D:Giant Cell Tumors

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Disease Term
Synonyms Cell Tumor Giant, Cell Tumors Giant, Giant Cell Tumor, Tumor Giant Cell, Tumors Giant Cell
Documents 199
Hot Single Events 45
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Giant Cell Tumors. They are ordered first by their relevance to Giant Cell Tumors and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT205057 MMP3 Negative_regulation of MMP2 1 0.35 3.02 0.2 78.32
2 INT205051 MMP3 Negative_regulation of TIMP1 1 0.36 3.02 0.2 78.32
3 INT205055 MMP3 Negative_regulation of COL1A2 1 0.32 1.52 0.1 78.32
4 INT324053 Binding of Banf1 and Lemd3 1 0.20 0.15 0 29.20
5 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0 9.52
6 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53 5.00
7 INT251297 Binding of C2 and CD4 1 0.04 0.35 0.47 5.00
8 INT251294 Binding of HR and MIR1249 1 0.00 0 0.15 5.00
9 INT251295 Binding of CD4 and Regulation of ITIH4 1 0.11 0.24 0.11 5.00
10 INT251292 Binding of ITIH4 and ERVW-1 1 0.22 0.07 0.08 5.00
11 INT251293 Regulation of Binding of ITIH4 and ERVW-1 1 0.27 0.07 0.08 5.00
12 INT241751 Negative_regulation of Binding of CD4 and ITIH4 3 0.18 1.07 0.04 5.00
13 INT251296 Binding of CCR5 and ITIH4 1 0.16 0.08 0.04 5.00
14 INT205046 MUC13 Negative_regulation of Localization of COL17A1 1 0.31 0.62 0 5.00
15 INT205048 MUC13 Negative_regulation of Localization of SLPI 1 0.06 0.61 0 5.00
16 INT205059 MUC13 Negative_regulation of Localization of ROPN1L 1 0.34 0.62 0 5.00
17 INT205047 MUC13 Negative_regulation of SLPI 1 0.06 0.61 0 5.00
18 INT205049 LGALS4 Negative_regulation of Localization of MUC13 1 0.34 0.61 0 5.00
19 INT205050 LGALS4 Negative_regulation of Localization of ROPN1L 1 0.36 0.62 0 5.00
20 INT205058 LGALS4 Negative_regulation of Localization of SLPI 1 0.06 0.61 0 5.00
21 INT205045 LGALS4 Negative_regulation of SLPI 1 0.06 0.61 0 5.00
22 INT205056 LGALS4 Negative_regulation of Localization of COL17A1 1 0.32 0.62 0 5.00
23 INT205053 MUC13 Negative_regulation of Localization of LGALS4 1 0.34 0.61 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Giant Cell Tumors. They are ordered first by their pain relevance and then by number of times they were reported in Giant Cell Tumors. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 99.84
2 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 99.84
3 INT143952 Regulation of Gene_expression of MMP9 14 0.53 10.16 2.73 99.84
4 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73 99.84
5 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 99.52
6 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 99.48
7 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 99.48
8 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 99.48
9 INT288060 Localization of Csf1 2 0.80 10.91 0.31 99.44
10 INT46621 Positive_regulation of Gene_expression of CSF1 17 0.47 10.53 3.59 99.34
11 INT263702 Binding of Csf1 2 0.36 1.3 0 99.28
12 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 99.16
13 INT178754 Positive_regulation of Localization of GOPC 32 0.43 10.1 4.73 99.16
14 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 98.90
15 INT187022 Positive_regulation of Transcription of MMP9 3 0.45 3.27 0.34 98.40
16 INT15610 Localization of GOPC 223 0.65 68.26 28.7 98.36
17 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 98.16
18 INT99608 Transcription of MMP9 18 0.65 9.67 4.11 97.98
19 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 97.56
20 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17 96.60
21 INT187793 Gene_expression of Csf1 10 0.77 22.35 0.66 96.44
22 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 96.40
