D:Giant Cell Arteritis

Disease Term Synonyms Aortic Arteritis Giant Cell, AORTITIDES GIANT CELL, Aortitis Giant Cell, ARTERITIDES CRANIAL, Arteritides Giant Cell, Arteritides Juvenile Temporal, Arteritides Temporal, ARTERITIS CRANIAL, ARTERITIS GIANT CELL, Arteritis Giant Cell Horton, Arteritis Giant Cell Horton S Documents 341 Hot Single Events 37 Hot Interactions 7

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Giant Cell Arteritis. They are ordered first by their relevance to Giant Cell Arteritis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT171942	Binding of HLA-DRB1 and ATP2C1	1	0.04	2.18	0.12	100.00
2	INT149541	Binding of GCA and TADA1	1	0.40	1.4	0.13	100.00
3	INT171940	Binding of TNF and ATP2C1	1	0.08	7.32	0.39	99.90
4	INT171945	PECAM1 Positive_regulation of Gene_expression of ICAM1	1	0.06	1.66	0.16	99.60
5	INT171944	ICAM1 Positive_regulation of Gene_expression of PECAM1	1	0.06	1.66	0.16	99.60
6	INT171938	Binding of HLA-DOA and ATP2C1	1	0.01	3.88	0.2	98.44
7	INT171939	Binding of HLA-DOA and TNF	1	0.05	6.8	0.26	94.08

