D:Generalized Epilepsy

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Disease Term
Synonyms Akinetic Epilepsies, Akinetic Epilepsy, Atonic Epilepsies, Atonic Epilepsy, Convulsive Epilepsies Generalized, CONVULSIVE EPILEPSY GENERALIZED, Convulsive Generalized Seizure Disorder, Convulsive Seizure Disorder Generalized, Epilepsies Akinetic, Epilepsies Atonic, Epilepsies Generalized
Documents 126
Hot Single Events 31
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Generalized Epilepsy. They are ordered first by their relevance to Generalized Epilepsy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT264209 Binding of Igh-Lev and Sv2a 1 0.17 1.78 0.38 80.92
2 INT84426 Binding of TSPO and INSRR 1 0.01 0.22 0.3 64.56
3 INT325838 Binding of Dnm1 and Dnm2 1 0.50 0.05 0 36.92
4 INT262336 Binding of Abat and Tmem132a 1 0.00 1.39 1.14 19.68
5 INT214410 Binding of ATP1A4 and CACNA1A 1 0.26 0.95 0.7 15.68
6 INT319581 Binding of PIAS1 and TNFSF14 1 0.02 1.58 2.13 5.00
7 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08 5.00
8 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37 5.00
9 INT214411 DNAH8 Regulation of CAPN1 1 0.00 1.01 0.94 5.00
10 INT214408 ATP1A4 Regulation of DNAH8 1 0.04 1.01 0.94 5.00
11 INT214409 ATP1A4 Regulation of CAPN1 1 0.01 1.01 0.93 5.00
12 INT291449 Car2 Positive_regulation of SK 1 0.03 0 0.39 5.00
13 INT262354 TRIP10 Negative_regulation of Cyp4a3 1 0.00 0.8 0.26 5.00
14 INT291446 Bdnf Positive_regulation of Positive_regulation of Ltp 1 0.02 0 0.26 5.00
15 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26 5.00
16 INT262329 TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26 5.00
17 INT262330 Positive_regulation of TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26 5.00
18 INT214412 CASQ1 Regulation of JUND 1 0.02 0.46 0.24 5.00
19 INT291448 Prkaca Regulation of Gene_expression of Kcnn2 1 0.04 0 0.23 5.00
20 INT291447 Bdnf Positive_regulation of Prkaca 1 0.04 0 0.23 5.00
21 INT234303 Gria3 Negative_regulation of Gria4 1 0.36 0 0.16 5.00
22 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
23 INT212139 Slc4a3 Positive_regulation of Cl 1 0.07 0 0.12 5.00
24 INT212138 Slc4a3 Positive_regulation of Gene_expression of Cl 1 0.07 0 0.12 5.00
25 INT234302 Negative_regulation of Gria3 Positive_regulation of Swd1 1 0.01 0.47 0.1 5.00
26 INT262335 Binding of Sv2a and Bri3 1 0.01 0.71 0.08 5.00
27 INT291450 Kcnn3 Negative_regulation of Gene_expression of SK 1 0.10 0.53 0.08 5.00
28 INT291451 Binding of CALM1 and Car2 1 0.00 0 0.05 5.00
29 INT319578 CYP3A4 Regulation of ALPPL2 1 0.00 0.56 0.05 5.00
30 INT234301 Gria3 Regulation of Swd1 1 0.01 0.09 0 5.00
31 INT234307 Binding of Gria4 and Gopc 1 0.14 0.16 0 5.00
32 INT314986 Ins1 Negative_regulation of CACNA1S 1 0.00 0.08 0 5.00
33 INT234304 Magt1 Regulation of Gopc 1 0.05 0.28 0 5.00
34 INT264210 Binding of Aes and Igh-Lev 1 0.07 0.41 0 5.00
35 INT234306 Binding of Gria4 and Hc 1 0.01 0 0 5.00
36 INT325836 Binding of Dnm2 and Gnas 1 0.00 0.22 0 5.00
37 INT325839 Binding of Dnm1 and Gnas 1 0.00 0.11 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Generalized Epilepsy. They are ordered first by their pain relevance and then by number of times they were reported in Generalized Epilepsy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 100.00
2 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 99.88
3 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 99.80
4 INT64386 Binding of Cyp11a1 13 0.46 5.09 3.01 99.70
5 INT19409 Binding of Cyp1a1 12 0.48 2.58 1.97 99.70
6 INT10570 Positive_regulation of Cyp11a1 9 0.47 2.67 1.4 99.32
7 INT212134 Regulation of Slc4a3 1 0.62 0.34 0 99.12
8 INT186 Positive_regulation of Cyp1a1 30 0.70 5 5.02 98.84
9 INT181868 Localization of ACLY 5 0.62 6.36 1.4 98.28
10 INT260049 Negative_regulation of PCDH19 1 0.58 4.41 0.04 97.80
11 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 97.68
12 INT84427 Positive_regulation of Gene_expression of TSPO 15 0.64 5.05 3.58 97.20