23 INT5844 Positive_regulation of Gene_expression of Vim 14 0.25 9.64 2.18 96.40
24 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 95.40
25 INT338112 Positive_regulation of Gene_expression of Csf1 1 0.69 4.94 0.04 94.96
26 INT62496 Binding of CSF1 6 0.36 4.55 1.14 94.96
27 INT80025 Positive_regulation of MIB1 5 0.40 5.41 0.64 94.48
28 INT79358 Gene_expression of ERVW-1 65 0.75 29.9 1.31 94.28
29 INT251306 Gene_expression of SGPL1 1 0.16 2.34 0.31 94.28
30 INT83295 Positive_regulation of Cd68 21 0.39 14.55 2.46 94.24
31 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 91.56
32 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 91.56
33 INT107388 Positive_regulation of Positive_regulation of Cd68 1 0.39 0.69 0.08 90.08
34 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 89.36
35 INT107387 Positive_regulation of Positive_regulation of Vim 1 0.25 0.69 0.08 89.36
36 INT52937 Gene_expression of Cd68 37 0.67 31.33 7.54 89.20
37 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 89.04
38 INT324044 Negative_regulation of Lemd3 1 0.43 2.86 0 88.60
39 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 85.84
40 INT2848 Localization of ABCA1 23 0.70 10.64 4.73 85.12
41 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75 83.84
42 INT338113 Negative_regulation of Csf1r 1 0.38 2.03 0 82.88
43 INT77925 Negative_regulation of TEP1 21 0.53 15.23 2.62 81.20
44 INT88070 Binding of Ema 7 0.18 7.39 0.31 81.20
45 INT127724 Localization of CSF1 12 0.73 9.35 1.56 80.08
46 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 77.84
47 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 76.24
48 INT53482 Gene_expression of ITIH4 75 0.77 58.87 26.05 75.72
49 INT338111 Regulation of Csf1 1 0.27 1.7 0.03 75.00
50 INT17049 Localization of CD4 57 0.75 35.33 6.89 73.12
51 INT176594 Gene_expression of SRA1 20 0.35 9.65 1.15 73.12
52 INT265794 Regulation of SRA1 3 0.23 3.05 0.35 73.12
53 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 72.16
54 INT336960 Localization of SPN 1 0.49 0.91 0.04 71.52
55 INT14301 Binding of CSF2 82 0.48 67.95 8.98 70.28
56 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 69.44
57 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 68.16
58 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 67.28
59 INT223534 Positive_regulation of Gene_expression of ERVW-1 4 0.67 1.29 0.05 66.60
60 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 58.40
61 INT103674 Positive_regulation of Gene_expression of CXCR4 32 0.69 37.1 3.08 58.40
62 INT193815 Regulation of Gene_expression of CXCR4 17 0.61 20.27 1.15 58.40
63 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 57.60
64 INT174486 Regulation of Gene_expression of CD4 12 0.36 6.09 1.39 57.60
65 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 51.80
66 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12 49.64
67 INT324047 Binding of Lemd3 1 0.48 3.18 0 44.00
68 INT136720 Gene_expression of PRSS2 6 0.50 4.99 1.43 43.28
69 INT36554 Gene_expression of PRSS1 70 0.78 50.25 15.33 42.72
70 INT36947 Gene_expression of PNLIP 13 0.45 11.04 1.23 41.04
71 INT172806 Localization of ISL1 4 0.26 2.64 0.29 40.60
72 INT69727 Gene_expression of QPCT 18 0.65 5.45 3.05 40.04
73 INT133081 Positive_regulation of Gene_expression of QPCT 1 0.49 1.43 0.26 40.04
74 INT205082 Gene_expression of CPA2 1 0.65 1.1 0.07 39.44
75 INT242264 Binding of ACAT1 3 0.12 1.05 0.06 37.36
76 INT48803 Gene_expression of CELA3B 9 0.22 7.24 2.06 37.28
77 INT205095 Gene_expression of CELA3A 1 0.62 2.58 0.06 36.72
78 INT2464 Gene_expression of AMY2A 21 0.75 13.76 2.78 35.28
79 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 32.72
80 INT324052 Binding of Banf1 1 0.18 0.48 0 27.44
