D:Genital Human Papilloma Virus

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Disease Term
Synonyms Condyloma, Condylomata Acuminata, Genital Human Papilloma Virus Infection, Genital Human Papilloma Virus Infections, Genital Papilloma Virus, Genital Wart, Genital Warts, Hpv, HUMAN PAPILLOMA VIRUS, PAPILLOMA ACUMINATUM, PAPILLOMA VENEREUM
Documents 143
Hot Single Events 33
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Genital Human Papilloma Virus. They are ordered first by their relevance to Genital Human Papilloma Virus and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT244401 Binding of HPV6AI1 and HEPACAM 1 0.00 4.33 0 100.00
2 INT327165 RETNLB Regulation of Gene_expression of CRP 1 0.01 2.25 0.59 83.84
3 INT327167 RETNLB Regulation of IL6 1 0.00 2.26 0.6 82.12
4 INT327164 RETNLB Regulation of TNF 1 0.00 2.27 0.6 82.12
5 INT327166 RETNLB Regulation of IL36RN 1 0.00 2.25 0.59 82.12
6 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87 5.00
7 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87 5.00
8 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
9 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55 5.00
10 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45 5.00
11 INT188194 OSM Regulation of IL6 1 0.16 1.12 0.43 5.00
12 INT188205 OSM Regulation of LIF 1 0.09 1.12 0.43 5.00
13 INT188211 IL6 Regulation of MAPK1 1 0.16 1.13 0.43 5.00
14 INT188207 LIF Regulation of IL6 1 0.17 1.12 0.43 5.00
15 INT178217 IFNA1 Regulation of Cxcl10 1 0.01 0.86 0.37 5.00
16 INT178218 IFNA1 Regulation of Tlr7 1 0.04 0.87 0.37 5.00
17 INT188193 Negative_regulation of EGF Positive_regulation of MAPK1 1 0.28 0.54 0.34 5.00
18 INT188204 Negative_regulation of IL6 Positive_regulation of STAT3 1 0.28 0.54 0.34 5.00
19 INT156831 EGF Positive_regulation of MAPK1 2 0.45 0.27 0.33 5.00
20 INT188209 OSM Positive_regulation of MAPK1 1 0.35 0.47 0.27 5.00
21 INT188200 IL6ST Positive_regulation of STAT3 1 0.25 0.38 0.23 5.00
22 INT188195 GOPC Positive_regulation of MAPK1 2 0.21 0.32 0.22 5.00
23 INT188203 EGF Positive_regulation of Protein_catabolism of OSM 1 0.30 0.17 0.21 5.00
24 INT188201 OSM Positive_regulation of Phosphorylation of STAT3 1 0.40 0.24 0.21 5.00
25 INT190381 IL1A Regulation of Transcription of DEFB4A 1 0.06 0.93 0.18 5.00
26 INT188199 IL6 Positive_regulation of MAPK1 1 0.27 0.25 0.16 5.00
27 INT175398 Binding of ERBB2 and VEGFA 2 0.16 1.34 0.13 5.00
28 INT175401 Binding of EGFR and VEGFA 2 0.13 1.49 0.13 5.00
29 INT188197 LIF Positive_regulation of STAT3 1 0.35 0.27 0.12 5.00
30 INT188198 OSM Positive_regulation of STAT3 1 0.52 0.24 0.12 5.00
31 INT188202 HBE1 Positive_regulation of MAPK1 1 0.01 0.14 0.11 5.00
32 INT188192 HBE1 Positive_regulation of LY6E 1 0.00 0.14 0.11 5.00
33 INT190382 IL1A Regulation of Regulation of DEFB4A 1 0.06 0.57 0.1 5.00
34 INT188210 EGF Positive_regulation of OSM 1 0.28 0 0.07 5.00
35 INT188208 EGF Regulation of STAT3 1 0.46 0 0.07 5.00
36 INT178207 Laq1 Negative_regulation of Pigl 1 0.00 1.26 0.07 5.00
37 INT173660 Map2k6 Positive_regulation of MAPK8 1 0.15 0.27 0.07 5.00
38 INT173659 Map2k3 Positive_regulation of MAPK8 1 0.15 0.28 0.07 5.00
39 INT173612 FGFR1 Positive_regulation of INCENP 1 0.00 0.28 0.03 5.00
40 INT173613 BMP2 Positive_regulation of INCENP 1 0.00 0.28 0.03 5.00
41 INT211883 Binding of RET and CDCP1 1 0.00 2.12 0 5.00
42 INT175400 RASGRP1 Positive_regulation of MAP3K5 1 0.00 1.2 0 5.00
43 INT308053 PLAT Positive_regulation of KRT20 1 0.00 0.24 0 5.00
44 INT175399 Binding of TP53 and SACM1L 1 0.00 2.37 0 5.00
45 INT178206 Binding of Cd4 and Spna1 1 0.02 0.51 0 5.00
46 INT211882 Binding of KIT and CDCP1 1 0.00 2.1 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Genital Human Papilloma Virus. They are ordered first by their pain relevance and then by number of times they were reported in Genital Human Papilloma Virus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT244405 Gene_expression of HPV6AI1 3 0.03 6.1 0.03 100.00
2 INT231586 Gene_expression of SIPA1L1 2 0.03 2.24 0 100.00
3 INT244403 Regulation of Gene_expression of HPV6AI1 1 0.01 2.18 0 100.00
4 INT244402 Negative_regulation of HPV6AI1 1 0.01 2.19 0 100.00
5 INT12628 Binding of Cish 4 0.30 2.45 0.78 99.98
6 INT244404 Binding of HEPACAM 21 0.02 35.88 0.09 99.72
7 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 99.70
8 INT5871 Binding of IFNA2 38 0.48 20.35 6.46 99.40
9 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26 99.14
10 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 99.14
11 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 99.14
12 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 99.14
13 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 99.14
14 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 99.02
15 INT198680 Gene_expression of Cbll1 1 0.01 0.44 0 98.82
16 INT48217 Gene_expression of SLC4A3 22 0.75 21.12 2.17 97.88
17 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 97.72
18 INT211679 Positive_regulation of HEPACAM 6 0.02 8.25 0.11 94.68
19 INT92941 Binding of ASAP1 24 0.39 12.38 1.25 93.12
20 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 92.96
21 INT100861 Binding of CRP 179 0.48 175.2 26.45 92.40
22 INT207897 Positive_regulation of TLR8 3 0.17 2.52 0.33 92.36
23 INT207896 Gene_expression of TLR8 3 0.36 2.82 0.26 90.72
24 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 89.60
