D:Germ Cell And Embryonal Neoplasms

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Disease Term
Synonyms Cancer Embryonal, Cancer Embryonal Mixed, Cancer Germ Cell, Cancers Embryonal, Cancers Germ Cell, Embryonal Cancer, EMBRYONAL CANCERS, Embryonal Neoplasm, EMBRYONAL NEOPLASMS, Germ Cell Cancer, Germ Cell Cancers
Documents 199
Hot Single Events 70
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Germ Cell And Embryonal Neoplasms. They are ordered first by their relevance to Germ Cell And Embryonal Neoplasms and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT350106 Binding of SLC4A3 and SLC4A1 1 0.13 2.78 0.09 80.96
2 INT192955 Binding of KIT and VCAM1 1 0.05 0.63 0 49.68
3 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 49.44
4 INT192956 Binding of CD2 and KIT 1 0.03 0.62 0 49.04
5 INT291358 Binding of CXCL12 and CXCR7 1 0.20 0.11 0.09 31.04
6 INT279145 Binding of VHL and RNF139 1 0.30 1.87 0 30.40
7 INT279144 RNF139 Regulation of TSN 1 0.24 3.47 0 19.88
8 INT291377 Binding of CX3CR1 and Cx3cl1 2 0.36 3.57 1.02 5.00
9 INT291352 Positive_regulation of CXCL12 Positive_regulation of ERBB2 1 0.17 0.88 0.22 5.00
10 INT291348 IL8 Positive_regulation of Phosphorylation of SHC1 1 0.11 1.16 0.2 5.00
11 INT291346 IL8 Positive_regulation of Binding of EGFR and GRB2 1 0.15 1.17 0.2 5.00
12 INT347446 CD99 Positive_regulation of Binding of DES 1 0.46 1.01 0.17 5.00
13 INT291354 CXCL12 Positive_regulation of EPHB2 1 0.42 2.02 0.16 5.00
14 INT347445 CD99 Positive_regulation of BCL2 1 0.17 0.95 0.16 5.00
15 INT291347 Positive_regulation of TXK Positive_regulation of CXCR4 Positive_regulation of EPHB2 1 0.02 0.61 0.13 5.00
16 INT291349 CXCR4 Positive_regulation of EPHB2 1 0.42 1.87 0.13 5.00
17 INT344314 PDPN Positive_regulation of Phosphorylation of MAPK8 1 0.35 0.67 0.13 5.00
18 INT291353 IL8 Positive_regulation of Binding of EGFR 1 0.32 0.52 0.1 5.00
19 INT191184 Binding of EGFR and GRB2 7 0.35 1.06 0.1 5.00
20 INT196444 Binding of ALPP and ALPPL2 1 0.17 0.59 0.1 5.00
21 INT291351 Binding of EGFR and SHC1 1 0.05 0.57 0.1 5.00
22 INT291350 IL8 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.52 0.1 5.00
23 INT239559 MSC Regulation of Gene_expression of BDNF 1 0.05 1 0.09 5.00
24 INT244640 AGK Negative_regulation of KIT 1 0.00 0.69 0.08 5.00
25 INT244639 AGK Negative_regulation of PDGFRB 1 0.01 0.69 0.08 5.00
26 INT244638 AGK Negative_regulation of KDR 1 0.00 0.68 0.08 5.00
27 INT291355 CXCL12 Positive_regulation of Gene_expression of HGF 1 0.06 1.53 0.06 5.00
28 INT244641 PDGFA Regulation of MTOR 1 0.07 2.55 0.06 5.00
29 INT344345 Mapk14 Regulation of Gene_expression of VEGFA 1 0.01 0.37 0.05 5.00
30 INT239560 MSC Regulation of Gene_expression of IFN1@ 1 0.11 0.87 0.04 5.00
31 INT344312 PDPN Positive_regulation of ITK 1 0.05 0.26 0.04 5.00
32 INT291356 CXCL12 Positive_regulation of AKT1 1 0.04 1.28 0.03 5.00
33 INT344317 PDPN Negative_regulation of VEGFA 1 0.08 0.67 0.03 5.00
34 INT291357 CXCR4 Positive_regulation of AKT1 1 0.08 1.27 0.03 5.00
35 INT344308 Positive_regulation of PDPN Negative_regulation of VEGFA 1 0.09 0.24 0.03 5.00
36 INT352840 Binding of Miox and Mirlet7a-1 1 0.00 0 0 5.00
37 INT344315 MAPK8 Positive_regulation of Negative_regulation of PDPN 1 0.35 0.56 0 5.00
38 INT279143 Binding of TSN and RNF139 1 0.31 0.83 0 5.00
39 INT196439 ALPPL2 Regulation of Localization of ALPP 1 0.21 0.65 0 5.00
40 INT344310 MAPK8 Positive_regulation of Negative_regulation of VEGFA 1 0.08 0.57 0 5.00
41 INT344313 PDPN Positive_regulation of VEGFA 1 0.09 0.8 0 5.00
42 INT344319 MAPK8 Positive_regulation of PDPN 1 0.35 0.5 0 5.00
43 INT196441 Binding of ALPP and PAEP 1 0.02 0 0 5.00
44 INT352841 Binding of Miox and Lin28a 1 0.00 0 0 5.00
45 INT344307 PDPN Negative_regulation of Gene_expression of VEGFA 1 0.08 0.36 0 5.00
46 INT344318 PDPN Positive_regulation of Positive_regulation of RHOA 1 0.11 0.92 0 5.00
47 INT352842 Binding of Lin28a and Mirlet7a-1 1 0.03 0 0 5.00
48 INT344316 VEGFA Positive_regulation of PDPN 1 0.09 0.4 0 5.00
49 INT344311 PDPN Positive_regulation of Negative_regulation of VEGFA 1 0.09 0.81 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Germ Cell And Embryonal Neoplasms. They are ordered first by their pain relevance and then by number of times they were reported in Germ Cell And Embryonal Neoplasms. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT745 Gene_expression of Afp 65 0.78 52.89 4.24 99.96