13 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05 96.80
14 INT35584 Binding of ACLY 22 0.35 31.78 7.17 96.56
15 INT185 Regulation of Cyp1a1 18 0.54 2.71 5.56 96.30
16 INT36364 Regulation of SK 19 0.28 3.16 3.71 95.52
17 INT150668 Binding of KCNJ9 2 0.32 1.46 0.47 92.76
18 INT11279 Positive_regulation of Penk 65 0.70 18.72 30.29 90.72
19 INT211036 Gene_expression of IGHMBP2 1 0.58 0.44 0.03 89.60
20 INT148658 Negative_regulation of Csnk1a1 2 0.08 0.99 0.75 89.08
21 INT148660 Negative_regulation of Ppp3ca 1 0.02 0.59 0.67 89.08
22 INT74486 Positive_regulation of SCN1A 4 0.67 1 2.2 87.80
23 INT148659 Positive_regulation of Scn3a 1 0.06 0.64 0.67 87.80
24 INT148661 Positive_regulation of LAMB1 2 0.05 0.64 0.67 87.80
25 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 85.04
26 INT264204 Regulation of Igh-Lev 1 0.20 3.17 0.1 84.76
27 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 83.84
28 INT264207 Binding of Igh-Lev 1 0.25 4.13 1.07 80.92
29 INT129695 Binding of Sv2a 6 0.47 4.96 2.51 80.76
30 INT88906 Gene_expression of Dnm1 5 0.78 10.48 3.7 80.60
31 INT72252 Gene_expression of Kcnma1 63 0.64 20.47 29.56 80.52
32 INT106599 Positive_regulation of Dnm2 8 0.69 0.28 7.01 79.40
33 INT325829 Positive_regulation of Dnm1 1 0.70 2.03 0.09 79.40
34 INT325818 Positive_regulation of Dnm3 1 0.45 0.28 0.06 79.40
35 INT71593 Gene_expression of Mpv17l 9 0.04 1.68 4.01 79.20
36 INT264206 Gene_expression of Igh-Lev 1 0.30 5.68 0.87 79.16
37 INT137960 Positive_regulation of FASLG 8 0.67 6.5 2.34 78.64
38 INT2415 Binding of MAOA 26 0.47 13.26 11.86 78.24
39 INT11934 Regulation of Sv2a 4 0.44 1.72 1.1 66.48
40 INT7883 Binding of ADRB2 18 0.47 5.49 7.37 65.88
41 INT130728 Binding of MMP1 14 0.47 4.7 1.95 65.76
42 INT214414 Binding of FGR 1 0.01 1.4 0.44 65.04
43 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 64.80
44 INT96467 Gene_expression of Lamb1 3 0.10 2.56 2.23 64.80
45 INT6335 Binding of TSPO 39 0.44 10.88 7.66 64.56
46 INT96466 Negative_regulation of Lamb1 1 0.01 0.54 0.75 64.36
47 INT14109 Positive_regulation of Mtr 1 0.03 0.49 0.6 62.72
48 INT67737 Negative_regulation of Pam 6 0.51 4.08 2.19 61.20
49 INT314985 Positive_regulation of Negative_regulation of Pam 1 0.05 2.1 0.15 61.20
50 INT12631 Positive_regulation of Binding of INSRR 11 0.45 6.13 6.04 59.88
51 INT9781 Binding of INSRR 64 0.31 19.1 25.2 59.12
52 INT71629 Negative_regulation of Swd1 6 0.15 1.42 1.1 58.72
53 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 55.12
54 INT262348 Gene_expression of Lgsn 12 0.58 12.64 2.08 54.60
55 INT264035 Regulation of Lgsn 5 0.39 6.2 0.86 54.60
56 INT259867 Binding of SCN1A 2 0.36 4.7 0.21 54.40
57 INT212128 Binding of Cl 5 0.11 0.92 0.75 51.84
58 INT263678 Negative_regulation of Igh-Lev 2 0.19 0.81 0.58 51.76
59 INT188168 Binding of Slc4a3 4 0.47 1.06 0.07 51.60
60 INT95136 Binding of FASLG 6 0.33 8.01 2.41 51.52
61 INT325819 Negative_regulation of Gene_expression of Dnm1 1 0.43 0.11 0 50.20
62 INT262344 Negative_regulation of Lgsn 4 0.37 3.6 0.67 48.04
63 INT51532 Negative_regulation of Sult1a1 2 0.50 1.72 0.55 46.64
64 INT7035 Regulation of CGA 87 0.45 29.04 28.45 46.32
65 INT88909 Positive_regulation of Gene_expression of Dnm1 6 0.70 3.43 4.59 45.64
66 INT212127 Positive_regulation of Gene_expression of Slc4a3 1 0.50 0.93 0.23 45.16
67 INT212131 Positive_regulation of Gene_expression of Cl 4 0.08 0.88 0.12 45.16
68 INT212126 Gene_expression of Slc4a4 7 0.55 0.19 0.06 45.04
69 INT212137 Transcription of Slc4a4 1 0.55 0 0 45.04
70 INT149125 Gene_expression of Slc4a3 25 0.78 3.45 2.41 44.80
71 INT212124 Gene_expression of Cl 18 0.11 6.72 1.93 44.80
72 INT95989 Positive_regulation of Kcnq2 9 0.68 2.58 4.75 44.48
73 INT120365 Positive_regulation of KCNQ2 3 0.67 1.13 1.58 44.48
74 INT311479 Gene_expression of Mllt1 4 0.58 4.92 2.39 43.80
75 INT311478 Positive_regulation of Mllt1 4 0.60 2.38 2.34 41.28
76 INT2212 Binding of Abat 89 0.48 18.36 63.99 39.92
