D:Genomic Instability

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Disease Term
Synonyms Genome Instabilities, Genome Instability, GENOME STABILITIES, Genome Stability, Genomic Instabilities, Genomic Stabilities, Genomic Stability, Instabilities Genome, Instabilities Genomic, Instability Genome, Instability Genomic
Documents 102
Hot Single Events 150
Hot Interactions 17

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Genomic Instability. They are ordered first by their relevance to Genomic Instability and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT323185 Binding of LIG4 and OGG1 1 0.02 0.32 0 99.92
2 INT197808 Binding of MEN1 and NME1 1 0.00 1.81 0 98.40
3 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0 96.60
4 INT205159 SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 0.8 0 96.20
5 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0 95.80
6 INT314678 Binding of CCNE1 and CCNE2 1 0.03 1.41 0 95.80
7 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0 94.44
8 INT315543 NARFL Regulation of Gene_expression of HIF1A 1 0.01 0.63 0 92.20
9 INT314740 Binding of ESR1 and Brca1 1 0.16 0.69 0 90.48
10 INT175400 RASGRP1 Positive_regulation of MAP3K5 1 0.00 1.2 0 90.12
11 INT354833 Csf2 Positive_regulation of Cd8a 1 0.01 0.98 0 86.40
12 INT337066 Binding of DPYD and FRA1E 1 0.19 0.8 0 85.76
13 INT259051 Binding of TP53 and UBE3A 1 0.01 3.48 0 84.84
14 INT182606 Binding of MSH2 and MSH3 1 0.12 1.4 0.21 84.28
15 INT182607 Binding of MLH1 and MSH3 1 0.04 0.81 0.11 84.04
16 INT314742 Binding of RAD51 and Brca2 1 0.06 1.05 0 81.20
17 INT314743 Binding of RAD51 and Brca1 1 0.06 1.06 0 81.20
18 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0 76.80
19 INT259050 Binding of HPV18I1 and OPN1LW 1 0.01 1.19 0 75.80
20 INT325375 Binding of Tp53 and Positive_regulation of Positive_regulation of PARP1 1 0.05 0.59 0 75.80
21 INT259049 Binding of BAK1 and HPV18I1 1 0.00 1.19 0 75.80
22 INT227840 Binding of ERCC2 and ERCC6 1 0.11 0.66 0 74.84
23 INT227838 Binding of ERCC6 and PGBD3 1 0.40 0.23 0 74.84
24 INT227831 Binding of ERCC2 and PGBD3 1 0.07 0.23 0 74.68
25 INT197809 Binding of MEN1 and VIM 1 0.04 0.52 0 74.24
26 INT197813 Binding of AMBP and MEN1 1 0.00 0.51 0 72.24
27 INT197812 Binding of AMBP and RDBP 1 0.00 0.51 0 72.24
28 INT267257 BCL11B Regulation of Transcription of BMI1 1 0.28 0.74 0 69.92
29 INT267259 BCL11B Regulation of BMI1 1 0.65 1.48 0 69.92
30 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0 56.76
31 INT197810 Binding of MEN1 and MUC1 1 0.06 0.47 0 55.20
32 INT149095 PITX2 Positive_regulation of Casp3 1 0.00 1.51 0.15 55.00
33 INT149092 PITX2 Positive_regulation of RFFL 1 0.00 1.51 0.15 55.00
34 INT201536 RASSF1 Regulation of ID2 1 0.41 1.42 0 52.24
35 INT201532 RASSF1 Regulation of NPC1 1 0.44 1.41 0 51.96
36 INT201534 RASSF1 Negative_regulation of ID2 1 0.33 1.41 0 50.40
37 INT201542 Positive_regulation of RASSF1 Negative_regulation of ID2 1 0.36 1.41 0 50.40
38 INT201533 RASSF1 Positive_regulation of Gene_expression of ID2 1 0.38 1.41 0 50.40
39 INT186989 Binding of Akt1 and Tert 1 0.00 0.61 0 50.24
40 INT305542 Binding of Rb1 and Trp53 1 0.00 0.9 0 49.00
41 INT305540 Binding of Trp53 and Tpt1 1 0.07 0.9 0 49.00
42 INT305541 Binding of Bcl2 and Trp53 1 0.05 0.9 0 49.00
43 INT305539 Binding of Mki67 and Trp53 1 0.20 0.91 0 49.00
44 INT305543 Binding of Top2a and Trp53 1 0.37 0.91 0 49.00
