D:Genitourinary Tract Cancer

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Disease Term
Synonyms Cancer Genito Urinary, Cancer Genitourinary, CANCER UROGENITAL, Cancers Genito Urinary, Cancers Genitourinary, Cancers Urogenital, GENITO URINARY CANCER, Genito Urinary Cancers, Genito Urinary Neoplasm, Genito Urinary Neoplasms, Genitourinary Cancer
Documents 59
Hot Single Events 6
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Genitourinary Tract Cancer. They are ordered first by their relevance to Genitourinary Tract Cancer and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT244640 AGK Negative_regulation of KIT 1 0.00 0.69 0.08 50.00
2 INT244639 AGK Negative_regulation of PDGFRB 1 0.01 0.69 0.08 50.00
3 INT244638 AGK Negative_regulation of KDR 1 0.00 0.68 0.08 50.00
4 INT244641 PDGFA Regulation of MTOR 1 0.07 2.55 0.06 50.00
5 INT196523 Binding of MMP2 and TIMP1 3 0.43 1.94 0.85 20.08
6 INT196525 Binding of MMP2 and MMP9 2 0.32 2.49 0.78 20.08
7 INT196521 Binding of MMP2 and TIMP2 1 0.30 0.68 0.52 20.08
8 INT196526 Binding of TIMP1 and TIMP2 1 0.45 1.49 0.71 19.44
9 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33 18.64
10 INT196527 Positive_regulation of Binding of MMP1 and MMP2 1 0.44 0.74 0.51 10.56
11 INT196524 Binding of MMP1 and MMP9 1 0.31 0.74 0.51 10.56
12 INT196519 Positive_regulation of Binding of MMP1 and MMP9 1 0.42 0.74 0.51 10.56
13 INT196520 Binding of MMP1 and MMP2 1 0.33 0.74 0.51 10.56
14 INT196522 Binding of MMP1 and TIMP1 1 0.39 0.29 0.53 5.00
15 INT337062 Binding of VEGFA and NMI 1 0.07 1.12 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Genitourinary Tract Cancer. They are ordered first by their pain relevance and then by number of times they were reported in Genitourinary Tract Cancer. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT2649 Regulation of Calca 433 0.62 146.05 330.95 98.24
2 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 98.12
3 INT97973 Positive_regulation of XRCC1 24 0.40 30.95 2.26 88.56
4 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 87.96
5 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76 86.04
6 INT180580 Binding of HEYL 7 0.17 4.49 1.15 83.84
7 INT92139 Binding of MLH1 12 0.42 15.62 1 75.76
8 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 75.00
9 INT16814 Negative_regulation of COX5A 74 0.57 33.72 28.63 75.00
10 INT76759 Positive_regulation of RFFL 31 0.35 29.15 9.9 71.20
11 INT174537 Positive_regulation of HEYL 7 0.39 3.07 0.68 63.44
12 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 60.00
13 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 50.00
14 INT22383 Binding of IL2 59 0.48 39.06 8.56 50.00
15 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73 50.00
16 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 50.00
17 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 50.00
18 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 50.00
19 INT105883 Positive_regulation of Phosphorylation of Bcl2 8 0.32 5.67 1.86 50.00
20 INT120519 Localization of XRCC1 15 0.78 17.03 1.51 50.00
21 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48 50.00
22 INT85829 Gene_expression of CA9 14 0.68 12.59 1.4 50.00
23 INT197105 Negative_regulation of FLT4 13 0.42 11.48 0.92 50.00
24 INT74021 Regulation of XRCC1 15 0.44 16.91 0.88 50.00
25 INT164756 Negative_regulation of PDGFRB 32 0.57 21.69 0.72 50.00
26 INT223599 Regulation of MTOR 14 0.42 8.52 0.49 50.00
27 INT244650 Positive_regulation of Binding of IL2 1 0.20 1.39 0.05 50.00
28 INT223605 Negative_regulation of ARAF 5 0.05 3.87 0.05 50.00
29 INT244649 Negative_regulation of CYP17A1 3 0.17 1.48 0.03 50.00
30 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 46.96
31 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 46.96
32 INT72127 Protein_catabolism of MMRN1 68 0.52 56 14.13 46.84
33 INT74018 Binding of XRCC1 19 0.31 24.78 1.24 43.16
34 INT187133 Protein_catabolism of TIMP1 19 0.73 11.3 5.51 42.12
35 INT82871 Protein_catabolism of MMP1 13 0.96 10.71 4.09 41.32
36 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 40.24
37 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 38.56
38 INT103210 Localization of MMP1 43 0.78 12.15 15.13 34.40
39 INT97280 Gene_expression of Tk1 11 0.77 16.17 1.32 30.12