2 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34 99.72
3 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67 98.76
4 INT51150 Positive_regulation of HTC2 10 0.67 6.8 2.95 98.76
5 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 98.72
6 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 98.52
7 INT192962 Positive_regulation of Transcription of KIT 1 0.46 2.74 0 98.20
8 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 98.08
9 INT158 Localization of Prl 2431 0.81 378.96 952.2 98.04
10 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 98.00
11 INT192957 Transcription of KIT 5 0.69 2.19 0.23 98.00
12 INT7035 Regulation of CGA 87 0.45 29.04 28.45 97.56
13 INT8670 Negative_regulation of Afp 27 0.58 19.85 2.87 97.52
14 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23 96.92
15 INT17574 Binding of CISH 23 0.31 4.3 0.93 96.76
16 INT152681 Gene_expression of PDPN 29 0.65 23.06 0.18 96.32
17 INT11918 Localization of CGB 35 0.51 8.21 15.01 95.44
18 INT1793 Localization of CGA 379 0.81 67.38 114.69 95.44
19 INT133474 Localization of SDHA 1 0.14 2.19 0.07 95.44
20 INT172678 Gene_expression of NUPL2 20 0.75 5.06 2.85 94.88
21 INT16235 Positive_regulation of CGB 27 0.70 15.71 4.06 94.40
22 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 94.40
23 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 94.32
24 INT871 Negative_regulation of Gene_expression of Prl 53 0.58 18.89 17.79 94.32
25 INT291368 Gene_expression of CXCR7 4 0.38 3.21 0.63 94.32
26 INT205654 Gene_expression of FUS 9 0.32 11.53 0.16 93.84
27 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 93.76
28 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 93.48
29 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99 93.48
30 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 93.12
31 INT15887 Gene_expression of Nbr1 39 0.77 23.91 7.34 92.68
32 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 92.64
33 INT4953 Positive_regulation of CGB5 16 0.60 7.63 2.49 91.88
34 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 91.40
35 INT4771 Gene_expression of CGB 23 0.67 14.22 3.42 91.36
36 INT23104 Positive_regulation of Cga 20 0.70 10.35 8.03 91.12
37 INT64709 Gene_expression of VTN 11 0.67 11.01 1.97 90.92
38 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 90.88
39 INT27222 Gene_expression of ALPPL2 4 0.52 24.57 2.05 90.88
40 INT35143 Negative_regulation of ANGPTL5 28 0.54 18.59 3.14 90.52
41 INT309915 Negative_regulation of F2RL3 2 0.01 2.06 0.27 90.52
42 INT309916 Negative_regulation of NR2F2 1 0.02 0.7 0.18 90.52
43 INT49195 Binding of CSF3R 6 0.34 4.23 0.15 90.32
44 INT57029 Positive_regulation of HEXB 6 0.40 4.52 0.55 89.16
45 INT62331 Gene_expression of TNFRSF8 26 0.72 17.75 2.08 88.72
46 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 88.48
47 INT34594 Negative_regulation of Gene_expression of ALPP 12 0.50 5.04 1.41 88.08
48 INT196471 Negative_regulation of Gene_expression of ICA1 2 0.10 1.51 0.32 88.08
49 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 88.00
50 INT66061 Positive_regulation of Gene_expression of AFP 6 0.70 8.67 0.81 87.12
51 INT76735 Positive_regulation of CGB7 3 0.38 2.91 0.28 87.12
52 INT150123 Positive_regulation of Gene_expression of CGB7 2 0.40 1.64 0.19 87.12
53 INT57028 Positive_regulation of CEACAM3 2 0.49 1.55 0.29 86.88
54 INT9908 Negative_regulation of IAPP 29 0.57 19.37 2.12 86.84
55 INT15692 Regulation of HTC2 4 0.27 4.75 1.61 86.72
56 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 86.68
57 INT134811 Gene_expression of ICA1 22 0.44 6.47 2.42 86.64
58 INT14971 Regulation of Afp 12 0.44 11.35 1.48 86.08
59 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 85.88
60 INT98471 Positive_regulation of Transcription of COL7A1 3 0.12 2.77 1.06 85.88
61 INT98470 Transcription of COL7A1 3 0.16 1.94 0.74 84.60
62 INT174329 Transcription of CATSPER3 1 0.43 0.15 0.05 83.08
63 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 82.88
64 INT129783 Positive_regulation of Gene_expression of KIT 16 0.50 18.12 0.58 82.08