45 INT314745 Binding of TP53 and Brca1 1 0.18 1.17 0 48.48
46 INT201535 Binding of NPC1 and XRCC1 1 0.26 1.6 0.05 45.60
47 INT305336 TP53 Negative_regulation of Phosphorylation of RB1 1 0.29 0.96 0 42.48
48 INT211875 Binding of CDS1 and SMUG1 1 0.03 1.04 0.07 39.36
49 INT149096 PITX2 Positive_regulation of Gene_expression of Egr1 1 0.01 1.23 0.19 36.00
50 INT201537 Binding of NPC1 and HHATL 1 0.16 1.43 0 35.80
51 INT181765 WISP3 Regulation of Gene_expression of RHOC 1 0.49 1.46 0.21 34.88
52 INT197811 Binding of SMS and SST 1 0.00 0.98 0.21 28.48
53 INT205156 CD44 Positive_regulation of MMP9 1 0.51 0.24 0 28.24
54 INT352615 Binding of Mdm4 and Trp53 1 0.30 1.36 0 22.12
55 INT207813 Atm Regulation of Gene_expression of Parp1 1 0.44 0.31 0 11.32
56 INT197815 Binding of MEN1 and TGFB1 1 0.16 0.13 0 8.32
57 INT190049 Binding of Mlh1 and Msh3 1 0.24 0.22 0 5.92
58 INT190048 Binding of Mlh1 and Msh2 1 0.31 0.22 0 5.92
59 INT190050 Binding of Msh2 and Pms2 2 0.32 0.49 0.04 5.72
60 INT190046 Binding of Msh3 and Pms2 2 0.25 0.5 0.04 5.72
61 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85 5.00
62 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15 5.00
63 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
64 INT306823 Binding of E2F4 and GOPC 1 0.06 0.23 0.91 5.00
65 INT306831 Positive_regulation of Binding of E2F4 and NOLC1 1 0.10 0.46 0.85 5.00
66 INT306826 Binding of E2F4 and NOLC1 1 0.08 0.41 0.84 5.00
67 INT196525 Binding of MMP2 and MMP9 2 0.32 2.49 0.78 5.00
68 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55 5.00
69 INT305547 VEGFA Positive_regulation of Gtf3a 2 0.00 1.83 0.48 5.00
70 INT306828 Binding of E2F2 and E2F3 1 0.20 0.15 0.46 5.00
71 INT306824 Binding of E2F1 and E2F2 1 0.15 0.15 0.46 5.00
72 INT311557 Binding of ROS1 and Ptpn2 1 0.02 2.32 0.46 5.00
73 INT290671 Binding of Socs3 and Stat3 2 0.23 1.59 0.45 5.00
74 INT306830 E2F2 Regulation of C1orf61 1 0.02 0.48 0.36 5.00
75 INT133307 Binding of CD44 and SPP1 5 0.26 2.6 0.35 5.00
76 INT306822 Binding of E2F2 and GOPC 1 0.05 0.53 0.35 5.00
77 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27 5.00
78 INT311533 ROS1 Positive_regulation of Positive_regulation of RYR3 1 0.28 0.18 0.26 5.00
79 INT311532 ROS1 Regulation of RYR3 1 0.43 0.18 0.25 5.00
80 INT190052 Binding of Cdx2 and Ebp 1 0.08 0.82 0.24 5.00
81 INT311531 IMMT Negative_regulation of Gene_expression of ROS1 1 0.11 1.09 0.24 5.00
82 INT205155 Negative_regulation of Binding of CD44 and MMP9 1 0.32 1.98 0.23 5.00
83 INT190045 Binding of Ebp and Scrib 1 0.10 0.79 0.22 5.00
84 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2 5.00
85 INT290672 Stat3 Negative_regulation of Il6 1 0.08 0.4 0.18 5.00
86 INT193695 Il2 Positive_regulation of Ctla4 1 0.01 1.63 0.18 5.00
87 INT290670 Binding of Nos2 and Ppara 1 0.17 0.41 0.16 5.00
88 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13 5.00
89 INT184704 Binding of Prrx2 and Sr1 1 0.21 1.65 0.13 5.00
90 INT175398 Binding of ERBB2 and VEGFA 2 0.16 1.34 0.13 5.00
91 INT175401 Binding of EGFR and VEGFA 2 0.13 1.49 0.13 5.00
92 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12 5.00
93 INT290673 Ppara Positive_regulation of Gtf3a 1 0.01 0.58 0.09 5.00
94 INT290674 Ppara Positive_regulation of Gtf3a Positive_regulation of Ppara 1 0.01 0.58 0.09 5.00
95 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09 5.00