77 INT106595 Negative_regulation of Dnm2 10 0.58 0.15 9.29 39.84
78 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 39.60
79 INT212142 Binding of CA14 1 0.08 0 0 38.72
80 INT325820 Binding of Dnm1 1 0.48 0.96 0.18 36.92
81 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 36.88
82 INT212133 Positive_regulation of Slc4a4 1 0.40 0 0 35.52
83 INT3439 Localization of Abat 1017 0.78 112.39 727.06 32.68
84 INT146340 Localization of Mllt1 10 0.69 4.6 5.45 32.64
85 INT27492 Gene_expression of Swd1 4 0.50 2.07 0.68 29.28
86 INT55671 Gene_expression of Ik 151 0.27 80.1 48.49 26.80
87 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 26.80
88 INT169560 Gene_expression of SK 20 0.54 6.83 2.64 26.80
89 INT128563 Binding of Mllt1 8 0.41 6.7 5.63 26.28
90 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 25.00
91 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23 25.00
92 INT542 Gene_expression of Fshb 14 0.75 5.22 3.24 25.00
93 INT32118 Regulation of Mcf2l 6 0.39 3.05 1.34 25.00
94 INT212125 Regulation of Gene_expression of Cl 2 0.06 1.88 1.05 19.52
95 INT73010 Gene_expression of Tmem132a 8 0.77 4.38 8.86 15.44
96 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23 13.72
97 INT310741 Gene_expression of POLG2 1 0.36 0.87 0.03 13.44
98 INT325821 Regulation of Gene_expression of Dnm1 1 0.62 1.23 0 10.16
99 INT204175 Localization of Mri1 12 0.60 2.73 2.35 9.68
100 INT215987 Regulation of Mri1 4 0.30 2.1 1.54 9.68
101 INT262351 Regulation of Localization of Mri1 1 0.02 0.82 0.37 9.68
102 INT260050 Gene_expression of PCDH19 1 0.77 12.52 0.09 6.16
103 INT262352 Localization of Lgsn 3 0.60 1.49 0.6 5.44
104 INT262346 Regulation of Localization of Lgsn 1 0.31 0.8 0.37 5.44
105 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
106 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 5.00
107 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 5.00
108 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
109 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
110 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
111 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
112 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
113 INT4829 Positive_regulation of Localization of Abat 199 0.55 20.91 150.48 5.00
114 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
115 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
116 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
117 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
118 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 5.00
119 INT100965 Positive_regulation of Nav1 85 0.70 37.74 75.35 5.00
120 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52 5.00
121 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52 5.00
122 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27 5.00
123 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
124 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
125 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38 5.00
126 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04 5.00
127 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 5.00
128 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 5.00
129 INT64918 Gene_expression of Gria2 108 0.74 29.95 29.67 5.00
130 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
131 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
132 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
133 INT102429 Negative_regulation of Gene_expression of Nav1 19 0.59 20.09 28.09 5.00
134 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 5.00
135 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
136 INT2912 Positive_regulation of Positive_regulation of Abat 29 0.66 6.48 27.54 5.00
137 INT63444 Regulation of Gene_expression of Abat 26 0.51 14.65 26.29 5.00
138 INT136268 Localization of NAV1 22 0.75 2.84 26.23 5.00
139 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 5.00
140 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 5.00
