D:Geographic Atrophy

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Disease Term
Synonyms Atrophies Geographic, Atrophy Geographic, Degeneration Dry Macular, DEGENERATIONS DRY MACULAR, Dry Macular Degeneration, Dry Macular Degenerations, Geographic Atrophies, Macular Degeneration Dry, MACULAR DEGENERATIONS DRY
Documents 12
Hot Single Events 10
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Geographic Atrophy. They are ordered first by their relevance to Geographic Atrophy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT243118 amd Regulation of Rpe 1 0.20 1.16 0 98.64
2 INT243120 Binding of amd and Rpe 1 0.26 1.18 0 96.56
3 INT353106 Binding of amd and C3 1 0.09 1.69 0 30.88
4 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
5 INT353109 Binding of VEGFA and Aes 1 0.02 3.93 0.43 5.00
6 INT243119 Binding of amd and Sod2 1 0.29 3.25 0.06 5.00
7 INT339583 Binding of ABCA1 and RPE 1 0.03 1.38 0.05 5.00
8 INT353105 Binding of Aes and Rgs9bp 1 0.01 0.35 0.05 5.00
9 INT339587 Positive_regulation of Binding of ABCA1 and RPE 1 0.04 1.38 0.05 5.00
10 INT353104 Binding of amd and Gtf3a 1 0.01 1.53 0.03 5.00
11 INT339582 AMD1 Regulation of C1QTNF5 1 0.07 2 0 5.00
12 INT353108 Binding of VEGFA and Pgf 1 0.02 2.17 0 5.00
13 INT339581 Binding of TIMP1 and TIMP3 1 0.30 0.54 0 5.00
14 INT353107 Binding of VEGFA and Vegfb 1 0.02 1.08 0 5.00
15 INT339580 TIMP3 Positive_regulation of ABCA1 1 0.16 0.73 0 5.00
16 INT339585 Binding of AMD1 and MDM1 1 0.06 2.02 0 5.00
17 INT353110 Binding of VEGFA and Eo 1 0.00 0.67 0 5.00
18 INT339586 TIMP3 Positive_regulation of RPE 1 0.16 0.72 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Geographic Atrophy. They are ordered first by their pain relevance and then by number of times they were reported in Geographic Atrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT260525 Gene_expression of AMD1 25 0.66 24.58 1.32 99.86
2 INT139863 Binding of amd 27 0.41 41.3 0.91 99.80
3 INT229940 Positive_regulation of amd 10 0.49 27.97 0.15 98.96
4 INT260172 Localization of Rpe 11 0.49 3.53 0.12 98.58
5 INT109925 Gene_expression of RPE 11 0.65 12.46 0.68 98.06
6 INT139862 Negative_regulation of amd 8 0.35 10.15 0.6 97.00
7 INT243112 Regulation of Rpe 5 0.40 3.14 0.1 96.88
8 INT228770 Gene_expression of amd 16 0.57 21.49 1.05 92.96
9 INT147818 Localization of amd 3 0.60 4.04 0.14 82.08
10 INT353100 Negative_regulation of Localization of amd 1 0.34 1.38 0 82.08
11 INT202940 Binding of AMD1 13 0.41 16.43 0.56 74.56
12 INT269749 Transcription of AMD1 1 0.59 1.04 0.05 71.56
13 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 68.40
14 INT109930 Positive_regulation of RPE 4 0.49 5.88 0.15 67.80
15 INT210228 Positive_regulation of Rpe 15 0.52 8.78 0.26 64.92
16 INT242922 Positive_regulation of Gene_expression of amd 2 0.43 5.99 0.1 63.36
17 INT269750 Localization of AMD1 2 0.64 2.82 0.13 60.64
18 INT43931 Binding of CFH 49 0.48 31.85 3.96 57.52
19 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 56.00
20 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 56.00
21 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 56.00
22 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 49.40
