D:Genu Valgum

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Disease Term
Synonyms Genu Valgums, Knock Knee, Knock Knees
Documents 54
Hot Single Events 6
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Genu Valgum. They are ordered first by their relevance to Genu Valgum and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT289793 Binding of Comp and Ecm1 1 0.05 2.5 0.12 63.76
2 INT289794 Binding of Comp and Fn1 1 0.07 2.59 0.12 63.76
3 INT312289 Binding of Col9a1 and Comp 1 0.09 1.38 0 63.76
4 INT312291 Binding of Comp and Matn3 1 0.06 1.37 0 63.76
5 INT238270 Binding of VMO1 and MSLNL 1 0.11 0.42 0 5.00
6 INT273136 Binding of CHED1 and VSX1 1 0.15 0.12 0 5.00
7 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 5.00
8 INT312290 Binding of Col9a1 and Matn3 1 0.02 0.65 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Genu Valgum. They are ordered first by their pain relevance and then by number of times they were reported in Genu Valgum. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 92.36
2 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 91.72
3 INT82828 Positive_regulation of COMP 45 0.61 35.12 6.2 91.64
4 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 84.60
5 INT183125 Negative_regulation of SULF1 2 0.42 2.26 0.13 80.84
6 INT4597 Regulation of SCD 5 0.39 2.25 0.5 80.40
7 INT73226 Regulation of Vmo1 2 0.18 2.19 0.68 79.56
8 INT141785 Negative_regulation of GALNS 3 0.59 1.92 0.09 69.92
9 INT233102 Regulation of VMO1 4 0.34 2.7 2.25 63.28
10 INT312286 Binding of Col9a1 1 0.10 1.37 0 52.92
11 INT312283 Binding of Matn3 1 0.06 1.31 0 52.92
12 INT312284 Binding of Comp 1 0.30 3.08 0 52.92
13 INT4596 Positive_regulation of SCD 18 0.42 22.59 3.26 35.64
14 INT84248 Gene_expression of MPEG1 5 0.48 3.38 0.66 35.32
15 INT35584 Binding of ACLY 22 0.35 31.78 7.17 34.04
16 INT47992 Gene_expression of Scn8a 14 0.78 4.15 3.83 25.76
17 INT45510 Binding of Scn8a 4 0.31 3.89 0.25 25.76
18 INT312282 Gene_expression of Col9a3 1 0.52 1.16 0 25.04
19 INT142340 Positive_regulation of Chkb 3 0.47 6.44 0.38 20.08
20 INT312285 Positive_regulation of Positive_regulation of Chkb 1 0.24 1.02 0 20.08
21 INT196714 Binding of VMO1 4 0.30 1.51 1.46 14.16
22 INT155565 Gene_expression of Efemp2 22 0.67 7.24 0.13 11.36
23 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 9.92
24 INT312287 Gene_expression of Col9a1 1 0.21 2.94 0 8.00
25 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
26 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
27 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 5.00
28 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
29 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95 5.00
30 INT11508 Positive_regulation of TGFBI 24 0.70 19.81 15.78 5.00
31 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
32 INT53189 Gene_expression of VSX1 32 0.69 10.59 7.21 5.00
33 INT55655 Gene_expression of DCN 17 0.75 7.98 5.98 5.00
34 INT103518 Negative_regulation of SCN2A 17 0.57 8.4 5.4 5.00
35 INT134966 Localization of Col7a1 23 0.42 16.4 5.24 5.00
36 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
37 INT52678 Positive_regulation of VSX1 15 0.42 3.94 3.64 5.00
38 INT23220 Positive_regulation of FOXG1 10 0.43 2.86 3.49 5.00
39 INT2117 Regulation of VSX1 15 0.30 3.38 3.38 5.00
40 INT98068 Gene_expression of SCN2A 19 0.75 14.42 3.31 5.00
41 INT44873 Negative_regulation of LCAT 16 0.59 6.92 3.13 5.00
42 INT196710 Positive_regulation of VMO1 9 0.64 3.49 3.08 5.00
43 INT184305 Gene_expression of Comp 53 0.77 31.66 2.2 5.00
44 INT68829 Binding of ELF3 14 0.47 7.96 2 5.00
45 INT2116 Negative_regulation of VSX1 29 0.36 10.67 1.89 5.00
46 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 5.00