25 INT178194 Gene_expression of Tpd52 1 0.14 2.3 0 88.88
26 INT117189 Binding of CXCR4 34 0.37 24.27 5.81 88.28
27 INT178192 Gene_expression of Cwc27 1 0.02 2.28 0 87.72
28 INT178196 Gene_expression of Vegfc 7 0.27 7.47 0.64 86.24
29 INT91667 Localization of IL12A 39 0.74 25.51 7.36 85.40
30 INT149710 Gene_expression of Pvr 10 0.46 8.92 0 83.76
31 INT19187 Gene_expression of Lgals3 24 0.73 19.72 5.03 81.64
32 INT8694 Binding of Lgals3 38 0.48 14.82 8.05 81.44
33 INT39358 Regulation of PDXP 3 0.23 2.7 0.63 80.80
34 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 79.68
35 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 79.68
36 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 78.48
37 INT197024 Binding of STIP1 11 0.35 10.84 0.52 78.40
38 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 74.96
39 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 74.96
40 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 73.28
41 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 73.28
42 INT94028 Regulation of Twist1 37 0.44 22.41 5.33 73.28
43 INT32032 Gene_expression of DMBT1 3 0.04 2.43 0.2 72.44
44 INT46088 Localization of F3 15 0.37 13.7 2.23 66.88
45 INT178198 Gene_expression of C3 62 0.78 39.5 7.69 64.92
46 INT68288 Positive_regulation of SERPINB3 14 0.51 16.87 0.41 64.80
47 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 61.72
48 INT275225 Negative_regulation of APOBEC3B 1 0.02 0.12 0 60.64
49 INT274742 Localization of TBL1XR1 2 0.24 1.4 0.26 59.28
50 INT299170 Positive_regulation of Localization of TBL1XR1 1 0.16 0.87 0.06 59.28
51 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 58.32
52 INT2111 Gene_expression of LIF 34 0.77 16.82 6.76 57.04
53 INT34933 Positive_regulation of Gene_expression of LIF 6 0.67 3.41 1.38 57.04
54 INT85963 Gene_expression of LIFR 23 0.75 9 0.98 56.48
55 INT178456 Positive_regulation of Gene_expression of LIFR 7 0.50 2.74 0.54 56.48
56 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 55.72
57 INT63230 Positive_regulation of GP6 2 0.68 2.5 0.17 55.24
58 INT128472 Negative_regulation of CD34 7 0.42 3.92 0.58 54.40
59 INT100275 Gene_expression of TBL1XR1 19 0.25 6.99 1.33 49.12
60 INT100277 Positive_regulation of Gene_expression of TBL1XR1 5 0.19 1.9 0.25 49.12
61 INT216873 Binding of TBL1XR1 3 0.36 4.44 0.4 48.68
62 INT62868 Gene_expression of Ifna 15 0.67 5.37 0.51 46.72
63 INT36779 Localization of HBG2 3 0.59 1.57 2 46.44
64 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 45.96
65 INT5286 Gene_expression of ANTXR2 46 0.75 21.06 3.41 45.68
66 INT286429 Positive_regulation of Gene_expression of ANTXR2 2 0.25 1.46 0.23 45.68
67 INT239599 Binding of Stt3b 1 0.01 3.55 0.85 45.52
68 INT94896 Regulation of TEP1 12 0.39 8.04 0.69 44.56
69 INT28521 Gene_expression of HBG2 56 0.77 16.62 8.64 43.92
70 INT135319 Positive_regulation of Positive_regulation of CRP 20 0.50 26.45 5.61 43.08
71 INT22431 Negative_regulation of HBG2 20 0.58 6.6 3.33 41.00
72 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 38.80
73 INT116540 Binding of Twist1 35 0.48 16.32 2.85 38.04
74 INT49801 Positive_regulation of SELP 21 0.48 21.34 5.25 37.96
75 INT173624 Negative_regulation of Positive_regulation of SELP 1 0.04 0.38 0 37.96
76 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 37.56
77 INT4046 Positive_regulation of HBG2 42 0.69 13.66 8.51 36.52
78 INT129848 Negative_regulation of CD5 3 0.42 3.01 0.67 34.52
79 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 33.56
80 INT178053 Positive_regulation of STIP1 7 0.44 5.09 0.11 28.48
81 INT8571 Gene_expression of B3GAT1 54 0.75 36.85 15.98 25.16
82 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 25.16
83 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 25.16
84 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 25.16
85 INT204257 Gene_expression of RTL1 3 0.08 3.09 0 25.16
86 INT174240 Negative_regulation of TYMS 12 0.57 6.35 1.82 22.64
87 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 18.40
88 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 15.44
89 INT178208 Regulation of SPA17 1 0.03 1.29 0 14.16
90 INT178204 Regulation of Spa17 1 0.09 1.23 0 13.44
91 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 13.20
92 INT89445 Gene_expression of MEPE 17 0.58 18.07 1.55 13.20
93 INT58755 Binding of PAM 6 0.34 3.09 0.97 5.80
94 INT178183 Binding of Cd8a 16 0.32 7.8 0.85 5.52
95 INT202628 Gene_expression of Wnt1 20 0.67 9.2 0.82 5.40
96 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
97 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
98 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
99 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
100 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
101 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
102 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
103 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
104 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
105 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
106 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
107 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
108 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
109 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
110 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
111 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