23 INT21546 Regulation of ABCA1 16 0.40 4.21 1.04 45.76
24 INT144322 Regulation of RPE 1 0.24 1.9 0.08 45.76
25 INT10873 Localization of Twist1 21 0.74 10.43 1.37 42.88
26 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 37.28
27 INT109124 Positive_regulation of TIMP3 8 0.61 5.57 5.72 35.68
28 INT134753 Gene_expression of TIMP3 19 0.68 15.24 0.88 35.68
29 INT26167 Positive_regulation of Hrasls 18 0.23 8.67 4.87 29.20
30 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51 17.28
31 INT45722 Negative_regulation of CFHR1 6 0.56 1.43 0.78 16.48
32 INT339599 Negative_regulation of CFHR3 1 0.33 1.05 0 16.48
33 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 15.12
34 INT353098 Phosphorylation of amd 1 0.65 1.26 0 9.68
35 INT339592 Regulation of ARMS2 2 0.26 2.27 0 9.16
36 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
37 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
38 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
39 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
40 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
41 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
42 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 5.00
43 INT2006 Gene_expression of fc 104 0.34 64.91 19.08 5.00
44 INT69769 Positive_regulation of Pscs 61 0.56 39.32 15.93 5.00
45 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
46 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 5.00
47 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 5.00
48 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
49 INT111992 Gene_expression of Pscs 40 0.76 27.47 10.74 5.00
50 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
51 INT59165 Binding of fc 67 0.36 37.51 8.68 5.00
52 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 5.00
53 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41 5.00
54 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17 5.00
55 INT48277 Regulation of BDKRB2 9 0.59 2.69 5.05 5.00
56 INT98357 Binding of Gnas 11 0.41 1.87 4.35 5.00
57 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34 5.00
58 INT19449 Binding of FANCB 22 0.47 7.4 4.27 5.00
59 INT18670 Negative_regulation of ABCA1 16 0.54 5.8 3.39 5.00
60 INT10132 Negative_regulation of Serpinf1 14 0.58 11.72 3.14 5.00
61 INT53348 Binding of BDKRB2 7 0.37 2.85 3 5.00
62 INT116540 Binding of Twist1 35 0.48 16.32 2.85 5.00
63 INT69768 Negative_regulation of Pscs 7 0.51 4.76 2.82 5.00
64 INT50080 Binding of APOE 38 0.45 29.61 2.67 5.00
65 INT115659 Gene_expression of ABCB6 29 0.75 13.59 1.43 5.00
66 INT111996 Positive_regulation of Gene_expression of Pscs 8 0.34 4.37 1.42 5.00
67 INT22871 Gene_expression of ELN 30 0.68 14.86 1.33 5.00
68 INT282590 Positive_regulation of Gene_expression of POU5F1 40 0.70 8.42 1.32 5.00
69 INT143759 Gene_expression of SOX2 46 0.55 11.12 1.24 5.00
70 INT15896 Gene_expression of FANCB 18 0.65 6.44 1.18 5.00
71 INT239497 Binding of Aes 8 0.29 3.61 0.84 5.00
72 INT173100 Binding of KDR 39 0.39 22.48 0.81 5.00
73 INT173082 Positive_regulation of Binding of VEGFA 20 0.48 11.16 0.79 5.00
74 INT257447 Binding of TBCE 4 0.08 4.68 0.66 5.00
75 INT40698 Positive_regulation of Aes 3 0.32 3.84 0.65 5.00