65 INT245872 Positive_regulation of HLA-G 1 0.02 0.78 0 82.00
66 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 81.60
67 INT76732 Gene_expression of CGB7 4 0.63 4.14 0.37 81.36
68 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 80.80
69 INT50950 Localization of Afp 9 0.50 5.04 0.18 80.80
70 INT36192 Localization of HTC2 11 0.70 2.95 3.3 80.52
71 INT324506 Regulation of 1810014F10Rik 1 0.34 0.23 0 77.84
72 INT54893 Positive_regulation of NUPL2 3 0.45 2.31 0.52 77.80
73 INT158722 Positive_regulation of SLC25A1 3 0.45 2.25 0.17 77.64
74 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 76.88
75 INT324493 Regulation of Localization of Afp 1 0.45 0.15 0.03 76.72
76 INT352832 Regulation of Miox 1 0.00 0.51 0.05 76.16
77 INT199681 Gene_expression of SERPINA5 13 0.36 15.42 1.25 75.52
78 INT41804 Localization of Afp 3 0.81 0.28 0.27 75.40
79 INT52937 Gene_expression of Cd68 37 0.67 31.33 7.54 75.00
80 INT324492 Protein_catabolism of Afp 1 0.65 0.15 0.03 74.88
81 INT282572 Positive_regulation of POU5F1 24 0.70 5.8 1.13 74.40
82 INT352838 Regulation of Dgcr8 1 0.12 0.3 0 74.40
83 INT90670 Positive_regulation of KRT1 10 0.44 6.25 1.16 73.96
84 INT192960 Regulation of Gene_expression of KIT 3 0.45 4.16 0 73.84
85 INT83531 Gene_expression of KITLG 54 0.65 26 7.07 73.24
86 INT272508 Regulation of DICER1 4 0.11 1.21 0.05 73.20
87 INT236335 Gene_expression of SFTPD 26 0.75 15.92 4.59 73.12
88 INT121678 Gene_expression of SRY 15 0.68 5.61 0.06 73.04
89 INT200107 Gene_expression of SDHA 9 0.37 5.29 1.02 72.48
90 INT39357 Binding of Afp 5 0.48 3.58 0.85 72.16
91 INT160606 Localization of AFP 6 0.74 3.39 1.29 70.80
92 INT20055 Gene_expression of CRTAC1 19 0.58 15.49 4.73 70.32
93 INT182372 Regulation of Afp 2 0.45 0.44 0.04 69.60
94 INT113110 Negative_regulation of CXCL12 8 0.43 6.01 1.63 67.08
95 INT163416 Positive_regulation of Sub1 2 0.25 0.52 0.12 66.20
96 INT324394 Positive_regulation of Miox 2 0.06 0.36 0.03 66.20
97 INT282576 Negative_regulation of Gene_expression of POU5F1 12 0.43 2.79 0.16 65.92
98 INT54438 Binding of ALPP 25 0.39 14.02 0.96 64.96
99 INT196461 Binding of ALPPL2 1 0.32 4.1 0.2 64.96
100 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 64.32
101 INT323078 Negative_regulation of Phosphorylation of SERPINA5 1 0.23 1.05 0 62.80
102 INT323079 Phosphorylation of SERPINA5 1 0.44 1.04 0 62.80
103 INT352833 Binding of Lin28a 1 0.19 0.54 0 62.32
104 INT2136 Gene_expression of Cga 21 0.77 9.83 2.62 60.88
105 INT109208 Gene_expression of Miox 3 0.15 1.19 1.16 59.96
106 INT108485 Gene_expression of CXCL12 61 0.75 49.34 13.79 59.20
107 INT108482 Positive_regulation of Gene_expression of CXCL12 7 0.53 9.72 2.36 59.20
108 INT121659 Positive_regulation of CXCL12 8 0.53 9.17 2.36 58.64
109 INT279147 Negative_regulation of RNF139 1 0.53 5.41 0.06 57.64
110 INT103674 Positive_regulation of Gene_expression of CXCR4 32 0.69 37.1 3.08 52.08
111 INT11062 Positive_regulation of MME 24 0.63 14.37 5.26 51.36
112 INT123766 Positive_regulation of EPHB6 1 0.49 1.37 0.1 51.36
113 INT45155 Negative_regulation of Polymerase 18 0.51 15.18 1.38 50.88
114 INT287286 Positive_regulation of Binding of CXCR4 2 0.53 0.78 0.39 49.96
115 INT291363 Positive_regulation of Binding of CXCL12 1 0.38 0.36 0.03 49.96
116 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 49.48
117 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 49.48
118 INT121661 Binding of CXCL12 25 0.37 11.27 3.82 49.44
119 INT117189 Binding of CXCR4 34 0.37 24.27 5.81 49.16
120 INT130647 Regulation of Gene_expression of CXCL12 6 0.39 5.01 1.38 49.12
121 INT193815 Regulation of Gene_expression of CXCR4 17 0.61 20.27 1.15 49.12
122 INT324499 Gene_expression of Fut9 5 0.27 1.27 0 48.80
123 INT108800 Negative_regulation of ALPPL2 2 0.28 1.83 0.99 46.96
124 INT160392 Negative_regulation of Tnfrsf8 2 0.08 3.06 0.12 45.04
125 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 41.36
126 INT173926 Positive_regulation of Atp6v1e1 21 0.27 11.39 4.24 40.56
127 INT206913 Localization of Atp6v1e1 8 0.32 3.55 0.43 40.56
128 INT324494 Regulation of Localization of Atp6v1e1 1 0.10 0.09 0 40.56
129 INT324500 Regulation of Positive_regulation of Atp6v1e1 1 0.06 0.17 0 40.56
130 INT282605 Regulation of POU5F1 4 0.55 0.4 0 40.24