96 INT205158 Gene_expression of SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 1.08 0.08 5.00
97 INT290669 Tlr4 Positive_regulation of Binding of Il6 1 0.02 0.07 0.08 5.00
98 INT193691 Positive_regulation of Positive_regulation of Bcr 1 0.01 0.07 0.08 5.00
99 INT201543 Binding of NPC1 and RNASE1 1 0.07 1.33 0.08 5.00
100 INT193692 IgG2a Positive_regulation of Bcr 1 0.02 0.07 0.08 5.00
101 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08 5.00
102 INT227836 Binding of ERCC6 and GPER 1 0.21 0.27 0.08 5.00
103 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07 5.00
104 INT205160 Binding of CD44 and MMP2 1 0.09 0.61 0.07 5.00
105 INT176257 Positive_regulation of p53-ps Positive_regulation of Gene_expression of Fas 1 0.04 0.32 0.06 5.00
106 INT352618 Tpt1 Regulation of Trp53 1 0.06 0.54 0.05 5.00
107 INT205154 Binding of MMP9 and SPP1 1 0.25 0.45 0.05 5.00
108 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05 5.00
109 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05 5.00
110 INT352623 Tpt1 Regulation of Olig2 1 0.02 0.54 0.05 5.00
111 INT352622 Olig2 Negative_regulation of Tpt1 1 0.06 0.54 0.05 5.00
112 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04 5.00
113 INT323392 SERPINH1 Negative_regulation of BCHE 1 0.02 0.52 0.04 5.00
114 INT205862 CNTN2 Positive_regulation of TNF 1 0.01 0.08 0.04 5.00
115 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04 5.00
116 INT352619 Bcl2l12 Negative_regulation of Trp53 1 0.27 0.94 0.04 5.00
117 INT311535 ROS1 Negative_regulation of CA2 1 0.19 0.61 0.04 5.00
118 INT352613 Binding of Trp53 and Bcl2l12 1 0.23 0.94 0.04 5.00
119 INT284916 IL1RN Negative_regulation of HDAC4 1 0.00 1.66 0.03 5.00
120 INT211873 TP53 Positive_regulation of Transcription of CD40 1 0.03 1.44 0.03 5.00
121 INT176283 Fasl Positive_regulation of Fas 1 0.21 0.3 0.03 5.00
122 INT352624 Trp53 Negative_regulation of CEL 1 0.01 1.01 0.03 5.00
123 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03 5.00
124 INT323395 Binding of BCHE and SERPINH1 1 0.02 0.74 0.03 5.00
125 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03 5.00
126 INT287479 PSMB10 Positive_regulation of TBK1 1 0.00 0.59 0.03 5.00
127 INT176254 Fasl Positive_regulation of Fas Negative_regulation of Gene_expression of PCNA 1 0.02 0.3 0.03 5.00
128 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03 5.00
129 INT354835 Binding of VEGFA and Pdgfa 1 0.00 1.5 0.03 5.00
130 INT176286 Fasl Positive_regulation of Gene_expression of Pcna 1 0.02 0.81 0.03 5.00
131 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03 5.00
132 INT287480 Protein_catabolism of NFKBIB Positive_regulation of TBK1 1 0.01 0.6 0.03 5.00
133 INT211872 TP53 Positive_regulation of CD40 1 0.03 1.44 0.03 5.00
134 INT176253 Fasl Positive_regulation of Fas Positive_regulation of Gene_expression of PCNA 1 0.02 0.3 0.03 5.00
135 INT294089 Negative_regulation of Binding of ERBB2 and ERBB4 1 0.08 0.6 0 5.00
136 INT294829 STAT3 Regulation of Gene_expression of REXO1 1 0.10 0.48 0 5.00
137 INT190061 Binding of MLH1 and Mlh1 1 0.01 0.92 0 5.00
138 INT189375 Rpa1 Regulation of ERCC6 1 0.04 0.05 0 5.00
139 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0 5.00
140 INT294091 Binding of PGF and VEGFA 1 0.02 1.21 0 5.00
141 INT201539 Binding of NPC1 and THY1 1 0.36 1.28 0 5.00
142 INT296163 Mcph1 Regulation of Tert 1 0.03 0.19 0 5.00