47 INT119540 Binding of Nfe2l2 29 0.48 6.34 1.74 5.00
48 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 5.00
49 INT121335 Localization of SCD 10 0.68 6.81 1.51 5.00
50 INT27762 Positive_regulation of Gene_expression of EPO 18 0.70 17.67 1.45 5.00
51 INT38990 Negative_regulation of IDUA 12 0.59 5.04 1.33 5.00
52 INT126370 Localization of VSX1 6 0.56 1.7 1.28 5.00
53 INT38989 Gene_expression of IDUA 22 0.78 16.99 1.26 5.00
54 INT9243 Gene_expression of FOXG1 14 0.53 7.52 1.02 5.00
55 INT69134 Positive_regulation of MPEG1 9 0.26 5.95 0.97 5.00
56 INT238271 Binding of WSN 2 0.04 2.61 0.81 5.00
57 INT205401 Gene_expression of Chkb 32 0.51 13.99 0.77 5.00
58 INT59175 Localization of TNMD 4 0.70 4.14 0.71 5.00
59 INT84250 Positive_regulation of IDUA 8 0.56 15.89 0.62 5.00
60 INT185240 Binding of Fgf2 14 0.37 7.39 0.59 5.00
61 INT196713 Gene_expression of VMO1 2 0.54 1.11 0.59 5.00
62 INT187090 Positive_regulation of Localization of Col7a1 4 0.07 3.16 0.51 5.00
63 INT189634 Regulation of DCN 3 0.25 1.69 0.49 5.00
64 INT128793 Gene_expression of HBB 16 0.78 10.69 0.42 5.00
65 INT165342 Gene_expression of TGFBI 13 0.59 5.81 0.39 5.00
66 INT273158 Binding of COL8A2 1 0.33 2.02 0.22 5.00
67 INT321259 Binding of MPEG1 1 0.20 2.25 0.21 5.00
68 INT218762 Localization of ZEB1 2 0.65 0.09 0.2 5.00
69 INT244330 Localization of ELF3 8 0.56 2.71 0.18 5.00
70 INT321258 Positive_regulation of Binding of MPEG1 1 0.26 1.59 0.16 5.00
71 INT156610 Negative_regulation of HBB 2 0.37 1.25 0.15 5.00
72 INT263804 Localization of MSLNL 3 0.55 2.13 0.14 5.00
73 INT335494 Binding of MSLNL 1 0.05 0.38 0.14 5.00
74 INT84245 Negative_regulation of MPEG1 2 0.20 1.46 0.1 5.00
75 INT41890 Positive_regulation of Gene_expression of FOXG1 2 0.32 1.04 0.09 5.00
76 INT74442 Binding of ATRX 2 0.41 3.2 0.09 5.00
77 INT279349 Localization of IDUA 7 0.76 4.97 0.07 5.00
78 INT128794 Negative_regulation of Gene_expression of HBB 1 0.59 5.98 0.06 5.00
79 INT245115 Positive_regulation of Gene_expression of ELF3 8 0.40 2.23 0.06 5.00
80 INT273145 Negative_regulation of COL8A2 1 0.40 0.83 0.06 5.00
81 INT273155 Gene_expression of COL8A2 1 0.53 0.74 0.05 5.00
82 INT234263 Negative_regulation of ELF3 6 0.39 3.9 0.04 5.00
83 INT180589 Phosphorylation of COL1A1 3 0.34 0.37 0.03 5.00
84 INT273154 Positive_regulation of Localization of SCD 1 0.03 0.94 0 5.00
85 INT273142 Gene_expression of Smc3 1 0.09 0.35 0 5.00
86 INT273144 Binding of CHED1 1 0.19 1.7 0 5.00
87 INT273157 Localization of COL8A2 1 0.26 0.09 0 5.00
88 INT273150 Regulation of CHED1 1 0.24 0.09 0 5.00
89 INT273143 Negative_regulation of Tat 1 0.01 2.3 0 5.00
90 INT232980 Binding of KRT3 2 0.29 0.43 0 5.00
91 INT207239 Binding of HBE1 2 0.20 1.53 0 5.00
92 INT273148 Localization of LCAT 1 0.38 0.91 0 5.00
93 INT279351 Regulation of IDUA 2 0.36 1.71 0 5.00
94 INT273146 Positive_regulation of Binding of TNMD 1 0.02 0.21 0 5.00
95 INT318137 Negative_regulation of PMCH 1 0.02 0.96 0 5.00
96 INT232943 Binding of KRT12 3 0.47 0.88 0 5.00
97 INT273152 Positive_regulation of Localization of LCAT 1 0.26 0.91 0 5.00
98 INT273156 Gene_expression of SLC4A11 1 0.41 0.84 0 5.00
99 INT279350 Regulation of Localization of IDUA 1 0.23 0 0 5.00
100 INT318136 Positive_regulation of Gene_expression of HBB 1 0.04 2.65 0 5.00
101 INT273147 Binding of TBCD 1 0.05 0 0 5.00
102 INT273160 Binding of TNMD 4 0.42 1.72 0 5.00
103 INT273151 Binding of GCDH 1 0.04 0.25 0 5.00
104 INT273153 Positive_regulation of CHED1 1 0.27 1.53 0 5.00
105 INT273159 Gene_expression of CHED1 1 0.36 1.83 0 5.00
106 INT273149 Localization of GCDH 1 0.06 0.77 0 5.00
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