81 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 26.96
82 INT43160 Gene_expression of EOS 3 0.65 5.03 0.81 23.04
83 INT180497 Binding of MRI1 45 0.42 28.35 14.77 22.80
84 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 22.08
85 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 11.60
86 INT214574 Positive_regulation of SDC1 4 0.32 3.24 1.28 10.80
87 INT185284 Binding of CDK4 7 0.25 4.79 0.07 9.52
88 INT113346 Binding of MDM2 10 0.35 5.73 0.15 8.40
89 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
90 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
91 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
92 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
93 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
94 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
95 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 5.00
96 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
97 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
98 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
99 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
100 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 5.00
101 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
102 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
103 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
104 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
105 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
106 INT4977 Binding of ITIH4 60 0.46 42.48 15.65 5.00
107 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15 5.00
108 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
109 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 5.00
110 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
111 INT46695 Positive_regulation of TNC 28 0.67 17.06 12.04 5.00
112 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
113 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
114 INT16404 Regulation of CD4 54 0.61 33.05 10.29 5.00
115 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 5.00
116 INT64849 Gene_expression of Ret 24 0.75 14.36 9.1 5.00
117 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 5.00
118 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
119 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59 5.00
120 INT167052 Gene_expression of Cr2 43 0.56 25.7 7.76 5.00
121 INT91758 Binding of CCR5 28 0.45 20.16 7.07 5.00
122 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 5.00
123 INT107315 Negative_regulation of CCR5 22 0.57 13.82 6.11 5.00
124 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96 5.00
125 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
126 INT84057 Positive_regulation of Gene_expression of ITIH4 12 0.50 10.5 4.92 5.00
127 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 5.00
128 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49 5.00
129 INT88390 Gene_expression of LGALS4 27 0.69 12.28 4.15 5.00
130 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 5.00
131 INT15375 Gene_expression of AXL 21 0.65 18.5 3.74 5.00
132 INT149332 Gene_expression of CD163 19 0.75 13.63 3.65 5.00
133 INT18670 Negative_regulation of ABCA1 16 0.54 5.8 3.39 5.00
134 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 5.00
135 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 5.00
136 INT8103 Binding of TP53 46 0.44 40.2 2.96 5.00
137 INT110233 Regulation of Gene_expression of CCR5 6 0.34 7.14 2.76 5.00
138 INT27935 Binding of Vim 21 0.36 15.65 2.61 5.00
139 INT205081 Positive_regulation of Gene_expression of AXL 10 0.58 11.27 2.37 5.00
140 INT55952 Transcription of TP53 16 0.61 12.14 2.36 5.00