112 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
113 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
114 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
115 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
116 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
117 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
118 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
119 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
120 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
121 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 5.00
122 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
123 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
124 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
125 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
126 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
127 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
128 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
129 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
130 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
131 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
132 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
133 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 5.00
134 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
135 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
136 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
137 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
138 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
139 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
140 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
141 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
142 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
143 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
144 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 5.00
145 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 5.00
146 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
147 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
148 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
149 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
150 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
151 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
152 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
153 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
154 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
155 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
156 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
157 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
158 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
159 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
160 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
161 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
162 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 5.00
163 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62 5.00
164 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
165 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
166 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
167 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
168 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68 5.00
169 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 5.00
170 INT69877 Positive_regulation of Positive_regulation of Nfkb1 53 0.68 31.44 20.7 5.00
171 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 5.00
172 INT78901 Localization of CCL5 67 0.78 40.79 20.59 5.00
173 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 5.00
174 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
175 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 5.00
176 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
177 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
178 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
179 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96 5.00
180 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
181 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
182 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
183 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
184 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 5.00
185 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
186 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
187 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 5.00
188 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
189 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
190 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86 5.00
191 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
192 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 5.00
193 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 5.00
194 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
195 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
196 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68 5.00
197 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 5.00
198 INT152729 Negative_regulation of Gene_expression of S100a8 33 0.42 32.25 13.64 5.00
199 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
200 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39 5.00
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