40 INT50212 Gene_expression of Ifx 33 0.75 32.17 7.26 29.92
41 INT187851 Gene_expression of Hbb-ar 40 0.65 16.34 2.3 29.92
42 INT98376 Gene_expression of tk 27 0.51 21.9 2.23 29.92
43 INT350386 Regulation of AES 2 0.36 1.55 0.55 28.56
44 INT210708 Regulation of Gene_expression of XRCC1 3 0.34 3.11 0 27.20
45 INT214704 Phosphorylation of Tk1 4 0.80 4.27 1.29 25.72
46 INT24199 Binding of Mrvi1 2 0.10 3.79 0.69 23.76
47 INT263487 Positive_regulation of Gene_expression of Tk1 1 0.38 1.78 0.09 20.52
48 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 12.04
49 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 12.04
50 INT214705 Localization of Tk1 2 0.57 2.15 0.21 11.84
51 INT107242 Binding of MMP3 14 0.47 12.06 5.11 10.56
52 INT133312 Binding of MMP9 25 0.42 16.79 3.83 10.56
53 INT130728 Binding of MMP1 14 0.47 4.7 1.95 10.56
54 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 10.16
55 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 9.44
56 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 8.88
57 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 8.88
58 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
59 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
60 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
61 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
62 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
63 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
64 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
65 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
66 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
67 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
68 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
69 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
70 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
71 INT99610 Localization of MMP9 126 0.79 48.46 32.67 5.00
72 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
73 INT34487 Localization of MMP2 56 0.81 31.41 23.61 5.00
74 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 5.00
75 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
76 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
77 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
78 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
79 INT81486 Localization of MMP3 31 0.81 12.94 15.21 5.00
80 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16 5.00
81 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 5.00
82 INT7776 Gene_expression of Abcb1b 63 0.75 21.35 14.92 5.00
83 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 5.00
84 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
85 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
86 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 5.00
87 INT89282 Regulation of MMP9 39 0.60 25.45 10.34 5.00
88 INT107606 Negative_regulation of MMP1 38 0.42 11.94 10.01 5.00
89 INT102987 Regulation of MMP3 23 0.60 9.35 9.54 5.00
90 INT93490 Gene_expression of GPM6A 14 0.69 3.14 9.08 5.00
91 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98 5.00
92 INT36678 Binding of TIMP1 33 0.36 14.99 7.87 5.00
93 INT93664 Gene_expression of TIMP2 33 0.67 36.67 7.14 5.00
94 INT264641 Binding of AES 25 0.42 18.56 6.98 5.00
95 INT22205 Gene_expression of CCT6A 7 0.29 0.86 6.63 5.00
96 INT95607 Regulation of MMP1 19 0.60 7.86 6.18 5.00
97 INT108628 Regulation of MMP2 27 0.60 14.85 6.06 5.00
98 INT34232 Regulation of TIMP1 37 0.61 18.76 6.05 5.00
99 INT57721 Localization of CCT6A 2 0.16 3.12 5.88 5.00
100 INT232663 Positive_regulation of CCT6A 1 0.13 3.08 5.27 5.00
101 INT201130 Localization of AES 31 0.63 25.45 5.12 5.00
102 INT117204 Gene_expression of Tcm 39 0.58 10.58 4.88 5.00
103 INT94433 Negative_regulation of TIMP2 16 0.55 9.38 4.78 5.00
104 INT21582 Regulation of Gene_expression of TIMP1 20 0.61 12.39 4.77 5.00
105 INT112458 Localization of Selenbp2 4 0.04 1.1 4.74 5.00
106 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71 5.00
107 INT18995 Binding of CEL 23 0.47 14.46 4.5 5.00
108 INT99608 Transcription of MMP9 18 0.65 9.67 4.11 5.00
109 INT149614 Localization of MMP13 13 0.81 6.12 3.65 5.00
110 INT192951 Negative_regulation of AES 15 0.38 6.38 3.5 5.00
111 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71 5.00