131 INT112530 Localization of Ptgs2 13 0.70 7.77 5.86 39.20
132 INT142835 Regulation of Localization of Ptgs2 2 0.25 0.26 0.5 39.20
133 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71 38.24
134 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14 37.76
135 INT200219 Positive_regulation of VHL 18 0.50 15.38 0.67 36.64
136 INT128376 Binding of KIT 26 0.48 14.24 0.47 35.72
137 INT218956 Regulation of RNF123 3 0.01 1.06 0.03 35.24
138 INT282590 Positive_regulation of Gene_expression of POU5F1 40 0.70 8.42 1.32 34.04
139 INT24325 Regulation of SRY 2 0.24 0.89 0.32 33.92
140 INT116717 Gene_expression of CCR7 37 0.76 34.1 7.48 31.68
141 INT291366 Binding of CXCR7 4 0.18 1.64 1.03 31.04
142 INT186998 Negative_regulation of Gene_expression of KIT 20 0.43 16.77 0.46 30.40
143 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 27.28
144 INT279159 Regulation of RNF139 1 0.56 2.98 0 25.68
145 INT88278 Binding of Kit 33 0.37 24.45 4.13 25.00
146 INT51066 Binding of S100B 24 0.48 13.5 0.97 25.00
147 INT160391 Binding of Tnfrsf8 2 0.07 2.52 0.07 25.00
148 INT4342 Localization of ALPP 27 0.69 15.19 5.32 22.40
149 INT196464 Localization of ALPPL2 1 0.50 2.22 0.09 22.40
150 INT283020 Binding of Afp 2 0.37 0.64 0 21.44
151 INT279151 Regulation of TSN 1 0.37 3.34 0 18.68
152 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 17.60
153 INT279152 Positive_regulation of RNF139 1 0.46 1.29 0 14.52
154 INT352834 Protein_catabolism of Adar 1 0.56 0.15 0.04 14.48
155 INT324503 Negative_regulation of Afp 1 0.51 1.17 0.03 11.12
156 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
157 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
158 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
159 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
160 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
161 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
162 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
163 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
164 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
165 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
166 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
167 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
168 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
169 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
170 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96 5.00
171 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
172 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
173 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
174 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
175 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
176 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
177 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
178 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
179 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
180 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
181 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
182 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
183 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
184 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
185 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 5.00
186 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
187 INT30817 Gene_expression of Th 142 0.76 33.56 38.12 5.00
188 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 5.00
189 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
190 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
191 INT234 Binding of Alb 151 0.48 52.34 32.97 5.00
192 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
193 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
194 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
195 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
196 INT121663 Gene_expression of CXCR3 76 0.77 50.96 30.62 5.00
197 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 5.00
198 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
199 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 5.00
200 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
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