141 INT256285 Gene_expression of Efnb1 32 0.70 36.25 24.73 5.00
142 INT64076 Positive_regulation of Kcnma1 47 0.40 11.52 24.19 5.00
143 INT113925 Localization of Bdnf 59 0.79 24.03 22.76 5.00
144 INT17962 Regulation of Car2 124 0.41 33.98 22.71 5.00
145 INT78571 Positive_regulation of Grm5 35 0.69 11.81 22.45 5.00
146 INT127435 Gene_expression of Per1 89 0.77 13.94 22.31 5.00
147 INT16851 Regulation of Localization of Gabrg1 34 0.39 4.34 22.29 5.00
148 INT23564 Negative_regulation of Car2 103 0.50 27.28 21.86 5.00
149 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 5.00
150 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
151 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 5.00
152 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
153 INT145971 Localization of Nav1 20 0.81 10.3 18.11 5.00
154 INT95930 Negative_regulation of Gria2 63 0.56 18.37 17.04 5.00
155 INT14587 Positive_regulation of Cl 44 0.20 20.37 16.72 5.00
156 INT62861 Regulation of Gria2 45 0.60 13.35 16.07 5.00
157 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
158 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13 5.00
159 INT123593 Gene_expression of Snca 58 0.78 35.76 12.87 5.00
160 INT80790 Positive_regulation of Flvcr2 22 0.45 4.92 12.35 5.00
161 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89 5.00
162 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 5.00
163 INT19575 Negative_regulation of Positive_regulation of Abat 14 0.43 2.07 11.05 5.00
164 INT158070 Localization of Aes 23 0.65 19.93 10.9 5.00
165 INT7458 Negative_regulation of Kcnma1 30 0.43 6.61 10.4 5.00
166 INT17824 Positive_regulation of Gene_expression of Flvcr2 15 0.41 6.66 10.23 5.00
167 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 5.00
168 INT53063 Positive_regulation of Slc1a1 10 0.70 3.23 9.89 5.00
169 INT1129 Binding of Car2 69 0.35 14.01 9.2 5.00
170 INT40609 Binding of Prkaca 23 0.36 3.42 9.19 5.00
171 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98 5.00
172 INT61399 Positive_regulation of Ik 21 0.22 10.17 8.75 5.00
173 INT71763 Gene_expression of Mri1 33 0.58 12.56 8.6 5.00
174 INT5359 Protein_catabolism of Abat 12 0.62 5.11 8.54 5.00
175 INT16460 Negative_regulation of PPBP 21 0.57 13.86 8.54 5.00
176 INT162393 Gene_expression of SMUG1 58 0.75 38.78 7.7 5.00
177 INT95133 Gene_expression of FASLG 38 0.75 44.09 7.51 5.00
178 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 5.00
179 INT264027 Positive_regulation of Positive_regulation of Flvcr2 2 0.08 2.67 7.27 5.00
180 INT111056 Negative_regulation of Gene_expression of Flvcr2 9 0.13 4.15 7.18 5.00
181 INT52132 Positive_regulation of Negative_regulation of Abat 9 0.50 0.53 7.03 5.00
182 INT52180 Binding of Aes 38 0.42 23.16 6.7 5.00
183 INT21545 Regulation of DNAH8 22 0.59 8.67 6.48 5.00
184 INT66925 Positive_regulation of Gene_expression of Ik 22 0.15 10.47 6.4 5.00
185 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33 5.00
186 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
187 INT95313 Gene_expression of Slc6a1 6 0.76 3.96 6.14 5.00
188 INT16573 Regulation of Cl 18 0.07 8.69 6.03 5.00
189 INT116055 Phosphorylation of PRKG1 33 0.80 2.22 5.58 5.00
190 INT52656 Negative_regulation of Ik 12 0.57 5.76 5.4 5.00
191 INT140142 Positive_regulation of Sigmar1 17 0.63 3.78 5.26 5.00
192 INT74051 Negative_regulation of Localization of Car2 27 0.38 9.58 5.1 5.00
193 INT55669 Negative_regulation of Gene_expression of Ik 14 0.13 11.28 5 5.00
194 INT209565 Regulation of Gene_expression of Ik 9 0.14 5.07 4.83 5.00
195 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 5.00
196 INT128353 Negative_regulation of Car3 16 0.37 4.93 4.61 5.00
197 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 5.00
198 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25 5.00
199 INT150144 Gene_expression of Kcnn3 31 0.78 7.67 4.24 5.00
200 INT224807 Gene_expression of Gria4 35 0.78 4.63 4.02 5.00
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