143 INT227830 CSH1 Regulation of ERCC6 1 0.11 0 0 5.00
144 INT314746 Akt1 Positive_regulation of Phosphorylation of MDM2 1 0.32 1.16 0 5.00
145 INT314741 Binding of VEGFA and Akt1 1 0.36 0.66 0 5.00
146 INT193696 Binding of CD8A and Trav6-3 1 0.00 0.85 0 5.00
147 INT311534 Binding of CISH and NFE2L2 1 0.02 0.64 0 5.00
148 INT176259 p53-ps Positive_regulation of Transcription of Fas 1 0.04 0.35 0 5.00
149 INT200211 Gh Positive_regulation of Localization of Igf1 1 0.38 2.05 0 5.00
150 INT351602 TXK Positive_regulation of ERBB2 1 0.02 0.58 0 5.00
151 INT227837 Positive_regulation of Binding of CSH1 and ERCC6 1 0.20 0.15 0 5.00
152 INT314692 Binding of TBX2 and TBX3 1 0.27 0.84 0 5.00
153 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0 5.00
154 INT306827 Binding of E2F2 and NOLC1 1 0.07 0.05 0 5.00
155 INT294825 Phosphorylation of GRAP2 Regulation of Gene_expression of REXO1 1 0.03 0.48 0 5.00
156 INT189373 Rpa1 Negative_regulation of ERCC6 1 0.03 0 0 5.00
157 INT314693 Binding of TBX2 and TBX5 1 0.16 0.84 0 5.00
158 INT259081 Binding of Hbb-ar and ENOPH1 1 0.00 1.36 0 5.00
159 INT225983 Binding of lec and Ros1 1 0.10 0.51 0 5.00
160 INT186999 Binding of KIT and Gtf3a 1 0.00 0.25 0 5.00
161 INT176289 Pcna Positive_regulation of Phosphorylation of Esr1 1 0.01 0.67 0 5.00
162 INT284919 XRCC6 Negative_regulation of BAX 1 0.01 0.64 0 5.00
163 INT201541 Binding of NPC1 and BRD7 1 0.35 1.59 0 5.00
164 INT267261 GOPC Regulation of BMI1 1 0.06 0.75 0 5.00
165 INT208017 Col4a4 Regulation of Gene_expression of Pgr 1 0.04 0.69 0 5.00
166 INT284920 Binding of HDAC1 and NCOR1 1 0.03 0.13 0 5.00
167 INT351604 TXK Positive_regulation of EGFR 1 0.02 1.78 0 5.00
168 INT205863 Binding of FDPS and HTLVR 1 0.00 0.07 0 5.00
169 INT352625 Trp53 Regulation of CEL 1 0.00 0.71 0 5.00
170 INT197816 Binding of MEN1 and NFKB1 1 0.05 0.07 0 5.00
171 INT176292 Fasl Regulation of Gene_expression of CDKN1A 1 0.34 0.84 0 5.00
172 INT227829 CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0 5.00
173 INT208018 Col4a4 Regulation of Gene_expression of Esr1 1 0.06 0.69 0 5.00
174 INT314682 Binding of TBX2 and TBX4 1 0.16 0.84 0 5.00
175 INT314687 ESR1 Regulation of PGR 1 0.27 0.88 0 5.00
176 INT279145 Binding of VHL and RNF139 1 0.30 1.87 0 5.00
177 INT284918 RUNX1T1 Regulation of DNMT1 1 0.21 1.09 0 5.00
178 INT176288 Binding of Cdk2 and Pcna 1 0.01 0.66 0 5.00
179 INT279143 Binding of TSN and RNF139 1 0.31 0.83 0 5.00
180 INT284917 RUNX1T1 Regulation of HDAC9 1 0.19 1.09 0 5.00
181 INT306825 Positive_regulation of Binding of E2F2 and RB1 1 0.04 0.05 0 5.00
182 INT294095 Binding of TXK and Gtf3a 1 0.00 2.33 0 5.00
183 INT323393 Positive_regulation of Binding of SERPINH1 and VRK1 1 0.01 0 0 5.00
184 INT294830 Phosphorylation of STAT3 Regulation of Gene_expression of REXO1 1 0.08 0.48 0 5.00
185 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0 5.00
186 INT315541 ACO1 Negative_regulation of Gene_expression of ALAS2 1 0.17 0.18 0 5.00
187 INT294088 Binding of ERBB2 and ERBB4 2 0.13 0.88 0 5.00
188 INT315534 Binding of ACO1 and ERN1 1 0.01 0.18 0 5.00
189 INT318378 Binding of Uevld and Vmn1r7 1 0.02 0.92 0 5.00
190 INT352617 Mdm2 Positive_regulation of Positive_regulation of Trp53 1 0.20 2.56 0 5.00
191 INT201540 GADD45G Negative_regulation of NPC1 1 0.32 1.7 0 5.00
192 INT294881 Phosphorylation of Mdk Regulation of Gene_expression of REXO1 1 0.02 0.48 0 5.00
