D:Giant Cell Arteritis

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pChart

Disease Term
Synonyms Aortic Arteritis Giant Cell, AORTITIDES GIANT CELL, Aortitis Giant Cell, ARTERITIDES CRANIAL, Arteritides Giant Cell, Arteritides Juvenile Temporal, Arteritides Temporal, ARTERITIS CRANIAL, ARTERITIS GIANT CELL, Arteritis Giant Cell Horton, Arteritis Giant Cell Horton S
Documents 341
Hot Single Events 37
Hot Interactions 7

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Giant Cell Arteritis. They are ordered first by their relevance to Giant Cell Arteritis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171942 Binding of HLA-DRB1 and ATP2C1 1 0.04 2.18 0.12 100.00
2 INT149541 Binding of GCA and TADA1 1 0.40 1.4 0.13 100.00
3 INT171940 Binding of TNF and ATP2C1 1 0.08 7.32 0.39 99.90
4 INT171945 PECAM1 Positive_regulation of Gene_expression of ICAM1 1 0.06 1.66 0.16 99.60
5 INT171944 ICAM1 Positive_regulation of Gene_expression of PECAM1 1 0.06 1.66 0.16 99.60
6 INT171938 Binding of HLA-DOA and ATP2C1 1 0.01 3.88 0.2 98.44
7 INT171939 Binding of HLA-DOA and TNF 1 0.05 6.8 0.26 94.08

Single Events

The table below shows the top 200 pain related interactions that have been reported for Giant Cell Arteritis. They are ordered first by their pain relevance and then by number of times they were reported in Giant Cell Arteritis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171955 Localization of ATP2C1 1 0.12 4.02 0.22 100.00
2 INT152763 Binding of ATP2C1 2 0.32 4.11 0.61 100.00
3 INT149542 Binding of GCA 1 0.47 1.4 0.13 100.00
4 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 99.82
5 INT149543 Binding of TADA1 1 0.37 1.4 0.13 99.80
6 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 99.78
7 INT63339 Transcription of ICAM1 6 0.69 3.92 1.37 99.64
8 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 99.60
9 INT15229 Positive_regulation of CNDP1 21 0.69 15.86 4.06 99.52
10 INT56448 Regulation of ICAM1 52 0.60 55.1 10.96 99.44
11 INT3957 Gene_expression of CNDP1 6 0.52 3.7 0.96 99.26
12 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 98.80
13 INT80549 Binding of ICAM1 53 0.47 42.76 9.72 98.58
14 INT6481 Binding of TNF 624 0.48 510.2 214.82 98.52
15 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 98.12
16 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 98.12
17 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 97.56
18 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 97.56
19 INT171951 Localization of CADM1 1 0.11 1.45 0.05 97.16
20 INT78901 Localization of CCL5 67 0.78 40.79 20.59 96.44
21 INT78895 Regulation of CCL5 30 0.46 20.45 10.18 96.32
22 INT37296 Binding of Esr1 117 0.43 62.51 27.33 95.28
23 INT6852 Localization of TNF 883 0.81 705.95 270.84 94.82
24 INT86128 Negative_regulation of ATP2C1 1 0.09 1.65 0.31 93.28
25 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 92.48
26 INT93717 Gene_expression of Mmp3 85 0.78 33.95 24.89 91.24
27 INT91758 Binding of CCR5 28 0.45 20.16 7.07 89.36
28 INT171946 Positive_regulation of Binding of CCR5 1 0.47 3.86 0.66 89.36
29 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 88.20
30 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 87.92
31 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 87.60
32 INT8798 Positive_regulation of Csrp1 61 0.69 63.86 14.14 87.16
33 INT117080 Localization of Csrp1 6 0.42 7.23 3.09 87.16
34 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 86.88
35 INT2038 Localization of Esr1 104 0.79 40.12 13.27 86.84
36 INT93350 Binding of Lepr 17 0.05 27.21 1.5 83.96
37 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 81.28
38 INT52740 Binding of ACLS 5 0.31 3 0.54 77.16
39 INT28784 Positive_regulation of Gene_expression of CNDP1 3 0.22 3.87 1 75.00
40 INT28783 Positive_regulation of Gc 13 0.52 7.89 1.76 75.00
41 INT107514 Positive_regulation of Akr1b1 6 0.70 7.64 3.21 74.88
42 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 71.36
43 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 71.36
44 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 70.80
45 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 62.64
46 INT51014 Transcription of IL2 42 0.71 21.56 12.7 57.68
47 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 55.04
48 INT6474 Positive_regulation of Gene_expression of IL1RN 34 0.69 21.87 10.99 55.04
49 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 54.80
50 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 54.40
51 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59 50.08
52 INT52625 Regulation of IL1RN 30 0.61 19.12 11.31 50.00
53 INT73902 Regulation of Gene_expression of IL1RN 6 0.61 4.59 6.14 50.00
54 INT171953 Regulation of ATP2C1 1 0.07 2.21 0.38 50.00
55 INT242921 Positive_regulation of Aoc2-ps1 1 0.12 1.82 0.04 47.20
56 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 36.92
57 INT118615 Negative_regulation of IL4 20 0.41 13.79 3.49 36.92
58 INT171021 Negative_regulation of IL5 18 0.41 14.74 3.39 36.92
59 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 26.12
60 INT62041 Negative_regulation of Gene_expression of IGHE 37 0.58 37.86 5.27 26.12
61 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 25.40
62 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 25.40
63 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 8.92
64 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 8.92
65 INT61628 Negative_regulation of Gene_expression of IL4 31 0.55 20.96 8.18 8.92
66 INT69160 Positive_regulation of IL5 41 0.65 36.04 7.75 8.92
67 INT73499 Positive_regulation of IL13 23 0.39 20.03 6.53 8.92
68 INT194380 Negative_regulation of Gene_expression of IL5 22 0.42 15.78 4.1 8.92
69 INT178572 Negative_regulation of Gene_expression of IL13 9 0.14 4.51 1.94 8.92
70 INT100694 Negative_regulation of Positive_regulation of IL4 5 0.34 3.27 1.58 8.92
71 INT226492 Negative_regulation of IL13 11 0.28 7.17 2.04 7.92
72 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
73 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
74 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
75 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
76 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
77 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 5.00
78 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 5.00
79 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 5.00
80 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
81 INT16997 Binding of PRTN3 34 0.48 33.44 6.45 5.00
82 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
83 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 5.00
84 INT17511 Negative_regulation of PRTN3 19 0.41 12 3.3 5.00
85 INT61684 Localization of COL1A2 20 0.73 9.31 2.26 5.00
86 INT20633 Positive_regulation of Gene_expression of LDHA 15 0.49 15.94 1.42 5.00
87 INT228770 Gene_expression of amd 16 0.57 21.49 1.05 5.00
88 INT282635 Positive_regulation of Binding of ADHD1 4 0.40 3.62 0.24 5.00
89 INT242922 Positive_regulation of Gene_expression of amd 2 0.43 5.99 0.1 5.00
90 INT189864 Positive_regulation of Positive_regulation of ADHD1 3 0.44 3.43 0.07 5.00
91 INT133103 Negative_regulation of Localization of COL1A2 2 0.04 1.49 0.03 5.00
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