76 INT200754 Gene_expression of Rpe 35 0.51 6.3 0.58 5.00
77 INT197512 Gene_expression of ABCA4 19 0.75 7.08 0.57 5.00
78 INT109904 Localization of RPE 5 0.73 4.9 0.56 5.00
79 INT109903 Positive_regulation of Gene_expression of RPE 3 0.49 0.59 0.46 5.00
80 INT239498 Localization of Aes 2 0.58 2.22 0.4 5.00
81 INT161027 Negative_regulation of RPE 7 0.37 4.34 0.38 5.00
82 INT165400 Positive_regulation of TST 13 0.68 4.25 0.35 5.00
83 INT243843 Negative_regulation of FMT 3 0.07 1.4 0.32 5.00
84 INT215454 Regulation of amd 4 0.38 8.07 0.29 5.00
85 INT269748 Positive_regulation of AMD1 4 0.43 3.56 0.28 5.00
86 INT339593 Gene_expression of FBLN1 2 0.14 3.01 0.24 5.00
87 INT63067 Localization of MYC 13 0.78 6.93 0.19 5.00
88 INT189564 Binding of TIMP3 4 0.31 2.45 0.17 5.00
89 INT243842 Localization of FMT 2 0.11 1.17 0.17 5.00
90 INT353099 Positive_regulation of Ctrcts 1 0.01 1.63 0.16 5.00
91 INT268715 Binding of RPE 3 0.09 2.36 0.09 5.00
92 INT282593 Gene_expression of KLF4 8 0.61 1.09 0.09 5.00
93 INT260526 Negative_regulation of Gene_expression of AMD1 2 0.36 0.71 0.09 5.00
94 INT206683 Negative_regulation of Binding of KDR 3 0.34 2.54 0.08 5.00
95 INT282591 Positive_regulation of Gene_expression of SOX2 4 0.36 1.07 0.08 5.00
96 INT274026 Positive_regulation of Gene_expression of AMD1 1 0.16 0.41 0.07 5.00
97 INT186637 Regulation of ABCA4 3 0.37 2.02 0.07 5.00
98 INT233399 Binding of ABCA4 9 0.46 9.49 0.07 5.00
99 INT273763 Gene_expression of PSMB5 1 0.65 0.36 0.06 5.00
100 INT260527 Negative_regulation of AMD1 6 0.37 5 0.05 5.00
101 INT282606 Positive_regulation of Gene_expression of KLF4 2 0.54 0.8 0.04 5.00
102 INT235796 Positive_regulation of Binding of amd 2 0.21 2.76 0.04 5.00
103 INT353103 Positive_regulation of ARMS2 1 0.05 1.47 0.03 5.00
104 INT139470 Positive_regulation of Htra1 2 0.48 1.58 0.03 5.00
105 INT172456 Negative_regulation of Rpe 2 0.32 1.18 0.03 5.00
106 INT353097 Positive_regulation of Plekha1 1 0.34 1.47 0.03 5.00
107 INT243113 Protein_catabolism of Smarca2 1 0.26 0 0.03 5.00
108 INT212458 Binding of Mtor 8 0.04 6.77 0.03 5.00
109 INT339590 Negative_regulation of Gene_expression of FBLN1 1 0.10 2.61 0 5.00
110 INT339598 Gene_expression of ARMS2 1 0.65 1.03 0 5.00
111 INT274183 Negative_regulation of Gene_expression of ELN 3 0.30 3.29 0 5.00
112 INT339591 Positive_regulation of Gene_expression of FBLN1 1 0.08 1.31 0 5.00
113 INT213395 Positive_regulation of Gene_expression of ABCA4 2 0.41 1.22 0 5.00
114 INT353102 Gene_expression of Htra1 1 0.46 1.29 0 5.00
115 INT339595 Negative_regulation of RPE65 1 0.34 0.64 0 5.00
116 INT339596 Localization of KLF4 1 0.26 0 0 5.00
117 INT282585 Localization of POU5F1 3 0.67 0.08 0 5.00
118 INT189570 Positive_regulation of Gene_expression of TIMP3 3 0.44 1.57 0 5.00
119 INT353101 Negative_regulation of Zfp787 1 0.01 0.46 0 5.00
120 INT339594 Localization of SOX2 2 0.69 0.7 0 5.00
121 INT339597 Gene_expression of RPE65 1 0.54 0.29 0 5.00
122 INT269746 Positive_regulation of Localization of AMD1 1 0.43 2.54 0 5.00
123 INT190446 Gene_expression of NR2E3 11 0.10 0.89 0 5.00
124 INT202939 Regulation of AMD1 4 0.38 2.68 0 5.00
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