193 INT294090 Negative_regulation of Binding of EGFR and ERBB2 1 0.14 0.6 0 5.00
194 INT189330 PPA1 Positive_regulation of ERCC6 1 0.10 0 0 5.00
195 INT294880 DPYD Positive_regulation of Ephb1 1 0.00 0.53 0 5.00
196 INT216465 Gh Positive_regulation of Ghr 1 0.26 0.23 0 5.00
197 INT197817 Binding of JUND and MEN1 1 0.18 0.14 0 5.00
198 INT227832 Binding of CSH1 and ERCC6 1 0.15 0.15 0 5.00
199 INT323394 Binding of SERPINH1 and VRK1 1 0.00 0 0 5.00
200 INT176291 Fasl Regulation of Gene_expression of Pcna 1 0.01 0.31 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Genomic Instability. They are ordered first by their pain relevance and then by number of times they were reported in Genomic Instability. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT317276 Protein_catabolism of Gfm1 4 0.06 2.41 0.15 100.00
2 INT182413 Binding of OGG1 17 0.46 2.44 0.22 99.92
3 INT197840 Binding of NME1 2 0.04 1.14 0.11 99.90
4 INT35896 Regulation of Mrc1 4 0.44 1.33 0.49 99.66
5 INT196916 Negative_regulation of Rb1 13 0.42 14.29 0.4 99.60
6 INT5320 Gene_expression of PTGFR 18 0.59 12.99 3.7 99.58
7 INT323201 Binding of LIG4 1 0.03 0.32 0 99.44
8 INT5319 Positive_regulation of PTGFR 9 0.32 4.96 1.44 99.34
9 INT205176 Protein_catabolism of TNFSF11 1 0.29 0.25 0 99.20
10 INT128916 Regulation of CES1 5 0.40 2.95 0.29 98.90
11 INT296151 Gene_expression of Mcph1 1 0.78 1.33 0.19 98.76
12 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34 98.72
13 INT284938 Regulation of DNMT1 2 0.22 1.17 0.24 98.52
14 INT216460 Positive_regulation of Gene_expression of Dclre1a 1 0.49 2.48 0 98.28
15 INT216443 Gene_expression of Dclre1a 1 0.55 1.98 0 98.28
16 INT300944 Regulation of DNMT3A 1 0.21 0.91 0.24 98.24
17 INT197834 Binding of MEN1 1 0.48 3.32 0 98.00
18 INT77925 Negative_regulation of TEP1 21 0.53 15.23 2.62 98.00
19 INT124375 Gene_expression of Wnt2 67 0.56 38.03 4.67 97.84
20 INT46336 Regulation of DNMT3B 12 0.53 4.91 1.25 97.76
21 INT205173 Regulation of Binding of ACTR1B 1 0.21 0.31 0 97.48
22 INT205163 Regulation of Binding of SPP1 1 0.31 0.31 0 97.48
23 INT147433 Gene_expression of BRCA2 7 0.62 7.02 0.79 97.40
24 INT221268 Localization of BRCA1 7 0.63 4.83 0.18 97.40
25 INT234186 Localization of BRCA2 2 0.69 1.48 0.07 97.40
26 INT126586 Binding of PARP1 15 0.43 4.96 0.53 97.24
27 INT173224 Regulation of BRCA2 1 0.21 1.3 0 97.00
28 INT133311 Binding of SPP1 10 0.37 9.47 1.65 96.92
29 INT205179 Binding of ACTR1B 2 0.17 2.17 0.12 96.76
30 INT99348 Negative_regulation of PARP1 38 0.58 30.96 3.36 96.52
31 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 96.52
32 INT131818 Binding of Parp1 14 0.46 8.74 1.76 96.52
33 INT189346 Positive_regulation of ERCC6 6 0.60 3.37 0.23 96.52
34 INT64233 Regulation of Trp53 35 0.62 27.11 1.53 96.28
35 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94 95.48
36 INT190023 Negative_regulation of Mrc1 15 0.25 12.36 0.16 95.28
37 INT176269 Phosphorylation of p53-ps 1 0.12 4.3 0.31 94.52
38 INT83236 Localization of PGR 14 0.73 8.26 2.23 94.28
39 INT194590 Localization of HOXA10 1 0.35 1.54 0.59 94.28
40 INT300943 Regulation of Localization of HOXA10 1 0.21 1.02 0.24 94.28
41 INT300941 Regulation of Localization of PGR 1 0.04 1.02 0.24 94.28
42 INT123813 Positive_regulation of Parp1 74 0.70 65.36 8.56 94.08
43 INT267269 Gene_expression of BCL11B 62 0.78 48.75 0.55 94.04