Single Events

The table below shows the top 200 pain related interactions that have been reported for Giant Cell Arteritis. They are ordered first by their pain relevance and then by number of times they were reported in Giant Cell Arteritis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT171955	Localization of ATP2C1	1	0.12	4.02	0.22	100.00
2	INT152763	Binding of ATP2C1	2	0.32	4.11	0.61	100.00
3	INT149542	Binding of GCA	1	0.47	1.4	0.13	100.00
4	INT56651	Binding of HLA-DRB1	58	0.48	52.25	13.68	99.82
5	INT149543	Binding of TADA1	1	0.37	1.4	0.13	99.80
6	INT48408	Gene_expression of ICAM1	494	0.78	340.08	88.6	99.78
7	INT63339	Transcription of ICAM1	6	0.69	3.92	1.37	99.64
8	INT63349	Gene_expression of PECAM1	199	0.75	166.03	36.76	99.60
9	INT15229	Positive_regulation of CNDP1	21	0.69	15.86	4.06	99.52
10	INT56448	Regulation of ICAM1	52	0.60	55.1	10.96	99.44
11	INT3957	Gene_expression of CNDP1	6	0.52	3.7	0.96	99.26
12	INT3361	Positive_regulation of Esr1	273	0.69	208.53	44.81	98.80
13	INT80549	Binding of ICAM1	53	0.47	42.76	9.72	98.58
14	INT6481	Binding of TNF	624	0.48	510.2	214.82	98.52
15	INT62827	Positive_regulation of ICAM1	184	0.70	180.95	36.28	98.12
16	INT48895	Gene_expression of Il10	333	0.78	221.2	138.52	98.12
17	INT6483	Gene_expression of TNF	3152	0.78	2515.62	929.82	97.56
18	INT78899	Gene_expression of CCL5	155	0.77	84.02	55.09	97.56
19	INT171951	Localization of CADM1	1	0.11	1.45	0.05	97.16
20	INT78901	Localization of CCL5	67	0.78	40.79	20.59	96.44
21	INT78895	Regulation of CCL5	30	0.46	20.45	10.18	96.32
22	INT37296	Binding of Esr1	117	0.43	62.51	27.33	95.28
23	INT6852	Localization of TNF	883	0.81	705.95	270.84	94.82
24	INT86128	Negative_regulation of ATP2C1	1	0.09	1.65	0.31	93.28
25	INT48244	Gene_expression of Il4	172	0.76	132.38	73.42	92.48
26	INT93717	Gene_expression of Mmp3	85	0.78	33.95	24.89	91.24
27	INT91758	Binding of CCR5	28	0.45	20.16	7.07	89.36
28	INT171946	Positive_regulation of Binding of CCR5	1	0.47	3.86	0.66	89.36
29	INT63340	Positive_regulation of Gene_expression of ICAM1	109	0.70	90.82	20.61	88.20
30	INT23402	Binding of HLA-DOA	74	0.48	52.01	10.89	87.92
31	INT18009	Positive_regulation of CRP	518	0.70	553.03	103.74	87.60
32	INT8798	Positive_regulation of Csrp1	61	0.69	63.86	14.14	87.16
33	INT117080	Localization of Csrp1	6	0.42	7.23	3.09	87.16
34	INT28872	Positive_regulation of CSRP1	49	0.70	47.23	11.7	86.88
35	INT2038	Localization of Esr1	104	0.79	40.12	13.27	86.84
36	INT93350	Binding of Lepr	17	0.05	27.21	1.5	83.96
37	INT1767	Positive_regulation of PROC	83	0.67	54.14	17	81.28
38	INT52740	Binding of ACLS	5	0.31	3	0.54	77.16
39	INT28784	Positive_regulation of Gene_expression of CNDP1	3	0.22	3.87	1	75.00
40	INT28783	Positive_regulation of Gc	13	0.52	7.89	1.76	75.00
41	INT107514	Positive_regulation of Akr1b1	6	0.70	7.64	3.21	74.88
42	INT3375	Gene_expression of IGHE	535	0.77	387.47	65.46	71.36
43	INT3988	Positive_regulation of Gene_expression of IGHE	98	0.68	91.46	9.61	71.36
44	INT3987	Positive_regulation of IGHE	316	0.70	283.2	40.16	70.80
45	INT88322	Gene_expression of CCR5	111	0.78	77.36	39.84	62.64
46	INT51014	Transcription of IL2	42	0.71	21.56	12.7	57.68
47	INT6477	Gene_expression of IL1RN	213	0.77	114.69	58.62	55.04
48	INT6474	Positive_regulation of Gene_expression of IL1RN	34	0.69	21.87	10.99	55.04
49	INT5117	Negative_regulation of Gene_expression of IL2	118	0.59	52.33	29.96	54.80
50	INT5116	Gene_expression of IL2	670	0.78	291.13	146.69	54.40
51	INT89292	Positive_regulation of CCR5	27	0.70	15.12	8.59	50.08
52	INT52625	Regulation of IL1RN	30	0.61	19.12	11.31	50.00
53	INT73902	Regulation of Gene_expression of IL1RN	6	0.61	4.59	6.14	50.00
54	INT171953	Regulation of ATP2C1	1	0.07	2.21	0.38	50.00
55	INT242921	Positive_regulation of Aoc2-ps1	1	0.12	1.82	0.04	47.20
56	INT7538	Negative_regulation of IL2	95	0.57	47.31	31.7	36.92
57	INT118615	Negative_regulation of IL4	20	0.41	13.79	3.49	36.92
58	INT171021	Negative_regulation of IL5	18	0.41	14.74	3.39	36.92
59	INT35164	Negative_regulation of IGHE	96	0.58	76.3	9.74	26.12
60	INT62041	Negative_regulation of Gene_expression of IGHE	37	0.58	37.86	5.27	26.12
61	INT56298	Gene_expression of IL4	306	0.78	182.18	72.92	25.40
62	INT69157	Gene_expression of IL5	127	0.77	102.58	26.81	25.40
63	INT73498	Gene_expression of IL13	117	0.44	83.85	32.26	8.92
64	INT56301	Positive_regulation of IL4	68	0.56	54.51	18.65	8.92
65	INT61628	Negative_regulation of Gene_expression of IL4	31	0.55	20.96	8.18	8.92
66	INT69160	Positive_regulation of IL5	41	0.65	36.04	7.75	8.92
67	INT73499	Positive_regulation of IL13	23	0.39	20.03	6.53	8.92
68	INT194380	Negative_regulation of Gene_expression of IL5	22	0.42	15.78	4.1	8.92
69	INT178572	Negative_regulation of Gene_expression of IL13	9	0.14	4.51	1.94	8.92
70	INT100694	Negative_regulation of Positive_regulation of IL4	5	0.34	3.27	1.58	8.92
71	INT226492	Negative_regulation of IL13	11	0.28	7.17	2.04	7.92
72	INT68684	Gene_expression of VEGFA	2371	0.78	1742.52	259.2	5.00
73	INT15516	Gene_expression of Crp	711	0.77	615.33	173.09	5.00
74	INT17612	Gene_expression of CRP	676	0.78	580.61	119.03	5.00
75	INT79494	Positive_regulation of Gene_expression of VEGFA	577	0.70	442.94	69.73	5.00
76	INT9408	Positive_regulation of Crp	296	0.69	242.27	57.35	5.00
77	INT5650	Gene_expression of Mpo	117	0.77	80.27	26.42	5.00
78	INT16996	Gene_expression of PRTN3	113	0.75	85.61	22.57	5.00
79	INT7581	Binding of ADHD1	132	0.46	135.1	19.73	5.00
80	INT20622	Gene_expression of LDHA	107	0.76	77.97	16.3	5.00
81	INT16997	Binding of PRTN3	34	0.48	33.44	6.45	5.00
82	INT157932	Positive_regulation of ADHD1	46	0.48	52.18	6.13	5.00
83	INT57368	Regulation of ADHD1	39	0.50	42.23	5.01	5.00
84	INT17511	Negative_regulation of PRTN3	19	0.41	12	3.3	5.00
85	INT61684	Localization of COL1A2	20	0.73	9.31	2.26	5.00
86	INT20633	Positive_regulation of Gene_expression of LDHA	15	0.49	15.94	1.42	5.00
87	INT228770	Gene_expression of amd	16	0.57	21.49	1.05	5.00
88	INT282635	Positive_regulation of Binding of ADHD1	4	0.40	3.62	0.24	5.00
89	INT242922	Positive_regulation of Gene_expression of amd	2	0.43	5.99	0.1	5.00
90	INT189864	Positive_regulation of Positive_regulation of ADHD1	3	0.44	3.43	0.07	5.00
91	INT133103	Negative_regulation of Localization of COL1A2	2	0.04	1.49	0.03	5.00