141 INT70297 Gene_expression of NEFH 12 0.75 4.85 2.33 5.00
142 INT113775 Negative_regulation of Gene_expression of CCR5 6 0.43 3.97 2.28 5.00
143 INT100620 Localization of VIM 8 0.76 5.47 2.16 5.00
144 INT205096 Localization of LGALS4 2 0.71 6.06 2.05 5.00
145 INT64787 Regulation of ITIH4 7 0.38 5.61 1.82 5.00
146 INT47889 Binding of MMP2 9 0.41 6.37 1.68 5.00
147 INT74392 Binding of LGALS4 4 0.43 7.23 1.65 5.00
148 INT102428 Binding of C2 17 0.32 5.12 1.58 5.00
149 INT102044 Regulation of ERVW-1 10 0.44 4.76 1.45 5.00
150 INT76477 Positive_regulation of CD99 14 0.50 14.77 1.42 5.00
151 INT11802 Gene_expression of KLF1 11 0.65 6.81 1.41 5.00
152 INT79357 Binding of ERVW-1 32 0.43 16.06 1.35 5.00
153 INT44746 Localization of Ret 3 0.48 1.23 1.28 5.00
154 INT63905 Regulation of RB1 13 0.62 12.67 1.28 5.00
155 INT66852 Gene_expression of Fcer2 15 0.14 9.74 1.27 5.00
156 INT241757 Localization of CCR5 6 0.71 5.7 1.14 5.00
157 INT8772 Positive_regulation of Gene_expression of HBG1 16 0.68 6.93 0.95 5.00
158 INT14866 Positive_regulation of SGPL1 3 0.60 0.55 0.91 5.00
159 INT167381 Localization of DES 4 0.73 4.15 0.77 5.00
160 INT36200 Gene_expression of S100A1 9 0.77 9.56 0.75 5.00
161 INT251303 Binding of HR 14 0.47 3.87 0.7 5.00
162 INT88317 Negative_regulation of Binding of ITIH4 6 0.36 4.46 0.69 5.00
163 INT202428 Positive_regulation of Binding of CD4 4 0.37 2.11 0.68 5.00
164 INT160961 Gene_expression of Fth1 4 0.28 3.89 0.63 5.00
165 INT76315 Gene_expression of Myog 15 0.41 6.79 0.6 5.00
166 INT140984 Regulation of Ihh 5 0.54 2.81 0.56 5.00
167 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 5.00
168 INT20924 Binding of SERPINA3 4 0.42 2.41 0.44 5.00
169 INT61102 Gene_expression of MEN1 12 0.78 17.7 0.43 5.00
170 INT194993 Binding of RB1 15 0.37 10.96 0.4 5.00
171 INT251304 Binding of MIR1249 1 0.01 0.25 0.37 5.00
172 INT233007 Negative_regulation of VIM 6 0.41 3.46 0.36 5.00
173 INT140336 Negative_regulation of Csf1 3 0.43 3.64 0.36 5.00
174 INT65673 Positive_regulation of DSE 4 0.41 2.86 0.33 5.00
175 INT164192 Localization of SLPI 4 0.73 1.51 0.32 5.00
176 INT205806 Positive_regulation of ERVW-1 16 0.49 6.43 0.31 5.00
177 INT75504 Gene_expression of CDK4 9 0.72 7.43 0.3 5.00
178 INT25465 Positive_regulation of ISL1 6 0.15 3.59 0.26 5.00
179 INT208157 Localization of LOC148709 2 0.73 0.52 0.2 5.00
180 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19 5.00
181 INT187950 Binding of RNU105A 7 0.47 3.31 0.18 5.00
182 INT49195 Binding of CSF3R 6 0.34 4.23 0.15 5.00
183 INT193017 Binding of SGPL1 2 0.11 0.23 0.14 5.00
184 INT205083 Positive_regulation of JUP 6 0.49 5.51 0.13 5.00
185 INT203282 Negative_regulation of Binding of CD4 2 0.30 0.63 0.11 5.00
186 INT210322 Gene_expression of HR 6 0.54 0.05 0.1 5.00
187 INT324046 Gene_expression of Lemd3 1 0.67 1.69 0.1 5.00
188 INT251302 Positive_regulation of Binding of HR 1 0.00 0 0.1 5.00
189 INT187951 Gene_expression of RNU105A 13 0.63 8.06 0.1 5.00
190 INT251307 Regulation of Binding of HR 1 0.00 0 0.07 5.00
191 INT14688 Gene_expression of CSF3R 7 0.46 3.93 0.06 5.00
192 INT301355 Binding of Ext1 2 0.37 4.07 0.03 5.00
193 INT205100 Gene_expression of MAFB 1 0.37 1.13 0.03 5.00
194 INT205098 Positive_regulation of Gene_expression of MAFB 1 0.33 1.13 0.03 5.00
195 INT205099 Positive_regulation of Gene_expression of AXIN2 1 0.48 3.48 0 5.00
196 INT194991 Positive_regulation of Regulation of FHIT 1 0.40 1.67 0 5.00
197 INT173697 Localization of HR 3 0.68 0.38 0 5.00
198 INT205074 Binding of MUC13 1 0.30 0.62 0 5.00
199 INT205084 Localization of MUC13 1 0.61 0.61 0 5.00
200 INT205090 Localization of COL17A1 1 0.57 0.61 0 5.00
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