44 INT267268 Positive_regulation of BCL11B 1 0.70 6.43 0 94.04
45 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42 93.76
46 INT214045 Negative_regulation of OGG1 5 0.36 3.49 0 93.60
47 INT142435 Gene_expression of NES 86 0.78 47.53 4.92 93.52
48 INT189357 Positive_regulation of Binding of ERCC6 1 0.42 0.15 0 93.52
49 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41 93.44
50 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61 93.32
51 INT151702 Binding of ERCC6 6 0.37 1.47 0.09 93.20
52 INT182623 Localization of MSH2 3 0.77 5.49 0.12 93.08
53 INT182627 Regulation of MSH2 1 0.26 2.27 0.18 93.08
54 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25 92.80
55 INT147244 Regulation of MLH1 3 0.08 2.64 0.12 92.80
56 INT182621 Localization of MLH1 9 0.64 9.31 0.12 92.80
57 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15 92.56
58 INT182626 Localization of MSH3 1 0.22 0.77 0.12 92.52
59 INT182622 Regulation of MSH3 1 0.08 0.77 0.12 92.52
60 INT163839 Regulation of CRAC1 2 0.45 1.42 0.54 92.24
61 INT182628 Localization of CRAC1 1 0.01 0.77 0.12 92.24
62 INT146792 Negative_regulation of Nf2 2 0.59 3.49 0.3 92.00
63 INT175532 Localization of Parp1 9 0.74 5.73 0.17 91.88
64 INT207807 Localization of Atm 4 0.74 0.21 0 91.88
65 INT138799 Regulation of Gene_expression of Ppara 40 0.60 29.42 6.89 91.64
66 INT117415 Negative_regulation of LIG4 4 0.04 1.59 2.17 91.52
67 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 90.76
68 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 90.76
69 INT225189 Binding of CCNE2 5 0.10 2.27 0.1 90.76
70 INT314728 Positive_regulation of Binding of CCNE2 1 0.14 0.7 0 90.76
71 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06 90.56
72 INT89689 Binding of Brca1 2 0.37 2.55 0.18 90.48
73 INT22110 Positive_regulation of Gene_expression of PTGFR 3 0.23 2.45 0.56 90.32
74 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 90.20
75 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 90.20
76 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 90.20
77 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25 89.84
78 INT289861 Negative_regulation of ECT2 1 0.26 1.3 0 89.76
79 INT182440 Gene_expression of CCNE2 39 0.53 22.07 7.44 89.72
80 INT201465 Positive_regulation of CCNE2 6 0.13 3.13 0.92 89.72
81 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78 89.72
82 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 89.68
83 INT212457 Phosphorylation of Brca1 2 0.51 0.96 0 89.68
84 INT25392 Positive_regulation of Gene_expression of Csf2 41 0.49 34.28 8.36 89.56
85 INT106261 Negative_regulation of DPYD 16 0.59 15.02 1.19 89.52
86 INT49866 Negative_regulation of Parp1 53 0.58 35.37 8.84 89.44
87 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 89.44
88 INT178927 Regulation of Gene_expression of Tp53 6 0.26 2.23 0 89.40
89 INT136921 Gene_expression of NOTCH3 5 0.67 4.27 0.16 89.28
90 INT175419 Positive_regulation of Gene_expression of NOTCH3 1 0.32 3 0 89.28
91 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02 89.16
92 INT289872 Negative_regulation of Gene_expression of ECT2 1 0.26 0.71 0 89.12
93 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 88.96
94 INT130866 Positive_regulation of Gene_expression of TNFSF11 25 0.69 7.11 1.82 88.40
95 INT174839 Localization of BSG 4 0.68 2.91 0.98 88.40
96 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 88.32