112 INT12485 Binding of DNAH8 17 0.48 4.24 2.54 5.00
113 INT129961 Regulation of Gene_expression of MMP1 15 0.46 4.88 2.51 5.00
114 INT63333 Gene_expression of RET 24 0.76 30.09 2.41 5.00
115 INT38871 Binding of TFPI 12 0.32 5.9 2.36 5.00
116 INT55736 Transcription of MMP2 11 0.68 5.78 2.28 5.00
117 INT60279 Gene_expression of VHL 70 0.78 75.21 2.21 5.00
118 INT121706 Negative_regulation of Positive_regulation of MMP3 4 0.38 2.68 2.19 5.00
119 INT185829 Negative_regulation of Positive_regulation of MMP2 7 0.40 4.93 2.02 5.00
120 INT121707 Negative_regulation of Positive_regulation of MMP1 4 0.37 3.1 2.01 5.00
121 INT101912 Regulation of TIMP2 8 0.44 5.55 2 5.00
122 INT52508 Positive_regulation of TIMP2 7 0.43 8.1 1.96 5.00
123 INT232662 Localization of MS 1 0.03 0.57 1.95 5.00
124 INT187128 Binding of TIMP2 11 0.41 6.43 1.9 5.00
125 INT232666 Negative_regulation of AK1 1 0.02 2.52 1.88 5.00
126 INT199591 Protein_catabolism of IL2 2 0.05 1.2 1.81 5.00
127 INT176495 Gene_expression of MMP28 6 0.57 3.82 1.64 5.00
128 INT66709 Transcription of IGF1 13 0.71 5.65 1.64 5.00
129 INT75694 Regulation of Gene_expression of CEL 9 0.60 6.08 1.53 5.00
130 INT53131 Transcription of TIMP1 8 0.68 3.89 1.5 5.00
131 INT102989 Regulation of Gene_expression of MMP3 10 0.53 3.29 1.47 5.00
132 INT150809 Localization of TIMP2 7 0.65 2.6 1.43 5.00
133 INT210399 Gene_expression of IGF2R 22 0.65 17.1 1.23 5.00
134 INT232661 Negative_regulation of Gene_expression of GPM6A 1 0.02 0.81 1.2 5.00
135 INT187123 Negative_regulation of Positive_regulation of MMP9 7 0.42 2.54 1.17 5.00
136 INT232665 Gene_expression of WIPF3 1 0.06 1.85 1.14 5.00
137 INT143956 Regulation of Positive_regulation of MMP9 5 0.40 2.61 1.11 5.00
138 INT74020 Negative_regulation of XRCC1 16 0.35 17.18 1.06 5.00
139 INT9551 Regulation of AK1 2 0.03 1.38 1.03 5.00
140 INT232664 Regulation of Positive_regulation of AK1 1 0.02 0.91 0.95 5.00
141 INT46369 Positive_regulation of AK1 3 0.09 1.24 0.94 5.00
142 INT55738 Positive_regulation of Transcription of MMP2 3 0.65 1.79 0.92 5.00
143 INT88000 Gene_expression of LAP 15 0.55 6.94 0.91 5.00
144 INT264849 Gene_expression of HTs 9 0.68 2.23 0.84 5.00
145 INT193019 Positive_regulation of Positive_regulation of SMUG1 6 0.39 4.7 0.83 5.00
146 INT191101 Regulation of Localization of MMP9 6 0.38 2.49 0.81 5.00
147 INT206929 Negative_regulation of Gene_expression of XRCC1 4 0.25 6.14 0.74 5.00
148 INT114842 Localization of RET 3 0.71 5.98 0.71 5.00
149 INT66940 Regulation of RET 7 0.52 5.61 0.69 5.00
150 INT143953 Regulation of Positive_regulation of MMP2 3 0.44 2.25 0.69 5.00
151 INT94429 Transcription of TIMP2 3 0.61 4.05 0.67 5.00
152 INT200219 Positive_regulation of VHL 18 0.50 15.38 0.67 5.00
153 INT96907 Positive_regulation of ABCA4 16 0.49 4.59 0.52 5.00
154 INT196533 Regulation of Positive_regulation of MMP1 3 0.50 1.35 0.43 5.00
155 INT150095 Regulation of Positive_regulation of TIMP1 2 0.44 0.76 0.41 5.00
156 INT187022 Positive_regulation of Transcription of MMP9 3 0.45 3.27 0.34 5.00
157 INT79253 Positive_regulation of ST3GAL4 3 0.61 1.2 0.23 5.00
158 INT196546 Regulation of Positive_regulation of MMP3 1 0.38 0.89 0.23 5.00
159 INT350385 Localization of ZMYND10 1 0.73 0.7 0.22 5.00
160 INT265903 Gene_expression of FOXO1 3 0.48 2.66 0.2 5.00
161 INT337064 Localization of NMI 1 0.13 0.93 0.19 5.00
162 INT350384 Negative_regulation of Binding of AES 1 0.34 0.58 0.16 5.00
163 INT184511 Positive_regulation of Negative_regulation of VEGFA 5 0.46 2.86 0.09 5.00
164 INT121495 Transcription of XRCC1 7 0.49 6.11 0.09 5.00
165 INT318819 Positive_regulation of Transcription of IGF1 1 0.33 1.94 0.07 5.00
166 INT251953 Positive_regulation of Transcription of XRCC1 1 0.29 1.07 0.04 5.00
167 INT264851 Regulation of Binding of DNAH8 1 0.10 0.45 0.04 5.00
168 INT264850 Positive_regulation of Binding of DNAH8 1 0.19 0.45 0.04 5.00
169 INT258075 Regulation of Negative_regulation of DNAH8 2 0.17 1.78 0 5.00
170 INT337065 Negative_regulation of NMI 1 0.07 0.96 0 5.00
171 INT337063 Regulation of NMI 1 0.05 1.11 0 5.00
172 INT264848 Transcription of ST3GAL4 1 0.10 0.09 0 5.00
173 INT195615 Localization of Mrvi1 1 0.10 0.65 0 5.00
174 INT251491 Negative_regulation of Pcsk9 1 0.34 0.86 0 5.00
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