Gene_expression of TRAP 1 0.34 0.07 0 72.36
132 INT285409 Positive_regulation of Positive_regulation of ELF3 2 0.27 1.21 0 71.60
133 INT352684 Regulation of Binding of RILP 1 0.01 0.22 0 70.68
134 INT298918 Binding of RILP 2 0.17 0.55 0 70.16
135 INT333988 Regulation of Negative_regulation of CHIT1 1 0.25 0.07 0 68.96
136 INT206971 Positive_regulation of Localization of MOCS1 2 0.01 0.71 0.16 68.92
137 INT20664 Binding of ACE 60 0.48 35.27 9.16 68.00
138 INT222076 Gene_expression of Sgsh 1 0.04 1.22 0.08 67.68
139 INT69768 Negative_regulation of Pscs 7 0.51 4.76 2.82 67.40
140 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 66.24
141 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 65.96
142 INT347808 Binding of SMAP2 1 0.00 0.47 0.12 65.60
143 INT86946 Localization of TRAP 5 0.74 2.87 0.34 64.40
144 INT277882 Gene_expression of Ids 5 0.71 1.6 0.26 63.60
145 INT86569 Gene_expression of AP2S1 2 0.15 0.55 0 63.40
146 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 63.00
147 INT288080 Regulation of Gene_expression of Racgap1 3 0.04 3.42 0.41 62.40
148 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 61.68
149 INT109925 Gene_expression of RPE 11 0.65 12.46 0.68 61.00
150 INT241801 Binding of CTSA 1 0.13 0.15 0 60.56
151 INT142724 Negative_regulation of A4GALT 11 0.53 8.23 2.61 60.52
152 INT36293 Gene_expression of Mtor 24 0.25 14.5 2.04 59.48
153 INT161248 Positive_regulation of Gene_expression of Mtor 2 0.06 6.47 0.51 59.48
154 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97 58.76
155 INT23542 Negative_regulation of B4galnt2 3 0.22 1.67 0.6 57.68
156 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 56.64
157 INT97861 Negative_regulation of Gene_expression of CTSA 3 0.13 1.11 0.09 55.72
158 INT97860 Gene_expression of CTSA 8 0.43 2.22 0.54 55.44
159 INT162258 Negative_regulation of Gene_expression of COMP 35 0.58 19.14 3.55 55.32
160 INT82829 Gene_expression of COMP 104 0.78 57 9.81 54.80
161 INT117348 Regulation of EGFR 75 0.61 47.73 3.09 53.84
162 INT268452 Binding of PILRA 1 0.00 0.15 0 51.12
163 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 50.72
164 INT63222 Negative_regulation of MGAM 8 0.43 4.33 0.37 50.52
165 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 50.00
166 INT6431 Positive_regulation of Ass1 36 0.24 8.08 10.43 50.00
167 INT46221 Positive_regulation of Gene_expression of IgG 46 0.53 33.66 7.7 50.00
168 INT333984 Localization of CHIT1 1 0.26 0.32 0.09 50.00
169 INT311173 Regulation of Gba 1 0.45 0.21 0 50.00
170 INT311176 Gene_expression of Crim1 1 0.17 0.5 0 50.00
171 INT311175 Protein_catabolism of Gba 1 0.88 0 0 50.00
172 INT346569 Positive_regulation of Gene_expression of Sh2d1b2 1 0.30 0.46 0.04 49.76
173 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 49.60
174 INT346575 Regulation of Rraga 1 0.03 0.58 0.13 48.72
175 INT16723 Regulation of GBE1 16 0.11 4.3 3.7 48.64
176 INT262274 Gene_expression of UGCG 8 0.27 1.62 0.22 44.56
177 INT316113 Positive_regulation of Gene_expression of UGCG 2 0.09 0.41 0 44.56
178 INT282977 Regulation of Becn1 4 0.25 2.29 0.04 43.52
179 INT268448 Negative_regulation of Binding of MRC1 1 0.01 0 0 41.20
180 INT172329 Binding of MRC1 8 0.36 3.88 0.03 40.88
181 INT296851 Localization of Atg7 1 0.60 0.82 0.14 39.64
182 INT277345 Localization of Mtor 3 0.08 1.89 0.09 39.64
183 INT277886 Localization of Ids 3 0.73 1.09 0.48 37.52
184 INT288084 Gene_expression of Rab9 2 0.27 1.05 0.13 33.12
185 INT70283 Gene_expression of Racgap1 19 0.44 9.64 2.33 32.56
186 INT288079 Positive_regulation of Gene_expression of Racgap1 1 0.06 0.74 0.04 32.56
187 INT123031 Positive_regulation of Sgsh 2 0.42 1.01 0.09 26.32
188 INT320842 Localization of Npc2 1 0.76 1.01 0.03 23.92
189 INT279130 Negative_regulation of Localization of COMP 5 0.51 3.75 0.69 20.56
190 INT307327 Negative_regulation of Localization of COL9A2 1 0.06 0.35 0 20.56
191 INT279128 Negative_regulation of Localization of MATN3 2 0.43 0.92 0 20.56
192 INT135879 Localization of MATN3 12 0.80 10.31 1.44 19.68
193 INT118097 Localization of COMP 18 0.70 9.99 1.42 19.68
194 INT279126 Localization of COL9A2 2 0.64 0.77 0 19.68
195 INT296857 Gene_expression of B4galnt2 1 0.07 9.46 0.55 18.56
196 INT210401 Binding of M6PR 2 0.01 1.23 0.1 18.44
197 INT185028 Binding of IGF2 4 0.46 1.72 0.07 18.44
198 INT137222 Positive_regulation of Sh2d1b2 5 0.30 1.26 0.6 16.80
199 INT234494 Positive_regulation of Syp 12 0.65 2.47 0.69 13.44
200 INT71946 Negative_regulation of Ass1 7 0.41 1.9 2.68 12.48
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