97 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 88.32
98 INT201547 Gene_expression of ERI3 4 0.20 2.19 0 88.32
99 INT176173 Positive_regulation of Nr1h2 19 0.52 10.95 1.88 88.08
100 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 87.92
101 INT289868 Gene_expression of ECT2 1 0.42 0.7 0 87.52
102 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 87.36
103 INT28118 Binding of Atm 13 0.38 12.24 0.68 87.32
104 INT162467 Gene_expression of ERN1 10 0.56 5.11 1.26 87.20
105 INT350588 Negative_regulation of Mlh1 1 0.38 3.05 0 87.00
106 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6 86.56
107 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 86.56
108 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 86.44
109 INT279178 Negative_regulation of Positive_regulation of MTOR 1 0.24 0.8 0 86.44
110 INT188001 Phosphorylation of H2afx 10 0.80 5.6 0.04 86.28
111 INT92142 Binding of MSH2 5 0.46 5.64 0.75 85.88
112 INT296155 Phosphorylation of Mdc1 1 0.19 0.59 0 85.32
113 INT296157 Phosphorylation of Trp53bp1 1 0.16 0.59 0 85.08
114 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64 85.04
115 INT49025 Positive_regulation of TYR 14 0.69 7.15 5.84 85.04
116 INT213923 Positive_regulation of MTOR 16 0.65 9.28 0.7 85.00
117 INT184997 Gene_expression of TOP2A 6 0.63 1.65 0.15 84.96
118 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 84.80
119 INT296144 Phosphorylation of Nbn 1 0.32 0.59 0 84.80
120 INT189355 Phosphorylation of ERCC6 1 0.79 1.11 0.16 84.24
121 INT350591 Positive_regulation of Gart 1 0.11 0.96 0.1 84.16
122 INT259063 Binding of UBE3A 2 0.36 1.15 0.09 84.08
123 INT172999 Positive_regulation of Gene_expression of MUC4 5 0.59 8.91 1.18 83.72
124 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 83.68
125 INT76759 Positive_regulation of RFFL 31 0.35 29.15 9.9 83.48
126 INT100612 Positive_regulation of Hsp90aa1 4 0.64 5.3 1.01 83.44
127 INT126583 Positive_regulation of PARP1 50 0.68 41.44 7.78 83.36
128 INT100059 Gene_expression of MUC4 30 0.75 31.58 4.95 83.24
129 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 83.20
130 INT314716 Positive_regulation of Gene_expression of CCNE1 1 0.16 1.48 0 83.20
131 INT314725 Gene_expression of CCNE1 3 0.52 2.45 0 82.80
132 INT104979 Gene_expression of MITF 51 0.62 54.83 6.91 82.64
133 INT201602 Positive_regulation of Uvbi1 2 0.04 1.17 0.04 82.44
134 INT114276 Gene_expression of Nr4a1 20 0.77 7.71 3.14 82.32
135 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 82.20
136 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96 82.12
137 INT53003 Positive_regulation of Positive_regulation of Egr1 6 0.64 2.36 1.44 82.12
138 INT267278 Negative_regulation of Gene_expression of BCL11B 1 0.51 2.67 0 81.96
139 INT241863 Binding of SLC40A1 4 0.28 3.86 0.22 81.92
140 INT20603 Positive_regulation of TNFRSF10B 40 0.67 32.61 11.44 81.84
141 INT119189 Positive_regulation of TNFRSF10A 10 0.67 10.58 1.93 81.68
142 INT18114 Gene_expression of NPC1 45 0.66 57.85 1.44 81.52
143 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36 81.28
144 INT107986 Gene_expression of PMS1 2 0.19 1.58 0.39 80.88
145 INT60585 Regulation of TP53 59 0.59 54.55 5.21 80.76
146 INT259061 Negative_regulation of Regulation of TP53 2 0.10 2.23 0.03 80.76
147 INT126582 Negative_regulation of Polb 1 0.01 0.54 0.19 80.72
148 INT97956 Negative_regulation of CDC42 3 0.27 1.58 0.55 80.32
149 INT227857 Positive_regulation of Gene_expression of PGBD3 1 0.47 0.69 0 80.16
150 INT227882 Gene_expression of PGBD3 1 0.63 1.05 0 80.16
151 INT101068 Negative_regulation of CDCP1 27 0.03 17.67 3.45 80.00
152 INT47689 Positive_regulation of Ntrk2 44 0.68 16.84 19.59 80.00
153 INT315588 Regulation of ACO1 1 0.18 0.57 0 79.56
154 INT267279 Positive_regulation of Gene_expression of BCL11B 1 0.70 14.02 0 79.52
155 INT126580 Gene_expression of sal 16 0.50 5.52 0.82 79.48
156 INT175422 Positive_regulation of SACM1L 1 0.00 2.11 0 78.96
157 INT232065 Binding of DDR1 3 0.04 0.81 0 78.88
158 INT190039 Gene_expression of Mlh1 3 0.68 6.14 0 78.72
159 INT181315 Regulation of DPYD 2 0.54 3.64 0 78.72
160 INT94423 Binding of ALAS2 4 0.32 2.1 0.61 78.00
161 INT315556 Positive_regulation of Binding of ALAS2 1 0.43 1.05 0 78.00
162 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3 77.84
163 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 77.76
164 INT338718 Positive_regulation of Localization of NOTCH1 1 0.04 0.6 0.13 77.56
165 INT131850 Gene_expression of RHOC 17 0.72 29.06 2.28 77.44
166 INT131848 Positive_regulation of Gene_expression of RHOC 9 0.64 15.43 1.36 77.44
167 INT289859 Localization of CCNB1 1 0.24 0.27 0 77.40
168 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14 77.12
169 INT12915 Gene_expression of MGP 18 0.75 7.53 4.15 77.04
170 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 77.04
171 INT193402 Gene_expression of UNC5B 5 0.27 1.82 0 77.04
172 INT188074 Gene_expression of GADD45A 12 0.65 5.11 0.28 77.04
173 INT76915 Localization of Gpx3 6 0.14 4.48 0.89 76.84
174 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 76.72
175 INT147743 Positive_regulation of Ntp 3 0.43 1.72 0.72 76.44
176 INT62296 Gene_expression of PDXP 8 0.67 6.48 1.44 75.84
177 INT275886 Gene_expression of Cm3 25 0.23 4.01 0 75.84
178 INT205793 Binding of POLD4 1 0.02 0.21 0 75.28
179 INT205790 Binding of MRPL28 1 0.02 0.21 0 75.28
180 INT172523 Gene_expression of WISP3 3 0.73 11.72 1.39 75.04
181 INT181779 Positive_regulation of Gene_expression of WISP3 1 0.57 1.62 0.25 75.04
182 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 74.56
183 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03 74.44
184 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 74.36
185 INT191678 Gene_expression of Xiap 60 0.71 57.25 1.37 74.36
186 INT91209 Binding of VIM 15 0.36 12.02 0.53 74.24
187 INT145221 Binding of Tp53 10 0.37 8.59 1.37 74.16
188 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 73.84
189 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7 73.84
190 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 73.60
191 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 73.60
192 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 73.60
193 INT175414 Gene_expression of TERC 1 0.17 0.94 0.05 73.60
194 INT100593 Gene_expression of UBAP1 8 0.65 13.81 5.74 73.56
195 INT211581 Binding of Pms2 2 0.32 2.49 0.04 73.52
196 INT190038 Binding of Mlh1 2 0.28 3.11 0 73.52
197 INT190035 Binding of Msh6 2 0.28 2.72 0 73.52
198 INT201466 Positive_regulation of Gene_expression of CCNE2 13 0.20 8.62 1.26 73.28
199 INT189349 Positive_regulation of HFM1 1 0.01 0.15 0 72.72
200 INT172953 Binding of Trp53 33 0.37 20.76 1.41 72.52
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